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Type 2 DiabetesT2DM_NLPNCT07659925

Periodization-Based Strength Exercise Training in İndividuals With Type 2 Diabetes

A study testing Non-linear Periodization-Based Strength Training and Linear Periodization-Based Strength Training in people with Type 2 Diabetes, run by Baskent University at 1 site in Turkey (Türkiye).

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
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Trial summary

This randomized controlled study aims to compare the effects of different periodization-based strength training approaches in individuals with type 2 diabetes mellitus. Participants will be allocated to non-linear periodization, linear periodization, or control groups. Read more about this study

Who is it for?
Ages 18 to 65 years
Conditions the study is for
Type 2 Diabetes
What is being tested?
Non-linear Periodization-Based Strength Training and Linear Periodization-Based Strength Training
Could I receive a placebo?
No, everyone receives an active treatment
How many people
48 participants
Where
1 siteTurkey (Türkiye)
Study dates
1 May 2026to Dec 2026
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 65 years
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Adults aged between 18 to 65 years
  • Diagnosis of Type 2 Diabetes Mellitus (T2DM)
  • Not having participated in any structured exercise program within the last 6 months
  • Willingness to participate in the study and provide written informed consent

Who cannot join

  • Presence of nephropathy, retinopathy, or peripheral neuropathy
  • Presence of neurological, cognitive, or orthopedic disorders that may affect outcome measurements
  • Severe respiratory disease (Forced Expiratory Volume in the first second [FEV1] <35% or Forced Vital Capacity [FVC] <50%)
  • Presence of ischemic heart disease or peripheral arterial disease
  • History of any cardiovascular event within the last 6 months
  • Current malignancy

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

Ayşegül Erkoç, PT contact

+90 553-301-36-73

erkcaysegl@gmail.com

Turkey (Türkiye)1 site, 1 recruiting

  • Baskent University Hospital

    Ankara, Ankara, 06790

    Ayşegül Erkoç, PT, +90 553-301-36-73, erkcaysegl@gmail.com

    Recruiting

Other trials in Turkey (Türkiye)

About this study

Official title: A Comparison of the Effects of Different Periodization-Based Strength Training Programs in Individuals With Type 2 Diabetes Mellitus

This randomized controlled study aims to compare the effects of different periodization-based strength training approaches in individuals with type 2 diabetes mellitus. Participants will be allocated to non-linear periodization, linear periodization, or control groups. The intervention program will be conducted for 8 weeks and will evaluate exercise capacity, muscle strength, quality of life, body composition, and metabolic parameters.

Read the detailed description

Type 2 diabetes mellitus is associated with reduced exercise capacity, decreased muscle strength, impaired quality of life, and metabolic dysfunction. Exercise training is recommended as an important component of diabetes management; however, the comparative effectiveness of different strength training periodization approaches remains unclear.

This randomized controlled trial aims to compare the effects of non-linear periodization and linear periodization strength training programs in individuals with type 2 diabetes mellitus. Participants will be randomized into three groups: a non-linear periodization training group, a linear periodization training group, and a control group receiving usual care.

The intervention will be conducted for 8 weeks, three times per week. Outcomes including exercise capacity, muscle strength, body composition, quality of life, and metabolic parameters will be evaluated before and after the intervention period.

Conditions
Type 2 Diabetes
Being tested
Non-linear Periodization-Based Strength Training, Linear Periodization-Based Strength Training, Usual Care
Keywords
Type 2 Diabetes Mellitus, Strength Training, Non-linear Periodization, Exercise Capacity, Muscle Strength, Quality of Life, Linear Periodization, Resistance Training
Medical subject headings
Diabetes Mellitus, Type 2

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Non-linear Periodization-Based Strength TrainingBehavioural

    Participants will perform supervised non-linear periodization-based strength training three times per week for 8 weeks.

  • Linear Periodization-Based Strength TrainingBehavioural

    Participants will perform supervised linear periodization-based strength training three times per week for 8 weeks.

  • Usual CareOther

    Participants will receive usual care and no structured exercise intervention during the study period.

Study groups in NCT07659925
Study groupRoleWhat they receive
Non-linear Periodization GroupExperimentalParticipants will receive non-linear periodization-based strength training three times per week for 8 weeks.
Receives: Behavioral: Non-linear Periodization-Based Strength Training
Linear Periodization GroupExperimentalParticipants will receive linear periodization-based strength training three times per week for 8 weeks.
Receives: Behavioral: Linear Periodization-Based Strength Training
Control GroupActive comparatorParticipants will receive usual care and no structured exercise intervention during the study period.
Receives: Other: Usual Care

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Exercise Capacity

    Exercise capacity will be assessed using the 6-Minute Walk Test (6MWT)

    Measured: Baseline and after 8 week

Secondary outcomes (8)

  1. Change in Peripheral Muscle Strength

    Peripheral muscle strength will be assessed using handheld dynamometry for upper and lower extremity muscle groups and reported in Newton (N).

    Measured: Baseline and after 8 weeks

  2. Change in Hand Grip Strength

    Hand grip strength will be assessed using a hand dynamometer and reported in kilograms (kg).

    Measured: Baseline and after 8 weeks

  3. Change in Diabetes Quality of Life Questionnaire Score

    Change in the Turkish version of the Diabetes Quality of Life Questionnaire (DQOL) total score and subscale scores from baseline to 8 weeks will be evaluated. The DQOL consists of 45 items assessing treatment satisfaction, psychological impact, concerns about future effects of diabetes, and social/vocational concerns. Each item is scored on a 1-5 scale, and higher scores indicate better diabetes-related quality of life.

    Measured: Baseline and after 8 weeks

  4. Change in Body Fat Percentage

    Body fat percentage (%) will be assessed using bioelectrical impedance analysis (BIA).

    Measured: Baseline and after 8 weeks

  5. Change in Skeletal Muscle Mass

    Skeletal muscle mass (kg) will be assessed using bioelectrical impedance analysis (BIA).

    Measured: Baseline and after 8 weeks

  6. Change in Resting Metabolic Rate

    Resting metabolic rate (kcal/day) will be assessed using indirect calorimetry (COSMED Fitmate Pro, Rome, Italy).

    Measured: Baseline and after 8 weeks

  7. Change in Hemoglobin A1c (HbA1c)

    Glycemic control will be assessed by measuring glycated hemoglobin (HbA1c) levels (%).

    Measured: Baseline and after 8 weeks

  8. Change in Fasting Blood Glucose

    Glycemic control will be assessed by measuring fasting blood glucose levels (mg/dL).

    Measured: Baseline and after 8 weeks

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted22 Jun 2026
  2. Study start1 May 2026
  3. Primary completionNov 2026 (estimated)
  4. Study completionDec 2026 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Model description
Participants will be assigned to one of three parallel groups: non-linear periodization-based strength training, linear periodization-based strength training, or control.
Masking
None (open label)
Enrolment
48 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07659925
Sponsor's protocol ID
T2DM-NLP-2026
Acronym
T2DM_NLP
Status last verified
Jun 2026
First submitted
6 Jun 2026
Last updated
22 Jun 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Questions about this trial

What is this clinical trial studying?

A study testing Non-linear Periodization-Based Strength Training and Linear Periodization-Based Strength Training in people with Type 2 Diabetes, run by Baskent University at 1 site in Turkey (Türkiye).

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 4 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 22 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Ayşegül Erkoç, PT (+90 553-301-36-73, erkcaysegl@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Exercise Capacity (time frame: Baseline and after 8 week). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07659925.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Jun 2026.

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