Uterine CavityNCT07662187
Endometrial Cavity After Conservative Management of PAS Patients by Hysteroscopy
A study testing Resection and reconstruction, Cervical eversion and pouch closure and Anterior and posterior sutures in people with Uterine Cavity and Conservative Management, run by Sohag University at 1 site in Egypt.
Trial summary
This study aimed to evaluate the endometrial cavity by hysteroscopy after different conservative management of placenta accrete spectrum (PAS), that has impact on the future fertility outcome and menstrual pattern of patients. Read more about this study
- Who is it for?
- Ages 20 to 40 years, women only
- Conditions the study is for
- Uterine Cavity, Conservative Management, Placenta Accreta
- What is being tested?
- Resection and reconstruction, Cervical eversion and pouch closure and Anterior and posterior sutures
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 150 participants
- Where
- 1 siteEgypt
- Study dates
- 13 May 2024to 1 Jun 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 40 years
- Women only
- No healthy volunteers
- Adult
Who may be able to join
- Age from 20 to 40 years.
- Pregnant women more than 28 weeks have a desire to preserve future fertility.
- Diagnosis of Placenta accreta spectrum (PAS) was evaluated by 2 D grey scale ultrasound and Doppler study of invasion of the placenta.
- History of at least previous caesarean section (CS) or any intrauterine operation like myomectomy.
- Females with history of different conservatives management methods of PAS in last three months.
Who cannot join
- Non placenta accreta spectrum and primigravida.
- Those who have congenital anomalies in the uterus.
- Those with bleeding tendency.
- Those women that had hysterectomy as a radical surgery.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Evaluation of Endometrial Cavity After Conservative Management of PAS Patients by Hysteroscopy
This study aimed to evaluate the endometrial cavity by hysteroscopy after different conservative management of placenta accrete spectrum (PAS), that has impact on the future fertility outcome and menstrual pattern of patients.
Read the detailed description
Placenta Accreta Spectrum is usually associated with maternal morbidity and mortality. The morbidly adherent placenta spectrum includes, placenta accreta when the placenta invades the endometrium beyond Nitabuch's layer of decidua basalis, placenta increta when the placenta invades the myometrium, and placenta percreta when the placenta invades the uterine serosa.
The risk factors of PAS include previous caesarean section (CS), previous myomectomy, placenta previa, and damage of Nitabuch's layer following intrauterine infection and/or endometrial curettage.
- Conditions
- Uterine Cavity, Conservative Management, Placenta Accreta
- Being tested
- Resection and reconstruction, Cervical eversion and pouch closure, Anterior and posterior sutures
- Medical subject headings
- Placenta Accreta
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Resection and reconstructionProcedure or surgery
Patients underwent resection and reconstruction.
Cervical eversion and pouch closureProcedure or surgery
Patients underwent cervical eversion and pouch closure.
Anterior and posterior suturesProcedure or surgery
Patients underwent anterior and posterior sutures.
| Study group | Role | What they receive |
|---|---|---|
| Group I | Experimental | Patients underwent resection and reconstruction. Receives: Procedure: Resection and reconstruction |
| Group II | Experimental | Patients underwent cervical eversion and pouch closure. Receives: Procedure: Cervical eversion and pouch closure |
| Group III | Experimental | Patients underwent anterior and posterior sutures. Receives: Procedure: Anterior and posterior sutures |
What is being measured
The primary outcome is the main question the study is designed to answer.
Number of participants with restoration of the endometrial cavity assessed by office hysteroscopy
Assessment of endometrial cavity restoration by office hysteroscopy 3 months after conservative management of placenta accreta spectrum.
Measured: 3 months after cesarean section
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Jun 2026
- Study start13 May 2024
- Primary completion1 Jun 2026
- Study completion1 Jun 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Uterine CavityStudies of the same condition, open and under way.
- More trials run by Sohag UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 150 participants (actual)
Sponsor and investigators
- Lead sponsor
- Sohag University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Rania Mahmoud Ahmed Elkhalily, Sohag University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07662187
- Sponsor's protocol ID
- Soh-Med-24-05--06PD.
- Status last verified
- Jun 2026
- First submitted
- 4 Jun 2026
- Last updated
- 29 Jun 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
Study at a glance
From the registry record, last updated by the sponsor on 29 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of Endometrial Cavity After Conservative Management of PAS Patients by Hysteroscopy
- ClinicalTrials.gov ID
- NCT07662187
- Acronym / sponsor ID
- Soh-Med-24-05--06PD.
- Conditions
- Uterine Cavity, Conservative Management, Placenta Accreta
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 150 participants (actual)
- Lead sponsor
- Sohag UniversityUniversity, hospital or other
- Study start
- 13 May 2024 (actual)
- Primary completion
- 1 Jun 2026 (actual)
- Study completion
- 1 Jun 2026 (actual)
- First posted
- 23 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aimed to evaluate the endometrial cavity by hysteroscopy after different conservative management of placenta accrete spectrum (PAS), that has impact on the future fertility outcome and menstrual pattern of patients.
Detailed description
Placenta Accreta Spectrum is usually associated with maternal morbidity and mortality. The morbidly adherent placenta spectrum includes, placenta accreta when the placenta invades the endometrium beyond Nitabuch's layer of decidua basalis, placenta increta when the placenta invades the myometrium, and placenta percreta when the placenta invades the uterine serosa.
The risk factors of PAS include previous caesarean section (CS), previous myomectomy, placenta previa, and damage of Nitabuch's layer following intrauterine infection and/or endometrial curettage.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Group I | Experimental | Procedure: Resection and reconstructionPatients underwent resection and reconstruction. |
| Group II | Experimental | Procedure: Cervical eversion and pouch closurePatients underwent cervical eversion and pouch closure. |
| Group III | Experimental | Procedure: Anterior and posterior suturesPatients underwent anterior and posterior sutures. |
Who may qualify
- Ages
- 20 to 40 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Age from 20 to 40 years.
- Pregnant women more than 28 weeks have a desire to preserve future fertility.
- Diagnosis of Placenta accreta spectrum (PAS) was evaluated by 2 D grey scale ultrasound and Doppler study of invasion of the placenta.
- History of at least previous caesarean section (CS) or any intrauterine operation like myomectomy.
- Females with history of different conservatives management methods of PAS in last three months.
Key exclusion criteria (4 listed)
- Non placenta accreta spectrum and primigravida.
- Those who have congenital anomalies in the uterus.
- Those with bleeding tendency.
- Those women that had hysterectomy as a radical surgery.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Resection and reconstructionPatients underwent resection and reconstruction. | Procedure or surgery | Group I |
| Cervical eversion and pouch closurePatients underwent cervical eversion and pouch closure. | Procedure or surgery | Group II |
| Anterior and posterior suturesPatients underwent anterior and posterior sutures. | Procedure or surgery | Group III |
Primary outcome
Number of participants with restoration of the endometrial cavity assessed by office hysteroscopy
Time frame: 3 months after cesarean section
Assessment of endometrial cavity restoration by office hysteroscopy 3 months after conservative management of placenta accreta spectrum.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Jun 2026.
- Individual participant dataSharing planned: Yes. The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Resection and reconstruction, Cervical eversion and pouch closure and Anterior and posterior sutures in people with Uterine Cavity and Conservative Management, run by Sohag University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 29 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Number of participants with restoration of the endometrial cavity assessed by office hysteroscopy (time frame: 3 months after cesarean section). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Jun 2026.