Fluid Responsiveness Predictability in SepsisNCT07653568
A Study Comparing Carotid Doppler Ultrasound and Echocardiography to Assess Fluid Responsiveness in Septic Patients on Ventilator
A study testing intravenous crystalloid fluid bolus in people with Fluid Responsiveness Predictability in Sepsis, run by Pakistan Institute of Medical Sciences at 1 site in Pakistan.
Trial summary
The goal of this clinical trial is to determine whether common carotid artery blood flow measured by bedside Doppler ultrasound can accurately identify fluid responsiveness in mechanically ventilated adults with sepsis. Read more about this study
- Who is it for?
- Ages 12 years and older
- Conditions the study is for
- Fluid Responsiveness Predictability in Sepsis
- What is being tested?
- intravenous crystalloid fluid bolus
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 94 participants
- Where
- 1 sitePakistan
- Study dates
- 1 May 2026to 29 May 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 12 years and older
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- • Adults with sepsis requiring mechanical ventilation in the intensive care unit
- Patients requiring fluid assessment or fluid resuscitation based on clinical findings, including one or more of the following:
- Heart rate greater than 100 beats per minute
- Systolic blood pressure less than 90 mmHg
- Mean arterial pressure less than 65 mmHg
- Urine output less than 0.5 mL/kg/hour for at least 2 hours
Who cannot join
- Intracranial pathology associated with raised intracranial pressure, including intracerebral hemorrhage or space-occupying lesions
- Recent neurosurgical procedures or conditions where passive leg raising may increase intracranial pressure
- Known heart failure
- Significant cardiac arrhythmias
- Significant valvular heart disease
- Status asthmaticus
Show all 13Show fewer
- Pulmonary hypertension
- Pulmonary embolism
- Pregnancy
- Lower limb conditions preventing passive leg raising, including fractures
- Intra-abdominal hypertension
- Recent abdominal surgery
- Known carotid artery disease or common carotid artery stenosis greater than 50%
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan1 site, 1 recruiting
- Recruiting
Pakistan Institute Of Medical Sciences
Islamabad, Federal Area, 44000
Syed Muneeb Ali, MBBS, MCCM, MD CCM, +923335329538, syed.muneeb.ali@gmail.com
About this study
Official title: Comparative Evaluation of Common Carotid Artery Blood Flow (CCABF) and Transthoracic Echocardiographic Cardiac Output (TTE-CO) for Assessing Fluid Responsiveness in Septic Patients on Ventilator.
The goal of this clinical trial is to determine whether common carotid artery blood flow measured by bedside Doppler ultrasound can accurately identify fluid responsiveness in mechanically ventilated adults with sepsis. The study will compare this method with transthoracic echocardiography-derived cardiac output, which is a commonly used non-invasive technique for assessing hemodynamic status in critically ill patients. The study also aims to evaluate whether carotid artery ultrasound can provide a faster and more practical bedside assessment during fluid resuscitation in the intensive care unit.
In patients with sepsis, giving too little intravenous fluid may worsen organ perfusion and shock, while excessive fluid administration may lead to complications such as pulmonary edema, worsening oxygenation, prolonged mechanical ventilation, and longer intensive care unit stay. Because of this, clinicians need reliable methods to identify which patients are likely to benefit from fluid administration. This concept is known as fluid responsiveness.
Read more
The main questions this study aims to answer are:
- Can common carotid artery blood flow measured by ultrasound predict fluid responsiveness as accurately as transthoracic echocardiography-derived cardiac output?
- How closely do changes in carotid artery blood flow correspond to changes in cardiac output during passive leg raising?
- Can carotid ultrasound provide a quicker and simpler bedside method for assessing fluid responsiveness in critically ill patients receiving mechanical ventilation? Researchers will compare two ultrasound-based methods during a passive leg raising test. Passive leg raising is a temporary bedside maneuver used to simulate a fluid challenge without immediately giving intravenous fluids. During this maneuver, the patient's legs are elevated while the upper body is lowered, allowing blood from the lower limbs to temporarily return to the central circulation. This increases blood flow to the heart and may increase cardiac output in patients who are likely to respond to fluid administration.
The study team will first record baseline measurements of common carotid artery blood flow and transthoracic echocardiographic cardiac output while the patient is in a semi-recumbent position. The passive leg raising maneuver will then be performed, and both measurements will be repeated to evaluate changes in blood flow and cardiac output. If the predefined criteria for fluid responsiveness are met, the participant will receive intravenous crystalloid fluid according to the study protocol.
Participants will:
- Undergo bedside Doppler ultrasound measurement of common carotid artery blood flow
- Undergo transthoracic echocardiography to measure cardiac output
- Have ultrasound measurements recorded before and after passive leg raising
- Receive intravenous fluid administration if fluid responsiveness criteria are met
- Continue routine monitoring of blood pressure, heart rate, oxygenation, urine output, and other intensive care parameters during the study period The findings from this study may help determine whether carotid artery ultrasound can be used as a practical bedside tool for fluid assessment in mechanically ventilated patients with sepsis, particularly in settings where rapid and non-invasive monitoring is needed.
Read the detailed description
This study is being conducted in the intensive care unit to examine a non-invasive ultrasound-based approach for evaluating circulatory response in adults with sepsis who are receiving mechanical ventilation. The investigation focuses on whether Doppler assessment of blood flow in the common carotid artery can provide clinically useful information comparable to cardiac output measurements obtained through transthoracic echocardiography during bedside hemodynamic assessment.
Management of septic patients frequently requires decisions regarding intravenous fluid administration. Both insufficient and excessive fluid therapy may negatively affect patient outcomes. Reliable bedside techniques that identify patients who are likely to benefit from additional fluid remain an important component of critical care practice. Current hemodynamic assessment methods often require specialized expertise, repeated examinations, or technically challenging image acquisition in ventilated patients.
This trial will assess circulatory changes produced by a passive leg raising maneuver. Passive leg raising temporarily increases venous return by transferring blood from the lower limbs toward the thoracic circulation. The maneuver provides a reversible physiologic preload challenge that allows evaluation of cardiovascular response without initially administering intravenous fluid.
Participants enrolled in the study will undergo sequential ultrasound-based hemodynamic assessments performed by trained investigators. Measurements will first be obtained while the participant is positioned with the head elevated. The participant will then undergo passive leg raising with elevation of both lower limbs and adjustment of trunk position according to study protocol. Repeat hemodynamic measurements will be recorded during the maneuver.
For carotid Doppler evaluation, the common carotid artery will be visualized in longitudinal orientation using a high-frequency linear ultrasound probe. Vessel diameter and Doppler flow measurements will be obtained from a standardized location proximal to the carotid bulb. Flow estimation will be derived from Doppler velocity measurements combined with arterial diameter and heart rate.
Cardiac output assessment will be performed separately using transthoracic echocardiography and Doppler evaluation of flow across the left ventricular outflow tract. Measurements will be obtained using standardized echocardiographic views and procedural methods.
Participants who demonstrate predefined hemodynamic changes during assessment may receive crystalloid administration according to the study protocol. Additional measurements may then be performed to evaluate circulatory response after fluid administration.
The primary analysis will evaluate the diagnostic performance of carotid Doppler-derived flow assessment for identifying preload responsiveness in comparison with transthoracic echocardiographic measurements. Agreement between both methods and the ability of carotid Doppler assessment to identify clinically significant hemodynamic change will also be examined.
Additional analyses will assess bedside practicality, including the ease and duration of ultrasound assessment in critically ill ventilated patients. Technical factors affecting image acquisition and measurement reliability will also be documented during the study.
Clinical information and ultrasound findings will be entered into standardized study forms. Data review procedures will include consistency checks, verification of recorded values, and evaluation of incomplete or missing variables before statistical analysis. Statistical methods will include correlation analysis, agreement testing, and calculation of diagnostic performance measures using predefined study thresholds.
This investigation may provide further evidence regarding the role of carotid Doppler ultrasound as a rapid bedside technique for circulatory assessment in mechanically ventilated adults with sepsis managed in the intensive care unit.
- Being tested
- intravenous crystalloid fluid bolus
- Keywords
- Fluid responsiveness, LVOT, Common carotid artery blood flow, Sepsis, TTE-CO, Carotid doppler, Ventilated patients
- Medical subject headings
- Sepsis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
intravenous crystalloid fluid bolusDrug
Intravenous isotonic crystalloid solution will be administered to participants who demonstrate predefined indicators of fluid responsiveness during hemodynamic assessment. A 500 mL fluid bolus will be infused according to intensive care unit protocol following passive leg raising-associated circulatory changes identified by ultrasound-based monitoring methods. Hemodynamic reassessment will be performed after fluid administration to evaluate changes in circulatory parameters.
| Study group | Role | What they receive |
|---|---|---|
| Mechanically ventilated septic patients undergoing fluid responsiveness assessment | Experimental | Participants enrolled in this study arm will undergo non-invasive bedside hemodynamic evaluation during passive leg raising. Doppler ultrasound of the common carotid artery and transthoracic echocardiographic assessment of cardiac output will be performed at predefined stages of assessment to examine circulatory changes associated with preload variation. Intravenous crystalloid administration may be provided when study-defined indicators of preload responsiveness are observed, followed by reassessment using the same ultrasound-based methods. Receives: Drug: intravenous crystalloid fluid bolus |
What is being measured
The primary outcome is the main question the study is designed to answer.
Diagnostic Accuracy of Common Carotid Artery Blood Flow- Cardiac Output in predicting fluid responsiveness.
This outcome will evaluate the ability of Doppler-derived common carotid artery blood flow measurements to identify fluid responsiveness in mechanically ventilated adults with sepsis using transthoracic echocardiography-derived cardiac output as the reference method. Diagnostic performance will be assessed through sensitivity, specificity, predictive values, overall accuracy, and agreement analysis during passive leg raising assessment.
Measured: Peri-Procedural
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Jun 2026
- Study start1 May 2026
- Primary completion1 Jan 2027 (estimated)
- Study completion29 May 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Fluid Responsiveness Predictability in SepsisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 94 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Pakistan Institute of Medical Sciences
- Sponsor type
- Other government
- Responsible party
- Principal investigator, Sana Zulfiqar, Pakistan Institute of Medical Sciences
- Investigators
- Rana Imran SIkander, MBBS, MCPS, FCPS, Study chair, Pakista Institute of Medical SciencesSyed Muneeb Ali, MBBS, MCCM, MD CCM, Study director, Pakistan Institute of Medical Sciences
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07653568
- Sponsor's protocol ID
- 20-4/AS&RB-M/SZAMU/2025-2378
- Status last verified
- Jun 2026
- First submitted
- 4 Jun 2026
- Last updated
- 18 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, Machado FR, Mcintyre L, Ostermann M, Prescott HC, Schorr C, Simpson S, Wiersinga WJ, Alshamsi F, Angus DC, Arabi Y, Azevedo L, Beale R, Beilman G, Belley-Cote E, Burry L, Cecconi M, Centofanti J, Coz Yataco A, De Waele J, Dellinger RP, Doi K, Du B, Estenssoro E, Ferrer R, Gomersall C, Hodgson C, Hylander Moller M, Iwashyna T, Jacob S, Kleinpell R, Klompas M, Koh Y, Kumar A, Kwizera A, Lobo S, Masur H, McGloughlin S, Mehta S, Mehta Y, Mer M, Nunnally M, Oczkowski S, Osborn T, Papathanassoglou E, Perner A, Puskarich M, Roberts J, Schweickert W, Seckel M, Sevransky J, Sprung CL, Welte T, Zimmerman J, Levy M. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. Crit Care Med. 2021 Nov 1;49(11):e1063-e1143. doi: 10.1097/CCM.0000000000005337. No abstract available.
PubMed 34605781
Study at a glance
From the registry record, last updated by the sponsor on 18 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Evaluation of Common Carotid Artery Blood Flow (CCABF) and Transthoracic Echocardiographic Cardiac Output (TTE-CO) for Assessing Fluid Responsiveness in Septic Patients on Ventilator.
- ClinicalTrials.gov ID
- NCT07653568
- Acronym / sponsor ID
- 20-4/AS&RB-M/SZAMU/2025-2378
- Keywords
- Fluid responsiveness, LVOT, Common carotid artery blood flow, Sepsis, TTE-CO, Carotid doppler, Ventilated patients
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 94 participants (estimated)
- Lead sponsor
- Pakistan Institute of Medical SciencesOther government
- Study start
- 1 May 2026 (actual)
- Primary completion
- 1 Jan 2027 (estimated)
- Study completion
- 29 May 2027 (estimated)
- First posted
- 17 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to determine whether common carotid artery blood flow measured by bedside Doppler ultrasound can accurately identify fluid responsiveness in mechanically ventilated adults with sepsis. The study will compare this method with transthoracic echocardiography-derived cardiac output, which is a commonly used non-invasive technique for assessing hemodynamic status in critically ill patients. The study also aims to evaluate whether carotid artery ultrasound can provide a faster and more practical bedside assessment during fluid resuscitation in the intensive care unit.
In patients with sepsis, giving too little intravenous fluid may worsen organ perfusion and shock, while excessive fluid administration may lead to complications such as pulmonary edema, worsening oxygenation, prolonged mechanical ventilation, and longer intensive care unit stay. Because of this, clinicians need reliable methods to identify which patients are likely to benefit from fluid administration. This concept is known as fluid responsiveness.
The main questions this study aims to answer are:
- Can common carotid artery blood flow measured by ultrasound predict fluid responsiveness as accurately as transthoracic echocardiography-derived cardiac output?
- How closely do changes in carotid artery blood flow correspond to changes in cardiac output during passive leg raising?
- Can carotid ultrasound provide a quicker and simpler bedside method for assessing fluid responsiveness in critically ill patients receiving mechanical ventilation? Researchers will compare two ultrasound-based methods during a passive leg raising test. Passive leg raising is a temporary bedside maneuver used to simulate a fluid challenge without immediately giving intravenous fluids. During this maneuver, the patient's legs are elevated while the upper body is lowered, allowing blood from the lower limbs to temporarily return to the central circulation. This increases blood flow to the heart and may increase cardiac output in patients who are likely to respond to fluid administration.
The study team will first record baseline measurements of common carotid artery blood flow and transthoracic echocardiographic cardiac output while the patient is in a semi-recumbent position. The passive leg raising maneuver will then be performed, and both measurements will be repeated to evaluate changes in blood flow and cardiac output. If the predefined criteria for fluid responsiveness are met, the participant will receive intravenous crystalloid fluid according to the study protocol.
Participants will:
- Undergo bedside Doppler ultrasound measurement of common carotid artery blood flow
- Undergo transthoracic echocardiography to measure cardiac output
- Have ultrasound measurements recorded before and after passive leg raising
- Receive intravenous fluid administration if fluid responsiveness criteria are met
- Continue routine monitoring of blood pressure, heart rate, oxygenation, urine output, and other intensive care parameters during the study period The findings from this study may help determine whether carotid artery ultrasound can be used as a practical bedside tool for fluid assessment in mechanically ventilated patients with sepsis, particularly in settings where rapid and non-invasive monitoring is needed.
Detailed description
This study is being conducted in the intensive care unit to examine a non-invasive ultrasound-based approach for evaluating circulatory response in adults with sepsis who are receiving mechanical ventilation. The investigation focuses on whether Doppler assessment of blood flow in the common carotid artery can provide clinically useful information comparable to cardiac output measurements obtained through transthoracic echocardiography during bedside hemodynamic assessment.
Management of septic patients frequently requires decisions regarding intravenous fluid administration. Both insufficient and excessive fluid therapy may negatively affect patient outcomes. Reliable bedside techniques that identify patients who are likely to benefit from additional fluid remain an important component of critical care practice. Current hemodynamic assessment methods often require specialized expertise, repeated examinations, or technically challenging image acquisition in ventilated patients.
This trial will assess circulatory changes produced by a passive leg raising maneuver. Passive leg raising temporarily increases venous return by transferring blood from the lower limbs toward the thoracic circulation. The maneuver provides a reversible physiologic preload challenge that allows evaluation of cardiovascular response without initially administering intravenous fluid.
Participants enrolled in the study will undergo sequential ultrasound-based hemodynamic assessments performed by trained investigators. Measurements will first be obtained while the participant is positioned with the head elevated. The participant will then undergo passive leg raising with elevation of both lower limbs and adjustment of trunk position according to study protocol. Repeat hemodynamic measurements will be recorded during the maneuver.
For carotid Doppler evaluation, the common carotid artery will be visualized in longitudinal orientation using a high-frequency linear ultrasound probe. Vessel diameter and Doppler flow measurements will be obtained from a standardized location proximal to the carotid bulb. Flow estimation will be derived from Doppler velocity measurements combined with arterial diameter and heart rate.
Cardiac output assessment will be performed separately using transthoracic echocardiography and Doppler evaluation of flow across the left ventricular outflow tract. Measurements will be obtained using standardized echocardiographic views and procedural methods.
Participants who demonstrate predefined hemodynamic changes during assessment may receive crystalloid administration according to the study protocol. Additional measurements may then be performed to evaluate circulatory response after fluid administration.
The primary analysis will evaluate the diagnostic performance of carotid Doppler-derived flow assessment for identifying preload responsiveness in comparison with transthoracic echocardiographic measurements. Agreement between both methods and the ability of carotid Doppler assessment to identify clinically significant hemodynamic change will also be examined.
Additional analyses will assess bedside practicality, including the ease and duration of ultrasound assessment in critically ill ventilated patients. Technical factors affecting image acquisition and measurement reliability will also be documented during the study.
Clinical information and ultrasound findings will be entered into standardized study forms. Data review procedures will include consistency checks, verification of recorded values, and evaluation of incomplete or missing variables before statistical analysis. Statistical methods will include correlation analysis, agreement testing, and calculation of diagnostic performance measures using predefined study thresholds.
This investigation may provide further evidence regarding the role of carotid Doppler ultrasound as a rapid bedside technique for circulatory assessment in mechanically ventilated adults with sepsis managed in the intensive care unit.
Study design
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Mechanically ventilated septic patients undergoing fluid responsiveness assessment | Experimental | Drug: intravenous crystalloid fluid bolusParticipants enrolled in this study arm will undergo non-invasive bedside hemodynamic evaluation during passive leg raising. Doppler ultrasound of the common carotid artery and transthoracic echocardiographic assessment of cardiac output will be performed at predefined stages of assessment to examine circulatory changes associated with preload variation. Intravenous crystalloid administration may be provided when study-defined indicators of preload responsiveness are observed, followed by reassessment using the same ultrasound-based methods. |
Who may qualify
- Ages
- 12 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (6 listed)
- • Adults with sepsis requiring mechanical ventilation in the intensive care unit
Key exclusion criteria (13 listed)
- Intracranial pathology associated with raised intracranial pressure, including intracerebral hemorrhage or space-occupying lesions
- Recent neurosurgical procedures or conditions where passive leg raising may increase intracranial pressure
- Known heart failure
- Significant cardiac arrhythmias
- Significant valvular heart disease
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| intravenous crystalloid fluid bolusIntravenous isotonic crystalloid solution will be administered to participants who demonstrate predefined indicators of fluid responsiveness during hemodynamic assessment. A 500 mL fluid bolus will be infused according to intensive care unit protocol following passive leg raising-associated circulatory changes identified by ultrasound-based monitoring methods. Hemodynamic reassessment will be performed after fluid administration to evaluate changes in circulatory parameters. | Drug | Mechanically ventilated septic patients undergoing fluid responsiveness assessment |
Primary outcome
Diagnostic Accuracy of Common Carotid Artery Blood Flow- Cardiac Output in predicting fluid responsiveness.
Time frame: Peri-Procedural
This outcome will evaluate the ability of Doppler-derived common carotid artery blood flow measurements to identify fluid responsiveness in mechanically ventilated adults with sepsis using transthoracic echocardiography-derived cardiac output as the reference method. Diagnostic performance will be assessed through sensitivity, specificity, predictive values, overall accuracy, and agreement analysis during passive leg raising assessment.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Jun 2026.
- Background: PubMed 34605781Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, Machado FR, Mcintyre L, Ostermann M, Prescott HC, Schorr C, Simpson S, Wiersinga WJ, Alshamsi F, Angus DC, Arabi Y, Azevedo L, Beale R, Beilman G, Belley-Cote E, Burry L, Cecconi M, Centofanti J, Coz Yataco A, De Waele J, Dellinger RP, Doi K, Du B, Estenssoro E, Ferrer R, Gomersall C, Hodgson C, Hylander Moller M, Iwashyna T, Jacob S, Kleinpell R, Klompas M, Koh Y, Kumar A, Kwizera A, Lobo S, Masur H, McGloughlin S, Mehta S, Mehta Y, Mer M, Nunnally M, Oczkowski S, Osborn T, Papathanassoglou E, Perner A, Puskarich M, Roberts J, Schweickert W, Seckel M, Sevransky J, Sprung CL, Welte T, Zimmerman J, Levy M. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. Crit Care Med. 2021 Nov 1;49(11):e1063-e1143. doi: 10.1097/CCM.0000000000005337. No abstract available.
- Individual participant dataSharing planned: Undecided
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Rana Imran SIkander, MBBS, MCPS, FCPS study chair
Pakista Institute of Medical Sciences
Syed Muneeb Ali, MBBS, MCCM, MD CCM study director
Pakistan Institute of Medical Sciences
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing intravenous crystalloid fluid bolus in people with Fluid Responsiveness Predictability in Sepsis, run by Pakistan Institute of Medical Sciences at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 13 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 18 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Sana Zulfiqar, MBBS (+923335329538, sanazulfiqar53@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Diagnostic Accuracy of Common Carotid Artery Blood Flow- Cardiac Output in predicting fluid responsiveness. (time frame: Peri-Procedural). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07653568, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Jun 2026; AzTrials last refreshed its copy on 7 Nov 2026.