Environmental Exposure Assessment in High-Risk and Early-Onset Breast Cancer Care

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

• Ages 18 years and older
• Women only
• Healthy volunteers accepted
• Adult, Older adult

Study population: Female patients aged 18 years or older who either are considered average risk for developing breast cancer or high-risk for developing breast cancer or have early-onset breast cancer as well as providers at City of Hope.

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

About this study

Official title: Precision Prevention: Environmental Exposure Assessment in High-Risk and Early-Onset Breast Cancer Care

Conditions

Breast Carcinoma

Being tested

Non-Interventional Study

Medical subject headings

Breast Neoplasms

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

• Non-Interventional StudyOther

  Also called Non-Interventional Observational Study, Noninterventional (Observational) Study

  Non-interventional study

What is being measured

The primary outcome is the main question the study is designed to answer.

1. Patient survey responses on perceived utility

   Will compare emotional responses, environmental health literacy, compensatory health behaviors, and cancer fatalism across the three participant groups (average risk, high risk, and early onset) using analysis of covariance (ANCOVA). Emotional response scores will be constructed by summing items within the positive and negative subscales separately, while the environmental health literacy, compensatory health behaviors and cancer fatalism will be calculated as summed total scores. ANCOVA will be used to estimate adjusted mean differences across groups and to evaluate whether post intervention responses differ after accounting for demographic factors. Interview sessions will be audio-recorded and transcribed verbatim.

   Measured: Up to one year

2. Patient survey responses on willingness to engage

   Will compare emotional responses, environmental health literacy, compensatory health behaviors, and cancer fatalism across the three participant groups (average risk, high risk, and early onset) using ANCOVA. Emotional response scores will be constructed by summing items within the positive and negative subscales separately, while the environmental health literacy, compensatory health behaviors and cancer fatalism will be calculated as summed total scores. ANCOVA will be used to estimate adjusted mean differences across groups and to evaluate whether post intervention responses differ after accounting for demographic factors. Interview sessions will be audio-recorded and transcribed verbatim.

   Measured: Up to one year

3. Patient survey responses on preferences for receiving EERA results

   Will compare emotional responses, environmental health literacy, compensatory health behaviors, and cancer fatalism across the three participant groups (average risk, high risk, and early onset) using ANCOVA. Emotional response scores will be constructed by summing items within the positive and negative subscales separately, while the environmental health literacy, compensatory health behaviors and cancer fatalism will be calculated as summed total scores. ANCOVA will be used to estimate adjusted mean differences across groups and to evaluate whether post intervention responses differ after accounting for demographic factors. Interview sessions will be audio-recorded and transcribed verbatim.

   Measured: Up to one year

4. Provider survey responses on perceived utility

   Descriptive analysis will be used to examine all quantitative variables.

   Measured: Up to one year

5. Provider survey responses on feasibility

   Descriptive analysis will be used to examine all quantitative variables.

   Measured: Up to one year

6. Provider survey responses on preferences for EERA disclosures into workflows

   Descriptive analysis will be used to examine all quantitative variables.

   Measured: Up to one year

7. Proportion of participants who wear the work wristband for a total of 1 week

   Feasibility will be defined as the proportion of participants who wear the work wristband for a total of 1 week. The feasibility rate will be summarized descriptively using point estimates and 95% confidence intervals.

   Measured: Up to one year

8. Chemical exposure measured by Fresh Air Clip wristband

   Acceptability will be measured in the follow-up survey using the question: "Overall, how acceptable did you find wearing the 'Fresh Air clip' wristband to measure chemical exposures in your daily life?" Participants who respond "No opinion," "Acceptable," or "Completely acceptable" will be categorized as finding the wristband acceptable. The acceptability rate will be summarized descriptively using point estimates and 95% confidence intervals.

   Measured: Up to one year

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

1. First posted8 Jul 2026
2. Study start6 Oct 2026
3. Primary completion26 Jan 2029 (estimated)
4. Study completion26 Feb 2029 (estimated)

Resources

• Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
• Other trials for Breast CarcinomaStudies of the same condition, open and under way.
• More trials run by City of Hope Medical CenterThe sponsor's other registered studies.
• What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.