Hip OsteoarthritisNCT07683663
QIPB vs SI-FICB for Postoperative Analgesia After Total Hip Arthroplasty
A study testing Supra-Inguinal Fascia Iliaca Compartment Block and Quadro-Iliac Plane Block in people with Hip Osteoarthritis and Total Hip Arthroplasty (THA), run by Dokuz Eylul University at 1 site in Turkey (Türkiye).
Trial summary
Total hip arthroplasty (THA) causes moderate-to-severe postoperative pain. The PROSPECT guideline recommends the supra-inguinal fascia iliaca compartment block (SI-FICB) for THA, whereas evidence for newer quadratus-lumborum-family blocks is limited. Read more about this study
- Who is it for?
- Ages 18 to 75 years
- Conditions the study is for
- Hip Osteoarthritis, Total Hip Arthroplasty (THA), Postoperative Pain
- What is being tested?
- Supra-Inguinal Fascia Iliaca Compartment Block and Quadro-Iliac Plane Block
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 84 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 30 Jun 2026to 1 Jun 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 75 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Adults aged 18-75 years
- Scheduled for elective primary total hip arthroplasty
- ASA physical status I-III
- Able to understand and communicate in Turkish and complete assessment scales
- Completed preoperative anesthesia evaluation and approved for surgery
- Signed written informed consent
Who cannot join
- Known allergy/contraindication to any local anesthetic, including bupivacaine
- Coagulopathy or anticoagulant/antiplatelet therapy contraindicating block (per ASRA 2022)
- Active infection or skin breakdown at the block site
- Chronic opioid use (≥3 months daily) or history of opioid dependence
- Morbid obesity (BMI > 40 kg/m²)
- Cognitive impairment or communication difficulty precluding reliable NRS/QoR-15 assessment
Show all 10Show fewer
- Pregnancy or breastfeeding
- Revision THA or emergency THA for fracture
- Intraoperative complications requiring major protocol deviation (e.g., >1000 mL blood loss, cardiac arrest)
- Technically failed block (no sensory change at any region on the T1 cold test)
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site
Dokuz Eylül University
Izmir, Balçova, 35340
Onur Küçük, associate professor, 5358543333 ext. +90, onur.kucuk@deu.edu.tr
About this study
Official title: Comparison of Quadro-Iliac Plane Block and Supra-Inguinal Fascia Iliaca Compartment Block for Postoperative Analgesia in Total Hip Arthroplasty: A Prospective, Double-Blind, Non-Inferiority Study
Total hip arthroplasty (THA) causes moderate-to-severe postoperative pain. The PROSPECT guideline recommends the supra-inguinal fascia iliaca compartment block (SI-FICB) for THA, whereas evidence for newer quadratus-lumborum-family blocks is limited. The quadro-iliac plane block (QIPB) is a recently described fascial plane block, and no study has compared QIPB with SI-FICB head-to-head in any surgical context. In this prospective, double-blind, patients undergoing elective THA who receive one of the two routinely used preoperative blocks (SI-FICB or QIPB, chosen by the attending anesthesiologist as part of routine care) are systematically observed and compared. The primary objective is to assess whether the postoperative analgesic efficacy of QIPB is non-inferior to SI-FICB, using the resting NRS pain score at 6 hours postoperatively as the primary endpoint (non-inferiority margin Δ = 1.3).
- Being tested
- Supra-Inguinal Fascia Iliaca Compartment Block, Quadro-Iliac Plane Block
- Keywords
- regional anesthesia, quadro-iliac plane block, fascia iliaca block, opioid consumption, quality of recovery
- Medical subject headings
- Osteoarthritis, Hip, Pain, Postoperative, Acute Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Supra-Inguinal Fascia Iliaca Compartment BlockProcedure or surgery
SIFICB is an ultrasound-guided fascial plane block performed via a supra-inguinal approach to the iliac fascia compartment, targeting the femoral nerve, lateral femoral cutaneous nerve, and obturator nerve. Single-shot, US-guided, 40 mL 0.25% bupivacaine, before GA induction.
Quadro-Iliac Plane BlockProcedure or surgery
QIPB is a facial plane block performed under ultrasound guidance with local anesthetic in the interfascial plane between the erector spinae and the quadratus lumborum muscle, at the distal attachment site of the quadratus lumborum muscle on the iliac crest. Single-shot, US-guided, 40 mL 0.25% bupivacaine, before GA induction.
| Study group | Role | What they receive |
|---|---|---|
| SI-FICB | Active comparator | Patients receiving supra-inguinal fascia iliaca compartment block (single-shot, US-guided, 40 mL 0.25% bupivacaine, preoperative). Receives: Procedure: Supra-Inguinal Fascia Iliaca Compartment Block |
| QIPB | Experimental | Patients receiving quadro-iliac plane block (single-shot, US-guided, 40 mL 0.25% bupivacaine, preoperative). Receives: Procedure: Quadro-Iliac Plane Block |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pain intensity at rest at 6 hours postoperatively
Numeric Rating Scale (NRS), 0 = no pain to 10 = worst imaginable pain, measured at rest by a blinded assessor. Non-inferiority margin Δ = 1.3 NRS points.
Measured: 6 hours after surgery
Secondary outcomes (3)
NRS pain at rest
Measured: 0, 2, 4, 6, 12, 24, 48 hours postoperatively
NRS pain on movement (active hip flexion)
Measured: 0, 2, 4, 6, 12, 24, 48 hours postoperatively
Cumulative opioid consumption
Measured: 24 hours and 48 hours
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Jul 2026
- Study start30 Jun 2026 (estimated)
- Primary completion1 Dec 2026 (estimated)
- Study completion1 Jun 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Hip OsteoarthritisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 84 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Dokuz Eylul University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Onur KUCUK, Dokuz Eylul University
- Investigators
- Onur Küçük, associate professor, Principal investigator, Dokuz Eylul University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07683663
- Sponsor's protocol ID
- 2026/11-01
- Status last verified
- Jun 2026
- First submitted
- 23 Jun 2026
- Last updated
- 6 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 6 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Quadro-Iliac Plane Block and Supra-Inguinal Fascia Iliaca Compartment Block for Postoperative Analgesia in Total Hip Arthroplasty: A Prospective, Double-Blind, Non-Inferiority Study
- ClinicalTrials.gov ID
- NCT07683663
- Acronym / sponsor ID
- 2026/11-01
- Keywords
- regional anesthesia, quadro-iliac plane block, fascia iliaca block, opioid consumption, quality of recovery
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 84 participants (estimated)
- Lead sponsor
- Dokuz Eylul UniversityUniversity, hospital or other
- Study start
- 30 Jun 2026 (estimated)
- Primary completion
- 1 Dec 2026 (estimated)
- Study completion
- 1 Jun 2027 (estimated)
- First posted
- 6 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Total hip arthroplasty (THA) causes moderate-to-severe postoperative pain. The PROSPECT guideline recommends the supra-inguinal fascia iliaca compartment block (SI-FICB) for THA, whereas evidence for newer quadratus-lumborum-family blocks is limited. The quadro-iliac plane block (QIPB) is a recently described fascial plane block, and no study has compared QIPB with SI-FICB head-to-head in any surgical context. In this prospective, double-blind, patients undergoing elective THA who receive one of the two routinely used preoperative blocks (SI-FICB or QIPB, chosen by the attending anesthesiologist as part of routine care) are systematically observed and compared. The primary objective is to assess whether the postoperative analgesic efficacy of QIPB is non-inferior to SI-FICB, using the resting NRS pain score at 6 hours postoperatively as the primary endpoint (non-inferiority margin Δ = 1.3).
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| SI-FICB | Active comparator | Procedure: Supra-Inguinal Fascia Iliaca Compartment BlockPatients receiving supra-inguinal fascia iliaca compartment block (single-shot, US-guided, 40 mL 0.25% bupivacaine, preoperative). |
| QIPB | Experimental | Procedure: Quadro-Iliac Plane BlockPatients receiving quadro-iliac plane block (single-shot, US-guided, 40 mL 0.25% bupivacaine, preoperative). |
Who may qualify
- Ages
- 18 to 75 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Adults aged 18-75 years
- Scheduled for elective primary total hip arthroplasty
- ASA physical status I-III
- Able to understand and communicate in Turkish and complete assessment scales
- Completed preoperative anesthesia evaluation and approved for surgery
Key exclusion criteria (10 listed)
- Known allergy/contraindication to any local anesthetic, including bupivacaine
- Coagulopathy or anticoagulant/antiplatelet therapy contraindicating block (per ASRA 2022)
- Active infection or skin breakdown at the block site
- Chronic opioid use (≥3 months daily) or history of opioid dependence
- Morbid obesity (BMI > 40 kg/m²)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Supra-Inguinal Fascia Iliaca Compartment BlockSIFICB is an ultrasound-guided fascial plane block performed via a supra-inguinal approach to the iliac fascia compartment, targeting the femoral nerve, lateral femoral cutaneous nerve, and obturator nerve. Single-shot, US-guided, 40 mL 0.25% bupivacaine, before GA induction. | Procedure or surgery | SI-FICB |
| Quadro-Iliac Plane BlockQIPB is a facial plane block performed under ultrasound guidance with local anesthetic in the interfascial plane between the erector spinae and the quadratus lumborum muscle, at the distal attachment site of the quadratus lumborum muscle on the iliac crest. Single-shot, US-guided, 40 mL 0.25% bupivacaine, before GA induction. | Procedure or surgery | QIPB |
Primary outcome
Pain intensity at rest at 6 hours postoperatively
Time frame: 6 hours after surgery
Numeric Rating Scale (NRS), 0 = no pain to 10 = worst imaginable pain, measured at rest by a blinded assessor. Non-inferiority margin Δ = 1.3 NRS points.
3 secondary outcomes
NRS pain at rest
Time frame: 0, 2, 4, 6, 12, 24, 48 hours postoperatively
NRS pain on movement (active hip flexion)
Time frame: 0, 2, 4, 6, 12, 24, 48 hours postoperatively
Cumulative opioid consumption
Time frame: 24 hours and 48 hours
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Jul 2026.
- Individual participant dataSharing planned: No
Related trials for Hip Osteoarthritis
Active, not recruiting
Effectiveness of Therapeutic Exercises on Spinopelvic Mobility
Osteoarthritis (OA) of the Hip
Recruiting
Intravenous Dexamethasone (0 vs 4 vs 8 mg) as an Adjunct to PENG Block for Postoperative Analgesia in Total Hip Arthroplasty
Osteoarthritis, Hip, Hip Osteoarthritis
Recruiting
Effects of EDUcation and EXercise Compared to Education Alone on Clinical and Physiological Outcomes in Patients With Hip Osteoarthritis
Hip Osteoarthritis
Recruiting
Comparison of Spinal Anesthesia With Intrathecal Morphine Versus PENG Block With or Without Dexamethasone in Hip Arthroplasty
Arthropathy of Hip, Hip Osteoarthritis
RecruitingPhase 4
PENG vs L-ESPB With S-ESPB for Analgesia in Total Hip Arthroplasty
Hip Osteoarthritis, Hip Arthropathy
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Onur Küçük, associate professor principal investigator
Dokuz Eylul University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Supra-Inguinal Fascia Iliaca Compartment Block and Quadro-Iliac Plane Block in people with Hip Osteoarthritis and Total Hip Arthroplasty (THA), run by Dokuz Eylul University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 6 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Onur Küçük, associate professor (5358543333 ext. +90, onur.kucuk@deu.edu.tr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pain intensity at rest at 6 hours postoperatively (time frame: 6 hours after surgery). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Jul 2026.