Temporomandibular Joint Disc Displacement, With ReductionNCT07643402
Clinical and Jaw Tracking Assessment Following Intra-articular Injection of PRP and HA in TMJ Disc Displacement With Reduction
A study testing Hyaluronic Acid (HA) and Platelet rich plasma in people with Temporomandibular Joint Disc Displacement, With Reduction, run by Mansoura University at 1 site in Egypt.
Trial summary
Assessment of intra-articular injection of hyaluronic acid and prp within TMJ using the Zebris jaw tracking device as an objective method Read more about this study
- Who is it for?
- Ages 18 to 45 years
- Conditions the study is for
- Temporomandibular Joint Disc Displacement, With Reduction
- What is being tested?
- Hyaluronic Acid (HA) and Platelet rich plasma
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Jul 2025to 5 May 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- The patients' ages range from 18 to 45.
- Patients experienced clicking sounds, painful joints, and restricted mouth opening.
- Individuals whose MRI confirms a unilateral internal abnormality with reduction.
- A patient who did not respond to conservative treatment. 5 • The patient's capacity and willingness to finish the course of therapy and subsequent appointments.
Who cannot join
- A patient suffering from a connective tissue or inflammatory condition.
- A patient who has had TMJ surgery in the past.
- A history of injecting any kind of material into the target TMJ.
- Drug allergy history.
- A patient who has previously had fibrous or bony adhesion.
- A patient experiencing psychological issues.
Trial locations and contacts
1 site in 1 country.
Egypt1 site
Faculty of Dentistry, Mansoura university
Al Mansurah, Dakahlia Governorate, 35516
About this study
Official title: Biomechanical Assessment of Platelet Rich Plasma and Hyaluronic Acid Intra-articular Injection in Temporomandibular Joint Internal Derangement Using a Jaw Tracking Device
Assessment of intra-articular injection of hyaluronic acid and prp within TMJ using the Zebris jaw tracking device as an objective method
- Being tested
- Hyaluronic Acid (HA) and Platelet rich plasma
- Keywords
- tmj, disc displacement with reduction, jaw tracking, hyaluronic acid, prp, Temporomandibular Disorders, Zebris, Joint clicking, Maximum Mouth Opening, Intra-articular Injection
- Medical subject headings
- Temporomandibular Joint Disorders, Insomnia, Fatal Familial
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Hyaluronic Acid (HA) and Platelet rich plasmaCombination product
A combination of Autologous Platelet-Rich Plasma prepared from the patient's blood and hyaluronic acid injected intra-articularly
| Study group | Role | What they receive |
|---|---|---|
| Hyaluronic acid + PRP | Experimental | patients with disc displacement with reduction will undergo intra-articular injection with hyaluronic acid and prp Receives: Combination Product: Hyaluronic Acid (HA) and Platelet rich plasma |
What is being measured
The primary outcome is the main question the study is designed to answer.
Mandibular movements assessed using the zebris JMA
changes in mandibular movements assessed using the Zebris Jaw Motion Analyzer (JMA) system following treatment
Measured: Baseline, 1month
Secondary outcomes (3)
Pain Assessment using the Visual Analogue Scale
Changes in pain intensity assessed using the Visual Analog Scale (VAS), a 0-10 scale where 0 indicates no pain and 10 indicates the worst imaginable pain; higher scores indicate greater pain severity. Measurements will be obtained at baseline, 1 week, 1 month, 3 months, and 6 months following intra-articular injection of hyaluronic acid and platelet-rich plasma (PRP) in patients with temporomandibular joint disc displacement with reduction.
Measured: baseline, 1 week, 1 month, 3months, 6 months
clicking sound
changes in clicking sound following treatment
Measured: Baseline, 6 months
MRI assessment of the temporomandibular joint
MRI assessment of the temporomandibular joint, including disc position and retrodiscal tissue changes,
Measured: At baseline and 6 months after treatment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Jun 2026
- Study start1 Jul 2025
- Primary completion15 Nov 2025
- Study completion5 May 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Temporomandibular Joint Disc Displacement, With ReductionStudies of the same condition, open and under way.
- More trials run by Mansoura UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 20 participants (actual)
Sponsor and investigators
- Lead sponsor
- Mansoura University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Eslam Elbatal, Mansoura University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07643402
- Sponsor's protocol ID
- MS.25.03.12
- Status last verified
- Sep 2026
- First submitted
- 7 Jun 2026
- Last updated
- 8 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 8 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Biomechanical Assessment of Platelet Rich Plasma and Hyaluronic Acid Intra-articular Injection in Temporomandibular Joint Internal Derangement Using a Jaw Tracking Device
- ClinicalTrials.gov ID
- NCT07643402
- Acronym / sponsor ID
- MS.25.03.12
- Keywords
- tmj, disc displacement with reduction, jaw tracking, hyaluronic acid, prp, Temporomandibular Disorders, Zebris, Joint clicking
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 20 participants (actual)
- Lead sponsor
- Mansoura UniversityUniversity, hospital or other
- Study start
- 1 Jul 2025 (actual)
- Primary completion
- 15 Nov 2025 (actual)
- Study completion
- 5 May 2026 (actual)
- First posted
- 11 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Assessment of intra-articular injection of hyaluronic acid and prp within TMJ using the Zebris jaw tracking device as an objective method
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Hyaluronic acid + PRP | Experimental | Combination Product: Hyaluronic Acid (HA) and Platelet rich plasmapatients with disc displacement with reduction will undergo intra-articular injection with hyaluronic acid and prp |
Who may qualify
- Ages
- 18 to 45 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- The patients' ages range from 18 to 45.
- Patients experienced clicking sounds, painful joints, and restricted mouth opening.
- Individuals whose MRI confirms a unilateral internal abnormality with reduction.
- A patient who did not respond to conservative treatment. 5 • The patient's capacity and willingness to finish the course of therapy and subsequent appointments.
Key exclusion criteria (6 listed)
- A patient suffering from a connective tissue or inflammatory condition.
- A patient who has had TMJ surgery in the past.
- A history of injecting any kind of material into the target TMJ.
- Drug allergy history.
- A patient who has previously had fibrous or bony adhesion.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Hyaluronic Acid (HA) and Platelet rich plasmaA combination of Autologous Platelet-Rich Plasma prepared from the patient's blood and hyaluronic acid injected intra-articularly | Combination product | Hyaluronic acid + PRP |
Primary outcome
Mandibular movements assessed using the zebris JMA
Time frame: Baseline, 1month
changes in mandibular movements assessed using the Zebris Jaw Motion Analyzer (JMA) system following treatment
3 secondary outcomes
Pain Assessment using the Visual Analogue Scale
Time frame: baseline, 1 week, 1 month, 3months, 6 months
clicking sound
Time frame: Baseline, 6 months
MRI assessment of the temporomandibular joint
Time frame: At baseline and 6 months after treatment
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Sep 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Hyaluronic Acid (HA) and Platelet rich plasma in people with Temporomandibular Joint Disc Displacement, With Reduction, run by Mansoura University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 8 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Mandibular movements assessed using the zebris JMA (time frame: Baseline, 1month). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Sep 2026; AzTrials last refreshed its copy on 8 Nov 2026.