Ischemic StrokeAUGMENTED CUESNCT07654582
Effect of Adding Augmented Cues /Hand Stroke Patient
A study testing Conventional physical therapy and musicgloves training in people with Ischemic Stroke, run by Cairo University at 1 site in Egypt.
Trial summary
This study aims to investigate the effect of adding augmented cues to conventional physical therapy intervention on hand function in patients with post-stroke hemiparesis. Fifty patients with subacute ischemic stroke will be randomly assigned to either a study group receiving augmented cue-based training in addition… Read more about this study
- Who is it for?
- Ages 40 to 60 years
- Conditions the study is for
- Ischemic Stroke
- What is being tested?
- Conventional physical therapy and musicgloves training
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Aug 2025to 1 Apr 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- - Male and female patients.
- Age between 40 and 60 years.
- First-ever subacute ischemic stroke.
- Time since stroke between 6 weeks and 6 months.
- Unilateral upper limb involvement.
- Able to understand and follow verbal instructions.
- Medically stable and able to participate in the rehabilitation program.
- Willing to provide informed consent.
Who cannot join
- - Hemorrhagic stroke.
- Bilateral stroke involvement.
- Severe cognitive impairment or severe aphasia interfering with participation.
- Severe visual or auditory deficits affecting training.
- Severe upper limb spasticity that prevents hand training.
- Other neurological disorders affecting upper limb function.
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- Severe musculoskeletal disorders of the upper limb.
- Participation in another rehabilitation trial during the study period.
- Unstable cardiovascular or medical conditions.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effect of Adding Augmented Cues to Physical Therapy Intervention on Hand Function Post Stroke Patients
This study aims to investigate the effect of adding augmented cues to conventional physical therapy intervention on hand function in patients with post-stroke hemiparesis. Fifty patients with subacute ischemic stroke will be randomly assigned to either a study group receiving augmented cue-based training in addition to conventional physical therapy or a control group receiving conventional physical therapy alone. Hand function will be assessed before and after the intervention period using the Nine-Hole Peg Test (NHPT), hand grip strength measured by a dynamometer, and pressure pain threshold measured by a pressure algometer. The findings of this study may provide evidence regarding the effectiveness of augmented cue-based rehabilitation strategies in improving hand function after stroke.
Read the detailed description
Stroke is one of the leading causes of long-term disability worldwide and frequently results in impaired hand function, reduced dexterity, decreased grip strength, and limitations in activities of daily living. Conventional physical therapy is commonly used to improve upper extremity function; however, recovery of hand performance remains challenging for many stroke survivors.
Augmented cues provide additional sensory information through visual, auditory, or sensorimotor feedback that may enhance motor learning and neuroplasticity. Incorporating augmented cues into rehabilitation programs may improve patient engagement, increase repetition of task-specific movements, and facilitate functional recovery.
The purpose of this randomized controlled trial is to examine the effectiveness of adding augmented cue-based training to conventional physical therapy intervention in improving hand function among patients with subacute ischemic stroke.
A total of 50 participants meeting the eligibility criteria will be recruited and randomly assigned into two equal groups:
Study Group: Participants will receive augmented cue-based training combined with conventional physical therapy.
Control Group: Participants will receive conventional physical therapy only.
The intervention will be conducted over an eight-week treatment period. Outcome measures will be collected before and after treatment and will include:
- Nine-Hole Peg Test (NHPT) to assess manual dexterity.
- Hand grip strength measured using a hand dynamometer.
- Pressure pain threshold measured using a pressure algometer.
The primary objective is to determine whether the addition of augmented cues results in greater improvement in hand function compared with conventional physical therapy alone. The results may contribute to the development of more effective rehabilitation strategies for individuals recovering from stroke.
- Conditions
- Ischemic Stroke
- Being tested
- Conventional physical therapy, musicgloves training
- Keywords
- augmented cues, stroke rehab, hand function, musical gloves, upper extremity rehabilition, grip strenght
- Medical subject headings
- Ischemic Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Conventional physical therapyOther
Participants will receive a conventional physical therapy program for upper limb and hand rehabilitation after stroke. The program includes stretching exercises, range of motion exercises, strengthening exercises, and task-oriented hand training. Treatment will be provided three times per week for eight weeks (24 sessions).
musicgloves trainingDevice
MusicGlove is a sensor-based rehabilitation device that provides augmented visual, auditory, and performance feedback during task-specific hand exercises. Participants perform repetitive thumb-to-finger opposition and grasping movements synchronized with computer-based musical activities. Training will be provided in addition to conventional physical therapy three times per week for eight weeks.
| Study group | Role | What they receive |
|---|---|---|
| control group | Active comparator | Participants will receive a conventional physical therapy program for hand rehabilitation after stroke. Treatment will be administered three times per week for eight weeks (24 sessions), with each session lasting 60 minutes and including range of motion exercises, strengthening exercises, stretching, and task-oriented hand training. Receives: Other: Conventional physical therapy |
| musical gloves | Experimental | articipants will receive the same conventional physical therapy program provided to the control group in addition to MusicGlove training. Treatment will be administered three times per week for eight weeks (24 sessions). MusicGlove will provide augmented visual, auditory, and performance feedback during task-specific hand training. Receives: Other: Conventional physical therapy; Device: musicgloves training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Nine-Hole peg Test (NHPT)
Manual dexterity assessed using the Nine-Hole Peg Test. The time required to place and remove nine pegs will be recorded in seconds. Lower scores indicate better hand dexterity.
Measured: Baseline and after 8 weeks of treatment
Secondary outcomes (2)
hand grip strength
Hand grip strength will be assessed using a calibrated hand dynamometer. Participants will perform maximal voluntary grip contractions, and the average value of three trials will be recorded in kilograms. Higher values indicate greater hand strength.
Measured: Baseline and after 8 weeks of treatment
pressure pain threshold
Pressure pain threshold of the Extensor Carpi Radialis Brevis muscle will be measured using a digital pressure algometer. Pressure will be applied at a standardized rate until the participant first perceives pain. Higher values indicate lower pain sensitivity.
Measured: Baseline and after 8 weeks of treatment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Jun 2026
- Study start1 Aug 2025
- Primary completion1 Apr 2026
- Study completion1 Apr 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Ischemic StrokeStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 50 participants (actual)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mostafa Abdullah Abdelazim Ahmed, Cairo University
- Investigators
- Moshera H Darwish, PHD, Study chair, Professor of Physical Therapy for Neurology and Neurosurgery Faculty of Physical Therapy Cairo Universitymariam m elsayed, phd, Study director, Lecturer in department of physical Therapy for Neurology and Neurosurgery Faculty of physical therapy Cairo UniversityEssam M Abdulwahab, PHD, Study director, Professor of Neurology Faculty of Medicine Al-Azhar university
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07654582
- Sponsor's protocol ID
- P.T.REC/012/006310
- Acronym
- AUGMENTED CUES
- Status last verified
- Jun 2026
- First submitted
- 13 Jun 2026
- Last updated
- 24 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data (IPD) will be available from the corresponding author upon reasonable request.
Study at a glance
From the registry record, last updated by the sponsor on 24 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Adding Augmented Cues to Physical Therapy Intervention on Hand Function Post Stroke Patients
- ClinicalTrials.gov ID
- NCT07654582
- Acronym / sponsor ID
- AUGMENTED CUES / P.T.REC/012/006310
- Conditions
- Ischemic Stroke
- Keywords
- augmented cues, stroke rehab, hand function, musical gloves, upper extremity rehabilition, grip strenght
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 50 participants (actual)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 1 Aug 2025 (actual)
- Primary completion
- 1 Apr 2026 (actual)
- Study completion
- 1 Apr 2026 (actual)
- First posted
- 17 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to investigate the effect of adding augmented cues to conventional physical therapy intervention on hand function in patients with post-stroke hemiparesis. Fifty patients with subacute ischemic stroke will be randomly assigned to either a study group receiving augmented cue-based training in addition to conventional physical therapy or a control group receiving conventional physical therapy alone. Hand function will be assessed before and after the intervention period using the Nine-Hole Peg Test (NHPT), hand grip strength measured by a dynamometer, and pressure pain threshold measured by a pressure algometer. The findings of this study may provide evidence regarding the effectiveness of augmented cue-based rehabilitation strategies in improving hand function after stroke.
Detailed description
Stroke is one of the leading causes of long-term disability worldwide and frequently results in impaired hand function, reduced dexterity, decreased grip strength, and limitations in activities of daily living. Conventional physical therapy is commonly used to improve upper extremity function; however, recovery of hand performance remains challenging for many stroke survivors.
Augmented cues provide additional sensory information through visual, auditory, or sensorimotor feedback that may enhance motor learning and neuroplasticity. Incorporating augmented cues into rehabilitation programs may improve patient engagement, increase repetition of task-specific movements, and facilitate functional recovery.
The purpose of this randomized controlled trial is to examine the effectiveness of adding augmented cue-based training to conventional physical therapy intervention in improving hand function among patients with subacute ischemic stroke.
A total of 50 participants meeting the eligibility criteria will be recruited and randomly assigned into two equal groups:
Study Group: Participants will receive augmented cue-based training combined with conventional physical therapy.
Control Group: Participants will receive conventional physical therapy only.
The intervention will be conducted over an eight-week treatment period. Outcome measures will be collected before and after treatment and will include:
- Nine-Hole Peg Test (NHPT) to assess manual dexterity.
- Hand grip strength measured using a hand dynamometer.
- Pressure pain threshold measured using a pressure algometer.
The primary objective is to determine whether the addition of augmented cues results in greater improvement in hand function compared with conventional physical therapy alone. The results may contribute to the development of more effective rehabilitation strategies for individuals recovering from stroke.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| control group | Active comparator | Other: Conventional physical therapyParticipants will receive a conventional physical therapy program for hand rehabilitation after stroke. Treatment will be administered three times per week for eight weeks (24 sessions), with each session lasting 60 minutes and including range of motion exercises, strengthening exercises, stretching, and task-oriented hand training. |
| musical gloves | Experimental | Other: Conventional physical therapy, Device: musicgloves trainingarticipants will receive the same conventional physical therapy program provided to the control group in addition to MusicGlove training. Treatment will be administered three times per week for eight weeks (24 sessions). MusicGlove will provide augmented visual, auditory, and performance feedback during task-specific hand training. |
Who may qualify
- Ages
- 40 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (8 listed)
- - Male and female patients.
- Age between 40 and 60 years.
- First-ever subacute ischemic stroke.
- Time since stroke between 6 weeks and 6 months.
- Unilateral upper limb involvement.
Key exclusion criteria (9 listed)
- - Hemorrhagic stroke.
- Bilateral stroke involvement.
- Severe cognitive impairment or severe aphasia interfering with participation.
- Severe visual or auditory deficits affecting training.
- Severe upper limb spasticity that prevents hand training.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Conventional physical therapyParticipants will receive a conventional physical therapy program for upper limb and hand rehabilitation after stroke. The program includes stretching exercises, range of motion exercises, strengthening exercises, and task-oriented hand training. Treatment will be provided three times per week for eight weeks (24 sessions). | Other | control group, musical gloves |
| musicgloves trainingMusicGlove is a sensor-based rehabilitation device that provides augmented visual, auditory, and performance feedback during task-specific hand exercises. Participants perform repetitive thumb-to-finger opposition and grasping movements synchronized with computer-based musical activities. Training will be provided in addition to conventional physical therapy three times per week for eight weeks. | Device | musical gloves |
Primary outcome
Nine-Hole peg Test (NHPT)
Time frame: Baseline and after 8 weeks of treatment
Manual dexterity assessed using the Nine-Hole Peg Test. The time required to place and remove nine pegs will be recorded in seconds. Lower scores indicate better hand dexterity.
2 secondary outcomes
hand grip strength
Time frame: Baseline and after 8 weeks of treatment
pressure pain threshold
Time frame: Baseline and after 8 weeks of treatment
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Jun 2026.
- Individual participant dataSharing planned: No. Individual participant data (IPD) will be available from the corresponding author upon reasonable request.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Moshera H Darwish, PHD study chair
Professor of Physical Therapy for Neurology and Neurosurgery Faculty of Physical Therapy Cairo University
mariam m elsayed, phd study director
Lecturer in department of physical Therapy for Neurology and Neurosurgery Faculty of physical therapy Cairo University
Essam M Abdulwahab, PHD study director
Professor of Neurology Faculty of Medicine Al-Azhar university
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Conventional physical therapy and musicgloves training in people with Ischemic Stroke, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 24 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Nine-Hole peg Test (NHPT) (time frame: Baseline and after 8 weeks of treatment). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Jun 2026.