Rhomboid Intercostal Sub-serratus Plane BlockNCT07642193
Rhomboid Intercostal Sub-serratus Plane Block Versus External Oblique Intercostal Block in Open Nephrectomy
A study testing Rhomboid intercostal subserratus plane block, External oblique intercostal block and Intravenous morphine in people with Rhomboid Intercostal Sub-serratus Plane Block and External Oblique Intercostal Block, run by Cairo University at 1 site in Egypt.
Trial summary
This study aims to compare time of first request of analgesia among patients undergoing rhomboid intercostal sub-serratus plane block versus external oblique intercostal block for perioperative pain management in open nephrectomy. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Rhomboid Intercostal Sub-serratus Plane Block, External Oblique Intercostal Block, Open Nephrectomy
- What is being tested?
- Rhomboid intercostal subserratus plane block, External oblique intercostal block and Intravenous morphine
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 90 participants
- Where
- 1 siteEgypt
- Study dates
- 2 May 2026to 30 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Both sexes.
- American Society of Anesthesiologists (ASA) physical status II, III.
- Body mass index (BMI): > 20 kg/ m2 and < 35 kg/ m2.
- Patients undergoing open nephrectomy.
Who cannot join
- Patient refusal.
- BMI <20 kg/m2 and >35 kg/m2
- Known sensitivity or contraindication to drug used in the study (local anesthetics, opioids).
- History of psychiatric and cognitive disorders or chronic pain.
- Contraindication to regional anesthesia e.g pre- existing peripheral neuropathies.
- Severe respiratory or cardiac disorders.
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- Advanced liver or kidney disease.
- Pregnancy.
- Physical status ASA IV.
- Coagulopathy with INR ≥ 1.6: hereditary (e.g. hemophilia, fibrinogen abnormalities \& deficiency of factor II) - acquired (e.g. impaired liver functions with prothrombin concentration less than 60 %, vitamin K deficiency \& therapeutic anticoagulants drugs).
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site, 1 recruiting
- Recruiting
Cairo University
Cairo, 12613
Amr R Seif, MD, 00201066588692, amroseifo40404@gmail.com
About this study
Official title: Ultrasound Guided Rhomboid Intercostal Sub-serratus Plane Block Versus External Oblique Intercostal Block in Open Nephrectomy: Randomized Controlled Study
This study aims to compare time of first request of analgesia among patients undergoing rhomboid intercostal sub-serratus plane block versus external oblique intercostal block for perioperative pain management in open nephrectomy.
Read the detailed description
Open nephrectomy is a common surgery usually performed for malignant and non-malignant renal pathologies. Open nephrectomy incision is associated with a high incidence of intense immediate postoperative pain and chronic pain the months following surgery.
The rhomboid intercostal block has previously been used for pain management in thoracic wall surgery.
Subserratus plane block in the treatment of post-abdominal surgical pain and the combination of the two blocks was subsequently renamed the "RISS block". The nerves targeted by the RISS block include the lateral cutaneous branches of the ventral branches of the thoracic intercostal nerves, located between the rhomboid muscle and the intercostal muscles, and deep into the scapula serratus anterior muscle. RISS block provides analgesia from T4 to T9 thoracic dermatomes and has been used in postoperative pain management for thoracic surgeries and upper abdominal surgeries.
- Conditions
- Rhomboid Intercostal Sub-serratus Plane Block, External Oblique Intercostal Block, Open Nephrectomy
- Being tested
- Rhomboid intercostal subserratus plane block, External oblique intercostal block, Intravenous morphine
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Rhomboid intercostal subserratus plane blockOther
Patients will receive the rhomboid intercostal subserratus plane block.
External oblique intercostal blockOther
Patients will receive the external oblique intercostal block.
Intravenous morphineDrug
Patients will not receive any interventions (Intravenous morphine 0.1mg/kg after induction of general anesthesia).
| Study group | Role | What they receive |
|---|---|---|
| Group (A) | Experimental | Patients will receive the rhomboid intercostal subserratus plane block. Receives: Other: Rhomboid intercostal subserratus plane block |
| Group (B) | Experimental | Patients will receive the external oblique intercostal block. Receives: Other: External oblique intercostal block |
| Control group | Active comparator | Patients will not receive any interventions (IV morphine 0.1mg/kg after induction of general anesthesia). Receives: Drug: Intravenous morphine |
What is being measured
The primary outcome is the main question the study is designed to answer.
Time of first request of analgesia
Time of first request of analgesia will be recorded from the end of surgery till first dose of morphine administrated.
Measured: 24 hours postoperatively
Secondary outcomes (6)
Heart rate
Heart rate will be noted immediately on arrival and at 0, 4, 8, 12, 18 and 24 h postoperatively.
Measured: 24 hours postoperatively
Mean arterial blood pressure
Mean arterial blood pressure will be noted immediately on arrival and at 0, 4, 8, 12, 18 and 24 h postoperatively.
Measured: 24 hours postoperatively
Total amount of fentanyl
Fentanyl 0.5 μg / kg will be given in case of heart rate or mean arterial blood pressure ≥ 20% of the baseline
Measured: 24 hours postoperatively
Total morphine consumption
Intravenous morphine (3 mg) will be provided as rescue of analgesia. The total amount of morphine given in 24 h will be recorded.
Measured: 24 hours postoperatively
Degree of pain
Each patient will be instructed about postoperative pain assessment with the numeric rating scale (NRS) score. NRS (0 represents "no pain" while 10 represents "the worst pain imaginable"). NRS will be recorded at 30 minutes, 2,4, 8, 12, 16, 24 hours postoperatively.
Measured: 24 hours postoperatively
Incidence of block related complications
Incidence of block related complications such as local anesthetic toxicity, hematoma formation, and pneumothorax will be recorded.
Measured: 24 hours postoperatively
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Jun 2026
- Study start2 May 2026
- Primary completion30 Dec 2026 (estimated)
- Study completion30 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Rhomboid Intercostal Sub-serratus Plane BlockStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 90 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Amr Raafat Mahmoud Seif, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07642193
- Sponsor's protocol ID
- AP2604-501-160-209
- Status last verified
- Jun 2026
- First submitted
- 7 Jun 2026
- Last updated
- 11 Jun 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
Study at a glance
From the registry record, last updated by the sponsor on 11 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Ultrasound Guided Rhomboid Intercostal Sub-serratus Plane Block Versus External Oblique Intercostal Block in Open Nephrectomy: Randomized Controlled Study
- ClinicalTrials.gov ID
- NCT07642193
- Acronym / sponsor ID
- AP2604-501-160-209
- Conditions
- Rhomboid Intercostal Sub-serratus Plane Block, External Oblique Intercostal Block, Open Nephrectomy
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 90 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 2 May 2026 (actual)
- Primary completion
- 30 Dec 2026 (estimated)
- Study completion
- 30 Dec 2026 (estimated)
- First posted
- 11 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to compare time of first request of analgesia among patients undergoing rhomboid intercostal sub-serratus plane block versus external oblique intercostal block for perioperative pain management in open nephrectomy.
Detailed description
Open nephrectomy is a common surgery usually performed for malignant and non-malignant renal pathologies. Open nephrectomy incision is associated with a high incidence of intense immediate postoperative pain and chronic pain the months following surgery.
The rhomboid intercostal block has previously been used for pain management in thoracic wall surgery.
Subserratus plane block in the treatment of post-abdominal surgical pain and the combination of the two blocks was subsequently renamed the "RISS block". The nerves targeted by the RISS block include the lateral cutaneous branches of the ventral branches of the thoracic intercostal nerves, located between the rhomboid muscle and the intercostal muscles, and deep into the scapula serratus anterior muscle. RISS block provides analgesia from T4 to T9 thoracic dermatomes and has been used in postoperative pain management for thoracic surgeries and upper abdominal surgeries.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Group (A) | Experimental | Other: Rhomboid intercostal subserratus plane blockPatients will receive the rhomboid intercostal subserratus plane block. |
| Group (B) | Experimental | Other: External oblique intercostal blockPatients will receive the external oblique intercostal block. |
| Control group | Active comparator | Drug: Intravenous morphinePatients will not receive any interventions (IV morphine 0.1mg/kg after induction of general anesthesia). |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Both sexes.
- American Society of Anesthesiologists (ASA) physical status II, III.
- Body mass index (BMI): > 20 kg/ m2 and < 35 kg/ m2.
- Patients undergoing open nephrectomy.
Key exclusion criteria (10 listed)
- Patient refusal.
- BMI <20 kg/m2 and >35 kg/m2
- Known sensitivity or contraindication to drug used in the study (local anesthetics, opioids).
- History of psychiatric and cognitive disorders or chronic pain.
- Contraindication to regional anesthesia e.g pre- existing peripheral neuropathies.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Rhomboid intercostal subserratus plane blockPatients will receive the rhomboid intercostal subserratus plane block. | Other | Group (A) |
| External oblique intercostal blockPatients will receive the external oblique intercostal block. | Other | Group (B) |
| Intravenous morphinePatients will not receive any interventions (Intravenous morphine 0.1mg/kg after induction of general anesthesia). | Drug | Control group |
Primary outcome
Time of first request of analgesia
Time frame: 24 hours postoperatively
Time of first request of analgesia will be recorded from the end of surgery till first dose of morphine administrated.
6 secondary outcomes
Heart rate
Time frame: 24 hours postoperatively
Mean arterial blood pressure
Time frame: 24 hours postoperatively
Total amount of fentanyl
Time frame: 24 hours postoperatively
Total morphine consumption
Time frame: 24 hours postoperatively
Degree of pain
Time frame: 24 hours postoperatively
Incidence of block related complications
Time frame: 24 hours postoperatively
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Jun 2026.
- Individual participant dataSharing planned: Yes. The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Rhomboid intercostal subserratus plane block, External oblique intercostal block and Intravenous morphine in people with Rhomboid Intercostal Sub-serratus Plane Block and External Oblique Intercostal Block, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 11 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Amr R Seif, MD (00201066588692, amroseifo40404@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Time of first request of analgesia (time frame: 24 hours postoperatively). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Jun 2026.