Patellofemoral Pain SyndromePPSNCT07642011
Relationship Between Knee Pain And Proprioception During Single Leg Squat In Patellofemoral Pain Syndrome
An observational study of Patellofemoral Pain Syndrome, run by Cairo University.
Trial summary
This study will be conducted to investigate the relationship between knee joint pain intensity and joint position sense accuracy in patients with patellofemoral pain syndrome (PFPS) in a single-leg squat position. Read more about this study
- Who is it for?
- Ages 18 to 35 years
- Conditions the study is for
- Patellofemoral Pain Syndrome
- What is being tested?
- patellofemoral pain syndrome patients
- How many people
- 82 participants
- Where
- No sites listed yet
- Study dates
- 1 Jul 2026to 20 Nov 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- No healthy volunteers
- Adult
Study population: eighty two patellofemoral pain syndrome had Positive eccentric step test,Anterior or retropatellar knee pain present during at least two of the following - ascending/descending stairs, hopping/running, squatting, kneeling and prolonged sitting and Pain on palpation of patellar facets. their ages between 18-35 years old.
Who may be able to join
- Age ranges from 18-35 years
- BMI ranges from 18-25 kg/m2
- Positive eccentric step test
- Anterior or retropatellar knee pain present during at least two of the following - ascending/descending stairs, hopping/running, squatting, kneeling and prolonged sitting
- Pain on palpation of patellar facets
- Insidious onset of symptoms vague and non-localized pain at anterior of knee for at least three months ( unrelated to a traumatic incident.
Who cannot join
- Knee pain is more than 6 score on ANPRS.
- History of traumatic patellar dislocation or subluxation
- Osteoarthritis in the knee, ankle or hip joints, injury of cruciate ligaments or menisci
- Previous orthopedic disorders or neurologic deficit of the lower limbs, any sensory problems, leg length discrepancy, neuromuscular disease like multiple sclerosis
- Athletic patients.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
This study will be conducted to investigate the relationship between knee joint pain intensity and joint position sense accuracy in patients with patellofemoral pain syndrome (PFPS) in a single-leg squat position.
Read the detailed description
Patellofemoral pain syndrome (PFPS) is one of the most prevalent knee problems that interfere with everyday activities and function. The prevalence of Patellofemoral pain syndrome varies, affecting between 22% and 40% of the general population and up to 70% in athletes engaged in running and jumping sports, with a higher incidence reported among females and individuals aged 15-30 years.Impaired proprioception and balance are recognized as intrinsic components in the etiology of PFPS, and research shows that PFPS patients have severe abnormalities in these domains when compared to healthy controls, particularly when performing dynamic tasks. The impaired balance and proprioception are hypothesized to result from altered neuromuscular control, decreased muscle strength, or changes in sensory feedback, which are crucial for maintaining stability and control over movements.The correlation between proprioceptive deficits and PFPS highlights the significance of including balance and proprioception-focused interventions in the PFPS treatment plan, as these can greatly enhance pain, function, and quality of life for those who are impacted. Addressing these deficits may not only improve symptoms associated with PFPS but also reduce the risk of further injury and enhance overall knee function.
To the best of the authors' knowledge, no previous study has specifically correlated knee JPS in a WB position (single-leg squat position) with PFPS. Thus, findings of this study might enhance the evidence-based clinical decisions made by the physical therapists regarding the management of PFPS, justifying for the patients the value of integrating proprioceptive and motor control training alongside traditional strengthening programs to improve functional outcomes. By addressing the neuromuscular factors linked to pain, rehabilitation strategies can become more precise and function-oriented, ultimately improving quality of life and physical performance.
- Conditions
- Patellofemoral Pain Syndrome
- Being tested
- patellofemoral pain syndrome patients
- Keywords
- Knee Pain, Proprioception, Single Leg Squat, Patellofemoral Pain Syndrome
- Medical subject headings
- Patellofemoral Pain Syndrome
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
patellofemoral pain syndrome patientsOther
eighty two patellofemoral pain syndrome had Positive eccentric step test,Anterior or retropatellar knee pain present during at least two of the following - ascending/descending stairs, hopping/running, squatting, kneeling and prolonged sitting and Pain on palpation of patellar facets. their ages between 18-35 years old.
| Study group | Role | What they receive |
|---|---|---|
| patellofemoral pain syndrome patients | Eighty-two patellofemoral pain syndrome patients will be included in this group. their ages range from 18 to 35 years old, with body mass index 18-25 kg/cm2 Receives: Other: patellofemoral pain syndrome patients |
What is being measured
The primary outcome is the main question the study is designed to answer.
pain intensity
nemerial pain rating scale will be used to assess pain intensity. It comprises of 11 point ''horizontal scale'' of 0-10 in Arabic numerals anchored by the two ends, the left (0 indicating no pain at all) and right (10 indicating the worst ).
Measured: up to one day
knee disability
The Arabic version of the Kujala patellofemoral pain scoring system is a questionnaire to assess the patient with PFP. It includes 13 points based on the following factors: presence of a limp, need for support, walking ability, stair climbing, squatting, running, jumping, prolonged sitting with knees flexed, pain, swelling, abnormal painful kneecap movement, atrophy of the thigh, and flexion deficiency. Each question has multiple answers with points reflecting the severity of symptoms and level of functional limitation. Each question is assigned a score of either up to 5 or 10, and the total score for the Kujala questionnaire is 100. The higher the score, the better the function
Measured: up to one day
knee joint position error (knee joint proprioception)
Digital-goniometer will be used to assess joint position error.the digital-goniometer will be attached to the knee joint in the neutral knee position. The fixed arm will be placed in parallel to an imaginary line between the head of the fibula and the lateral malleolus. The movable arm will be placed in parallel to an imaginary line between the greater trochanter and the lateral condyle of the femur. The digital-goniometer will be zeroed when the subject is standing motionless in the anatomic position. To prevent slippage during knee joint motion, the end blocks will be adhered to the tested leg with double-sided adhesive tape and further secured in place with adhesive tape. Digital-goniometer readings records knee joint angular displacements relative to zero
Measured: up to one day
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Jun 2026
- Study start1 Jul 2026 (estimated)
- Primary completion20 Nov 2026 (estimated)
- Study completion20 Nov 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Patellofemoral Pain SyndromeStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Cross-sectional
- Enrolment
- 82 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Esraa Adel El-sayed Bastawi, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07642011
- Sponsor's protocol ID
- P.T.REC/012/006507
- Acronym
- PPS
- Status last verified
- Jun 2026
- First submitted
- 6 Jun 2026
- Last updated
- 11 Jun 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 11 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Relationship Between Knee Pain And Proprioception During Single Leg Squat In Patellofemoral Pain Syndrome
- ClinicalTrials.gov ID
- NCT07642011
- Acronym / sponsor ID
- PPS / P.T.REC/012/006507
- Conditions
- Patellofemoral Pain Syndrome
- Keywords
- Knee Pain, Proprioception, Single Leg Squat, Patellofemoral Pain Syndrome
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 82 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 1 Jul 2026 (estimated)
- Primary completion
- 20 Nov 2026 (estimated)
- Study completion
- 20 Nov 2026 (estimated)
- First posted
- 11 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study will be conducted to investigate the relationship between knee joint pain intensity and joint position sense accuracy in patients with patellofemoral pain syndrome (PFPS) in a single-leg squat position.
Detailed description
Patellofemoral pain syndrome (PFPS) is one of the most prevalent knee problems that interfere with everyday activities and function. The prevalence of Patellofemoral pain syndrome varies, affecting between 22% and 40% of the general population and up to 70% in athletes engaged in running and jumping sports, with a higher incidence reported among females and individuals aged 15-30 years.Impaired proprioception and balance are recognized as intrinsic components in the etiology of PFPS, and research shows that PFPS patients have severe abnormalities in these domains when compared to healthy controls, particularly when performing dynamic tasks. The impaired balance and proprioception are hypothesized to result from altered neuromuscular control, decreased muscle strength, or changes in sensory feedback, which are crucial for maintaining stability and control over movements.The correlation between proprioceptive deficits and PFPS highlights the significance of including balance and proprioception-focused interventions in the PFPS treatment plan, as these can greatly enhance pain, function, and quality of life for those who are impacted. Addressing these deficits may not only improve symptoms associated with PFPS but also reduce the risk of further injury and enhance overall knee function.
To the best of the authors' knowledge, no previous study has specifically correlated knee JPS in a WB position (single-leg squat position) with PFPS. Thus, findings of this study might enhance the evidence-based clinical decisions made by the physical therapists regarding the management of PFPS, justifying for the patients the value of integrating proprioceptive and motor control training alongside traditional strengthening programs to improve functional outcomes. By addressing the neuromuscular factors linked to pain, rehabilitation strategies can become more precise and function-oriented, ultimately improving quality of life and physical performance.
Study design
- Observational model
- Other
- Time perspective
- Cross-sectional
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| patellofemoral pain syndrome patients | – | Other: patellofemoral pain syndrome patientsEighty-two patellofemoral pain syndrome patients will be included in this group. their ages range from 18 to 35 years old, with body mass index 18-25 kg/cm2 |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
- Study population
- eighty two patellofemoral pain syndrome had Positive eccentric step test,Anterior or retropatellar knee pain present during at least two of the following - ascending/descending stairs, hopping/running, squatting, kneeling and prolonged sitting and Pain on palpation of patellar facets. their ages between 18-35 years old.
Key inclusion criteria (6 listed)
- Age ranges from 18-35 years
- BMI ranges from 18-25 kg/m2
- Positive eccentric step test
- Anterior or retropatellar knee pain present during at least two of the following - ascending/descending stairs, hopping/running, squatting, kneeling and prolonged sitting
- Pain on palpation of patellar facets
Key exclusion criteria (5 listed)
- Knee pain is more than 6 score on ANPRS.
- History of traumatic patellar dislocation or subluxation
- Osteoarthritis in the knee, ankle or hip joints, injury of cruciate ligaments or menisci
- Previous orthopedic disorders or neurologic deficit of the lower limbs, any sensory problems, leg length discrepancy, neuromuscular disease like multiple sclerosis
- Athletic patients.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| patellofemoral pain syndrome patientseighty two patellofemoral pain syndrome had Positive eccentric step test,Anterior or retropatellar knee pain present during at least two of the following - ascending/descending stairs, hopping/running, squatting, kneeling and prolonged sitting and Pain on palpation of patellar facets. their ages between 18-35 years old. | Other | patellofemoral pain syndrome patients |
Primary outcome
pain intensity
Time frame: up to one day
nemerial pain rating scale will be used to assess pain intensity. It comprises of 11 point ''horizontal scale'' of 0-10 in Arabic numerals anchored by the two ends, the left (0 indicating no pain at all) and right (10 indicating the worst ).
knee disability
Time frame: up to one day
The Arabic version of the Kujala patellofemoral pain scoring system is a questionnaire to assess the patient with PFP. It includes 13 points based on the following factors: presence of a limp, need for support, walking ability, stair climbing, squatting, running, jumping, prolonged sitting with knees flexed, pain, swelling, abnormal painful kneecap movement, atrophy of the thigh, and flexion deficiency. Each question has multiple answers with points reflecting the severity of symptoms and level of functional limitation. Each question is assigned a score of either up to 5 or 10, and the total score for the Kujala questionnaire is 100. The higher the score, the better the function
knee joint position error (knee joint proprioception)
Time frame: up to one day
Digital-goniometer will be used to assess joint position error.the digital-goniometer will be attached to the knee joint in the neutral knee position. The fixed arm will be placed in parallel to an imaginary line between the head of the fibula and the lateral malleolus. The movable arm will be placed in parallel to an imaginary line between the greater trochanter and the lateral condyle of the femur. The digital-goniometer will be zeroed when the subject is standing motionless in the anatomic position. To prevent slippage during knee joint motion, the end blocks will be adhered to the tested leg with double-sided adhesive tape and further secured in place with adhesive tape. Digital-goniometer readings records knee joint angular displacements relative to zero
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Jun 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
An observational study of Patellofemoral Pain Syndrome, run by Cairo University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 11 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact esraa el-sayed, master (01158527892, esraabastawi@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
pain intensity (time frame: up to one day). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Jun 2026.