Closed Sinus LiftNCT07678749
Closed Sinus Lifting Using Xenograft With or Without Liposomal Apigenin-Loaded Scaffold
A study testing sinus lifting in people with Closed Sinus Lift and Apigenin Loaded Scaffold, run by Al-Azhar University at 1 site in Egypt.
Trial summary
aims to evaluate the effectiveness of closed sinus lifting using xenograft with or without a liposomal Apigenin-loaded scaffold in the posterior maxilla. Read more about this study
- Who is it for?
- Ages 18 to 50 yearsHealthy volunteers can take part
- Conditions the study is for
- Closed Sinus Lift, Apigenin Loaded Scaffold
- What is being tested?
- sinus lifting
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 22 participants
- Where
- 1 siteEgypt
- Study dates
- 5 Nov 2025to 1 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- 1. Partially edentulous patients with a maxillary posterior edentulous ridge for more than 4 months after extraction.
- 2. Both males and females. 3. Adults aged between 18-50 years. 4. Systemically healthy individuals.
- 5. Residual alveolar ridge height ranging from 4 to 6 mm (measured by preoperative CBCT) 6. No previous surgical or radiation treatment involving the maxillary sinus.
Who cannot join
- -
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Clinical and Radiographic Evaluation of Closed Sinus Lifting Using Xenograft With or Without Liposomal Apigenin-Loaded Scaffold : A Randomized Controlled Clinical Study
aims to evaluate the effectiveness of closed sinus lifting using xenograft with or without a liposomal Apigenin-loaded scaffold in the posterior maxilla.
- Conditions
- Closed Sinus Lift, Apigenin Loaded Scaffold
- Being tested
- sinus lifting
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
sinus liftingProcedure or surgery
closed sinus lifting using xenograft + liposomal Apigenin-loaded scaffold, followed by implant placement.
| Study group | Role | What they receive |
|---|---|---|
| control | Sham comparator | closed sinus lifting using xenograft alone, followed by implant placement. Receives: Procedure: sinus lifting |
| test group | Experimental | closed sinus lifting using xenograft + liposomal Apigenin-loaded scaffold, followed by implant placement. Receives: Procedure: sinus lifting |
What is being measured
The primary outcome is the main question the study is designed to answer.
1. Bone height ( Apical Bone Height Gain ): Measured from first implant thread to sinus floor.
Measured: 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Jul 2026
- Study start5 Nov 2025
- Primary completion10 Nov 2026 (estimated)
- Study completion1 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Closed Sinus LiftStudies of the same condition, open and under way.
- More trials run by Al-Azhar UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 22 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Al-Azhar University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Nora Abdelgawad Mohamed, Al-Azhar University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07678749
- Sponsor's protocol ID
- P-ME-25-11
- Status last verified
- Jun 2026
- First submitted
- 25 Jun 2026
- Last updated
- 1 Jul 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 1 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Clinical and Radiographic Evaluation of Closed Sinus Lifting Using Xenograft With or Without Liposomal Apigenin-Loaded Scaffold : A Randomized Controlled Clinical Study
- ClinicalTrials.gov ID
- NCT07678749
- Acronym / sponsor ID
- P-ME-25-11
- Conditions
- Closed Sinus Lift, Apigenin Loaded Scaffold
- Study type
- Interventional
- Recruitment status
- Enrolling by invitation
- Enrolment
- 22 participants (estimated)
- Lead sponsor
- Al-Azhar UniversityUniversity, hospital or other
- Study start
- 5 Nov 2025 (actual)
- Primary completion
- 10 Nov 2026 (estimated)
- Study completion
- 1 Dec 2026 (estimated)
- First posted
- 1 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
aims to evaluate the effectiveness of closed sinus lifting using xenograft with or without a liposomal Apigenin-loaded scaffold in the posterior maxilla.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| control | Sham comparator | Procedure: sinus liftingclosed sinus lifting using xenograft alone, followed by implant placement. |
| test group | Experimental | Procedure: sinus liftingclosed sinus lifting using xenograft + liposomal Apigenin-loaded scaffold, followed by implant placement. |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- 1. Partially edentulous patients with a maxillary posterior edentulous ridge for more than 4 months after extraction.
- 2. Both males and females. 3. Adults aged between 18-50 years. 4. Systemically healthy individuals.
- 5. Residual alveolar ridge height ranging from 4 to 6 mm (measured by preoperative CBCT) 6. No previous surgical or radiation treatment involving the maxillary sinus.
Key exclusion criteria (1 listed)
- -
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| sinus liftingclosed sinus lifting using xenograft + liposomal Apigenin-loaded scaffold, followed by implant placement. | Procedure or surgery | control, test group |
Primary outcome
1. Bone height ( Apical Bone Height Gain ): Measured from first implant thread to sinus floor.
Time frame: 6 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 Jul 2026.
Related trials for Closed Sinus Lift
Not yet recruitingEarly Phase 1
Radiographic Changes in the Maxillary Sinus Following Closed Sinus Augmentation With Leukocyte Platelet Rich Fibrin
Partially Edentulous Maxilla
Enrolling by invitation
Closed Sinus Augmentation With a Calcium Phosphosilicate Putty
Dental Implant, Maxillary Sinus Floor Augmentation
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing sinus lifting in people with Closed Sinus Lift and Apigenin Loaded Scaffold, run by Al-Azhar University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 1 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
1. Bone height ( Apical Bone Height Gain ): Measured from first implant thread to sinus floor. (time frame: 6 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Jul 2026.