Non-sarcopenic SubjectsGSOMNCT07658612
Research on the Possible Relationship Between Sarcopenia and Oral Muscle Function
An observational study of Non-sarcopenic Subjects and Possible Sarcopenia, run by Chang Gung University of Science and Technology at 1 site in Taiwan.
Trial summary
This study will focus on community-dwelling elderly individuals and will follow the community screening process recommended by AWGS. It is expected to recruit 100 individuals who may have sarcopenia and 300 healthy or sub-healthy elderly individuals who are not likely to have sarcopenia, totaling 400… Read more about this study
- Who is it for?
- Ages 60 years and olderHealthy volunteers can take part
- Conditions the study is for
- Non-sarcopenic Subjects, Possible Sarcopenia, Sarcopenia (With Low ASM by BIM)
- What is being tested?
- Non interventional study
- How many people
- 251 participants
- Where
- 1 siteTaiwan
- Study dates
- 14 Nov 2025to 4 Jun 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 60 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: The research locations are the multimedia classroom on the 5th floor of the Department of Health and Nutrition at Chang Gung University, as well as community care centers in various districts of Taoyuan City and New Taipei City.
Case group - Inclusion Criteria:
- aged 60 years (inclusive) or older
- general public or residing in an institution for 3 months (inclusive) or more
- willing to participate in the experimental design and sign the consent form
- able to eat independently by mouth
- identified by researchers as possibly having sarcopenia
Control group-Inclusion Criteria:
- aged 60 years (inclusive) or older
- general public or residing in an institution for 3 months (inclusive) or more ●willing to participate in the experimental design and sign the consent form
- able to eat independently by mouth
- identified by researchers as not possibly having sarcopenia
Case group 、Control group- Exclusion Criteria:
- having comorbidities, critical illnesses, undergoing major surgeries, cancer, renal failure, liver failure, kidney diseases, liver diseases, having malignant tumors in the past five years, inflammation symptoms (C-reactive protein >10mg/dl)
- severely malnourished individuals (GNRI < 82)
- long-term tube-fed individuals.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: A Study on the Correlation Between the Genetic Polymorphisms of Elderly Individuals in the Community and Possible Sarcopenia and Oral Muscle Function
This study will focus on community-dwelling elderly individuals and will follow the community screening process recommended by AWGS.
It is expected to recruit 100 individuals who may have sarcopenia and 300 healthy or sub-healthy elderly individuals who are not likely to have sarcopenia, totaling 400 participants.Basic data such as age and body composition will be collected, as well as dietary records (three days), nutritional status assessments (Mini Nutritional Assessment, MNA), and oral health status records (including records of missing teeth, the number of opposing teeth, and whether participants wear fixed or removable dentures).
Read more
Chewing and swallowing abilities will be recorded using the Eating Assessment Tool (EAT-10). In a non-invasive manner, saliva samples will be collected for genomic DNA (gDNA) extraction, followed by quantitative gDNA typing analysis of seven gene loci (shown in Table 3).
Genotype data will be statistically analyzed along with participants' basic information, relevant sarcopenia screening data, and parameters related to oral health and swallowing function. This study adopts a case-control experimental design with the following objectives:
- to explore the incidence of possible sarcopenia in community-dwelling elderly.
- to investigate the relationship between oral function and possible sarcopenia in community-dwelling elderly using tongue pressure measurements.
- to understand the correlation between sarcopenia risk in community-dwelling elderly and seven specific genes.
- to examine the relationship between oral function and seven specific genes in community-dwelling elderly.
- to investigate the relationship between tongue pressure measurements and the values measured using edible chewing gum.
- to establish a standard test for evaluating oral chewing function using edible chewing gum.
By examining the possible mechanisms of the different genes involved in the causes of sarcopenia, we aim to find prevention strategies that are suitable for participants with different gene types.
- Being tested
- Non interventional study
- Keywords
- Genetic polymorphisms, Sarcopenia, Community-dwelling elderly, Chewing ability, Swallowing function, Genotype analysis
- Medical subject headings
- Sarcopenia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Non interventional studyOther
NON
| Study group | Role | What they receive |
|---|---|---|
| Case group | Possible sarcopenia Receives: Other: Non interventional study | |
| Control group | Non-possible sarcopenia Receives: Other: Non interventional study |
What is being measured
The primary outcome is the main question the study is designed to answer.
Based on the results of empirical research on sarcopenia in Asian countries, a diagnostic consensus was established.
- The cut-off point for abnormal grip strength is less than 28 kg for men and less than 18 kg for women
- 6-meter walking speed less than 1.0 second/meter
- 5-time chair stand test greater than or equal to 12 seconds
- Short physical performance battery, SPPB greater than or equal to 9 points The above data will be combined to determine whether sarcopenia is possible
Measured: baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Jun 2026
- Study start14 Nov 2025
- Primary completion4 Jun 2026
- Study completion4 Jun 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Non-sarcopenic SubjectsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Enrolment
- 251 participants (actual)
Sponsor and investigators
- Lead sponsor
- Chang Gung University of Science and Technology
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07658612
- Sponsor's protocol ID
- 202402045B0
- Other IDs
- NMRPF3Q0291
- Acronym
- GSOM
- Status last verified
- Jun 2026
- First submitted
- 10 Jun 2026
- Last updated
- 22 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 22 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Study on the Correlation Between the Genetic Polymorphisms of Elderly Individuals in the Community and Possible Sarcopenia and Oral Muscle Function
- ClinicalTrials.gov ID
- NCT07658612
- Acronym / sponsor ID
- GSOM / 202402045B0
- Keywords
- Genetic polymorphisms, Sarcopenia, Community-dwelling elderly, Chewing ability, Swallowing function, Genotype analysis
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 251 participants (actual)
- Lead sponsor
- Chang Gung University of Science and TechnologyUniversity, hospital or other
- Study start
- 14 Nov 2025 (actual)
- Primary completion
- 4 Jun 2026 (actual)
- Study completion
- 4 Jun 2026 (actual)
- First posted
- 22 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study will focus on community-dwelling elderly individuals and will follow the community screening process recommended by AWGS.
It is expected to recruit 100 individuals who may have sarcopenia and 300 healthy or sub-healthy elderly individuals who are not likely to have sarcopenia, totaling 400 participants.Basic data such as age and body composition will be collected, as well as dietary records (three days), nutritional status assessments (Mini Nutritional Assessment, MNA), and oral health status records (including records of missing teeth, the number of opposing teeth, and whether participants wear fixed or removable dentures).
Chewing and swallowing abilities will be recorded using the Eating Assessment Tool (EAT-10). In a non-invasive manner, saliva samples will be collected for genomic DNA (gDNA) extraction, followed by quantitative gDNA typing analysis of seven gene loci (shown in Table 3).
Genotype data will be statistically analyzed along with participants' basic information, relevant sarcopenia screening data, and parameters related to oral health and swallowing function. This study adopts a case-control experimental design with the following objectives:
- to explore the incidence of possible sarcopenia in community-dwelling elderly.
- to investigate the relationship between oral function and possible sarcopenia in community-dwelling elderly using tongue pressure measurements.
- to understand the correlation between sarcopenia risk in community-dwelling elderly and seven specific genes.
- to examine the relationship between oral function and seven specific genes in community-dwelling elderly.
- to investigate the relationship between tongue pressure measurements and the values measured using edible chewing gum.
- to establish a standard test for evaluating oral chewing function using edible chewing gum.
By examining the possible mechanisms of the different genes involved in the causes of sarcopenia, we aim to find prevention strategies that are suitable for participants with different gene types.
Study design
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Case group | – | Other: Non interventional studyPossible sarcopenia |
| Control group | – | Other: Non interventional studyNon-possible sarcopenia |
Who may qualify
- Ages
- 60 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- The research locations are the multimedia classroom on the 5th floor of the Department of Health and Nutrition at Chang Gung University, as well as community care centers in various districts of Taoyuan City and New Taipei City.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Non interventional studyNON | Other | Case group, Control group |
Primary outcome
Based on the results of empirical research on sarcopenia in Asian countries, a diagnostic consensus was established.
Time frame: baseline
* The cut-off point for abnormal grip strength is less than 28 kg for men and less than 18 kg for women * 6-meter walking speed less than 1.0 second/meter * 5-time chair stand test greater than or equal to 12 seconds * Short physical performance battery, SPPB greater than or equal to 9 points The above data will be combined to determine whether sarcopenia is possible
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Jun 2026.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Non-sarcopenic Subjects and Possible Sarcopenia, run by Chang Gung University of Science and Technology at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 22 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Based on the results of empirical research on sarcopenia in Asian countries, a diagnostic consensus was established. (time frame: baseline). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Jun 2026.