Chronic Post-surgical PainEVATHONCT07687082
Prevalence and Risk Factors for Chronic Post-Surgical Pain Following Video-Assisted Thoracic Surgery : The EVATHO Prospective Bicentric Cohort Study.
An observational study of Chronic Post-surgical Pain and Postoperative Pain After Thoracic Surgery, run by University Hospital, Montpellier.
Trial summary
Chronic post-surgical pain (CPSP) remains a common complication after thoracic surgery and may significantly impair patients' quality of life. Although the widespread adoption of video-assisted thoracic surgery (VATS) has reduced surgical trauma and improved postoperative recovery, a substantial proportion of patients… Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Chronic Post-surgical Pain, Postoperative Pain After Thoracic Surgery, Neuropathic Pain
- How many people
- 400 participants
- Where
- No sites listed yet
- Study dates
- 1 Aug 2026to 1 Aug 2028
- Phase
- Observational
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Adult patients undergoing video-assisted thoracic surgery (VATS) for pulmonary resection, pleural procedures, chest wall surgery, or lung biopsy at Montpellier and Nice University Hospitals.
Who may be able to join
- Adult patients undergoing video-assisted thoracic surgery (VATS) for thoracic surgery
Who cannot join
- Age <18 years
- Adults under legal protection or unable to provide informed non-opposition
- Patients unable to understand or complete the study questionnaires
- Patients not affiliated with a French health insurance scheme.
- Adults under legal protection, including judicial safeguard, guardianship, or curatorship.
- Participation in another clinical study involving an ongoing exclusion period.
- Pregnant or breastfeeding women.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
Sophie Bringuier, MD contact
About this study
Official title: Study of the Prevalence of Chronic Postoperative Pain After Video-Assisted Thoracic Surgery: A Bicentric Cohort Study
Chronic post-surgical pain (CPSP) remains a common complication after thoracic surgery and may significantly impair patients' quality of life. Although the widespread adoption of video-assisted thoracic surgery (VATS) has reduced surgical trauma and improved postoperative recovery, a substantial proportion of patients still develop persistent pain.
The EVATHO study is a multicenter prospective observational cohort designed to determine the prevalence of CPSP three months after VATS and to identify perioperative factors associated with its development. Adult patients undergoing thoracic surgery by VATS at Montpellier and Nice University Hospitals will be prospectively enrolled.
Pain intensity, neuropathic pain characteristics, anxiety, depression, quality of life, and analgesic consumption will be assessed using validated questionnaires during the perioperative period and at 1 and 3 months after surgery. The results of this study may help identify patients at increased risk of CPSP and improve perioperative pain management strategies following thoracic surgery.
- Conditions
- Chronic Post-surgical Pain, Postoperative Pain After Thoracic Surgery, Neuropathic Pain, Thoracic Surgical Procedures
- Medical subject headings
- Pain, Postoperative, Neuralgia
What is being measured
The primary outcome is the main question the study is designed to answer.
Number of participants with chronic post-surgical pain
Chronic post-surgical pain defined as a Brief Pain Inventory (BPI) average pain score greater than 3 at the 3-month postoperative follow-up.
Measured: 3 months after surgery.
Secondary outcomes (9)
Postoperative pain at 1 month after VATS
Post-surgical pain defined as a Brief Pain Inventory (BPI) average pain score greater than 3 at the 1-month postoperative follow-up.
Measured: 1 month after thoracic surgery
Visual Analogue Scale (VAS) pain score
Pain intensity measured using the Visual Analogue Scale (VAS), with scores ranging from 0 (no pain) to 10 (worst imaginable pain).
Measured: Preoperative assessment, postoperative day 1, postoperative day 2, 1 month, and 3 months after surgery.
Cumulative postoperative opioid consumption.
Total opioid consumption during the postoperative period as morphine milligram equivalents
Measured: Postoperative day 1, postoperative day 2, 1 month, and 3 months after surgery.
Douleur Neuropathie 4 (DN4) score
Neuropathic pain measured using the Douleur Neuropathique 4 (DN4) questionnaire. Scores range from 0 to 10, with scores greater than or equal to 4 indicating neuropathic pain.
Measured: Preoperative assessment, postoperative day 1, postoperative day 2, 1 month, and 3 months after surgery.
Hospitalier Anxiety and depression Scale (HADS) anxiety score
Anxiety measured using the hospital Anxiety and Depression Scale (HADS-A). Scores range from 0 to 21, with scores greater than or equal to 11 indicating clinically significant anxiety.
Measured: Preoperative assessment, 1 month, and 3 months after surgery.
Hospital Anxiety and Depression Scale (HADS) depression score
Depression measured using the Hospital Anxiety and Depression Scale (HADS-D). Scores range from 0 to 21, with scores greater than or equal to 11 indicating clinically significant depression.
Measured: Preoperative assessment, 1 month, and 3 months after surgery
Brief Pain Inventory (BPI) pain interference score
Pain interference with daily activities measured using the Brief Pain Inventory (BPI) interference subscale
Measured: 1 month and 3 months after surgery.
Short Form-12 Physical component summary score
Physical health-related quality of life measured using the Physical Component Summary (PCS) score of the Short Form-12 (SF-12) questionnaire.
Measured: Preoperative assessment, 1 month, and 3 months after surgery.
Short form-12 Mental Component Summary score
Mental health-related quality of life measured using the Mental Component Summary (MCS) score of the Short Form-12 (SF-12) questionnaire.
Measured: Preoperative assessment, 1 month and 3 months after surgery
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Jul 2026
- Study start1 Aug 2026 (estimated)
- Primary completion1 Apr 2028 (estimated)
- Study completion1 Aug 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Chronic Post-surgical PainStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 400 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital, Montpellier
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07687082
- Sponsor's protocol ID
- RECHMPL 25_0555
- Acronym
- EVATHO
- Status last verified
- Jun 2026
- First submitted
- 21 Jun 2026
- Last updated
- 7 Jul 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No