Midline CatheterNCT07654101
Isometric Hand-Grip Exercise for Preventing Thrombosis and Occlusion of Midline Venous Catheters: A Randomized Controlled Trial
A study testing handgrip in people with Midline Catheter, run by University Hospital Padova.
Trial summary
evaluate whether hand-grip ball exercises reduce thrombosis and occlusions of Midline catheters in hospitalized patients. Read more about this study
- Who is it for?
- Ages 18 to 70 years
- Conditions the study is for
- Midline Catheter
- What is being tested?
- handgrip
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 840 participants
- Where
- No sites listed yet
- Study dates
- 6 Jul 2026to 1 Sep 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Midline catheter insertion for planned intravenous therapy lasting ≥ 7 days. Age between 18 and 70 years. Catheter inserted in the upper limb (forearm). Ability to understand and perform hand exercises with the limb bearing the venous catheter.
- Written informed consent.
Who cannot join
- Pre-existing superficial or deep venous thrombosis of the limb used for the Midline catheter.
- Limb injuries or amputations. Motor or neurological impairment of the hand. Life expectancy < 7 days. Cognitive impairment/delirium. Medical contraindications to active upper-limb movement.
About this study
Official title: Effectiveness of Isometric Hand-grip Exercise in Preventing Thrombosis and Occlusion of Midline Peripheral Venous Catheters: a Randomized Controlled Trial.
evaluate whether hand-grip ball exercises reduce thrombosis and occlusions of Midline catheters in hospitalized patients.
Read the detailed description
The proposed intervention consists of low-intensity, short-duration, non-invasive, and non-pharmacological exercises, with an expected minimal risk profile. The aim of the study is therefore to systematically evaluate the effectiveness and safety of this practice in patients with Midline catheters, in a context of genuine scientific uncertainty, in order to generate evidence useful for clinical practice.
Primary objective To compare the effectiveness of a structured upper-limb exercise program versus usual care in reducing the incidence of Midline catheter-related thrombosis/occlusions in a population of hospitalized patients.
Associated endpoints
Incidence of Midline thrombosis (%) confirmed by ultrasound.
- Conditions
- Midline Catheter
- Being tested
- handgrip
- Keywords
- midline, occlusion, handgrip
- Medical subject headings
- Bites and Stings
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
handgripOther
handgrip in patients with midline catethers
| Study group | Role | What they receive |
|---|---|---|
| standard | No intervention | usual care |
| handgrip | Experimental | use of handgrip exercises in patients with midline catether Receives: Other: handgrip |
What is being measured
The primary outcome is the main question the study is designed to answer.
To compare the effectiveness of a structured upper-limb exercise program versus usual care in reducing the incidence of Midline catheter-related thrombosis/occlusions in a population of hospitalized patients.
Incidence of Midline thrombosis (%) confirmed by ultrasound.
Measured: from enrollment until catether removal
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Jun 2026
- Study start6 Jul 2026 (estimated)
- Primary completion1 May 2027 (estimated)
- Study completion1 Sep 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Midline CatheterStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 840 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital Padova
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Cesaro Elisabetta, University Hospital Padova
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07654101
- Sponsor's protocol ID
- CET 6514/AO/26
- Status last verified
- Jun 2026
- First submitted
- 11 Jun 2026
- Last updated
- 17 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 17 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effectiveness of Isometric Hand-grip Exercise in Preventing Thrombosis and Occlusion of Midline Peripheral Venous Catheters: a Randomized Controlled Trial.
- ClinicalTrials.gov ID
- NCT07654101
- Acronym / sponsor ID
- CET 6514/AO/26
- Conditions
- Midline Catheter
- Keywords
- midline, occlusion, handgrip
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 840 participants (estimated)
- Lead sponsor
- University Hospital PadovaUniversity, hospital or other
- Study start
- 6 Jul 2026 (estimated)
- Primary completion
- 1 May 2027 (estimated)
- Study completion
- 1 Sep 2027 (estimated)
- First posted
- 17 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
evaluate whether hand-grip ball exercises reduce thrombosis and occlusions of Midline catheters in hospitalized patients.
Detailed description
The proposed intervention consists of low-intensity, short-duration, non-invasive, and non-pharmacological exercises, with an expected minimal risk profile. The aim of the study is therefore to systematically evaluate the effectiveness and safety of this practice in patients with Midline catheters, in a context of genuine scientific uncertainty, in order to generate evidence useful for clinical practice.
Primary objective To compare the effectiveness of a structured upper-limb exercise program versus usual care in reducing the incidence of Midline catheter-related thrombosis/occlusions in a population of hospitalized patients.
Associated endpoints
Incidence of Midline thrombosis (%) confirmed by ultrasound.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| standard | No intervention | –usual care |
| handgrip | Experimental | Other: handgripuse of handgrip exercises in patients with midline catether |
Who may qualify
- Ages
- 18 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- Midline catheter insertion for planned intravenous therapy lasting ≥ 7 days. Age between 18 and 70 years. Catheter inserted in the upper limb (forearm). Ability to understand and perform hand exercises with the limb bearing the venous catheter.
- Written informed consent.
Key exclusion criteria (2 listed)
- Pre-existing superficial or deep venous thrombosis of the limb used for the Midline catheter.
- Limb injuries or amputations. Motor or neurological impairment of the hand. Life expectancy < 7 days. Cognitive impairment/delirium. Medical contraindications to active upper-limb movement.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| handgriphandgrip in patients with midline catethers | Other | handgrip |
Primary outcome
To compare the effectiveness of a structured upper-limb exercise program versus usual care in reducing the incidence of Midline catheter-related thrombosis/occlusions in a population of hospitalized patients.
Time frame: from enrollment until catether removal
Incidence of Midline thrombosis (%) confirmed by ultrasound.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Jun 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
A study testing handgrip in people with Midline Catheter, run by University Hospital Padova.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 17 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
To compare the effectiveness of a structured upper-limb exercise program versus usual care in reducing the incidence of Midline catheter-related thrombosis/occlusions in a population of hospitalized patients. (time frame: from enrollment until catether removal). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Jun 2026.