Exercise-Induced Upper Extremity FatigueNCT07682103
Neural Mobilization After Upper Extremity Fatigue in Amateur Athletes
A study testing Neural Mobilization and Dynamic Stretching in people with Exercise-Induced Upper Extremity Fatigue and Hand-Eye Coordination, run by Uludag University at 1 site in Turkey (Türkiye).
Trial summary
This randomized controlled trial evaluated the acute effects of neural mobilization and dynamic stretching after upper extremity fatigue on upper extremity performance and hand-eye coordination in amateur athletes. Read more about this study
- Who is it for?
- Ages 18 to 25 yearsHealthy volunteers can take part
- Conditions the study is for
- Exercise-Induced Upper Extremity Fatigue, Hand-Eye Coordination, Athletic Performance
- What is being tested?
- Neural Mobilization and Dynamic Stretching
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 45 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 19 Dec 2025to 29 May 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 25 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Aged between 18 and 25 years
- Amateur athlete participating in a sport requiring active use of the upper extremity, such as basketball, volleyball, tennis, or table tennis
- Able to understand and perform the fatigue protocol, recovery intervention, and outcome assessments
- Volunteered to participate and provided written informed consent
Who cannot join
- Current upper extremity, cervical, or trunk pain or injury that could affect test performance
- History of upper extremity surgery, fracture, or major musculoskeletal trauma that could limit participation
- Neurological, vestibular, or systemic condition affecting upper extremity function, balance, coordination, or exercise tolerance
- Any cardiovascular, respiratory, or medical condition contraindicating participation in fatiguing upper extremity exercise
- Inability to complete the fatigue protocol or outcome assessments safely
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Acute Effects of Neural Mobilization After Physical Fatigue on Upper Extremity Performance and Hand-Eye Coordination in Amateur Athletes: A Randomized Controlled Trial
This randomized controlled trial evaluated the acute effects of neural mobilization and dynamic stretching after upper extremity fatigue on upper extremity performance and hand-eye coordination in amateur athletes. Participants were amateur athletes aged 18 to 25 years who regularly participated in sports involving active use of the upper extremity. After baseline assessment, all participants completed a standardized upper extremity fatigue protocol. They were then randomly allocated to one of three groups: neural mobilization, dynamic stretching, or passive rest. Outcomes were assessed at baseline, immediately after fatigue, and after the assigned recovery intervention or rest period. The study aimed to determine whether active recovery strategies, particularly neural mobilization, provide greater short-term recovery of upper extremity performance and hand-eye coordination compared with passive rest.
- Being tested
- Neural Mobilization, Dynamic Stretching
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Neural MobilizationOther
Upper extremity neural mobilization was applied after the standardized fatigue protocol. The intervention targeted the median, radial, and ulnar nerves using non-painful mobilization techniques. Each technique was performed for 2 sets of 20 repetitions, with each repetition lasting approximately 1 to 3 seconds
Dynamic StretchingOther
A structured dynamic stretching protocol was performed after the standardized fatigue protocol. The protocol lasted approximately 10 minutes and included dynamic upper extremity and whole-body movements such as arm swings, arm crossovers, walking lunges with trunk rotation, lateral shuffling, heel kicks, inchworms, and modified shuttle movements.
| Study group | Role | What they receive |
|---|---|---|
| Neural Mobilization | Experimental | Participants assigned to this arm received upper extremity neural mobilization after completion of the standardized upper extremity fatigue protocol. Neural mobilization techniques targeted the median, radial, and ulnar nerves and were applied during the recovery period before post-intervention outcome assessment. Receives: Other: Neural Mobilization |
| Dynamic Stretching | Experimental | Participants assigned to this arm performed a structured dynamic stretching protocol after completion of the standardized upper extremity fatigue protocol. The protocol included dynamic upper and lower body movements performed during the recovery period before post-intervention outcome assessment. Receives: Other: Dynamic Stretching |
| Control | No intervention | Participants assigned to this control arm rested passively after completion of the standardized upper extremity fatigue protocol. No active recovery intervention was administered during the recovery period before post-intervention outcome assessment. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Alternate Hand Wall Toss Test
Hand-eye coordination was assessed using the Alternate Hand Wall Toss Test. Participants stood 2 meters from a wall and repeatedly threw a ball against the wall, catching it with the opposite hand. The number of successful catches completed within 30 seconds was recorded. Higher scores indicate better hand-eye coordination performance.
Measured: Baseline, immediately after the fatigue protocol, and after the 15-minute recovery period
Upper Quarter Y Balance Test
Upper quarter dynamic balance was assessed using the Upper Quarter Y Balance Test. Participants maintained a push-up position and reached with the free hand in the medial, superolateral, and inferolateral directions. Reach distances were recorded and used to calculate a composite score normalized to upper limb length. Higher scores indicate better upper quarter dynamic balance performance.
Measured: Baseline, immediately after the fatigue protocol, and after the 15-minute recovery period
Secondary outcomes (1)
Closed Kinetic Chain Upper Extremity Stability Test
Upper extremity functional performance was assessed using the Closed Kinetic Chain Upper Extremity Stability Test. Participants performed alternating hand touches across two marked lines while maintaining a push-up position. The number of touches completed within 15 seconds was recorded. Higher scores indicate better upper extremity functional performance.
Measured: Baseline, immediately after the fatigue protocol, and after the 15-minute recovery period
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Jul 2026
- Study start19 Dec 2025
- Primary completion28 May 2026
- Study completion29 May 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Exercise-Induced Upper Extremity FatigueStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 45 participants (actual)
Sponsor and investigators
- Lead sponsor
- Uludag University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Selim Mahmut GÜNAY, Mustafa Kemal University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07682103
- Sponsor's protocol ID
- 2025/16-42
- Status last verified
- Jun 2026
- First submitted
- 27 Jun 2026
- Last updated
- 2 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be publicly shared because explicit consent for external data sharing was not obtained from participants.
Publications
Kim MK, Cha HG, Ji SG. The initial effects of an upper extremity neural mobilization technique on muscle fatigue and pressure pain threshold of healthy adults: a randomized control trial. J Phys Ther Sci. 2016 Mar;28(3):743-6. doi: 10.1589/jpts.28.743. Epub 2016 Mar 31.
PubMed 27134351Hodgetts CJ, McLeish T, Thomas E, Walker BF. Association Between Chiropractic Students' Hand-Eye Coordination or General Self-efficacy and Their Performance on a Spinal Manipulative Therapy Examination: A Cross-sectional Study. J Chiropr Med. 2021 Dec;20(4):183-190. doi: 10.1016/j.jcm.2021.12.011. Epub 2022 Apr 6.
PubMed 35496722Dupuis F, Sole G, Mercier C, Roy JS. Impact of fatigue at the shoulder on the contralateral upper limb kinematics and performance. PLoS One. 2022 Apr 1;17(4):e0266370. doi: 10.1371/journal.pone.0266370. eCollection 2022.
PubMed 35363812
Study at a glance
From the registry record, last updated by the sponsor on 2 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Acute Effects of Neural Mobilization After Physical Fatigue on Upper Extremity Performance and Hand-Eye Coordination in Amateur Athletes: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07682103
- Acronym / sponsor ID
- 2025/16-42
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 45 participants (actual)
- Lead sponsor
- Uludag UniversityUniversity, hospital or other
- Study start
- 19 Dec 2025 (actual)
- Primary completion
- 28 May 2026 (actual)
- Study completion
- 29 May 2026 (actual)
- First posted
- 2 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled trial evaluated the acute effects of neural mobilization and dynamic stretching after upper extremity fatigue on upper extremity performance and hand-eye coordination in amateur athletes. Participants were amateur athletes aged 18 to 25 years who regularly participated in sports involving active use of the upper extremity. After baseline assessment, all participants completed a standardized upper extremity fatigue protocol. They were then randomly allocated to one of three groups: neural mobilization, dynamic stretching, or passive rest. Outcomes were assessed at baseline, immediately after fatigue, and after the assigned recovery intervention or rest period. The study aimed to determine whether active recovery strategies, particularly neural mobilization, provide greater short-term recovery of upper extremity performance and hand-eye coordination compared with passive rest.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Neural Mobilization | Experimental | Other: Neural MobilizationParticipants assigned to this arm received upper extremity neural mobilization after completion of the standardized upper extremity fatigue protocol. Neural mobilization techniques targeted the median, radial, and ulnar nerves and were applied during the recovery period before post-intervention outcome assessment. |
| Dynamic Stretching | Experimental | Other: Dynamic StretchingParticipants assigned to this arm performed a structured dynamic stretching protocol after completion of the standardized upper extremity fatigue protocol. The protocol included dynamic upper and lower body movements performed during the recovery period before post-intervention outcome assessment. |
| Control | No intervention | –Participants assigned to this control arm rested passively after completion of the standardized upper extremity fatigue protocol. No active recovery intervention was administered during the recovery period before post-intervention outcome assessment. |
Who may qualify
- Ages
- 18 to 25 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Aged between 18 and 25 years
- Amateur athlete participating in a sport requiring active use of the upper extremity, such as basketball, volleyball, tennis, or table tennis
- Able to understand and perform the fatigue protocol, recovery intervention, and outcome assessments
- Volunteered to participate and provided written informed consent
Key exclusion criteria (5 listed)
- Current upper extremity, cervical, or trunk pain or injury that could affect test performance
- History of upper extremity surgery, fracture, or major musculoskeletal trauma that could limit participation
- Neurological, vestibular, or systemic condition affecting upper extremity function, balance, coordination, or exercise tolerance
- Any cardiovascular, respiratory, or medical condition contraindicating participation in fatiguing upper extremity exercise
- Inability to complete the fatigue protocol or outcome assessments safely
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Neural MobilizationUpper extremity neural mobilization was applied after the standardized fatigue protocol. The intervention targeted the median, radial, and ulnar nerves using non-painful mobilization techniques. Each technique was performed for 2 sets of 20 repetitions, with each repetition lasting approximately 1 to 3 seconds | Other | Neural Mobilization |
| Dynamic StretchingA structured dynamic stretching protocol was performed after the standardized fatigue protocol. The protocol lasted approximately 10 minutes and included dynamic upper extremity and whole-body movements such as arm swings, arm crossovers, walking lunges with trunk rotation, lateral shuffling, heel kicks, inchworms, and modified shuttle movements. | Other | Dynamic Stretching |
Primary outcome
Alternate Hand Wall Toss Test
Time frame: Baseline, immediately after the fatigue protocol, and after the 15-minute recovery period
Hand-eye coordination was assessed using the Alternate Hand Wall Toss Test. Participants stood 2 meters from a wall and repeatedly threw a ball against the wall, catching it with the opposite hand. The number of successful catches completed within 30 seconds was recorded. Higher scores indicate better hand-eye coordination performance.
Upper Quarter Y Balance Test
Time frame: Baseline, immediately after the fatigue protocol, and after the 15-minute recovery period
Upper quarter dynamic balance was assessed using the Upper Quarter Y Balance Test. Participants maintained a push-up position and reached with the free hand in the medial, superolateral, and inferolateral directions. Reach distances were recorded and used to calculate a composite score normalized to upper limb length. Higher scores indicate better upper quarter dynamic balance performance.
1 secondary outcome
Closed Kinetic Chain Upper Extremity Stability Test
Time frame: Baseline, immediately after the fatigue protocol, and after the 15-minute recovery period
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Jul 2026.
- Background: PubMed 27134351Kim MK, Cha HG, Ji SG. The initial effects of an upper extremity neural mobilization technique on muscle fatigue and pressure pain threshold of healthy adults: a randomized control trial. J Phys Ther Sci. 2016 Mar;28(3):743-6. doi: 10.1589/jpts.28.743. Epub 2016 Mar 31.
- Background: PubMed 35496722Hodgetts CJ, McLeish T, Thomas E, Walker BF. Association Between Chiropractic Students' Hand-Eye Coordination or General Self-efficacy and Their Performance on a Spinal Manipulative Therapy Examination: A Cross-sectional Study. J Chiropr Med. 2021 Dec;20(4):183-190. doi: 10.1016/j.jcm.2021.12.011. Epub 2022 Apr 6.
- Background: PubMed 35363812Dupuis F, Sole G, Mercier C, Roy JS. Impact of fatigue at the shoulder on the contralateral upper limb kinematics and performance. PLoS One. 2022 Apr 1;17(4):e0266370. doi: 10.1371/journal.pone.0266370. eCollection 2022.
- Individual participant dataSharing planned: No. Individual participant data will not be publicly shared because explicit consent for external data sharing was not obtained from participants.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Neural Mobilization and Dynamic Stretching in people with Exercise-Induced Upper Extremity Fatigue and Hand-Eye Coordination, run by Uludag University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 2 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Alternate Hand Wall Toss Test (time frame: Baseline, immediately after the fatigue protocol, and after the 15-minute recovery period). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07682103, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Jul 2026; AzTrials last refreshed its copy on 7 Nov 2026.