Dental ImplantVIDOSNCT07684404
Effect of Systemic Vitamin D on Dental Implant Osseointegration
A study testing Vit D in people with Dental Implant and Dental Implant Failed, run by Future University in Egypt at 1 site in Egypt.
Trial summary
The primary goal for any oral implantologist is to obtain satisfactory healing and long-term treatment success. Osseointegration is the key to dental implant success8 and is required to achieve direct structural and functional connection between living bone and the surface of a load-bearing artificial implant, is… Read more about this study
- Who is it for?
- Ages 20 to 60 yearsHealthy volunteers can take part
- Conditions the study is for
- Dental Implant, Dental Implant Failed, Vitamin D Deficiency
- What is being tested?
- Vit D
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 10 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Nov 2025to 1 Nov 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 60 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Adults aged 20-60 with diagnosed vitamin D deficiency (<20 ng/mL).
- Edentulous area in the posterior mandible or maxilla.
- No history of previous dental implant failure, metabolic bone diseases, or conditions affecting bone healing.
- Both genders are included
Who cannot join
- Severe systemic diseases that could interfere with healing.
- Patients already on vitamin D or calcium supplements.
- Smokers or patients with poor oral hygiene practices.
- Pregnant females
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site, 1 recruiting
- Recruiting
Future University in Egypt (FUE)
Cairo, New Cairo, 11511
Ahmed Kamal Abo Zekry, Professor, +201012162020, ahmed.kamal@fue.edu.eg
Aya Magdy Abdel Rady, Lecturer, +201000252400, aya.magdy@fue.edu.eg
About this study
Official title: Effect of Systemic Vitamin D on Dental Implant Osseointegration in Patients With Vitamin D Deficiency: A Randomized Controlled Clinical Study)
The primary goal for any oral implantologist is to obtain satisfactory healing and long-term treatment success. Osseointegration is the key to dental implant success8 and is required to achieve direct structural and functional connection between living bone and the surface of a load-bearing artificial implant, is critical for the long-term success of dental implants.
Successful dental implant therapy relies on achieving proper osseointegration, which ensures a stable structural and functional bond between the implant surface and surrounding bone. Although dental implants show a high overall success rate of around 95%.
Read the detailed description
Implant success depends on several factors surgical and prosthetic factors (surgical technique and operator experience, timing and type of prosthetic loading and quality of pros-thetic rehabilitation), implant-related factors (material, design and surface), and patient-related factors (bone volume/quality at the recipient site and host response.
Despite the high success rate of dental implants, which is reported to be around 95%, failures due to lack of osseointegration remain a significant challenge Implant failures are classified according to the timing of the loss to Early Dental Implant Failure (EDIF) or late dental implant failure (LDIF). Early implant failure occurs due to improper implant placement and restoration, low bone volume or density, systemic conditions, or smoking.
Recent research has indicated that systemic health factors, particularly nutritional status, can significantly influence the process of osseointegration. Vitamin D is a major determinant of mineral homeostasis, promoting intestinal calcium and phosphorus absorption, which are required for optimal mineralization of bone.
Vitamin D also exerts direct actions on bone (probably by regulating the expression of several bone growth factors). It controls mineral metabolism and the bone homeostasis by increasing calcium availability, by regulating PTH secretion, and by direct effects on bone formation and resorption.
- Conditions
- Dental Implant, Dental Implant Failed, Vitamin D Deficiency
- Being tested
- Vit D
- Keywords
- Vitamin D Deficiency, IMPLANT OSSEOINTEGRATION, Implant Failure, Factors Affect Implant Success
- Medical subject headings
- Vitamin D Deficiency
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Vit DDrug
Also called Dental Implant
to address the relation between Vitamin D deficiency and Dental implant osseointegration for the identification of the participants whom may be non-responders to the vitamin D treatment
| Study group | Role | What they receive |
|---|---|---|
| supplemental group | Active comparator | About 5 Participants will receive systemic vitamin D supplementation prior to and/or after dental implant placement. The purpose is to correct vitamin D deficiency and evaluate its effect on implant osseointegration and bone healing. Receives: Drug: Vit D |
| Control Group | Active comparator | About 5 Participants will not receive vitamin D supplementation. They will undergo standard dental implant placement and follow-up care without any intervention to correct vitamin D deficiency. Receives: Drug: Vit D |
What is being measured
The primary outcome is the main question the study is designed to answer.
Treatment of Dental Implant Osseointegration
Evaluation of the Primary implant stability measured immediately after implant placement using the Ostell device, which assesses resonance frequency analysis (RFA) values expressed as Implant Stability Quotient (ISQ). This measurement reflects the initial mechanical stability of the implant within the bone at the time of surgery.
Measured: 3 Months
marginal bone loss after prosthesis placement
Marginal bone loss will be evaluated using cone beam computed tomography (CBCT) taken six months after prosthesis placement. The vertical distance between the implant shoulder and the first bone-to-implant contact will be measured on both mesial and distal aspects to assess the amount of peri-implant bone resorption over time.
Measured: six months after proshtesis placement
Secondary outcomes (1)
Implant Survival Rate
Implant survival rate will be determined by the presence of the implant at the 6-month follow-up without any clinical or radiographic signs of failure, such as mobility, pain, infection, or significant bone loss. This outcome reflects the short-term success of the dental implant.
Measured: six months after prosthesis placement
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Jul 2026
- Study start1 Nov 2025
- Primary completion20 Oct 2026 (estimated)
- Study completion1 Nov 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Dental ImplantStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 10 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Future University in Egypt
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Rana Mohamed Emam Abuhaiba, Future University in Egypt
- Investigators
- Ahmed Kamal Abo Zekry, Professor, Study chair, Oral & Maxillofacial Surgery, Future University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07684404
- Sponsor's protocol ID
- Dental Osseointegration
- Acronym
- VIDOS
- Status last verified
- Oct 2025
- First submitted
- 29 Jun 2026
- Last updated
- 6 Jul 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 6 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Systemic Vitamin D on Dental Implant Osseointegration in Patients With Vitamin D Deficiency: A Randomized Controlled Clinical Study)
- ClinicalTrials.gov ID
- NCT07684404
- Acronym / sponsor ID
- VIDOS / Dental Osseointegration
- Conditions
- Dental Implant, Dental Implant Failed, Vitamin D Deficiency
- Keywords
- Vitamin D Deficiency, IMPLANT OSSEOINTEGRATION, Implant Failure, Factors Affect Implant Success
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 10 participants (estimated)
- Lead sponsor
- Future University in EgyptUniversity, hospital or other
- Study start
- 1 Nov 2025 (actual)
- Primary completion
- 20 Oct 2026 (estimated)
- Study completion
- 1 Nov 2026 (estimated)
- First posted
- 6 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The primary goal for any oral implantologist is to obtain satisfactory healing and long-term treatment success. Osseointegration is the key to dental implant success8 and is required to achieve direct structural and functional connection between living bone and the surface of a load-bearing artificial implant, is critical for the long-term success of dental implants.
Successful dental implant therapy relies on achieving proper osseointegration, which ensures a stable structural and functional bond between the implant surface and surrounding bone. Although dental implants show a high overall success rate of around 95%.
Detailed description
Implant success depends on several factors surgical and prosthetic factors (surgical technique and operator experience, timing and type of prosthetic loading and quality of pros-thetic rehabilitation), implant-related factors (material, design and surface), and patient-related factors (bone volume/quality at the recipient site and host response.
Despite the high success rate of dental implants, which is reported to be around 95%, failures due to lack of osseointegration remain a significant challenge Implant failures are classified according to the timing of the loss to Early Dental Implant Failure (EDIF) or late dental implant failure (LDIF). Early implant failure occurs due to improper implant placement and restoration, low bone volume or density, systemic conditions, or smoking.
Recent research has indicated that systemic health factors, particularly nutritional status, can significantly influence the process of osseointegration. Vitamin D is a major determinant of mineral homeostasis, promoting intestinal calcium and phosphorus absorption, which are required for optimal mineralization of bone.
Vitamin D also exerts direct actions on bone (probably by regulating the expression of several bone growth factors). It controls mineral metabolism and the bone homeostasis by increasing calcium availability, by regulating PTH secretion, and by direct effects on bone formation and resorption.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| supplemental group | Active comparator | Drug: Vit DAbout 5 Participants will receive systemic vitamin D supplementation prior to and/or after dental implant placement. The purpose is to correct vitamin D deficiency and evaluate its effect on implant osseointegration and bone healing. |
| Control Group | Active comparator | Drug: Vit DAbout 5 Participants will not receive vitamin D supplementation. They will undergo standard dental implant placement and follow-up care without any intervention to correct vitamin D deficiency. |
Who may qualify
- Ages
- 20 to 60 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Adults aged 20-60 with diagnosed vitamin D deficiency (<20 ng/mL).
- Edentulous area in the posterior mandible or maxilla.
- No history of previous dental implant failure, metabolic bone diseases, or conditions affecting bone healing.
- Both genders are included
Key exclusion criteria (4 listed)
- Severe systemic diseases that could interfere with healing.
- Patients already on vitamin D or calcium supplements.
- Smokers or patients with poor oral hygiene practices.
- Pregnant females
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Vit DAlso: Dental Implantto address the relation between Vitamin D deficiency and Dental implant osseointegration for the identification of the participants whom may be non-responders to the vitamin D treatment | Drug | Control Group, supplemental group |
Primary outcome
Treatment of Dental Implant Osseointegration
Time frame: 3 Months
Evaluation of the Primary implant stability measured immediately after implant placement using the Ostell device, which assesses resonance frequency analysis (RFA) values expressed as Implant Stability Quotient (ISQ). This measurement reflects the initial mechanical stability of the implant within the bone at the time of surgery.
marginal bone loss after prosthesis placement
Time frame: six months after proshtesis placement
Marginal bone loss will be evaluated using cone beam computed tomography (CBCT) taken six months after prosthesis placement. The vertical distance between the implant shoulder and the first bone-to-implant contact will be measured on both mesial and distal aspects to assess the amount of peri-implant bone resorption over time.
1 secondary outcome
Implant Survival Rate
Time frame: six months after prosthesis placement
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Jul 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Ahmed Kamal Abo Zekry, Professor study chair
Oral & Maxillofacial Surgery, Future University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Vit D in people with Dental Implant and Dental Implant Failed, run by Future University in Egypt at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 6 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Rana Mohamed Abu haiba, DSC (+201151306588, rana.emam99@hotmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Treatment of Dental Implant Osseointegration (time frame: 3 Months). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Jul 2026.