HPV KnowledgeAIHPVNCT07684378
AI Chatbot Education for Improving HPV Knowledge Among University Students
A study testing AI Chatbot-Based Education and Standard Written Education in people with HPV Knowledge, run by Near East University, Turkey at 1 site in Cyprus.
Trial summary
Human papillomavirus (HPV) is one of the most common sexually transmitted infections worldwide and is associated with several cancers. Adequate knowledge about HPV and vaccination remains limited among university students. Read more about this study
- Who is it for?
- Any ageHealthy volunteers can take part
- Conditions the study is for
- HPV Knowledge
- What is being tested?
- AI Chatbot-Based Education and Standard Written Education
- Type of treatment
- Vaccines, Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 68 participants
- Where
- 1 siteCyprus
- Study dates
- 1 Mar 2026to 30 May 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Who may be able to join
- All students, both female and male, first semester of bachelor's degree, studying in nursing department Enrollment at Cyprus International University
- Willingness to participate and provide written informed consent
- No prior formal education on HPV
Who cannot join
- Withdrawal of consent at any stage of the study
- Failure to complete either the pre-test or post-test assessments
- Incomplete participation in the educational intervention
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effect of an AI Chatbot-Based Educational Program on HPV Knowledge Among University Students
Human papillomavirus (HPV) is one of the most common sexually transmitted infections worldwide and is associated with several cancers. Adequate knowledge about HPV and vaccination remains limited among university students. This randomized controlled trial aims to evaluate the effectiveness of an artificial intelligence (AI) chatbot-based educational program in improving HPV knowledge among undergraduate nursing students at Cyprus International University. Participants will be randomly assigned to either an AI chatbot-based personalized education group or a control group receiving standard written educational materials. HPV knowledge will be assessed before and after the intervention using the validated HPV Knowledge Questionnaire. The findings will provide evidence regarding the effectiveness of AI-supported educational strategies for improving HPV-related knowledge among university students
Read the detailed description
Study Purpose
The purpose of this study was to evaluate the effectiveness of an AI chatbot-based educational program in improving Human Papillomavirus (HPV) knowledge among undergraduate nursing students.
Study Design
This study was designed as a parallel-group randomized controlled trial conducted among undergraduate nursing students at Cyprus International University, Northern Cyprus. Participants were randomly assigned to either the intervention group (AI chatbot-based personalized education) or the control group (standard written educational materials) using block randomization.
Sample Size
Based on a previous educational intervention study and the two-sample mean comparison formula, with a significance level of 0.05 and a statistical power of 80%, the required sample size was calculated as 30 participants per group. After allowing for a 10% dropout rate, a total of 68 participants were enrolled, with 34 participants allocated to each study group.
Data Collection Tools
Data were collected using:
A demographic questionnaire (age, gender, faculty, year of study, previous HPV education, source of HPV information, and HPV vaccination status).
The validated 29-item HPV Knowledge Questionnaire developed , assessing general HPV knowledge, HPV testing knowledge, and HPV vaccination knowledge.
Intervention
Participants were randomly assigned to one of two groups.
AI Chatbot Group:
Participants received personalized HPV education through an artificial intelligence (AI) chatbot. Educational content was tailored according to each participant's baseline HPV knowledge and included information on HPV transmission, risk factors, HPV-related diseases, vaccination, prevention strategies, and common misconceptions.
Control Group:
Participants received standard written educational materials covering the same HPV-related topics without chatbot interaction or personalized educational content.
Outcome Assessment
HPV knowledge was measured before and after the educational intervention using the validated HPV Knowledge Questionnaire.
Ethical Considerations
The study received approval from the Cyprus International University Ethics Review Board (Approval No. EKK25-26/15/08). The study was conducted in accordance with the Declaration of Helsinki, and written informed consent was obtained from all participants before enrollment.
Statistical Analysis
Data will be analyzed using SPSS version 26. Descriptive statistics, independent t-tests, paired t-tests, Chi-square tests, Fisher's exact tests, and non-parametric tests will be performed as appropriate. Statistical significance will be be set at a two-sided P value of less than 0.05.
- Conditions
- HPV Knowledge
- Being tested
- AI Chatbot-Based Education, Standard Written Education
- Keywords
- Papillomavirus Vaccines, Health Education, Educational Technology, AI Chatbot, Health Knowledge
- Medical subject headings
- Health Education
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
AI Chatbot-Based EducationBehavioural
Participants received personalized education through an artificial intelligence (AI) chatbot. Educational content was tailored according to each participant's baseline HPV knowledge and included information on HPV transmission, risk factors, HPV-related diseases, HPV vaccination, prevention strategies, and common misconceptions. The chatbot provided interactive, personalized educational support throughout the intervention
Standard Written EducationBehavioural
Participants received standard written educational materials covering HPV transmission, risk factors, HPV-related diseases, HPV vaccination, and prevention strategies. The educational materials were identical in content to the intervention group but were provided without personalization or AI chatbot interaction
| Study group | Role | What they receive |
|---|---|---|
| AI Chatbot-Based Education | Experimental | Participants in this group received personalized education about Human Papillomavirus (HPV) through an artificial intelligence (AI) chatbot. The educational content was tailored according to each participant's baseline HPV knowledge and covered HPV transmission, risk factors, HPV-related diseases, HPV vaccination, prevention strategies, and common misconceptions Receives: Behavioral: AI Chatbot-Based Education |
| Standard Written Education | Active comparator | Participants in this group received standard written educational materials covering the same HPV-related topics, including HPV transmission, risk factors, HPV-related diseases, HPV vaccination, and prevention strategies. No personalized feedback or AI chatbot interaction was provided Receives: Behavioral: Standard Written Education |
What is being measured
The primary outcome is the main question the study is designed to answer.
HPV Knowledge Score
The primary outcome measure assesses changes in participants' knowledge of Human Papillomavirus (HPV) following the educational intervention. HPV knowledge is measured using the validated 29-item HPV Knowledge Questionnaire developed by Waller et al. (2013). The questionnaire evaluates three domains: general HPV knowledge, HPV testing knowledge, and HPV vaccination knowledge. Higher total scores indicate greater HPV-related knowledge
Measured: Baseline (before the educational intervention) and 1 month after completion of the educational intervention.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Jul 2026
- Study start1 Mar 2026
- Primary completion20 Apr 2026
- Study completion30 May 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HPV KnowledgeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants were randomly assigned to one of two groups: an AI chatbot-based personalized education group and a control group receiving standard written educational materials. Both interventions were designed to improve knowledge of Human Papillomavirus (HPV), HPV-related diseases, and HPV vaccination. HPV knowledge was assessed before and after the educational intervention using the validated HPV Knowledge Questionnaire to evaluate the effectiveness of the AI chatbot-based educational program.
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 68 participants (actual)
Sponsor and investigators
- Lead sponsor
- Near East University, Turkey
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Pouran Varvani Farahani, Cyprus International University
- Investigators
- Pouran Varvani Farahani, PhD, Principal investigator, PhD in Pediatric Nursing, Department of Nursing, Faculty of Health Science, Cyprus International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07684378
- Sponsor's protocol ID
- PVF-HPV-AI-2026
- Other IDs
- EKK25-26/15/08
- Acronym
- AIHPV
- Status last verified
- Jul 2026
- First submitted
- 29 Jun 2026
- Last updated
- 7 Jul 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: No There is no plan to make IPD available to other researchers
Study at a glance
From the registry record, last updated by the sponsor on 7 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of an AI Chatbot-Based Educational Program on HPV Knowledge Among University Students
- ClinicalTrials.gov ID
- NCT07684378
- Acronym / sponsor ID
- AIHPV / PVF-HPV-AI-2026
- Conditions
- HPV Knowledge
- Keywords
- Papillomavirus Vaccines, Health Education, Educational Technology, AI Chatbot, Health Knowledge
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 68 participants (actual)
- Lead sponsor
- Near East University, TurkeyUniversity, hospital or other
- Study start
- 1 Mar 2026 (actual)
- Primary completion
- 20 Apr 2026 (actual)
- Study completion
- 30 May 2026 (actual)
- First posted
- 6 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Human papillomavirus (HPV) is one of the most common sexually transmitted infections worldwide and is associated with several cancers. Adequate knowledge about HPV and vaccination remains limited among university students. This randomized controlled trial aims to evaluate the effectiveness of an artificial intelligence (AI) chatbot-based educational program in improving HPV knowledge among undergraduate nursing students at Cyprus International University. Participants will be randomly assigned to either an AI chatbot-based personalized education group or a control group receiving standard written educational materials. HPV knowledge will be assessed before and after the intervention using the validated HPV Knowledge Questionnaire. The findings will provide evidence regarding the effectiveness of AI-supported educational strategies for improving HPV-related knowledge among university students
Detailed description
Study Purpose
The purpose of this study was to evaluate the effectiveness of an AI chatbot-based educational program in improving Human Papillomavirus (HPV) knowledge among undergraduate nursing students.
Study Design
This study was designed as a parallel-group randomized controlled trial conducted among undergraduate nursing students at Cyprus International University, Northern Cyprus. Participants were randomly assigned to either the intervention group (AI chatbot-based personalized education) or the control group (standard written educational materials) using block randomization.
Sample Size
Based on a previous educational intervention study and the two-sample mean comparison formula, with a significance level of 0.05 and a statistical power of 80%, the required sample size was calculated as 30 participants per group. After allowing for a 10% dropout rate, a total of 68 participants were enrolled, with 34 participants allocated to each study group.
Data Collection Tools
Data were collected using:
A demographic questionnaire (age, gender, faculty, year of study, previous HPV education, source of HPV information, and HPV vaccination status).
The validated 29-item HPV Knowledge Questionnaire developed , assessing general HPV knowledge, HPV testing knowledge, and HPV vaccination knowledge.
Intervention
Participants were randomly assigned to one of two groups.
AI Chatbot Group:
Participants received personalized HPV education through an artificial intelligence (AI) chatbot. Educational content was tailored according to each participant's baseline HPV knowledge and included information on HPV transmission, risk factors, HPV-related diseases, vaccination, prevention strategies, and common misconceptions.
Control Group:
Participants received standard written educational materials covering the same HPV-related topics without chatbot interaction or personalized educational content.
Outcome Assessment
HPV knowledge was measured before and after the educational intervention using the validated HPV Knowledge Questionnaire.
Ethical Considerations
The study received approval from the Cyprus International University Ethics Review Board (Approval No. EKK25-26/15/08). The study was conducted in accordance with the Declaration of Helsinki, and written informed consent was obtained from all participants before enrollment.
Statistical Analysis
Data will be analyzed using SPSS version 26. Descriptive statistics, independent t-tests, paired t-tests, Chi-square tests, Fisher's exact tests, and non-parametric tests will be performed as appropriate. Statistical significance will be be set at a two-sided P value of less than 0.05.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- Participants were randomly assigned to one of two groups: an AI chatbot-based personalized education group and a control group receiving standard written educational materials. Both interventions were designed to improve knowledge of Human Papillomavirus (HPV), HPV-related diseases, and HPV vaccination. HPV knowledge was assessed before and after the educational intervention using the validated HPV Knowledge Questionnaire to evaluate the effectiveness of the AI chatbot-based educational program.
| Arm | Type | Receives |
|---|---|---|
| AI Chatbot-Based Education | Experimental | Behavioral: AI Chatbot-Based EducationParticipants in this group received personalized education about Human Papillomavirus (HPV) through an artificial intelligence (AI) chatbot. The educational content was tailored according to each participant's baseline HPV knowledge and covered HPV transmission, risk factors, HPV-related diseases, HPV vaccination, prevention strategies, and common misconceptions |
| Standard Written Education | Active comparator | Behavioral: Standard Written EducationParticipants in this group received standard written educational materials covering the same HPV-related topics, including HPV transmission, risk factors, HPV-related diseases, HPV vaccination, and prevention strategies. No personalized feedback or AI chatbot interaction was provided |
Who may qualify
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (3 listed)
- All students, both female and male, first semester of bachelor's degree, studying in nursing department Enrollment at Cyprus International University
- Willingness to participate and provide written informed consent
- No prior formal education on HPV
Key exclusion criteria (3 listed)
- Withdrawal of consent at any stage of the study
- Failure to complete either the pre-test or post-test assessments
- Incomplete participation in the educational intervention
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| AI Chatbot-Based EducationParticipants received personalized education through an artificial intelligence (AI) chatbot. Educational content was tailored according to each participant's baseline HPV knowledge and included information on HPV transmission, risk factors, HPV-related diseases, HPV vaccination, prevention strategies, and common misconceptions. The chatbot provided interactive, personalized educational support throughout the intervention | Behavioural | AI Chatbot-Based Education |
| Standard Written EducationParticipants received standard written educational materials covering HPV transmission, risk factors, HPV-related diseases, HPV vaccination, and prevention strategies. The educational materials were identical in content to the intervention group but were provided without personalization or AI chatbot interaction | Behavioural | Standard Written Education |
Primary outcome
HPV Knowledge Score
Time frame: Baseline (before the educational intervention) and 1 month after completion of the educational intervention.
The primary outcome measure assesses changes in participants' knowledge of Human Papillomavirus (HPV) following the educational intervention. HPV knowledge is measured using the validated 29-item HPV Knowledge Questionnaire developed by Waller et al. (2013). The questionnaire evaluates three domains: general HPV knowledge, HPV testing knowledge, and HPV vaccination knowledge. Higher total scores indicate greater HPV-related knowledge
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Jul 2026.
- Individual participant dataSharing planned: No. No There is no plan to make IPD available to other researchers
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Pouran Varvani Farahani, PhD principal investigator
PhD in Pediatric Nursing, Department of Nursing, Faculty of Health Science, Cyprus International University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing AI Chatbot-Based Education and Standard Written Education in people with HPV Knowledge, run by Near East University, Turkey at 1 site in Cyprus.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 7 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Cyprus. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
HPV Knowledge Score (time frame: Baseline (before the educational intervention) and 1 month after completion of the educational intervention.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Jul 2026.