Cerebral PalsyNCT07675343
Functional Progressive Resistive Training and Cerebral Palsy
A study testing functional progressive resistive exercise and designed physical therapy program and designed physical therapy program in people with Cerebral Palsy, run by Cairo University at 1 site in Egypt.
Trial summary
Functional Progressive Resistive Exercise (FPRE) is a strengthening approach that combines functional movement activities with progressively increased resistance. It involves performing task-oriented exercises, such as sit-to-stand, stair climbing, and walking-related activities, while gradually increasing the load to… Read more about this study
- Who is it for?
- Ages 6 to 10 years
- Conditions the study is for
- Cerebral Palsy
- What is being tested?
- functional progressive resistive exercise and designed physical therapy program and designed physical therapy program
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Jul 2026to 9 Oct 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 6 to 10 years
- All sexes
- No healthy volunteers
- Child
Who may be able to join
- A diagnosis of spastic diplegic CP
- Degree of spasticity ranges from 1+ and 2, according to modified Ashworth scale (MAS)
- The age of the selected children will range from 6 to 10 years old.
- Children are levels II and III according to GMFCS
Who cannot join
- 1 - Children with visual or auditory problems. 2. Children with severe intellectual disability (IQ less than 65 according to Stanford Binet intelligence scale).
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effect of Functional Progressive Resistance Training on Bone Mineral Density and Balance in Children With Cerebral Palsy
Functional Progressive Resistive Exercise (FPRE) is a strengthening approach that combines functional movement activities with progressively increased resistance. It involves performing task-oriented exercises, such as sit-to-stand, stair climbing, and walking-related activities, while gradually increasing the load to enhance muscle strength, endurance, and functional performance. FPRE is widely used in rehabilitation programs to improve mobility and the ability to perform activities of daily living in various populations, including children with neurological and musculoskeletal disorders.
- Conditions
- Cerebral Palsy
- Being tested
- functional progressive resistive exercise and designed physical therapy program, designed physical therapy program
- Keywords
- cerebral palsy, functional progressive resistive exercise, bone mineral density, balance
- Medical subject headings
- Cerebral Palsy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
functional progressive resistive exercise and designed physical therapy programOther
specially designed physical therapy program in addition to functional progressive resistive exercises for 60 min (30 min designed P.T program and other 30 min for brain gym exercises), 3 sessions/ week for 3 successive months. 6 functional progressive resistive exercises will be selected:
- Sit-to-Stand Exercise
- Step-Up Exercise
- Squats
- Lunges
- Stair Climbing
- Loaded Walking
designed physical therapy programOther
conventional physical therapy program including reinforcement of the normal motor development, reflex inhibiting patterns, postural reaction, stretching, strengthening exercises, and gait training was applied to children in the control group
| Study group | Role | What they receive |
|---|---|---|
| functional progressive resistive exercise and designed physical therapy program | Experimental | Not described Receives: Other: functional progressive resistive exercise and designed physical therapy program |
| designed physical therapy program | Experimental | Not described Receives: Other: designed physical therapy program |
What is being measured
The primary outcome is the main question the study is designed to answer.
Dual-energy X-ray absorptiometry (DXA)
The most common test for bone mineral density is a Dual-energy X-ray absorptiometry (DXA) scan. It is:
Painless and non-invasive Quick (usually 10-20 minutes) Low radiation exposure Most often performed on the hip and lower spine. Bone mineral density (BMD) is a measure of the amount of mineral (mainly calcium and phosphorus) present in a specific volume of bone. It reflects bone strength and is used to assess the risk of fractures and diagnose osteoporosis.
Measured: 3month
biodex balance system
The Biodex Balance System is a computerized device used to assess and improve static and dynamic balance, postural stability, and neuromuscular control. It consists of a movable platform that can be adjusted to different levels of stability, allowing clinicians and researchers to evaluate an individual's ability to maintain balance under varying conditions.
Measured: 3 month
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Jun 2026
- Study start1 Jul 2026
- Primary completion22 Sep 2026
- Study completion9 Oct 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cerebral PalsyStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Alaa Fahmy Hassan Al Nemr, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07675343
- Sponsor's protocol ID
- P.T.REC/012/006662
- Status last verified
- Oct 2026
- First submitted
- 23 Jun 2026
- Last updated
- 28 Oct 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 28 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Functional Progressive Resistance Training on Bone Mineral Density and Balance in Children With Cerebral Palsy
- ClinicalTrials.gov ID
- NCT07675343
- Acronym / sponsor ID
- P.T.REC/012/006662
- Conditions
- Cerebral Palsy
- Keywords
- cerebral palsy, functional progressive resistive exercise, bone mineral density, balance
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 60 participants (actual)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 1 Jul 2026 (actual)
- Primary completion
- 22 Sep 2026 (actual)
- Study completion
- 9 Oct 2026 (actual)
- First posted
- 30 Jun 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Functional Progressive Resistive Exercise (FPRE) is a strengthening approach that combines functional movement activities with progressively increased resistance. It involves performing task-oriented exercises, such as sit-to-stand, stair climbing, and walking-related activities, while gradually increasing the load to enhance muscle strength, endurance, and functional performance. FPRE is widely used in rehabilitation programs to improve mobility and the ability to perform activities of daily living in various populations, including children with neurological and musculoskeletal disorders.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| functional progressive resistive exercise and designed physical therapy program | Experimental | Other: functional progressive resistive exercise and designed physical therapy program |
| designed physical therapy program | Experimental | Other: designed physical therapy program |
Who may qualify
- Ages
- 6 to 10 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child
Key inclusion criteria (4 listed)
- A diagnosis of spastic diplegic CP
- Degree of spasticity ranges from 1+ and 2, according to modified Ashworth scale (MAS)
- The age of the selected children will range from 6 to 10 years old.
- Children are levels II and III according to GMFCS
Key exclusion criteria (1 listed)
- 1 - Children with visual or auditory problems. 2. Children with severe intellectual disability (IQ less than 65 according to Stanford Binet intelligence scale).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| functional progressive resistive exercise and designed physical therapy programspecially designed physical therapy program in addition to functional progressive resistive exercises for 60 min (30 min designed P.T program and other 30 min for brain gym exercises), 3 sessions/ week for 3 successive months. 6 functional progressive resistive exercises will be selected: 1. Sit-to-Stand Exercise 2. Step-Up Exercise 3. Squats 4. Lunges 5. Stair Climbing 6. Loaded Walking | Other | functional progressive resistive exercise and designed physical therapy program |
| designed physical therapy programconventional physical therapy program including reinforcement of the normal motor development, reflex inhibiting patterns, postural reaction, stretching, strengthening exercises, and gait training was applied to children in the control group | Other | designed physical therapy program |
Primary outcome
Dual-energy X-ray absorptiometry (DXA)
Time frame: 3month
The most common test for bone mineral density is a Dual-energy X-ray absorptiometry (DXA) scan. It is: Painless and non-invasive Quick (usually 10-20 minutes) Low radiation exposure Most often performed on the hip and lower spine. Bone mineral density (BMD) is a measure of the amount of mineral (mainly calcium and phosphorus) present in a specific volume of bone. It reflects bone strength and is used to assess the risk of fractures and diagnose osteoporosis.
biodex balance system
Time frame: 3 month
The Biodex Balance System is a computerized device used to assess and improve static and dynamic balance, postural stability, and neuromuscular control. It consists of a movable platform that can be adjusted to different levels of stability, allowing clinicians and researchers to evaluate an individual's ability to maintain balance under varying conditions.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing functional progressive resistive exercise and designed physical therapy program and designed physical therapy program in people with Cerebral Palsy, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 28 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Dual-energy X-ray absorptiometry (DXA) (time frame: 3month). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Oct 2026.