Psychological Well-being and Immune Health ProfileNCT07690605
The Genomic and Well-Being Impacts of an Extraverted Behavior Intervention
A study testing Sociable (extraverted) behavior in people with Psychological Well-being and Immune Health Profile, run by University of California, Riverside at 1 site in United States.
Trial summary
8-week randomized intervention (with 3-month follow-up) that examines the impact of increased sociable behavior on emotional well-being and immune health profile Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Psychological Well-being and Immune Health Profile
- What is being tested?
- Sociable (extraverted) behavior
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 119 participants
- Where
- 1 siteUnited States
- Study dates
- 8 Mar 2024to 22 Dec 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Age 18 or older
Who cannot join
- Younger than 18 years of age
Trial locations and contacts
1 site in 1 country.
United States1 site
Department of Psychology
Riverside, California, 92521
About this study
8-week randomized intervention (with 3-month follow-up) that examines the impact of increased sociable behavior on emotional well-being and immune health profile
- Being tested
- Sociable (extraverted) behavior
- Medical subject headings
- Psychological Well-Being
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Sociable (extraverted) behaviorBehavioural
Participants asked to act more sociable (extraverted) 3 days a week for 6 weeks on days of their choosing with the goal of promoting social connection. 8-week study includes week 0 pre-test measures and week 1 baseline of sociable behavior "as usual."
| Study group | Role | What they receive |
|---|---|---|
| Sociable (extraverted) behavior | Experimental | Participants asked to act more outgoing and talkative Receives: Behavioral: Sociable (extraverted) behavior |
| Daily routine list | Sham comparator | Participants asked to list their daily routines without changing behavior Receives: Behavioral: Sociable (extraverted) behavior |
What is being measured
The primary outcome is the main question the study is designed to answer.
Self-reported loneliness (survey)
Responses to loneliness sub-scale of Comprehensive Inventory of Thriving
Measured: From enrollment to end of study period at 8 weeks
Self-reported positive and negative affect (survey)
Responses to 12-item survey, Affect-Adjective Scale
Measured: From enrollment to end of study period at 8 weeks
Immune gene profile
Changes to immune gene profile assayed in dried blood spots
Measured: From enrollment to end of study period at 8 weeks
Secondary outcomes (1)
Self-reported psychological well-being (survey)
Responses to the Mental Health Continuum-Short Form
Measured: From enrollment to end of study period at 8 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Jul 2026
- Study start8 Mar 2024
- Primary completion5 Dec 2024
- Study completion22 Dec 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Psychological Well-being and Immune Health ProfileStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 119 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of California, Riverside
- Sponsor type
- University, hospital or other
- Collaborators
- National Institute on Aging (NIA)
- Responsible party
- Principal investigator, Ramona Martinez, University of California, Riverside
- Investigators
- Elissa Eppel, PhD, Principal investigator, UC San Francisco
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07690605
- Sponsor's protocol ID
- 15154
- Other IDs
- U24AG072699
- Status last verified
- Jul 2026
- First submitted
- 1 Jul 2026
- Last updated
- 8 Jul 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Yang YS, Wynn JK, Cole S, Green MF. Stress-related gene regulation: Do isolated and connected individuals differ? Brain Behav Immun. 2024 Aug;120:372-378. doi: 10.1016/j.bbi.2024.06.013. Epub 2024 Jun 17.
PubMed 38897331Cole SW. Social regulation of human gene expression. Curr Dir Psychol Sci. 2009 Jun 1;18(3):132-137. doi: 10.1111/j.1467-8721.2009.01623.x.
PubMed 21243077Ricon-Becker I, West TN, Fredrickson BL, Kaplan DM, Mehl MR, Raison CL, Cole SW. Predicting psychosocial intervention response from baseline gene expression. Brain Behav Immun. 2024 Oct;121:331-339. doi: 10.1016/j.bbi.2024.08.004. Epub 2024 Aug 2.
PubMed 39098435Cole SW. Elevating the perspective on human stress genomics. Psychoneuroendocrinology. 2010 Aug;35(7):955-62. doi: 10.1016/j.psyneuen.2010.06.008. Epub 2010 Jul 13.
PubMed 20630660
Study at a glance
From the registry record, last updated by the sponsor on 8 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Genomic and Well-Being Impacts of an Extraverted Behavior Intervention
- ClinicalTrials.gov ID
- NCT07690605
- Acronym / sponsor ID
- 15154
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 119 participants (actual)
- Lead sponsor
- University of California, RiversideUniversity, hospital or other
- Collaborators
- National Institute on Aging (NIA)
- Study start
- 8 Mar 2024 (actual)
- Primary completion
- 5 Dec 2024 (actual)
- Study completion
- 22 Dec 2024 (actual)
- First posted
- 8 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
8-week randomized intervention (with 3-month follow-up) that examines the impact of increased sociable behavior on emotional well-being and immune health profile
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Sociable (extraverted) behavior | Experimental | Behavioral: Sociable (extraverted) behaviorParticipants asked to act more outgoing and talkative |
| Daily routine list | Sham comparator | Behavioral: Sociable (extraverted) behaviorParticipants asked to list their daily routines without changing behavior |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Age 18 or older
Key exclusion criteria (1 listed)
- Younger than 18 years of age
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Sociable (extraverted) behaviorParticipants asked to act more sociable (extraverted) 3 days a week for 6 weeks on days of their choosing with the goal of promoting social connection. 8-week study includes week 0 pre-test measures and week 1 baseline of sociable behavior "as usual." | Behavioural | Daily routine list, Sociable (extraverted) behavior |
Primary outcome
Self-reported loneliness (survey)
Time frame: From enrollment to end of study period at 8 weeks
Responses to loneliness sub-scale of Comprehensive Inventory of Thriving
Self-reported positive and negative affect (survey)
Time frame: From enrollment to end of study period at 8 weeks
Responses to 12-item survey, Affect-Adjective Scale
Immune gene profile
Time frame: From enrollment to end of study period at 8 weeks
Changes to immune gene profile assayed in dried blood spots
1 secondary outcome
Self-reported psychological well-being (survey)
Time frame: From enrollment to end of study period at 8 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Jul 2026.
- Background: PubMed 38897331Yang YS, Wynn JK, Cole S, Green MF. Stress-related gene regulation: Do isolated and connected individuals differ? Brain Behav Immun. 2024 Aug;120:372-378. doi: 10.1016/j.bbi.2024.06.013. Epub 2024 Jun 17.
- Background: PubMed 21243077Cole SW. Social regulation of human gene expression. Curr Dir Psychol Sci. 2009 Jun 1;18(3):132-137. doi: 10.1111/j.1467-8721.2009.01623.x.
- Background: PubMed 39098435Ricon-Becker I, West TN, Fredrickson BL, Kaplan DM, Mehl MR, Raison CL, Cole SW. Predicting psychosocial intervention response from baseline gene expression. Brain Behav Immun. 2024 Oct;121:331-339. doi: 10.1016/j.bbi.2024.08.004. Epub 2024 Aug 2.
- Background: PubMed 20630660Cole SW. Elevating the perspective on human stress genomics. Psychoneuroendocrinology. 2010 Aug;35(7):955-62. doi: 10.1016/j.psyneuen.2010.06.008. Epub 2010 Jul 13.
- Individual participant dataSharing planned: No
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Elissa Eppel, PhD principal investigator
UC San Francisco
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Sociable (extraverted) behavior in people with Psychological Well-being and Immune Health Profile, run by University of California, Riverside at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 8 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Self-reported loneliness (survey) (time frame: From enrollment to end of study period at 8 weeks). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07690605, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Jul 2026.