Ventilation Acquired PneumoniaTEA-VAPNCT07688057
Comparison of Green Tea, White Tea, and Chlorhexidine Oral Care for Prevention of Ventilator-Associated Pneumonia
A study testing Clorhexidine group, Green Tea group and white tea group in people with Ventilation Acquired Pneumonia and Mechanical Ventilation, run by Recep Tayyip Erdogan University at 1 site in Turkey (Türkiye).
Trial summary
This study was conducted to compare the effects of oral care performed using chlorhexidine (CHX), green tea, and white tea solutions on oral health, functional status, and the development of ventilator-associated pneumonia (VAP) in intensive care unit patients receiving mechanical ventilation (MV) Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Ventilation Acquired Pneumonia, Mechanical Ventilation, Oral Care
- What is being tested?
- Clorhexidine group, Green Tea group and white tea group
- Type of treatment
- Pill or oral medicine, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 63 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Jan 2024to 1 Apr 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Aged over 18 years
- With no known allergies
- Receiving invasive mechanical ventilator support
- With a negative endotracheal aspirate culture on the day of ICU admission
- Within the first 24 hours of mechanical ventilator support
- Patients whose relatives agreed to participate in the study
Who cannot join
- Patients with positive endotracheal aspirate cultures within the first 48 hours of intensive care admission,
- Patients undergoing radiotherapy or chemotherapy,
- Patients with contraindications for oral care,
- Patients with a platelet count below 30,000/mm³,
- Patients who cannot be positioned appropriately,
- Patients with agitation severe enough to prevent the procedure from being performed
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Recep Tayyip Erdogan University Research and Training Hospital
Rize, Merkez, 53020
About this study
Official title: Comparison of Chlorhexidine, Green Tea, and White Tea Oral Care for the Prevention of Ventilator- Associated Pneumonia in Mechanically Ventilated Patients
This study was conducted to compare the effects of oral care performed using chlorhexidine (CHX), green tea, and white tea solutions on oral health, functional status, and the development of ventilator-associated pneumonia (VAP) in intensive care unit patients receiving mechanical ventilation (MV)
Read the detailed description
This prospective controlled interventional study included 63 mechanically ventilated adult intensive care unit patients. Participants were assigned to one of three oral care groups receiving chlorhexidine (CHX), green tea, or white tea according to the study protocol. Oral health was assessed using the Bedside Oral Examination (BOE) guide on days 1, 3, and 7. The primary objective was to compare the incidence of ventilator-associated pneumonia (VAP) among the study groups. Secondary outcomes included changes in oral health status and functional oral assessment during follow-up.
- Being tested
- Clorhexidine group, Green Tea group, white tea group
- Keywords
- VAP, Oral care, green tea, white tea, clorhexidine
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Clorhexidine groupProcedure or surgery
Also called clorhexidine
oral care using clorhexidine solution, green tea and white tea
Green Tea groupProcedure or surgery
Also called green tea
Participants received oral care using green tea according to the study protocol.
white tea groupProcedure or surgery
Participants received oral care using white tea according to the study protocol.
| Study group | Role | What they receive |
|---|---|---|
| chlorhexidine group | Experimental | Participants received oral care using chlorhexidine solution according to the study protocol. Receives: Procedure: Clorhexidine group |
| green tea group | Experimental | Participants received oral care using green tea according to the study protocol. Receives: Procedure: Green Tea group |
| white tea group | Experimental | Participants received oral care using white tea according to the study protocol. Receives: Procedure: white tea group |
What is being measured
The primary outcome is the main question the study is designed to answer.
ventilator associated pneumonia devolopment
Comparison of the incidence of ventilator-associated pneumonia among the chlorhexidine, green tea, and white tea oral care groups.
Measured: 7 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Jul 2026
- Study start1 Jan 2024
- Primary completion31 Dec 2025
- Study completion1 Apr 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Ventilation Acquired PneumoniaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Model description
- Participants were assigned to one of three parallel intervention groups receiving chlorhexidine, green tea, or white tea oral care throughout the study period.
- Masking
- None (open label)
- Enrolment
- 63 participants (actual)
Sponsor and investigators
- Lead sponsor
- Recep Tayyip Erdogan University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Guleren Yartas Dumanli, Recep Tayyip Erdogan University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07688057
- Sponsor's protocol ID
- RTEU-2024-TEAVAP
- Other IDs
- 2024-KAEK-25
- Acronym
- TEA-VAP
- Status last verified
- Jul 2026
- First submitted
- 30 Jun 2026
- Last updated
- 8 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 8 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Chlorhexidine, Green Tea, and White Tea Oral Care for the Prevention of Ventilator- Associated Pneumonia in Mechanically Ventilated Patients
- ClinicalTrials.gov ID
- NCT07688057
- Acronym / sponsor ID
- TEA-VAP / RTEU-2024-TEAVAP
- Keywords
- VAP, Oral care, green tea, white tea, clorhexidine
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 63 participants (actual)
- Lead sponsor
- Recep Tayyip Erdogan UniversityUniversity, hospital or other
- Study start
- 1 Jan 2024 (actual)
- Primary completion
- 31 Dec 2025 (actual)
- Study completion
- 1 Apr 2026 (actual)
- First posted
- 7 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study was conducted to compare the effects of oral care performed using chlorhexidine (CHX), green tea, and white tea solutions on oral health, functional status, and the development of ventilator-associated pneumonia (VAP) in intensive care unit patients receiving mechanical ventilation (MV)
Detailed description
This prospective controlled interventional study included 63 mechanically ventilated adult intensive care unit patients. Participants were assigned to one of three oral care groups receiving chlorhexidine (CHX), green tea, or white tea according to the study protocol. Oral health was assessed using the Bedside Oral Examination (BOE) guide on days 1, 3, and 7. The primary objective was to compare the incidence of ventilator-associated pneumonia (VAP) among the study groups. Secondary outcomes included changes in oral health status and functional oral assessment during follow-up.
Study design
- Primary purpose
- Prevention
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
- Model description
- Participants were assigned to one of three parallel intervention groups receiving chlorhexidine, green tea, or white tea oral care throughout the study period.
| Arm | Type | Receives |
|---|---|---|
| chlorhexidine group | Experimental | Procedure: Clorhexidine groupParticipants received oral care using chlorhexidine solution according to the study protocol. |
| green tea group | Experimental | Procedure: Green Tea groupParticipants received oral care using green tea according to the study protocol. |
| white tea group | Experimental | Procedure: white tea groupParticipants received oral care using white tea according to the study protocol. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Aged over 18 years
- With no known allergies
- Receiving invasive mechanical ventilator support
- With a negative endotracheal aspirate culture on the day of ICU admission
- Within the first 24 hours of mechanical ventilator support
Key exclusion criteria (6 listed)
- Patients with positive endotracheal aspirate cultures within the first 48 hours of intensive care admission,
- Patients undergoing radiotherapy or chemotherapy,
- Patients with contraindications for oral care,
- Patients with a platelet count below 30,000/mm³,
- Patients who cannot be positioned appropriately,
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Clorhexidine groupAlso: clorhexidineoral care using clorhexidine solution, green tea and white tea | Procedure or surgery | chlorhexidine group |
| Green Tea groupAlso: green teaParticipants received oral care using green tea according to the study protocol. | Procedure or surgery | green tea group |
| white tea groupParticipants received oral care using white tea according to the study protocol. | Procedure or surgery | white tea group |
Primary outcome
ventilator associated pneumonia devolopment
Time frame: 7 days
Comparison of the incidence of ventilator-associated pneumonia among the chlorhexidine, green tea, and white tea oral care groups.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Jul 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Clorhexidine group, Green Tea group and white tea group in people with Ventilation Acquired Pneumonia and Mechanical Ventilation, run by Recep Tayyip Erdogan University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 8 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
ventilator associated pneumonia devolopment (time frame: 7 days). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Jul 2026.