Mosquito RepellentNCT07686159
Evaluation of Mosquito Repellent Products' Efficacy, Safety, and Public Health Implications
A study testing Mosquito Repellent Products (Topical and Spatial Formulations) in people with Mosquito Repellent and Mosquito Bite, run by Military Institute of science and Technology at 1 site in Bangladesh.
Trial summary
Human Volunteer Participation: A total of six (6) healthy adult volunteers participated in the study, including three males and three females aged between 18 and 22 years. The volunteers participated in: Arm-in-Cage Test Procedure Dermatological Safety Test All participants were: Non-tobacco users Free from dermatosis… Read more about this study
- Who is it for?
- Ages 18 to 30 years
- Conditions the study is for
- Mosquito Repellent, Mosquito Bite
- What is being tested?
- Mosquito Repellent Products (Topical and Spatial Formulations)
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 6 participants
- Where
- 1 siteBangladesh
- Study dates
- 25 Sep 2025to 5 Nov 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- healthy adult volunteers participated
Who cannot join
- Sick and children
Trial locations and contacts
1 site in 1 country.
Bangladesh1 site
Biomedical Engineering Department, Military Institute of Science and Technology
Dhaka, Dhaka Division, 1216
About this study
Official title: Comparative Evaluation of Mosquito Repellent Products in South Asia and North America: Efficacy, Safety, and Public Health Implications
Human Volunteer Participation:
A total of six (6) healthy adult volunteers participated in the study, including three males and three females aged between 18 and 22 years. The volunteers participated in:
Read more
- Arm-in-Cage Test Procedure
- Dermatological Safety Test
All participants were:
- Non-tobacco users
- Free from dermatosis or chronic skin disease
- Free from known allergic reactions to arthropod bites or mosquito repellents
- Informed regarding the objectives, procedures, risks, and benefits of the study Written informed consent was obtained from all volunteers before participation. Participants were instructed not to apply perfumes, aromatics, skincare products, or other mosquito repellents on the hands for at least 12 hours before and during the experiment to minimize experimental bias.
Safety and Ethical Considerations:
- All experiments were conducted under controlled laboratory conditions.
- Appropriate safety precautions and monitoring procedures were maintained throughout the study.
- Volunteers retained the right to withdraw from the study at any stage without penalty.
- Confidentiality and anonymity of volunteer information were strictly maintained.
- No severe physical or psychological risk was associated with participation.
- Immediate medical support and first-aid facilities were available during experimentation.
- Conditions
- Mosquito Repellent, Mosquito Bite
- Being tested
- Mosquito Repellent Products (Topical and Spatial Formulations)
- Keywords
- mosquito repellent, efficacy test, mosquito bite, protection time
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Mosquito Repellent Products (Topical and Spatial Formulations)Device
Specialized rubber gloves designed to expose only a 4 × 4 cm area of dorsal hand skin while protecting the rest of the hand. Gloves were replaced between trials to prevent cross-contamination or residual repellent effects.
| Study group | Role | What they receive |
|---|---|---|
| Arm-in-Cage Test Procedure | Experimental | This arm evaluates the efficacy of commercially available skin-applied mosquito repellent formulations against Aedes albopictus females using a standardized WHO-recommended Arm-in-Cage Test (ACT). The study assesses mosquito landing/biting protection under controlled laboratory conditions using human volunteers and standardized exposure procedures. Receives: Device: Mosquito Repellent Products (Topical and Spatial Formulations) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Number of Mosquito Landings on the Treated Forearm During the WHO Arm-in-Cage Test
The number of mosquito landings on the treated forearm will be counted during each exposure period using the standardized WHO Arm-in-Cage Test with 50 unfed female Aedes aegypti mosquitoes.
Measured: Measured at 0, 1, 2, 4, 6, and 8 hours after repellent application.
Number of Confirmed Mosquito Bites During the WHO Arm-in-Cage Test
The number of confirmed mosquito bites occurring on the treated forearm will be recorded during each exposure period.
Measured: Measured at 0, 1, 2, 4, 6, and 8 hours after repellent application.
Complete Protection Time Measured by the WHO Arm-in-Cage Test
Complete Protection Time is defined as the elapsed time from repellent application until the first confirmed mosquito landing or bite.
Measured: Up to 8 hours after application.
Percentage Protection Against Mosquito Landing
Percentage protection will be calculated by comparing the number of mosquito landings on treated skin with the corresponding control observations.
Measured: Measured at 0, 1, 2, 4, 6, and 8 hours after application
Secondary outcomes (1)
Number of Participants With Treatment-Related Skin Reactions
The number of participants experiencing erythema, itching, rash, burning sensation, or other treatment-related skin reactions after topical repellent application.
Measured: Within 8 hours after application.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Jul 2026
- Study start25 Sep 2025
- Primary completion25 Oct 2025
- Study completion5 Nov 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Mosquito RepellentStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- Six healthy adult volunteers (three males and three females, aged 18-22 years) participated in the study. All volunteers underwent the Arm-in-Cage repellency bioassay and dermatological safety testing. Each participant was exposed to multiple commercially available mosquito repellent products according to the study protocol, allowing comparative assessment of efficacy, protection duration, and skin safety. No separate participant groups were established; therefore, all participants belonged to a single study arm.
- Masking
- None (open label)
- Enrolment
- 6 participants (actual)
Sponsor and investigators
- Lead sponsor
- Military Institute of science and Technology
- Sponsor type
- University, hospital or other
- Collaborators
- Texas A&M University, University of Washington, Swiss Tropical and Public Health Institute (Switzerland), Chinese Academy of Sciences, Tsinghua University, University of Basel
- Responsible party
- Principal investigator, Ushama Shafoyat, Military Institute of science and Technology
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07686159
- Sponsor's protocol ID
- 2025H009
- Status last verified
- Jul 2026
- First submitted
- 5 Jun 2026
- Last updated
- 7 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Yoon JK, Kim KC, Cho Y, Gwon YD, Cho HS, Heo Y, Park K, Lee YW, Kim M, Oh YK, Kim YB. Comparison of Repellency Effect of Mosquito Repellents for DEET, Citronella, and Fennel Oil. J Parasitol Res. 2015;2015:361021. doi: 10.1155/2015/361021. Epub 2015 Oct 7.
PubMed 26527362
Study at a glance
From the registry record, last updated by the sponsor on 7 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Evaluation of Mosquito Repellent Products in South Asia and North America: Efficacy, Safety, and Public Health Implications
- ClinicalTrials.gov ID
- NCT07686159
- Acronym / sponsor ID
- 2025H009
- Conditions
- Mosquito Repellent, Mosquito Bite
- Keywords
- mosquito repellent, efficacy test, mosquito bite, protection time
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 6 participants (actual)
- Lead sponsor
- Military Institute of science and TechnologyUniversity, hospital or other
- Collaborators
- Texas A&M University, University of Washington, Swiss Tropical and Public Health Institute (Switzerland), Chinese Academy of Sciences, Tsinghua University, University of Basel
- Study start
- 25 Sep 2025 (actual)
- Primary completion
- 25 Oct 2025 (actual)
- Study completion
- 5 Nov 2025 (actual)
- First posted
- 7 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Human Volunteer Participation:
A total of six (6) healthy adult volunteers participated in the study, including three males and three females aged between 18 and 22 years. The volunteers participated in:
- Arm-in-Cage Test Procedure
- Dermatological Safety Test
All participants were:
- Non-tobacco users
- Free from dermatosis or chronic skin disease
- Free from known allergic reactions to arthropod bites or mosquito repellents
- Informed regarding the objectives, procedures, risks, and benefits of the study Written informed consent was obtained from all volunteers before participation. Participants were instructed not to apply perfumes, aromatics, skincare products, or other mosquito repellents on the hands for at least 12 hours before and during the experiment to minimize experimental bias.
Safety and Ethical Considerations:
- All experiments were conducted under controlled laboratory conditions.
- Appropriate safety precautions and monitoring procedures were maintained throughout the study.
- Volunteers retained the right to withdraw from the study at any stage without penalty.
- Confidentiality and anonymity of volunteer information were strictly maintained.
- No severe physical or psychological risk was associated with participation.
- Immediate medical support and first-aid facilities were available during experimentation.
Study design
- Primary purpose
- Prevention
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- Six healthy adult volunteers (three males and three females, aged 18-22 years) participated in the study. All volunteers underwent the Arm-in-Cage repellency bioassay and dermatological safety testing. Each participant was exposed to multiple commercially available mosquito repellent products according to the study protocol, allowing comparative assessment of efficacy, protection duration, and skin safety. No separate participant groups were established; therefore, all participants belonged to a single study arm.
| Arm | Type | Receives |
|---|---|---|
| Arm-in-Cage Test Procedure | Experimental | Device: Mosquito Repellent Products (Topical and Spatial Formulations)This arm evaluates the efficacy of commercially available skin-applied mosquito repellent formulations against Aedes albopictus females using a standardized WHO-recommended Arm-in-Cage Test (ACT). The study assesses mosquito landing/biting protection under controlled laboratory conditions using human volunteers and standardized exposure procedures. |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- healthy adult volunteers participated
Key exclusion criteria (1 listed)
- Sick and children
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Mosquito Repellent Products (Topical and Spatial Formulations)Specialized rubber gloves designed to expose only a 4 × 4 cm area of dorsal hand skin while protecting the rest of the hand. Gloves were replaced between trials to prevent cross-contamination or residual repellent effects. | Device | Arm-in-Cage Test Procedure |
Primary outcome
Number of Mosquito Landings on the Treated Forearm During the WHO Arm-in-Cage Test
Time frame: Measured at 0, 1, 2, 4, 6, and 8 hours after repellent application.
The number of mosquito landings on the treated forearm will be counted during each exposure period using the standardized WHO Arm-in-Cage Test with 50 unfed female Aedes aegypti mosquitoes.
Number of Confirmed Mosquito Bites During the WHO Arm-in-Cage Test
Time frame: Measured at 0, 1, 2, 4, 6, and 8 hours after repellent application.
The number of confirmed mosquito bites occurring on the treated forearm will be recorded during each exposure period.
Complete Protection Time Measured by the WHO Arm-in-Cage Test
Time frame: Up to 8 hours after application.
Complete Protection Time is defined as the elapsed time from repellent application until the first confirmed mosquito landing or bite.
Percentage Protection Against Mosquito Landing
Time frame: Measured at 0, 1, 2, 4, 6, and 8 hours after application
Percentage protection will be calculated by comparing the number of mosquito landings on treated skin with the corresponding control observations.
1 secondary outcome
Number of Participants With Treatment-Related Skin Reactions
Time frame: Within 8 hours after application.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Jul 2026.
- Results publication: PubMed 26527362Yoon JK, Kim KC, Cho Y, Gwon YD, Cho HS, Heo Y, Park K, Lee YW, Kim M, Oh YK, Kim YB. Comparison of Repellency Effect of Mosquito Repellents for DEET, Citronella, and Fennel Oil. J Parasitol Res. 2015;2015:361021. doi: 10.1155/2015/361021. Epub 2015 Oct 7.
- Individual participant dataSharing planned: No
Related trials for Mosquito Repellent
Not yet recruiting
Long-acting Spatial Emanators / Repellents (LASER)
Malaria Transmission, Malaria Prevention
Active, not recruiting
Evaluation of IR3535 as a Spatial Repellent for Malaria Control.
Malaria
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Mosquito Repellent Products (Topical and Spatial Formulations) in people with Mosquito Repellent and Mosquito Bite, run by Military Institute of science and Technology at 1 site in Bangladesh.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 7 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Bangladesh. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Number of Mosquito Landings on the Treated Forearm During the WHO Arm-in-Cage Test (time frame: Measured at 0, 1, 2, 4, 6, and 8 hours after repellent application.). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07686159, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Jul 2026.