Hip Fracture SurgeriesNCT07687290
Comparative Study Between Pericapsular Nerve Group Block (PENG) And Pericapsular Nerve Group (PENG) Block Combined With Lateral Femoral Cutaneous Nerve (LFCN) Block for Positioning Analgesia Prior to Spinal Anesthesia in Hip Fracture Patients
A study testing PENG Block, LCFN block and bupivacaine 0.25%. in people with Hip Fracture Surgeries, run by Ain Shams University at 1 site in Egypt.
Trial summary
To evaluate and compare the effectiveness of the Pericapsular Nerve Group (PENG) block alone versus the PENG block combined with the Lateral Femoral Cutaneous Nerve (LFCN) block in providing adequate analgesia for patient positioning during spinal anesthesia in individuals undergoing surgery for hip fracture. Read more about this study
- Who is it for?
- Ages 18 to 70 years
- Conditions the study is for
- Hip Fracture Surgeries
- What is being tested?
- PENG Block, LCFN block and bupivacaine 0.25%.
- Type of treatment
- Injection or infusion, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 24 participants
- Where
- 1 siteEgypt
- Study dates
- 18 Jun 2026to Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age 18-70 years.
- ASA I-II.
- Confirmed primary unilateral hip fracture.
- Scheduled for surgery under spinal anesthesia.
- Patients able to provide informed consent.
Who cannot join
- Allergy to local anesthetics.
- Coagulopathy or on anticoagulant therapy.
- Infection at injection site.
- Pre-existing neurological deficits in the lower limbs.
- Multiple trauma or polytrauma (If other injuries might interfere with positioning or pain scoring).
- Previous surgery on the ipsilateral hip affecting anatomy or nerve distribution.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site, 1 recruiting
- Recruiting
Ain Shams University
Cairo
Maha Salah, lecturer, +201007269331, mahata5deer@gmail.com
About this study
To evaluate and compare the effectiveness of the Pericapsular Nerve Group (PENG) block alone versus the PENG block combined with the Lateral Femoral Cutaneous Nerve (LFCN) block in providing adequate analgesia for patient positioning during spinal anesthesia in individuals undergoing surgery for hip fracture.
Read the detailed description
Hip fractures are common among adult patients and often necessitate urgent surgical intervention. Positioning these patients for spinal anesthesia in sitting position is often difficult due to intense pain from the fracture. PENG block is a novel regional technique that targets the articular branches of the femoral nerve, obturator nerve, and accessory obturator nerve, providing excellent anterior hip analgesia sparing the motor function. It is performed under ultrasound guidance and has shown promising results in perioperative pain management. By combining LFCN block with the PENG block, more complete sensory blockade may be achieved. The effectiveness of this combination has not yet been adequately studied, particularly regarding positioning for spinal anesthesia. Therefore, this trial aims to compare the analgesic efficacy of PENG block alone versus PENG +LFCN block in this specific context.
- Conditions
- Hip Fracture Surgeries
- Being tested
- PENG Block, LCFN block, bupivacaine 0.25%., Xylocaine 2 %
- Keywords
- hip surgeries, positioning for spinal anesthesia, PENG block, LCFN block
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
PENG BlockProcedure or surgery
Pericapsular Nerve Group Block
LCFN blockProcedure or surgery
Lateral Femoral Cutaneous Nerve block
bupivacaine 0.25%.Drug
0.25% of Bupivacaine (Bupivacaine 0.5% is added to Lidocaine 2% in the same volume)
Xylocaine 2 %Drug
local infilteration at the insertion site
| Study group | Role | What they receive |
|---|---|---|
| group A (PENG BLOCK) | Active comparator | The patient is positioned supine and hip extended. 3 mL of 2% lidocaine is injected at the insertion site using a hyperechoic needle guided by ultrasound using a low-frequency probe. At the anterior superior iliac spine level, the probe is placed parallel to the inguinal fold, and scanning is performed with a gradual movement of the probe head. When the lower anterior inferior iliac spine is observed, the probe is rotated slightly median until a continuous hyperechoic shadow of the upper pubic ramus is visible. This maneuver help to identify the psoas muscle with a prominent tendon above the pubic ramus. The target is located in the plane between these 2 structures. The pubic ramus should be aligned in the center of the image to target the pubic ramus just inside the anterior inferior iliac spine. A 100-mm nerve block needle can be introduced, and 20 ml of 0.25% of Bupivacaine (10 ml of Bupivacaine 0.5% is added to 10ml of Lidocaine 2%) is administered Receives: Procedure: PENG Block; Drug: bupivacaine 0.25%.; Drug: Xylocaine 2 % |
| Group B (PENG block and LCFN block) | Active comparator | in addition to PENG block ( as described before), LFCN block is performed by using a linear array ultrasound probe a cross-sectional view of the LFCN was obtained by identifying the anterior superior iliac spine, then the probe is moved in a medial and caudal direction until the nerve was encountered. The needle was advanced to the LFCN under ultrasound guidance via a lateral to medial approach. Injection of 8ml of 0.25% of Bupivacaine (4 ml of Bupivacaine 0.5% is added to 4 ml of Lidocaine 2%) Receives: Procedure: PENG Block; Procedure: LCFN block; Drug: bupivacaine 0.25%.; Drug: Xylocaine 2 % |
What is being measured
The primary outcome is the main question the study is designed to answer.
To compare the time taken to achieve optimal positioning for spinal anesthesia in both groups
time taken in seconds for positioning for spinal anesthesia 15 minutes post- block
Measured: from initiation of patient positioning until optimal positioning is achieved during the spinal anesthesia procedure
Secondary outcomes (4)
To assess Numerical Rating Pain Score in both groups at 0,5,10 and 15 minutes post block
It refers to the common method used in healthcare where patients rate their pain on a scale from 0 to 10 (0 = No pain 10 = Worst pain imaginable).
Measured: at baseline (0 minutes) and at 5,10 and 15 minutes after completion of the block
To assess patient satisfaction and comfort during positioning using Likert scale
5-Point scale (1=strongly disagree and 5=strongly agree). The participants measure it 15 minutes post- block during positioning for spinal anesthesia
Measured: during patient positioning 15 minutes after completion of the block
To monitor mean arterial blood pressure
Comparing mean arterial blood pressure between the 2 groups by millimeter of mercury (mmhg) at 0,5,10 and 15 minutes post-block.
Measured: at baseline (0 minutes) and at 5,10 and 15 minutes after completion of the block
To monitor heart rate
Comparing the heart rate ( by beats per minute) in the 2 groups at 0,5,10 and 15 minutes post-block.
Measured: At baseline (0 minutes) and at 5,10 and 15 minutes after completion of the block
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Jul 2026
- Study start18 Jun 2026
- Primary completionDec 2026 (estimated)
- Study completionDec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Hip Fracture SurgeriesStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 24 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Ain Shams University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Maha Salah, Ain Shams University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07687290
- Sponsor's protocol ID
- FMASU MS 25 / 2026
- Status last verified
- Jun 2026
- First submitted
- 18 Jun 2026
- Last updated
- 9 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 9 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Study Between Pericapsular Nerve Group Block (PENG) And Pericapsular Nerve Group (PENG) Block Combined With Lateral Femoral Cutaneous Nerve (LFCN) Block for Positioning Analgesia Prior to Spinal Anesthesia in Hip Fracture Patients
- ClinicalTrials.gov ID
- NCT07687290
- Acronym / sponsor ID
- FMASU MS 25 / 2026
- Conditions
- Hip Fracture Surgeries
- Keywords
- hip surgeries, positioning for spinal anesthesia, PENG block, LCFN block
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 24 participants (estimated)
- Lead sponsor
- Ain Shams UniversityUniversity, hospital or other
- Study start
- 18 Jun 2026 (actual)
- Primary completion
- Dec 2026 (estimated)
- Study completion
- Dec 2026 (estimated)
- First posted
- 7 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To evaluate and compare the effectiveness of the Pericapsular Nerve Group (PENG) block alone versus the PENG block combined with the Lateral Femoral Cutaneous Nerve (LFCN) block in providing adequate analgesia for patient positioning during spinal anesthesia in individuals undergoing surgery for hip fracture.
Detailed description
Hip fractures are common among adult patients and often necessitate urgent surgical intervention. Positioning these patients for spinal anesthesia in sitting position is often difficult due to intense pain from the fracture. PENG block is a novel regional technique that targets the articular branches of the femoral nerve, obturator nerve, and accessory obturator nerve, providing excellent anterior hip analgesia sparing the motor function. It is performed under ultrasound guidance and has shown promising results in perioperative pain management. By combining LFCN block with the PENG block, more complete sensory blockade may be achieved. The effectiveness of this combination has not yet been adequately studied, particularly regarding positioning for spinal anesthesia. Therefore, this trial aims to compare the analgesic efficacy of PENG block alone versus PENG +LFCN block in this specific context.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| group A (PENG BLOCK) | Active comparator | Procedure: PENG Block, Drug: bupivacaine 0.25%., Drug: Xylocaine 2 %The patient is positioned supine and hip extended. 3 mL of 2% lidocaine is injected at the insertion site using a hyperechoic needle guided by ultrasound using a low-frequency probe. At the anterior superior iliac spine level, the probe is placed parallel to the inguinal fold, and scanning is performed with a gradual movement of the probe head. When the lower anterior inferior iliac spine is observed, the probe is rotated slightly median until a continuous hyperechoic shadow of the upper pubic ramus is visible. This maneuver help to identify the psoas muscle with a prominent tendon above the pubic ramus. The target is located in the plane between these 2 structures. The pubic ramus should be aligned in the center of the image to target the pubic ramus just inside the anterior inferior iliac spine. A 100-mm nerve block needle can be introduced, and 20 ml of 0.25% of Bupivacaine (10 ml of Bupivacaine 0.5% is added to 10ml of Lidocaine 2%) is administered |
| Group B (PENG block and LCFN block) | Active comparator | Procedure: PENG Block, Procedure: LCFN block, Drug: bupivacaine 0.25%., Drug: Xylocaine 2 %in addition to PENG block ( as described before), LFCN block is performed by using a linear array ultrasound probe a cross-sectional view of the LFCN was obtained by identifying the anterior superior iliac spine, then the probe is moved in a medial and caudal direction until the nerve was encountered. The needle was advanced to the LFCN under ultrasound guidance via a lateral to medial approach. Injection of 8ml of 0.25% of Bupivacaine (4 ml of Bupivacaine 0.5% is added to 4 ml of Lidocaine 2%) |
Who may qualify
- Ages
- 18 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Age 18-70 years.
- ASA I-II.
- Confirmed primary unilateral hip fracture.
- Scheduled for surgery under spinal anesthesia.
- Patients able to provide informed consent.
Key exclusion criteria (6 listed)
- Allergy to local anesthetics.
- Coagulopathy or on anticoagulant therapy.
- Infection at injection site.
- Pre-existing neurological deficits in the lower limbs.
- Multiple trauma or polytrauma (If other injuries might interfere with positioning or pain scoring).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| PENG BlockPericapsular Nerve Group Block | Procedure or surgery | Group B (PENG block and LCFN block), group A (PENG BLOCK) |
| LCFN blockLateral Femoral Cutaneous Nerve block | Procedure or surgery | Group B (PENG block and LCFN block) |
| bupivacaine 0.25%.0.25% of Bupivacaine (Bupivacaine 0.5% is added to Lidocaine 2% in the same volume) | Drug | Group B (PENG block and LCFN block), group A (PENG BLOCK) |
| Xylocaine 2 %local infilteration at the insertion site | Drug | Group B (PENG block and LCFN block), group A (PENG BLOCK) |
Primary outcome
To compare the time taken to achieve optimal positioning for spinal anesthesia in both groups
Time frame: from initiation of patient positioning until optimal positioning is achieved during the spinal anesthesia procedure
time taken in seconds for positioning for spinal anesthesia 15 minutes post- block
4 secondary outcomes
To assess Numerical Rating Pain Score in both groups at 0,5,10 and 15 minutes post block
Time frame: at baseline (0 minutes) and at 5,10 and 15 minutes after completion of the block
To assess patient satisfaction and comfort during positioning using Likert scale
Time frame: during patient positioning 15 minutes after completion of the block
To monitor mean arterial blood pressure
Time frame: at baseline (0 minutes) and at 5,10 and 15 minutes after completion of the block
To monitor heart rate
Time frame: At baseline (0 minutes) and at 5,10 and 15 minutes after completion of the block
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Jul 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing PENG Block, LCFN block and bupivacaine 0.25%. in people with Hip Fracture Surgeries, run by Ain Shams University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 9 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Maha Salah, lecturer (+201007269331, mahata5deer@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
To compare the time taken to achieve optimal positioning for spinal anesthesia in both groups (time frame: from initiation of patient positioning until optimal positioning is achieved during the spinal anesthesia procedure). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Jul 2026.