Older Adults (65 Years and Older)RECAPNCT07680036
RESISTANCE TRAINING AND CAPILLARIZATION - ROLE ON THE ANABOLIC RESPONSE IN OLDER ADULTS
A study testing Exercise in people with Older Adults (65 Years and Older), run by University of Padova at 1 site in Italy.
Trial summary
The goal of this clinical trial is to learn how muscle capillaries influence the response to resistance exercise training in older adults. The study will include older men and women who may experience age-related declines in muscle mass and function. Read more about this study
- Who is it for?
- Ages 65 years and olderHealthy volunteers can take part
- Conditions the study is for
- Older Adults (65 Years and Older)
- What is being tested?
- Exercise
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteItaly
- Study dates
- 1 Jan 2024to 31 May 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 65 years and older
- All sexes
- Healthy volunteers accepted
- Older adult
Who may be able to join
- Age ≥ 65 years
- Body Mass Index (BMI) >18 and <30 kg/m²
- Stable body weight for at least 3 months prior to enrollment
Who cannot join
- Prediabetes or diabetes according to ADA criteria
- Chronic diseases, including cardiovascular, liver, respiratory diseases, or cancer
- Acute inflammatory conditions, infections, or other clinically significant illnesses
- Regular participation in vigorous physical activity (≥2 sessions per week)
- Current or recent (within the previous 3 months) treatment with steroid medications
- Regular use of protein supplements
Trial locations and contacts
1 site in 1 country.
About this study
The goal of this clinical trial is to learn how muscle capillaries influence the response to resistance exercise training in older adults. The study will include older men and women who may experience age-related declines in muscle mass and function. The main questions it aims to answer are:
- Does baseline muscle capillarization influence the increase in muscle size and function following resistance exercise training?
- Can resistance exercise stimulate the formation of new capillaries in older adults with lower baseline capillarization, and how is this related to muscle growth?
Read more
Participants will:
- Undergo assessments of muscle structure, capillarization, and physical function before and after the intervention.
- Participate in a supervised resistance exercise training program.
- Provide muscle samples and other physiological measurements to evaluate changes in muscle growth and blood vessel formation.
Researchers will analyze the relationship between baseline muscle capillarization, exercise-induced angiogenesis, and improvements in muscle mass and function to better understand why some older adults respond more effectively to resistance exercise than others.
Read the detailed description
This randomized clinical trial will investigate the effects of different exercise training strategies on skeletal muscle adaptations in older adults. Participants will be randomly assigned to one of three training groups and will complete a supervised 12-week exercise program, consisting of three sessions per week.
The interventions will include different combinations and sequencing of resistance and aerobic exercise during the first 8 weeks of training, followed by a standardized resistance training program during the final 4 weeks. The study is designed to determine whether the timing and type of exercise influence muscle growth, vascular adaptations, and functional outcomes.
Participants will undergo assessments before the intervention and after 4, 8, and 12 weeks of training. Measurements will include body composition, muscle size and architecture, muscle strength, aerobic fitness, and physical function. A subgroup of participants may also undergo optional muscle biopsies to evaluate changes in muscle capillarization and biological markers associated with muscle adaptation.
The results will help identify exercise strategies that optimize muscle and vascular adaptations in older adults and improve understanding of the mechanisms underlying individual variability in training responsiveness.
- Conditions
- Older Adults (65 Years and Older)
- Being tested
- Exercise
- Keywords
- resistance training, capillary density, muscle hypertrophy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ExerciseOther
2 months of different combination of aerobic and resistance training before undergoing to 1 month of resistance training at 80% 1RM
| Study group | Role | What they receive |
|---|---|---|
| RRR | Active comparator | Effect of 3 months of progressive resistance training on muscle adaptation in older adults Receives: Other: Exercise |
| ARR | Active comparator | Effect of 1 month of aerobic training followed by 2 months of progressive resistance training on muscle adaptation in older adults Receives: Other: Exercise |
| RAR | Active comparator | Effect of the combination of 1 month of resistance training followed by 1 month of aerobic training and 1 months of progressive resistance training on muscle adaptation in older adults Receives: Other: Exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
muscle hypertrophy
difference of kilograms of Lean Body Mass from baseline measured by DEXA
Measured: 3 months
capillary density
change on the number of capillary per muscle fiber measured histochemically trought muscle biopsy.
Measured: 3 month
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Jul 2026
- Study start1 Jan 2024
- Primary completion31 Dec 2025
- Study completion31 May 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Older Adults (65 Years and Older)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Padova
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07680036
- Sponsor's protocol ID
- RECAP
- Acronym
- RECAP
- Status last verified
- Jan 2024
- First submitted
- 25 Jun 2026
- Last updated
- 7 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 7 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- RESISTANCE TRAINING AND CAPILLARIZATION - ROLE ON THE ANABOLIC RESPONSE IN OLDER ADULTS
- ClinicalTrials.gov ID
- NCT07680036
- Acronym / sponsor ID
- RECAP / RECAP
- Conditions
- Older Adults (65 Years and Older)
- Keywords
- resistance training, capillary density, muscle hypertrophy
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- University of PadovaUniversity, hospital or other
- Study start
- 1 Jan 2024 (actual)
- Primary completion
- 31 Dec 2025 (actual)
- Study completion
- 31 May 2026 (actual)
- First posted
- 1 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to learn how muscle capillaries influence the response to resistance exercise training in older adults. The study will include older men and women who may experience age-related declines in muscle mass and function. The main questions it aims to answer are:
- Does baseline muscle capillarization influence the increase in muscle size and function following resistance exercise training?
- Can resistance exercise stimulate the formation of new capillaries in older adults with lower baseline capillarization, and how is this related to muscle growth?
Participants will:
- Undergo assessments of muscle structure, capillarization, and physical function before and after the intervention.
- Participate in a supervised resistance exercise training program.
- Provide muscle samples and other physiological measurements to evaluate changes in muscle growth and blood vessel formation.
Researchers will analyze the relationship between baseline muscle capillarization, exercise-induced angiogenesis, and improvements in muscle mass and function to better understand why some older adults respond more effectively to resistance exercise than others.
Detailed description
This randomized clinical trial will investigate the effects of different exercise training strategies on skeletal muscle adaptations in older adults. Participants will be randomly assigned to one of three training groups and will complete a supervised 12-week exercise program, consisting of three sessions per week.
The interventions will include different combinations and sequencing of resistance and aerobic exercise during the first 8 weeks of training, followed by a standardized resistance training program during the final 4 weeks. The study is designed to determine whether the timing and type of exercise influence muscle growth, vascular adaptations, and functional outcomes.
Participants will undergo assessments before the intervention and after 4, 8, and 12 weeks of training. Measurements will include body composition, muscle size and architecture, muscle strength, aerobic fitness, and physical function. A subgroup of participants may also undergo optional muscle biopsies to evaluate changes in muscle capillarization and biological markers associated with muscle adaptation.
The results will help identify exercise strategies that optimize muscle and vascular adaptations in older adults and improve understanding of the mechanisms underlying individual variability in training responsiveness.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| RRR | Active comparator | Other: ExerciseEffect of 3 months of progressive resistance training on muscle adaptation in older adults |
| ARR | Active comparator | Other: ExerciseEffect of 1 month of aerobic training followed by 2 months of progressive resistance training on muscle adaptation in older adults |
| RAR | Active comparator | Other: ExerciseEffect of the combination of 1 month of resistance training followed by 1 month of aerobic training and 1 months of progressive resistance training on muscle adaptation in older adults |
Who may qualify
- Ages
- 65 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Older adult
Key inclusion criteria (3 listed)
- Age ≥ 65 years
- Body Mass Index (BMI) >18 and <30 kg/m²
- Stable body weight for at least 3 months prior to enrollment
Key exclusion criteria (6 listed)
- Prediabetes or diabetes according to ADA criteria
- Chronic diseases, including cardiovascular, liver, respiratory diseases, or cancer
- Acute inflammatory conditions, infections, or other clinically significant illnesses
- Regular participation in vigorous physical activity (≥2 sessions per week)
- Current or recent (within the previous 3 months) treatment with steroid medications
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Exercise2 months of different combination of aerobic and resistance training before undergoing to 1 month of resistance training at 80% 1RM | Other | ARR, RAR, RRR |
Primary outcome
muscle hypertrophy
Time frame: 3 months
difference of kilograms of Lean Body Mass from baseline measured by DEXA
capillary density
Time frame: 3 month
change on the number of capillary per muscle fiber measured histochemically trought muscle biopsy.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Jul 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Exercise in people with Older Adults (65 Years and Older), run by University of Padova at 1 site in Italy.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 7 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Italy. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
muscle hypertrophy (time frame: 3 months). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Jul 2026; AzTrials last refreshed its copy on 26 Oct 2026.