Cesarean SectionSTRIP-CSNCT07686913
Steri-Strip Application Versus Standard Wound Closure for Cesarean Section Incisions
A study testing Steri-Strip™ Skin Closures and Standard Cesarean Wound Closure in people with Cesarean Section and Surgical Site Infection, run by Riverside University Health System Medical Center at 1 site in United States.
Trial summary
This study is evaluating whether Steri-Strips® provide additional benefits when used after cesarean section (C-section) surgery. Steri-Strips are adhesive strips that are commonly placed over a surgical incision to provide support while the wound heals. Read more about this study
- Who is it for?
- Ages 18 years and older, women only
- Conditions the study is for
- Cesarean Section, Surgical Site Infection, Wound Dehiscence
- What is being tested?
- Steri-Strip™ Skin Closures and Standard Cesarean Wound Closure
- Type of treatment
- Medical device, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 610 participants
- Where
- 1 siteUnited States
- Study dates
- Jun 2026to Dec 2027
- Phase
- Interventional
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- Women only
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Female patients age 18 years or older
- Pregnant patients undergoing cesarean delivery at Riverside University Health System Medical Center (RUHS)
- Able and willing to provide informed consent
Who cannot join
- Known allergy or hypersensitivity to Steri-Strip™ materials or adhesives
- Inability or unwillingness to provide informed consent
- Anticipated inability to complete the 30-day postpartum follow-up evaluation
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Riverside University Health System Medical Center
Moreno Valley, California, 92555
Matthew X Perera, DO, MS, 8184800214, mattpereraruhs@gmail.com
About this study
Official title: A Randomized Prospective Trial Comparing Steri-Strip Application Versus Standard Wound Closure for Cesarean Section Incisions
This study is evaluating whether Steri-Strips® provide additional benefits when used after cesarean section (C-section) surgery. Steri-Strips are adhesive strips that are commonly placed over a surgical incision to provide support while the wound heals. At our hospital, Steri-Strips are routinely used after C-sections in addition to standard wound closure techniques, although they are not considered part of the standard recommended closure method.
Researchers want to determine whether adding Steri-Strips actually reduces wound complications such as infection, fluid collection under the skin, or reopening of the incision. Previous studies have shown mixed results, with some suggesting little difference in wound healing outcomes while others reported differences in scar appearance. Steri-Strips may also increase costs, add time to the surgery, and occasionally cause skin irritation or allergic reactions.
Read more
Participants in this study will be randomly assigned to one of two groups. One group will receive standard cesarean wound closure with Steri-Strips, while the other group will receive standard wound closure without Steri-Strips. Researchers will compare wound healing, complications, patient outcomes, and costs between the two groups.
The goal of this study is to determine whether Steri-Strips improve recovery after cesarean delivery and whether their routine use is beneficial and cost-effective. The findings may help guide future recommendations for cesarean wound care and improve outcomes for patients undergoing C-section delivery.
- Conditions
- Cesarean Section, Surgical Site Infection, Wound Dehiscence, Seroma
- Being tested
- Steri-Strip™ Skin Closures, Standard Cesarean Wound Closure
- Keywords
- Cesarean Section, Cesarean Delivery, C-Section, Steri-Strips, Skin Closure, Wound Closure, Surgical Site Infection, Wound Dehiscence, Seroma, Postoperative Wound Complications, Obstetric Surgery, Incision Management, Surgical Wound Healing, Maternal Morbidity, Randomized Controlled Trial
- Medical subject headings
- Surgical Wound Infection, Seroma
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Steri-Strip™ Skin ClosuresDevice
Application of Steri-Strip adhesive skin closure strips following standard cesarean section wound closure according to a standardized protocol.
Standard Cesarean Wound ClosureProcedure or surgery
Standard skin closure performed following cesarean delivery according to institutional practice.
| Study group | Role | What they receive |
|---|---|---|
| Standard Closure + Steri-Strips | Experimental | Participants undergo standard cesarean skin closure followed by application of Steri-Strip™ skin closure strips according to a standardized study protocol. Receives: Device: Steri-Strip™ Skin Closures; Procedure: Standard Cesarean Wound Closure |
| Standard Closure Alone | Active comparator | Participants undergo standard cesarean skin closure without application of Steri-Strip™ skin closure strips. Receives: Procedure: Standard Cesarean Wound Closure |
What is being measured
The primary outcome is the main question the study is designed to answer.
Incidence of Cesarean Section Wound Complications
Composite incidence of postoperative wound complications including surgical site infection, wound seroma, and wound separation/dehiscence following cesarean delivery.
Measured: Within 30 days postpartum
Secondary outcomes (3)
Length of Hospital Stay
Duration of hospitalization measured from cesarean delivery until discharge.
Measured: From cesarean delivery until hospital discharge (up to 7 days)
Readmission Related to Wound Complications
Hospital readmission attributable to wound infection, seroma, or wound separation/dehiscence following cesarean delivery.
Measured: Within 30 days postpartum
Cost of Wound Management
Comparison of direct healthcare costs associated with wound closure materials and management of postoperative wound complications between study groups.
Measured: From cesarean delivery through 30 days postpartum
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Jul 2026
- Study startJun 2026 (estimated)
- Primary completionJun 2027 (estimated)
- Study completionDec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (5)Papers the sponsor has linked to this study.
- Other trials for Cesarean SectionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants will be assigned using 1:1 block randomization to one of two study arms. The intervention arm will receive Steri-Strip application following standard cesarean wound closure, while the control arm will receive standard wound closure alone. Participants will remain in their assigned group throughout the study, and outcomes will be assessed within 30 days postpartum.
- Masking
- None (open label)
- Enrolment
- 610 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Riverside University Health System Medical Center
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Matthew X Perera, DO, Riverside University Health System Medical Center
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07686913
- Sponsor's protocol ID
- 2357408
- Acronym
- STRIP-CS
- Status last verified
- Jun 2026
- First submitted
- 24 Jun 2026
- Last updated
- 7 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- Yes
- Individual data sharing
- No
Publications
Herman A, Kerre S, Stras A, Desmedt B. Two Additional Cases of Allergic Contact Dermatitis Caused by Wound Closure Tape Steri-Strip3M. Contact Dermatitis. 2025 Jul;93(1):68-70. doi: 10.1111/cod.14788. Epub 2025 Mar 20. No abstract available.
PubMed 40114334Hall JD, Schwartz E. Solving "T" Junction Wound Breakdown With a Single Tension-reducing Device. Plast Reconstr Surg Glob Open. 2025 Aug 15;13(8):e6882. doi: 10.1097/GOX.0000000000006882. eCollection 2025 Aug.
PubMed 40821899Dominoni M, Torella M, Molitierno R, Fordellone M, Saccone G, Colacurci D, Lagana AS, Pano MR, Gardella B, La Verde M. Single-versus double-layer uterine closure at the time of cesarean delivery and risk of uterine scar niche: a systematic review and meta-analysis of randomized trials. Arch Gynecol Obstet. 2025 Oct;312(4):1095-1106. doi: 10.1007/s00404-025-08151-y. Epub 2025 Aug 20.
PubMed 40833607Zempsky WT, Parrotti D, Grem C, Nichols J. Randomized controlled comparison of cosmetic outcomes of simple facial lacerations closed with Steri Strip Skin Closures or Dermabond tissue adhesive. Pediatr Emerg Care. 2004 Aug;20(8):519-24. doi: 10.1097/01.pec.0000136068.45198.ae.
PubMed 15295247Sah N, Punga R, Kumar A, Shivhare P, Singh AK, Sah S, Shekhar A. The surgical outcome of sutureless skin closures using Octyl-2-cyanoacrylate (Dermabond) versus Steri-Strip. Natl J Maxillofac Surg. 2024 May-Aug;15(2):307-312. doi: 10.4103/njms.njms_102_22. Epub 2024 Jul 24.
PubMed 39234130