Intoxication by DrugNCT07690358
Concentrations of Nitrous Oxide in Blood, Exhaled Air and Urine After Various Types of Exposure.
A study testing Nitrous Oxide 99 % and Nitrous Oxide + Oxygen Gas in people with Intoxication by Drug, run by University of Aarhus at 1 site in Denmark.
Trial summary
The study examines the concentrations of nitrous oxide that are achieved in blood, exhaled air, and urine after three different exposures to nitrous oxide: inhalation of three or four cartridges of nitrous oxide released in a car cabin in a switched-off car, consumption of 100 g of whipped cream in which nitrous oxide… Read more about this study
- Who is it for?
- Ages 18 to 65 yearsHealthy volunteers can take part
- Conditions the study is for
- Intoxication by Drug
- What is being tested?
- Nitrous Oxide 99 % and Nitrous Oxide + Oxygen Gas
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteDenmark
- Study dates
- 1 Jun 2026to 31 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Age 18-65 years
- Able to understand Danish
- Willing to use effective contraception for 24 hours after the end of exposure (oral contraceptives, contraceptive implant, transdermal patch, vaginal ring, or injectable contraceptives)
- Written informed consent
Who cannot join
- Current or past abuse of drugs, nitrous oxide (N₂O), or alcohol
- A psychiatric disorder requiring medical treatment, including severe depression
- A diagnosis of epilepsy
- Symptoms of peripheral neuropathy
- Significant cardiac or pulmonary disease
- Previous allergic or adverse reaction to N₂O
Show all 14Show fewer
- Diving within the past 2 days
- Inability to refrain from diving for 2 days after the study
- Occupational exposure to N₂O
- Use of N₂O within the past 3 months
- Treatment with methotrexate, benzodiazepines, opioids, or other centrally depressant drugs
- Recent intraocular gas injection
- Known impaired liver or kidney function
- Pregnant or breastfeeding women (fertile women, defined as amenorrhea for less than 12 months, must have a negative hCG pregnancy test prior to receiving the study intervention)
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Denmark1 site, 1 recruiting
- Recruiting
Department of Forensic Medicine
Aarhus, 8200
Charlotte U Andersen, Associate Professor, +4560128430, cua@biomed.au.dk
About this study
Official title: Undersøgelse af Lattergaskoncentrationer i Blod, udåndingsluft og Urin Ved Forskellige Eksponeringer
The study examines the concentrations of nitrous oxide that are achieved in blood, exhaled air, and urine after three different exposures to nitrous oxide:
inhalation of three or four cartridges of nitrous oxide released in a car cabin in a switched-off car, consumption of 100 g of whipped cream in which nitrous oxide is used as a propellant, and exposure through work as a midwife in a delivery room.
The concentrations in blood and exhaled air are measured for up to 1 hour after exposure, and in urine for up to 2 hours after exposure. The concentrations in blood and urine are measued with gas chromatography and mass spectrometry, while the concentration in exhaled air is measured by a sensor using an NDIR sensor (Olythe, France).
- Conditions
- Intoxication by Drug
- Being tested
- Nitrous Oxide 99 %, Nitrous Oxide + Oxygen Gas
- Keywords
- Nitrous oxide, Forensic chemistry, driving under the influence, laughing gas
- Medical subject headings
- Driving Under the Influence
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Nitrous Oxide 99 %Other
Passive exposure to Nitrous Oxide
Nitrous Oxide + Oxygen GasOther
Midwifes are exposed through work in a delivery room
| Study group | Role | What they receive |
|---|---|---|
| Passive exposure in car, 3 cartridges | Experimental | A person sits for 15 minutes after releasing 4 x 8.4 g of nitrous oxide into the cabin Receives: Other: Nitrous Oxide 99 % |
| Passive exposure in car, 4 cartridges | Experimental | A person sits for 15 minutes after releasing 4 x 8.4 g of nitrous oxide into the cabin Receives: Other: Nitrous Oxide 99 % |
| Whipped cream, 100 g | Experimental | A person ingests 100 g of whipped cream with nitrous oxide as propellant Receives: Other: Nitrous Oxide 99 % |
| Environmental exposure | Active comparator | concentrations of nitrous oxide are measured after exposure through work as a midwife in a delivery room Receives: Other: Nitrous Oxide + Oxygen Gas |
What is being measured
The primary outcome is the main question the study is designed to answer.
Detection time of Nitrous Oxide in blood
The time after exposure in which Nitrous Oxide can be detected in blood
Measured: From end of exposure to 1 hour after end of exposure
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Jul 2026
- Study start1 Jun 2026
- Primary completion31 Dec 2026 (estimated)
- Study completion31 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Intoxication by DrugStudies of the same condition, open and under way.
- More trials run by University of AarhusThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Aarhus
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07690358
- Sponsor's protocol ID
- 1-10-72-156-25
- Status last verified
- Jun 2026
- First submitted
- 29 Jun 2026
- Last updated
- 8 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 8 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Undersøgelse af Lattergaskoncentrationer i Blod, udåndingsluft og Urin Ved Forskellige Eksponeringer
- ClinicalTrials.gov ID
- NCT07690358
- Acronym / sponsor ID
- 1-10-72-156-25
- Conditions
- Intoxication by Drug
- Keywords
- Nitrous oxide, Forensic chemistry, driving under the influence, laughing gas
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- University of AarhusUniversity, hospital or other
- Study start
- 1 Jun 2026 (actual)
- Primary completion
- 31 Dec 2026 (estimated)
- Study completion
- 31 Dec 2026 (estimated)
- First posted
- 8 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The study examines the concentrations of nitrous oxide that are achieved in blood, exhaled air, and urine after three different exposures to nitrous oxide:
inhalation of three or four cartridges of nitrous oxide released in a car cabin in a switched-off car, consumption of 100 g of whipped cream in which nitrous oxide is used as a propellant, and exposure through work as a midwife in a delivery room.
The concentrations in blood and exhaled air are measured for up to 1 hour after exposure, and in urine for up to 2 hours after exposure. The concentrations in blood and urine are measued with gas chromatography and mass spectrometry, while the concentration in exhaled air is measured by a sensor using an NDIR sensor (Olythe, France).
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Passive exposure in car, 3 cartridges | Experimental | Other: Nitrous Oxide 99 %A person sits for 15 minutes after releasing 4 x 8.4 g of nitrous oxide into the cabin |
| Passive exposure in car, 4 cartridges | Experimental | Other: Nitrous Oxide 99 %A person sits for 15 minutes after releasing 4 x 8.4 g of nitrous oxide into the cabin |
| Whipped cream, 100 g | Experimental | Other: Nitrous Oxide 99 %A person ingests 100 g of whipped cream with nitrous oxide as propellant |
| Environmental exposure | Active comparator | Other: Nitrous Oxide + Oxygen Gasconcentrations of nitrous oxide are measured after exposure through work as a midwife in a delivery room |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Age 18-65 years
- Able to understand Danish
- Willing to use effective contraception for 24 hours after the end of exposure (oral contraceptives, contraceptive implant, transdermal patch, vaginal ring, or injectable contraceptives)
- Written informed consent
Key exclusion criteria (14 listed)
- Current or past abuse of drugs, nitrous oxide (N₂O), or alcohol
- A psychiatric disorder requiring medical treatment, including severe depression
- A diagnosis of epilepsy
- Symptoms of peripheral neuropathy
- Significant cardiac or pulmonary disease
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Nitrous Oxide 99 %Passive exposure to Nitrous Oxide | Other | Passive exposure in car, 3 cartridges, Passive exposure in car, 4 cartridges, Whipped cream, 100 g |
| Nitrous Oxide + Oxygen GasMidwifes are exposed through work in a delivery room | Other | Environmental exposure |
Primary outcome
Detection time of Nitrous Oxide in blood
Time frame: From end of exposure to 1 hour after end of exposure
The time after exposure in which Nitrous Oxide can be detected in blood
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Jul 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Nitrous Oxide 99 % and Nitrous Oxide + Oxygen Gas in people with Intoxication by Drug, run by University of Aarhus at 1 site in Denmark.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 14 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 8 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Denmark. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Charlotte U Andersen, Associate Professor (+4560128430, cua@biomed.au.dk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Detection time of Nitrous Oxide in blood (time frame: From end of exposure to 1 hour after end of exposure). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Jul 2026.