Shoulder InstabilityNCT07689045
Modified PENG Plus Suprascapular Nerve Block Versus Interscalene Block for Bankart and Latarjet Surgery
A study testing • Modified PENG Block combined with Suprascapular Nerve Block and • Interscalene Brachial Plexus Block in people with Shoulder Instability, run by Cairo University at 1 site in Egypt.
Trial summary
This randomized controlled trial aims to compare the analgesic efficacy and safety of a Modified Pericapsular Nerve Group (PENG) Block combined with Suprascapular Nerve Block (SSNB) versus Interscalene Brachial Plexus Block (ISB) in adult patients undergoing elective Bankart repair or Latarjet surgery under general… Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Shoulder Instability
- What is being tested?
- • Modified PENG Block combined with Suprascapular Nerve Block and • Interscalene Brachial Plexus Block
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 70 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Jun 2026to 29 Nov 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- • Male or female patients aged 18 to 65 years.
- Patients undergoing elective Bankart repair or Latarjet surgery.
- American Society of Anesthesiologists (ASA) physical status I or II.
Who cannot join
- History of allergy to local anesthetics.
- Chronic opioid use (>3 months).
- Coagulation disorders.
- Pre-existing neurological or musculoskeletal disorders.
- Respiratory compromise (e.g., COPD)
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site, 1 recruiting
- Recruiting
Faculty of Medicine , Cairo University Hospitals
Cairo, Cairo Governorate
ahmed hamza ibrahem mohamed, md, +201159518716, ahmedmedohamza@gmail.com
Ahmed Zaghloul Foaad, Professor of Anaesthesia
About this study
Official title: Comparative Efficacy of Modified PENG Block Combined With Suprascapular Nerve Block Versus Interscalene Block for Bankart Repair and the Latarjet Surgery : A Randomized Controlled Trial
This randomized controlled trial aims to compare the analgesic efficacy and safety of a Modified Pericapsular Nerve Group (PENG) Block combined with Suprascapular Nerve Block (SSNB) versus Interscalene Brachial Plexus Block (ISB) in adult patients undergoing elective Bankart repair or Latarjet surgery under general anesthesia. Seventy patients will be randomized to receive either Modified PENG plus SSNB or ISB. The primary outcome is postoperative pain intensity measured by the Visual Analog Scale (VAS) at 24 hours. Secondary outcomes include opioid consumption, time to first rescue analgesia, functional recovery, range of motion, and block-related complications including respiratory compromise, motor weakness, Horner syndrome, hoarseness, and local anesthetic systemic toxicity. This randomized controlled trial aims to compare the analgesic efficacy and safety of a Modified Pericapsular Nerve Group (PENG) Block combined with Suprascapular Nerve Block (SSNB) versus Interscalene Brachial Plexus Block (ISB) in adult patients undergoing elective Bankart repair or Latarjet surgery under general anesthesia. Seventy patients will be randomized to receive either Modified PENG plus SSNB or ISB. The primary outcome is postoperative pain intensity measured by the Visual Analog Scale (VAS) at 24 hours. Secondary outcomes include opioid consumption, time to first rescue analgesia, functional recovery, range of motion, and block-related complications including respiratory compromise, motor weakness, Horner syndrome, hoarseness, and local anesthetic systemic toxicity.
Read the detailed description
Shoulder stabilization procedures such as Bankart repair and the Latarjet procedure are associated with significant postoperative pain. The interscalene brachial plexus block is considered the standard regional anesthetic technique but is associated with complications including phrenic nerve paralysis and motor weakness. This study evaluates whether a Modified PENG Block combined with Suprascapular Nerve Block can provide comparable postoperative analgesia while reducing block-related complications. This is a prospective, single-center, randomized controlled trial involving 70 ASA I-II adult patients undergoing elective shoulder stabilization surgery at Kasr Al-Ainy Hospital, Cairo University. Participants will be randomly allocated to receive either Modified PENG plus SSNB or ISB before general anesthesia. Pain scores, opioid consumption, time to first rescue analgesia, functional recovery, hemodynamic parameters, and adverse events will be assessed during the first 24 postoperative hours and during follow-up according to the study protocol
- Conditions
- Shoulder Instability
- Being tested
- • Modified PENG Block combined with Suprascapular Nerve Block, • Interscalene Brachial Plexus Block
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
• Modified PENG Block combined with Suprascapular Nerve BlockProcedure or surgery
Ultrasound-guided Modified Pericapsular Nerve Group (PENG) Block combined with Suprascapular Nerve Block (SSNB) performed before induction of general anesthesia. The Modified PENG Block is performed with 20 mL of 0.25% bupivacaine and the SSNB with 10 mL of 0.25% bupivacaine for postoperative analgesia in patients undergoing elective Bankart repair or Latarjet surgery
• Interscalene Brachial Plexus BlockProcedure or surgery
Ultrasound-guided Interscalene Brachial Plexus Block performed before induction of general anesthesia using 20 mL of 0.25% bupivacaine for postoperative analgesia in patients undergoing elective Bankart repair or Latarjet surgery
| Study group | Role | What they receive |
|---|---|---|
| Modified PENG + Suprascapular Nerve Block (SSNB) | Experimental | Participants receive an ultrasound-guided Modified Pericapsular Nerve Group (PENG) Block combined with Suprascapular Nerve Block (SSNB) before induction of general anesthesia for elective Bankart repair or Latarjet surgery. The Modified PENG Block is performed with 20 mL of 0.25% bupivacaine and the SSNB with 10 mL of 0.25% bupivacaine. Receives: Procedure: • Modified PENG Block combined with Suprascapular Nerve Block |
| Interscalene Brachial Plexus Block (ISB) | Active comparator | Participants receive an ultrasound-guided Interscalene Brachial Plexus Block (ISB) using 20 mL of 0.25% bupivacaine before induction of general anesthesia for elective Bankart repair or Latarjet surgery Receives: Procedure: • Interscalene Brachial Plexus Block |
What is being measured
The primary outcome is the main question the study is designed to answer.
Visual Analog Scale (VAS) Pain Score at Rest at 24 Hours Postoperatively
Pain intensity at rest will be assessed using the Visual Analog Scale (VAS) for pain, ranging from 0 (no pain) to 10 (worst imaginable pain), 24 hours after surgery. Higher scores indicate worse pain. The primary comparison is between the Modified PENG Block combined with Suprascapular Nerve Block and the Interscalene Brachial Plexus Block.
Measured: 24 hours after surgery
Secondary outcomes (2)
Visual Analog Scale (VAS) Pain Scores at Postoperative Time Points
Pain intensity will be assessed using the Visual Analog Scale (VAS) for pain, ranging from 0 (no pain) to 10 (worst imaginable pain). Higher scores indicate worse pain. Scores will be recorded at multiple postoperative time points.
Measured: multiple postoperative time points.
Total opioid consumption
Measured: during the first 24 hours.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Jul 2026
- Study start1 Jun 2026
- Primary completion1 Nov 2026 (estimated)
- Study completion29 Nov 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Shoulder InstabilityStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants will be randomly assigned in a 1:1 ratio to one of two parallel groups: Modified PENG Block combined with Suprascapular Nerve Block (SSNB) or Interscalene Brachial Plexus Block (ISB). Participants remain in their assigned group throughout the study.
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 70 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ahmed hamza ibrahim mohamed, Cairo University
- Investigators
- Ahmed Zaghloul Foaad, Professor of Anaesthesia, Principal investigator, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07689045
- Sponsor's protocol ID
- MD-248-2025
- Status last verified
- Jul 2026
- First submitted
- 30 Jun 2026
- Last updated
- 8 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared because there is no plan for public data sharing. Only aggregated study results will be reported in scientific publications while maintaining participant confidentiality.Individual participant data will not be shared because there is no plan for public data sharing. Only aggregated study results will be reported in scientific publications while maintaining participant confidentiality.
Study at a glance
From the registry record, last updated by the sponsor on 8 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Efficacy of Modified PENG Block Combined With Suprascapular Nerve Block Versus Interscalene Block for Bankart Repair and the Latarjet Surgery : A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07689045
- Acronym / sponsor ID
- MD-248-2025
- Conditions
- Shoulder Instability
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 70 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 1 Jun 2026 (actual)
- Primary completion
- 1 Nov 2026 (estimated)
- Study completion
- 29 Nov 2026 (estimated)
- First posted
- 7 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled trial aims to compare the analgesic efficacy and safety of a Modified Pericapsular Nerve Group (PENG) Block combined with Suprascapular Nerve Block (SSNB) versus Interscalene Brachial Plexus Block (ISB) in adult patients undergoing elective Bankart repair or Latarjet surgery under general anesthesia. Seventy patients will be randomized to receive either Modified PENG plus SSNB or ISB. The primary outcome is postoperative pain intensity measured by the Visual Analog Scale (VAS) at 24 hours. Secondary outcomes include opioid consumption, time to first rescue analgesia, functional recovery, range of motion, and block-related complications including respiratory compromise, motor weakness, Horner syndrome, hoarseness, and local anesthetic systemic toxicity. This randomized controlled trial aims to compare the analgesic efficacy and safety of a Modified Pericapsular Nerve Group (PENG) Block combined with Suprascapular Nerve Block (SSNB) versus Interscalene Brachial Plexus Block (ISB) in adult patients undergoing elective Bankart repair or Latarjet surgery under general anesthesia. Seventy patients will be randomized to receive either Modified PENG plus SSNB or ISB. The primary outcome is postoperative pain intensity measured by the Visual Analog Scale (VAS) at 24 hours. Secondary outcomes include opioid consumption, time to first rescue analgesia, functional recovery, range of motion, and block-related complications including respiratory compromise, motor weakness, Horner syndrome, hoarseness, and local anesthetic systemic toxicity.
Detailed description
Shoulder stabilization procedures such as Bankart repair and the Latarjet procedure are associated with significant postoperative pain. The interscalene brachial plexus block is considered the standard regional anesthetic technique but is associated with complications including phrenic nerve paralysis and motor weakness. This study evaluates whether a Modified PENG Block combined with Suprascapular Nerve Block can provide comparable postoperative analgesia while reducing block-related complications. This is a prospective, single-center, randomized controlled trial involving 70 ASA I-II adult patients undergoing elective shoulder stabilization surgery at Kasr Al-Ainy Hospital, Cairo University. Participants will be randomly allocated to receive either Modified PENG plus SSNB or ISB before general anesthesia. Pain scores, opioid consumption, time to first rescue analgesia, functional recovery, hemodynamic parameters, and adverse events will be assessed during the first 24 postoperative hours and during follow-up according to the study protocol
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
- Model description
- Participants will be randomly assigned in a 1:1 ratio to one of two parallel groups: Modified PENG Block combined with Suprascapular Nerve Block (SSNB) or Interscalene Brachial Plexus Block (ISB). Participants remain in their assigned group throughout the study.
| Arm | Type | Receives |
|---|---|---|
| Modified PENG + Suprascapular Nerve Block (SSNB) | Experimental | Procedure: • Modified PENG Block combined with Suprascapular Nerve BlockParticipants receive an ultrasound-guided Modified Pericapsular Nerve Group (PENG) Block combined with Suprascapular Nerve Block (SSNB) before induction of general anesthesia for elective Bankart repair or Latarjet surgery. The Modified PENG Block is performed with 20 mL of 0.25% bupivacaine and the SSNB with 10 mL of 0.25% bupivacaine. |
| Interscalene Brachial Plexus Block (ISB) | Active comparator | Procedure: • Interscalene Brachial Plexus BlockParticipants receive an ultrasound-guided Interscalene Brachial Plexus Block (ISB) using 20 mL of 0.25% bupivacaine before induction of general anesthesia for elective Bankart repair or Latarjet surgery |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- • Male or female patients aged 18 to 65 years.
Key exclusion criteria (5 listed)
- History of allergy to local anesthetics.
- Chronic opioid use (>3 months).
- Coagulation disorders.
- Pre-existing neurological or musculoskeletal disorders.
- Respiratory compromise (e.g., COPD)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| • Modified PENG Block combined with Suprascapular Nerve BlockUltrasound-guided Modified Pericapsular Nerve Group (PENG) Block combined with Suprascapular Nerve Block (SSNB) performed before induction of general anesthesia. The Modified PENG Block is performed with 20 mL of 0.25% bupivacaine and the SSNB with 10 mL of 0.25% bupivacaine for postoperative analgesia in patients undergoing elective Bankart repair or Latarjet surgery | Procedure or surgery | Modified PENG + Suprascapular Nerve Block (SSNB) |
| • Interscalene Brachial Plexus BlockUltrasound-guided Interscalene Brachial Plexus Block performed before induction of general anesthesia using 20 mL of 0.25% bupivacaine for postoperative analgesia in patients undergoing elective Bankart repair or Latarjet surgery | Procedure or surgery | Interscalene Brachial Plexus Block (ISB) |
Primary outcome
Visual Analog Scale (VAS) Pain Score at Rest at 24 Hours Postoperatively
Time frame: 24 hours after surgery
Pain intensity at rest will be assessed using the Visual Analog Scale (VAS) for pain, ranging from 0 (no pain) to 10 (worst imaginable pain), 24 hours after surgery. Higher scores indicate worse pain. The primary comparison is between the Modified PENG Block combined with Suprascapular Nerve Block and the Interscalene Brachial Plexus Block.
2 secondary outcomes
Visual Analog Scale (VAS) Pain Scores at Postoperative Time Points
Time frame: multiple postoperative time points.
Total opioid consumption
Time frame: during the first 24 hours.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Jul 2026.
- Individual participant dataSharing planned: No. Individual participant data will not be shared because there is no plan for public data sharing. Only aggregated study results will be reported in scientific publications while maintaining participant confidentiality.Individual participant data will not be shared because there is no plan for public data sharing. Only aggregated study results will be reported in scientific publications while maintaining participant confidentiality.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Ahmed Zaghloul Foaad, Professor of Anaesthesia principal investigator
Cairo University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing • Modified PENG Block combined with Suprascapular Nerve Block and • Interscalene Brachial Plexus Block in people with Shoulder Instability, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 8 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Ahmed Hamza Ibrahem Mohamed, MD (+201159518716 ext. +20 1159518716, ahmedmedohamza@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Visual Analog Scale (VAS) Pain Score at Rest at 24 Hours Postoperatively (time frame: 24 hours after surgery). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Jul 2026.