Relevant Conditions IdentificationLAMP-1NCT07651280
Improving the Reliability of LLMs as Medical Assistants for the General Public
A study testing three minutes six dimensions education, ChatGPT and Gemini in people with Relevant Conditions Identification, run by Capital Medical University at 1 site in China.
Trial summary
This study will evaluate whether three-minute six-dimensions education(3M-6D education) can improve the reliability of large language models as medical assistants for the general public. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Relevant Conditions Identification
- What is being tested?
- three minutes six dimensions education, ChatGPT and Gemini
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 527 participants
- Where
- 1 siteChina
- Study dates
- 3 Jul 2026to 26 Aug 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Age 18 years or greater, male or female;
- Completed primary school or higher education;
- Able to use a smartphone or computer to complete online interaction;
- No history of acute ischemic stroke, systemic lupus erythematosus, gastric ulcer, pneumonia, acute cardiac infarction, urinary tract infection, uterine fibroids, diabetes, osteoarthritis, or migraine.
- Able to understand and comply with study procedures and to provide written informed consent.
Who cannot join
- Currently or previously employed as a healthcare worker;
- Previously received systematic medical training;
- Currently involved in concurrent research that may interfere with the results of the present trial;
- The investigator considered that the participant had other conditions that might affect compliance or preclude participation.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Improving the Reliability of LLMs as Medical Assistants for the General Public: a Proof of Concept Simulation Trial
This study will evaluate whether three-minute six-dimensions education(3M-6D education) can improve the reliability of large language models as medical assistants for the general public. Participants will be randomly assigned to receive or not receive 3M-6D education and then use ChatGPT, Gemini, or non-AI information resources. The study will assess relevant condition identification, disposition concordance, red-flag identification, and NASA-TLX score.
Read the detailed description
This randomized, controlled, proof-of-concept simulation trial will evaluate whether three-minute six-dimensions education (3M-6D education) can improve the reliability of large language models as medical assistants for the general public.
Eligible participants will be randomly assigned in a 1:1:1:1:1 ratio to one of five study groups: the 3M-6D education GPT group, the GPT group, the 3M-6D education Gemini group, the Gemini group, or the control group. Participants in the 3M-6D education GPT and 3M-6D education Gemini groups will receive approximately three minutes of education before using ChatGPT or Gemini.Each participant will be randomly assigned one of 10 standardized clinical scenarios and complete a simulated counseling task in unrestricted natural language within approximately 10 minutes. The study will assess relevant condition identification, disposition concordance, red-flag identification, and NASA-TLX score.
- Conditions
- Relevant Conditions Identification
- Being tested
- three minutes six dimensions education, ChatGPT, Gemini
- Keywords
- 3M-6D education, Large Language Models, relevant conditions identification, Cognitive Load Theory
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
three minutes six dimensions educationBehavioural
3M-6D education is designed based on Cognitive Load Theory to reduce the cognitive burden on patients during medical interactions with AI and to improve the clarity and completeness of symptom reporting.
Guided by cognitive load theory and the natural process physicians use to take medical histories, the investigators identified candidate information dimensions and developed a structured expression framework with six dimensions for public health queries through a Delphi expert consensus process. Participants were instructed to use the framework to describe their symptoms across these six dimensions; this process can typically be completed within three minutes, so the investigators call this approach three minutes six dimensions education (3M-6D education).
ChatGPTOther
Participants use ChatGPT to complete a standardized simulated clinical scenarios in unrestricted natural language.
GeminiOther
Participants use Gemini to complete a standardized simulated clinical scenarios in unrestricted natural language.
| Study group | Role | What they receive |
|---|---|---|
| 3M-6D education GPT Group | Experimental | Participants will first be trained in 3M-6D education, then use ChatGPT to complete a consultation task in unrestricted natural language in approximately 10 minutes. Receives: Behavioral: three minutes six dimensions education; Other: ChatGPT |
| 3M-6D education Gemini Group | Experimental | Participants will first be trained in 3M-6D education, then use Gemini to complete a consultation task in unrestricted natural language in approximately 10 minutes. Receives: Behavioral: three minutes six dimensions education; Other: Gemini |
| GPT Group | Active comparator | Participants will use ChatGPT to complete a consultation task in unrestricted natural language in approximately 10 minutes. Receives: Other: ChatGPT |
| Gemini Group | Active comparator | Participants will use Gemini to complete a consultation task in unrestricted natural language in approximately 10 minutes. Receives: Other: Gemini |
| Control group | No intervention | Participants will use non-AI tools such as internet searches and medical websites to complete a consultation task in unrestricted natural language in approximately 10 minutes. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Relevant conditions identification of the 3M-6D education GPT group compared with the GPT group
Relevant conditions identification is defined as the proportion of participants whose final response includes the expert-defined final diagnosis or a relevant differential diagnosis.
Measured: 1 hour.
Disposition concordance of the 3M-6D education GPT group compared with the GPT group
Disposition concordance is defined as the proportion of participants whose final care recommendation matches the expert-defined level. The five levels are self-care, routine outpatient care, urgent outpatient care, emergency department visit, and emergency medical services.
Measured: 1 hour.
Relevant conditions identification of the 3M-6D education Gemini group compared with the Gemini group
Measured: 1 hour.
Disposition concordance of the 3M-6D education Gemini group compared with the Gemini group
Measured: 1 hour.
Secondary outcomes (16)
Relevant conditions identification of the 3M-6D education GPT group compared with the control group
Measured: 1 hour.
Relevant conditions identification of the 3M-6D education Gemini group compared with the control group
Measured: 1 hour.
Disposition concordance of the 3M-6D education GPT group compared with the control group
Measured: 1 hour.
Disposition concordance of the 3M-6D education Gemini group compared with the control group
Measured: 1 hour.
Red-flag identification in the 3M-6D education GPT group compared with the GPT group
Red-flag identification is defined as the proportion of participants whose final response includes the key warning signs that experts defined for the assigned scenario.
Measured: 1 hour.
Red-flag identification in the 3M-6D education GPT group compared with the control group
Measured: 1 hour.
Red-flag identification in the 3M-6D education Gemini group compared with the Gemini group
Measured: 1 hour.
Red-flag identification in the 3M-6D education Gemini group compared with the control group
Measured: 1 hour.
NASA Task Load Index score of the 3M-6D education GPT group compared with the GPT group
NASA-TLX score is a self-reported task-load score measured after the simulated consultation with a physician. It includes six domains: mental demand, physical demand, temporal demand, effort, frustration, and performance. Each domain is scored from 0 to 100. The total score is the mean of the six domains. Higher scores indicate greater perceived task load.
Measured: 1 hour.
NASA Task Load Index score of the 3M-6D education GPT group compared with the control group
NASA-TLX score is a self-reported task-load score measured after the simulated consultation with a physician. It includes six domains: mental demand, physical demand, temporal demand, effort, frustration, and performance. Each domain is scored from 0 to 100. The total score is the mean of the six domains. Higher scores indicate greater perceived task load.
Measured: 1 hour.
NASA Task Load Index score of the 3M-6D education Gemini group compared with the Gemini group
NASA-TLX score is a self-reported task-load score measured after the simulated consultation with a physician. It includes six domains: mental demand, physical demand, temporal demand, effort, frustration, and performance. Each domain is scored from 0 to 100. The total score is the mean of the six domains. Higher scores indicate greater perceived task load.
Measured: 1 hour.
NASA Task Load Index score of the 3M-6D education Gemini group compared with the control group
NASA-TLX score is a self-reported task-load score measured after the simulated consultation with a physician. It includes six domains: mental demand, physical demand, temporal demand, effort, frustration, and performance. Each domain is scored from 0 to 100. The total score is the mean of the six domains. Higher scores indicate greater perceived task load.
Measured: 1 hour.
Relevant conditions identification of the 3M-6D education GPT group compared with the 3M-6D education Gemini group
Measured: 1 hour.
Disposition concordance of the 3M-6D education GPT group compared with the 3M-6D education Gemini group
Measured: 1 hour.
Red-flag identification in the 3M-6D education GPT group compared with the 3M-6D education Gemini group
Measured: 1 hour.
NASA Task Load Index score of the 3M-6D education GPT group compared with the 3M-6D education Gemini group
NASA-TLX score is a self-reported task-load score measured after the simulated consultation with a physician. It includes six domains: mental demand, physical demand, temporal demand, effort, frustration, and performance. Each domain is scored from 0 to 100. The total score is the mean of the six domains. Higher scores indicate greater perceived task load.
Measured: 1 hour.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Jun 2026
- Study start3 Jul 2026
- Primary completion26 Aug 2026
- Study completion26 Aug 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Relevant Conditions IdentificationStudies of the same condition, open and under way.
- More trials run by Capital Medical UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants will be randomly assigned in a 1:1:1:1:1 ratio to one of five parallel groups: the 3M-6D education GPT group, the GPT group, the 3M-6D education Gemini group, the Gemini group, or the control group. Each participant will complete one standardized simulated clinical scenario.
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 527 participants (actual)
Sponsor and investigators
- Lead sponsor
- Capital Medical University
- Sponsor type
- University, hospital or other
- Collaborators
- Xuanwu Hospital, Beijing
- Responsible party
- Principal investigator, Ji Xunming,MD,PhD, Capital Medical University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07651280
- Sponsor's protocol ID
- LAMP-1
- Acronym
- LAMP-1
- Status last verified
- Sep 2026
- First submitted
- 11 Jun 2026
- Last updated
- 3 Sep 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 3 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Improving the Reliability of LLMs as Medical Assistants for the General Public: a Proof of Concept Simulation Trial
- ClinicalTrials.gov ID
- NCT07651280
- Acronym / sponsor ID
- LAMP-1 / LAMP-1
- Conditions
- Relevant Conditions Identification
- Keywords
- 3M-6D education, Large Language Models, relevant conditions identification, Cognitive Load Theory
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 527 participants (actual)
- Lead sponsor
- Capital Medical UniversityUniversity, hospital or other
- Collaborators
- Xuanwu Hospital, Beijing
- Study start
- 3 Jul 2026 (actual)
- Primary completion
- 26 Aug 2026 (actual)
- Study completion
- 26 Aug 2026 (actual)
- First posted
- 16 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study will evaluate whether three-minute six-dimensions education(3M-6D education) can improve the reliability of large language models as medical assistants for the general public. Participants will be randomly assigned to receive or not receive 3M-6D education and then use ChatGPT, Gemini, or non-AI information resources. The study will assess relevant condition identification, disposition concordance, red-flag identification, and NASA-TLX score.
Detailed description
This randomized, controlled, proof-of-concept simulation trial will evaluate whether three-minute six-dimensions education (3M-6D education) can improve the reliability of large language models as medical assistants for the general public.
Eligible participants will be randomly assigned in a 1:1:1:1:1 ratio to one of five study groups: the 3M-6D education GPT group, the GPT group, the 3M-6D education Gemini group, the Gemini group, or the control group. Participants in the 3M-6D education GPT and 3M-6D education Gemini groups will receive approximately three minutes of education before using ChatGPT or Gemini.Each participant will be randomly assigned one of 10 standardized clinical scenarios and complete a simulated counseling task in unrestricted natural language within approximately 10 minutes. The study will assess relevant condition identification, disposition concordance, red-flag identification, and NASA-TLX score.
Study design
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 5
- Model description
- Participants will be randomly assigned in a 1:1:1:1:1 ratio to one of five parallel groups: the 3M-6D education GPT group, the GPT group, the 3M-6D education Gemini group, the Gemini group, or the control group. Each participant will complete one standardized simulated clinical scenario.
| Arm | Type | Receives |
|---|---|---|
| 3M-6D education GPT Group | Experimental | Behavioral: three minutes six dimensions education, Other: ChatGPTParticipants will first be trained in 3M-6D education, then use ChatGPT to complete a consultation task in unrestricted natural language in approximately 10 minutes. |
| 3M-6D education Gemini Group | Experimental | Behavioral: three minutes six dimensions education, Other: GeminiParticipants will first be trained in 3M-6D education, then use Gemini to complete a consultation task in unrestricted natural language in approximately 10 minutes. |
| GPT Group | Active comparator | Other: ChatGPTParticipants will use ChatGPT to complete a consultation task in unrestricted natural language in approximately 10 minutes. |
| Gemini Group | Active comparator | Other: GeminiParticipants will use Gemini to complete a consultation task in unrestricted natural language in approximately 10 minutes. |
| Control group | No intervention | –Participants will use non-AI tools such as internet searches and medical websites to complete a consultation task in unrestricted natural language in approximately 10 minutes. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Age 18 years or greater, male or female;
- Completed primary school or higher education;
- Able to use a smartphone or computer to complete online interaction;
- No history of acute ischemic stroke, systemic lupus erythematosus, gastric ulcer, pneumonia, acute cardiac infarction, urinary tract infection, uterine fibroids, diabetes, osteoarthritis, or migraine.
- Able to understand and comply with study procedures and to provide written informed consent.
Key exclusion criteria (4 listed)
- Currently or previously employed as a healthcare worker;
- Previously received systematic medical training;
- Currently involved in concurrent research that may interfere with the results of the present trial;
- The investigator considered that the participant had other conditions that might affect compliance or preclude participation.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| three minutes six dimensions education3M-6D education is designed based on Cognitive Load Theory to reduce the cognitive burden on patients during medical interactions with AI and to improve the clarity and completeness of symptom reporting. Guided by cognitive load theory and the natural process physicians use to take medical histories, the investigators identified candidate information dimensions and developed a structured expression framework with six dimensions for public health queries through a Delphi expert consensus process. Participants were instructed to use the framework to describe their symptoms across these six dimensions; this process can typically be completed within three minutes, so the investigators call this approach three minutes six dimensions education (3M-6D education). | Behavioural | 3M-6D education GPT Group, 3M-6D education Gemini Group |
| ChatGPTParticipants use ChatGPT to complete a standardized simulated clinical scenarios in unrestricted natural language. | Other | 3M-6D education GPT Group, GPT Group |
| GeminiParticipants use Gemini to complete a standardized simulated clinical scenarios in unrestricted natural language. | Other | 3M-6D education Gemini Group, Gemini Group |
Primary outcome
Relevant conditions identification of the 3M-6D education GPT group compared with the GPT group
Time frame: 1 hour.
Relevant conditions identification is defined as the proportion of participants whose final response includes the expert-defined final diagnosis or a relevant differential diagnosis.
Disposition concordance of the 3M-6D education GPT group compared with the GPT group
Time frame: 1 hour.
Disposition concordance is defined as the proportion of participants whose final care recommendation matches the expert-defined level. The five levels are self-care, routine outpatient care, urgent outpatient care, emergency department visit, and emergency medical services.
Relevant conditions identification of the 3M-6D education Gemini group compared with the Gemini group
Time frame: 1 hour.
Disposition concordance of the 3M-6D education Gemini group compared with the Gemini group
Time frame: 1 hour.
16 secondary outcomes
Relevant conditions identification of the 3M-6D education GPT group compared with the control group
Time frame: 1 hour.
Relevant conditions identification of the 3M-6D education Gemini group compared with the control group
Time frame: 1 hour.
Disposition concordance of the 3M-6D education GPT group compared with the control group
Time frame: 1 hour.
Disposition concordance of the 3M-6D education Gemini group compared with the control group
Time frame: 1 hour.
Red-flag identification in the 3M-6D education GPT group compared with the GPT group
Time frame: 1 hour.
Red-flag identification in the 3M-6D education GPT group compared with the control group
Time frame: 1 hour.
Red-flag identification in the 3M-6D education Gemini group compared with the Gemini group
Time frame: 1 hour.
Red-flag identification in the 3M-6D education Gemini group compared with the control group
Time frame: 1 hour.
NASA Task Load Index score of the 3M-6D education GPT group compared with the GPT group
Time frame: 1 hour.
NASA Task Load Index score of the 3M-6D education GPT group compared with the control group
Time frame: 1 hour.
NASA Task Load Index score of the 3M-6D education Gemini group compared with the Gemini group
Time frame: 1 hour.
NASA Task Load Index score of the 3M-6D education Gemini group compared with the control group
Time frame: 1 hour.
Relevant conditions identification of the 3M-6D education GPT group compared with the 3M-6D education Gemini group
Time frame: 1 hour.
Disposition concordance of the 3M-6D education GPT group compared with the 3M-6D education Gemini group
Time frame: 1 hour.
Red-flag identification in the 3M-6D education GPT group compared with the 3M-6D education Gemini group
Time frame: 1 hour.
NASA Task Load Index score of the 3M-6D education GPT group compared with the 3M-6D education Gemini group
Time frame: 1 hour.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Sep 2026.
- Individual participant dataSharing planned: Undecided
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing three minutes six dimensions education, ChatGPT and Gemini in people with Relevant Conditions Identification, run by Capital Medical University at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Relevant conditions identification of the 3M-6D education GPT group compared with the GPT group (time frame: 1 hour.). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Sep 2026.