MonochromaticNCT07691463
Evaluating How Well Different Types of Light-sensitive Cells in the Eye Contribute to Its Focusing Ability
A study testing Color in people with Monochromatic and L- and S-cone Modulation Only, run by Rochester Institute of Technology at 1 site in United States.
Trial summary
In this experiment, subjects will view shapes on a screen with varying colors and be asked to focus their eyes on the shapes. The shapes will look as though they are jumping to random distances away from the eye. Read more about this study
- Who is it for?
- Ages Up to 35 yearsHealthy volunteers can take part
- Conditions the study is for
- Monochromatic, L- and S-cone Modulation Only, L- and M-cone Modulation Only
- What is being tested?
- Color
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- 1 siteUnited States
- Study dates
- 2 Jul 2026to 15 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Up to 35 years
- All sexes
- Healthy volunteers accepted
- Child, Adult
Who may be able to join
- Between 18-35 years of age
- Normal or corrected-to-normal (glasses/contact lenses) vision.
Who cannot join
- Vision worse than 20/20 while wearing glasses / contact lenses.
- Fragile or loose teeth (participants need to bite a piece of dental clay to stabilize their heads so that measurements can be taken from their eyes)
- Current pregnancy (experiment requires sitting down without moving for stretches of time)
- Heart disease
- Personal/familial history of epilepsy
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Chester F. Carlson Center for Imaging Science
Rochester, New York, 14623
Benjamin M Chin, Doctorate, 8454534320, bmccis@rit.edu
Benjamin M Chin, Doctorate
About this study
Official title: A Randomized, Repeated-measures Study to Evaluate the Contributions of Different Cone Photoreceptor Classes to a Step Ocular Accommodation Task
In this experiment, subjects will view shapes on a screen with varying colors and be asked to focus their eyes on the shapes. The shapes will look as though they are jumping to random distances away from the eye. As the subjects focus their eyes on the shapes, the investigators will measure the focus of their eyes using a device called a wavefront sensor. This device uses infrared light to measure the optical properties of the eye in real time. Our goal is to find out how well the eye focuses on different colors. Our broad goal is to better understand how the eye focuses because that process is a major part of having clear and good vision.
Read the detailed description
In this experiment, subjects will view Gabor patterns on a display through a Badal relay. The Gabor patterns will vary in their color. The colors will be picked to selectively modulate cone photoreceptor activity in different directions in cone contrast space. Subjects will be instructed to accommodate to the patterns while the virtual distance of the screen is manipulated with a focus-adjustable lens. As they do so, the investigators will measure the wavefronts of their eyes using a Shack-Hartmann wavefront sensor.
- Conditions
- Monochromatic, L- and S-cone Modulation Only, L- and M-cone Modulation Only, M and S-cone Modulation Only
- Being tested
- Color
- Keywords
- Ocular accommodation, Visual acuity, Physiological optics, Visual psychophysics, Color science
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ColorOther
Each intervention involves showing a participant a stimulus with a particular color on a screen display, and asking the participant to focus their eyes on the stimulus. The 4 colors are: 1) grayscale (L, M, and S-cone modulation), 2) L and S cone modulation only, 3) L and M cone modulation only, and 4) M and S cone modulation only.
| Study group | Role | What they receive |
|---|---|---|
| Color variation in visual stimulus | Experimental | Each participant undergoes all experimental conditions, in a within-subjects design. Each intervention corresponds to a different stimulus color. The 4 colors are: 1) grayscale (L, M, and S-cone modulation), 2) L and S cone modulation only, 3) L and M cone modulation only, and 4) M and S cone modulation only. Receives: Other: Color |
What is being measured
The primary outcome is the main question the study is designed to answer.
Accuracy of ocular accommodation
Ocular accommodation is the focusing response of the lens in the eye. When the stimulus viewed by the participant changes in distance, the eye automatically refocuses. The investigators measure this refocusing using a device called a wavefront sensor. The investigators are particularly interested in how accurate this refocusing is, which is measured in units of diopters.
Measured: Because this is a basic science experiment, each measurement takes place at the same time as the intervention. There will be two sessions, each lasting approximately 1 hour, on separate days (day 1 and day 2).
Speed of ocular accommodation
The investigators are interested in how quickly the eye refocuses when a near object moves farther away. Typically, this process takes around 1 second, but it can take longer or shorter depending on the individual and on the object being viewed. By analyzing data collected by the wavefront sensor, the investigators will calculate how long it took for the eye to refocus during each measurement.
Measured: Because this is a basic science experiment, each measurement takes place at the same time as the intervention. There will be two sessions, each lasting approximately 1 hour, on separate days (day 1 and day 2).
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Jul 2026
- Study start2 Jul 2026
- Primary completion15 Dec 2026 (estimated)
- Study completion15 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for MonochromaticStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 20 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Rochester Institute of Technology
- Sponsor type
- University, hospital or other
- Collaborators
- National Eye Institute (NEI)
- Responsible party
- Principal investigator, Benjamin Chin, Rochester Institute of Technology
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07691463
- Sponsor's protocol ID
- IRB0000131-Exp1
- Other IDs
- 4R00EY036497-03
- Status last verified
- Jul 2026
- First submitted
- 30 Jun 2026
- Last updated
- 17 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 17 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Randomized, Repeated-measures Study to Evaluate the Contributions of Different Cone Photoreceptor Classes to a Step Ocular Accommodation Task
- ClinicalTrials.gov ID
- NCT07691463
- Acronym / sponsor ID
- IRB0000131-Exp1
- Conditions
- Monochromatic, L- and S-cone Modulation Only, L- and M-cone Modulation Only, M and S-cone Modulation Only
- Keywords
- Ocular accommodation, Visual acuity, Physiological optics, Visual psychophysics, Color science
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 20 participants (estimated)
- Lead sponsor
- Rochester Institute of TechnologyUniversity, hospital or other
- Collaborators
- National Eye Institute (NEI)
- Study start
- 2 Jul 2026 (actual)
- Primary completion
- 15 Dec 2026 (estimated)
- Study completion
- 15 Dec 2026 (estimated)
- First posted
- 9 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
In this experiment, subjects will view shapes on a screen with varying colors and be asked to focus their eyes on the shapes. The shapes will look as though they are jumping to random distances away from the eye. As the subjects focus their eyes on the shapes, the investigators will measure the focus of their eyes using a device called a wavefront sensor. This device uses infrared light to measure the optical properties of the eye in real time. Our goal is to find out how well the eye focuses on different colors. Our broad goal is to better understand how the eye focuses because that process is a major part of having clear and good vision.
Detailed description
In this experiment, subjects will view Gabor patterns on a display through a Badal relay. The Gabor patterns will vary in their color. The colors will be picked to selectively modulate cone photoreceptor activity in different directions in cone contrast space. Subjects will be instructed to accommodate to the patterns while the virtual distance of the screen is manipulated with a focus-adjustable lens. As they do so, the investigators will measure the wavefronts of their eyes using a Shack-Hartmann wavefront sensor.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Color variation in visual stimulus | Experimental | Other: ColorEach participant undergoes all experimental conditions, in a within-subjects design. Each intervention corresponds to a different stimulus color. The 4 colors are: 1) grayscale (L, M, and S-cone modulation), 2) L and S cone modulation only, 3) L and M cone modulation only, and 4) M and S cone modulation only. |
Who may qualify
- Ages
- Up to 35 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult
Key inclusion criteria (2 listed)
- Between 18-35 years of age
- Normal or corrected-to-normal (glasses/contact lenses) vision.
Key exclusion criteria (5 listed)
- Vision worse than 20/20 while wearing glasses / contact lenses.
- Fragile or loose teeth (participants need to bite a piece of dental clay to stabilize their heads so that measurements can be taken from their eyes)
- Current pregnancy (experiment requires sitting down without moving for stretches of time)
- Heart disease
- Personal/familial history of epilepsy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| ColorEach intervention involves showing a participant a stimulus with a particular color on a screen display, and asking the participant to focus their eyes on the stimulus. The 4 colors are: 1) grayscale (L, M, and S-cone modulation), 2) L and S cone modulation only, 3) L and M cone modulation only, and 4) M and S cone modulation only. | Other | Color variation in visual stimulus |
Primary outcome
Accuracy of ocular accommodation
Time frame: Because this is a basic science experiment, each measurement takes place at the same time as the intervention. There will be two sessions, each lasting approximately 1 hour, on separate days (day 1 and day 2).
Ocular accommodation is the focusing response of the lens in the eye. When the stimulus viewed by the participant changes in distance, the eye automatically refocuses. The investigators measure this refocusing using a device called a wavefront sensor. The investigators are particularly interested in how accurate this refocusing is, which is measured in units of diopters.
Speed of ocular accommodation
Time frame: Because this is a basic science experiment, each measurement takes place at the same time as the intervention. There will be two sessions, each lasting approximately 1 hour, on separate days (day 1 and day 2).
The investigators are interested in how quickly the eye refocuses when a near object moves farther away. Typically, this process takes around 1 second, but it can take longer or shorter depending on the individual and on the object being viewed. By analyzing data collected by the wavefront sensor, the investigators will calculate how long it took for the eye to refocus during each measurement.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Jul 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Color in people with Monochromatic and L- and S-cone Modulation Only, run by Rochester Institute of Technology at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 17 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Benjamin M Chin, Doctorate (8454534320, bmccis@rit.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Accuracy of ocular accommodation (time frame: Because this is a basic science experiment, each measurement takes place at the same time as the intervention. There will be two sessions, each lasting approximately 1 hour, on separate days (day 1 and day 2).). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Jul 2026.