Postoperative PainSRVATSNCT07655336
SPSIP Versus RISS Block in Volume-Preserving VATS
A study testing Serratus posterior superior intercostal plane block and Rhomboid Intercostal and Subserratus Block in people with Postoperative Pain and Thoracic Surgery, run by Ferit Yetik at 1 site in Turkey (Türkiye).
Trial summary
This prospective randomized controlled study aims to compare the effects of Serratus Posterior Superior Intercostal Plane (SPSIP) block and Rhomboid Intercostal and Subserratus (RISS) block on postoperative pain, respiratory function, and recovery quality in patients undergoing volume-preserving video-assisted… Read more about this study
- Who is it for?
- Ages 18 to 75 years
- Conditions the study is for
- Postoperative Pain, Thoracic Surgery
- What is being tested?
- Serratus posterior superior intercostal plane block and Rhomboid Intercostal and Subserratus Block
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 84 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 18 Jun 2026to Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 75 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients scheduled for elective biportal video-assisted thoracoscopic surgery (VATS) with lung parenchyma-preserving thoracic procedures under general anesthesia
- American Society of Anesthesiologists (ASA) physical status I-III
- Age between 18 and 75 years
- Provision of written informed consent
Who cannot join
- Use of anticoagulant or antiplatelet therapy
- Bleeding diathesis
- Known allergy to local anesthetics
- Infection at the planned block site
- Severe chronic pulmonary disease or advanced respiratory failure (e.g., severe COPD or restrictive lung disease)
- Cognitive impairment preventing reliable NRS assessment
Show all 12Show fewer
- Pregnancy or lactation
- Chronic opioid use (regular use for ≥3 months)
- Severe hepatic or renal failure
- Refusal to participate
- Technical failure or unsuccessful regional block
- Conversion to open thoracotomy during surgery
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Bursa City Hospital
Bursa, Nilüfer, 16100
Yusuf Alan, MD, 05396210977, dryusufalan@gmail.com
Yusuf Alan, MD
About this study
Official title: Comparison of Serratus Posterior Superior Intercostal Plane Block and Rhomboid Intercostal-Subserratus Plane Block on Postoperative Analgesia and Respiratory Functions in Volume-Preserving Video-Assisted Thoracoscopic Surgery: A Prospective Randomized Controlled Trial
This prospective randomized controlled study aims to compare the effects of Serratus Posterior Superior Intercostal Plane (SPSIP) block and Rhomboid Intercostal and Subserratus (RISS) block on postoperative pain, respiratory function, and recovery quality in patients undergoing volume-preserving video-assisted thoracoscopic surgery (VATS). Eighty-four patients will be randomized in a 1:1 ratio to receive either SPSIP block or RISS block. The primary outcome is the incidence of somatic pain at the chest drain insertion site at postoperative 2 hours. Secondary outcomes include pain scores, opioid consumption, quality of recovery, diaphragmatic function, pulmonary function, rescue analgesic requirements, postoperative nausea and vomiting, and block-related complications.
Read the detailed description
Video-assisted thoracoscopic surgery (VATS) is associated with significant postoperative pain that may impair respiratory function and delay recovery. Regional anesthesia techniques are increasingly used to improve analgesia while minimizing opioid-related adverse effects.
The Serratus Posterior Superior Intercostal Plane (SPSIP) block and the Rhomboid Intercostal and Subserratus (RISS) block are novel ultrasound-guided fascial plane blocks that provide thoracic analgesia through different mechanisms. However, comparative clinical evidence regarding their efficacy in VATS patients remains limited.
This prospective, randomized, controlled study will enroll 84 adult patients scheduled for volume-preserving VATS. Participants will be randomly assigned to receive either SPSIP block or RISS block in a 1:1 ratio (42 patients per group).
The primary endpoint is the incidence of somatic pain at the chest drain insertion site at postoperative 2 hours.
Secondary endpoints include postoperative pain scores at rest and during movement, total intravenous morphine consumption during the first 24 postoperative hours, Quality of Recovery-15 (QoR-15) score at postoperative 24 hours, diaphragmatic excursion measured by ultrasonography, peak expiratory flow measurements, rescue analgesic requirements, time to first rescue analgesia, incidence of postoperative nausea and vomiting, and block-related complications.
The study has been approved by the Bursa Sehir Hospital Clinical Research Ethics Committee and will be conducted in accordance with the Declaration of Helsinki and Good Clinical Practice principles.
- Conditions
- Postoperative Pain, Thoracic Surgery
- Being tested
- Serratus posterior superior intercostal plane block, Rhomboid Intercostal and Subserratus Block
- Keywords
- Video-Assisted Thoracic Surgery, VATS, Serratus Posterior Superior Intercostal Plane Block, Rhomboid Intercostal and Subserratus Block, Diaphragmatic Excursion, Peak Expiratory Flow
- Medical subject headings
- Pain, Postoperative
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Serratus posterior superior intercostal plane blockProcedure or surgery
Ultrasound-guided Serratus Posterior Superior Intercostal Plane (SPSIP) block performed before induction of general anesthesia using local anesthetic for postoperative analgesia in patients undergoing video-assisted thoracic surgery.
Rhomboid Intercostal and Subserratus BlockProcedure or surgery
Ultrasound-guided Rhomboid Intercostal and Subserratus (RISS) block performed before induction of general anesthesia using local anesthetic for postoperative analgesia in patients undergoing video-assisted thoracic surgery.
| Study group | Role | What they receive |
|---|---|---|
| SPSIP Block Group | Experimental | Patients will receive an ultrasound-guided Serratus Posterior Superior Intercostal Plane (SPSIP) block before induction of general anesthesia for postoperative analgesia after video-assisted thoracic surgery (VATS). Receives: Procedure: Serratus posterior superior intercostal plane block |
| RISS Block Group | Experimental | Patients will receive an ultrasound-guided Rhomboid Intercostal and Subserratus (RISS) block before induction of general anesthesia for postoperative analgesia after video-assisted thoracic surgery (VATS). Receives: Procedure: Rhomboid Intercostal and Subserratus Block |
What is being measured
The primary outcome is the main question the study is designed to answer.
Incidence of Somatic Pain at Chest Tube Insertion Site
Incidence of somatic pain localized at the chest tube insertion site, defined as sharp localized pain aggravated by coughing or deep inspiration, recorded as present or absent.
Measured: Postoperative 2 hours
Secondary outcomes (7)
Postoperative Pain Scores at Rest
Static postoperative pain scores assessed using the Numeric Rating Scale (NRS) at rest.
Measured: Postoperative 2, 6, 12, and 24 hours
Postoperative Pain Scores During Movement
Dynamic postoperative pain scores assessed using the Numeric Rating Scale (NRS) during movement.
Measured: Postoperative 2, 6, 12, and 24 hours
Total Intravenous Morphine Consumption
Total intravenous morphine consumption during the first 24 hours after surgery.
Measured: Postoperative 24 hours
Interval Intravenous Morphine Consumption
Intravenous morphine consumption recorded separately for postoperative 0-8, 8-16, and 16-24 hour intervals.
Measured: Postoperative 0-8, 8-16, and 16-24 hours
Right Hemidiaphragm Excursion
Right hemidiaphragm excursion measured by ultrasonography to evaluate diaphragmatic function.
Measured: Preoperative and postoperative 6 hours
Peak Expiratory Flow
Peak expiratory flow measured using a peak flowmeter to evaluate respiratory performance.
Measured: Preoperative and postoperative 6 hours
Quality of Recovery-15 Score
Postoperative recovery quality assessed using the Quality of Recovery-15 (QoR-15) questionnaire.
Measured: Postoperative 24 hours
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Jun 2026
- Study start18 Jun 2026
- Primary completionDec 2026 (estimated)
- Study completionDec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Postoperative PainStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Prospective, randomized, double-blind, parallel-group clinical trial comparing Serratus Posterior Superior Intercostal Plane (SPSIP) block and Rhomboid Intercostal and Subserratus (RISS) block for postoperative analgesia after video-assisted thoracic surgery (VATS). Eighty-four participants will be randomized in a 1:1 ratio to receive SPSIP block or RISS block.
- Masking
- Quadruple blind
- Who is masked
- Participant, Care provider, Investigator, Outcomes assessor
- Enrolment
- 84 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Ferit Yetik
- Sponsor type
- Other government
- Collaborators
- Bursa Sehir Hastanesi
- Responsible party
- Sponsor-investigator, Ferit Yetik, Bursa Yuksek Ihtisas Training and Research Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07655336
- Sponsor's protocol ID
- 26-AKD-150
- Other IDs
- 2025-KAEK-47
- Acronym
- SRVATS
- Status last verified
- Jun 2026
- First submitted
- 12 Jun 2026
- Last updated
- 22 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: Individual participant data (IPD) sharing has not yet been determined. The decision regarding data sharing will be made after study completion and in accordance with institutional policies, ethical considerations, and participant confidentiality requirements.
Study at a glance
From the registry record, last updated by the sponsor on 22 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Serratus Posterior Superior Intercostal Plane Block and Rhomboid Intercostal-Subserratus Plane Block on Postoperative Analgesia and Respiratory Functions in Volume-Preserving Video-Assisted Thoracoscopic Surgery: A Prospective Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07655336
- Acronym / sponsor ID
- SRVATS / 26-AKD-150
- Conditions
- Postoperative Pain, Thoracic Surgery
- Keywords
- Video-Assisted Thoracic Surgery, VATS, Serratus Posterior Superior Intercostal Plane Block, Rhomboid Intercostal and Subserratus Block, Diaphragmatic Excursion, Peak Expiratory Flow
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 84 participants (estimated)
- Lead sponsor
- Ferit YetikOther government
- Collaborators
- Bursa Sehir Hastanesi
- Study start
- 18 Jun 2026 (actual)
- Primary completion
- Dec 2026 (estimated)
- Study completion
- Dec 2026 (estimated)
- First posted
- 17 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This prospective randomized controlled study aims to compare the effects of Serratus Posterior Superior Intercostal Plane (SPSIP) block and Rhomboid Intercostal and Subserratus (RISS) block on postoperative pain, respiratory function, and recovery quality in patients undergoing volume-preserving video-assisted thoracoscopic surgery (VATS). Eighty-four patients will be randomized in a 1:1 ratio to receive either SPSIP block or RISS block. The primary outcome is the incidence of somatic pain at the chest drain insertion site at postoperative 2 hours. Secondary outcomes include pain scores, opioid consumption, quality of recovery, diaphragmatic function, pulmonary function, rescue analgesic requirements, postoperative nausea and vomiting, and block-related complications.
Detailed description
Video-assisted thoracoscopic surgery (VATS) is associated with significant postoperative pain that may impair respiratory function and delay recovery. Regional anesthesia techniques are increasingly used to improve analgesia while minimizing opioid-related adverse effects.
The Serratus Posterior Superior Intercostal Plane (SPSIP) block and the Rhomboid Intercostal and Subserratus (RISS) block are novel ultrasound-guided fascial plane blocks that provide thoracic analgesia through different mechanisms. However, comparative clinical evidence regarding their efficacy in VATS patients remains limited.
This prospective, randomized, controlled study will enroll 84 adult patients scheduled for volume-preserving VATS. Participants will be randomly assigned to receive either SPSIP block or RISS block in a 1:1 ratio (42 patients per group).
The primary endpoint is the incidence of somatic pain at the chest drain insertion site at postoperative 2 hours.
Secondary endpoints include postoperative pain scores at rest and during movement, total intravenous morphine consumption during the first 24 postoperative hours, Quality of Recovery-15 (QoR-15) score at postoperative 24 hours, diaphragmatic excursion measured by ultrasonography, peak expiratory flow measurements, rescue analgesic requirements, time to first rescue analgesia, incidence of postoperative nausea and vomiting, and block-related complications.
The study has been approved by the Bursa Sehir Hospital Clinical Research Ethics Committee and will be conducted in accordance with the Declaration of Helsinki and Good Clinical Practice principles.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind (participant, care provider, investigator, outcomes assessor)
- Number of arms
- 2
- Model description
- Prospective, randomized, double-blind, parallel-group clinical trial comparing Serratus Posterior Superior Intercostal Plane (SPSIP) block and Rhomboid Intercostal and Subserratus (RISS) block for postoperative analgesia after video-assisted thoracic surgery (VATS). Eighty-four participants will be randomized in a 1:1 ratio to receive SPSIP block or RISS block.
| Arm | Type | Receives |
|---|---|---|
| SPSIP Block Group | Experimental | Procedure: Serratus posterior superior intercostal plane blockPatients will receive an ultrasound-guided Serratus Posterior Superior Intercostal Plane (SPSIP) block before induction of general anesthesia for postoperative analgesia after video-assisted thoracic surgery (VATS). |
| RISS Block Group | Experimental | Procedure: Rhomboid Intercostal and Subserratus BlockPatients will receive an ultrasound-guided Rhomboid Intercostal and Subserratus (RISS) block before induction of general anesthesia for postoperative analgesia after video-assisted thoracic surgery (VATS). |
Who may qualify
- Ages
- 18 to 75 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Patients scheduled for elective biportal video-assisted thoracoscopic surgery (VATS) with lung parenchyma-preserving thoracic procedures under general anesthesia
- American Society of Anesthesiologists (ASA) physical status I-III
- Age between 18 and 75 years
- Provision of written informed consent
Key exclusion criteria (12 listed)
- Use of anticoagulant or antiplatelet therapy
- Bleeding diathesis
- Known allergy to local anesthetics
- Infection at the planned block site
- Severe chronic pulmonary disease or advanced respiratory failure (e.g., severe COPD or restrictive lung disease)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Serratus posterior superior intercostal plane blockUltrasound-guided Serratus Posterior Superior Intercostal Plane (SPSIP) block performed before induction of general anesthesia using local anesthetic for postoperative analgesia in patients undergoing video-assisted thoracic surgery. | Procedure or surgery | SPSIP Block Group |
| Rhomboid Intercostal and Subserratus BlockUltrasound-guided Rhomboid Intercostal and Subserratus (RISS) block performed before induction of general anesthesia using local anesthetic for postoperative analgesia in patients undergoing video-assisted thoracic surgery. | Procedure or surgery | RISS Block Group |
Primary outcome
Incidence of Somatic Pain at Chest Tube Insertion Site
Time frame: Postoperative 2 hours
Incidence of somatic pain localized at the chest tube insertion site, defined as sharp localized pain aggravated by coughing or deep inspiration, recorded as present or absent.
7 secondary outcomes
Postoperative Pain Scores at Rest
Time frame: Postoperative 2, 6, 12, and 24 hours
Postoperative Pain Scores During Movement
Time frame: Postoperative 2, 6, 12, and 24 hours
Total Intravenous Morphine Consumption
Time frame: Postoperative 24 hours
Interval Intravenous Morphine Consumption
Time frame: Postoperative 0-8, 8-16, and 16-24 hours
Right Hemidiaphragm Excursion
Time frame: Preoperative and postoperative 6 hours
Peak Expiratory Flow
Time frame: Preoperative and postoperative 6 hours
Quality of Recovery-15 Score
Time frame: Postoperative 24 hours
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Jun 2026.
- Individual participant dataSharing planned: Undecided. Individual participant data (IPD) sharing has not yet been determined. The decision regarding data sharing will be made after study completion and in accordance with institutional policies, ethical considerations, and participant confidentiality requirements.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Serratus posterior superior intercostal plane block and Rhomboid Intercostal and Subserratus Block in people with Postoperative Pain and Thoracic Surgery, run by Ferit Yetik at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 12 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 22 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Yusuf Alan (+905396210977, dryusufalan@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Incidence of Somatic Pain at Chest Tube Insertion Site (time frame: Postoperative 2 hours). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Jun 2026.