Cannulation of Internal Jugular VeinNCT07691554
Comparison of Short-Axis and Long-Axis Internal Jugular Vein Cannulation for First-Pass Success
A study testing Short-Axis Ultrasound-Guided Internal Jugular Vein Cannulation and Long-Axis Ultrasound-Guided Internal Jugular Vein Cannulation in people with Cannulation of Internal Jugular Vein, run by University of Health Sciences Lahore at 1 site in Pakistan.
Trial summary
To compare the frequency of first pass success by short axis versus long axis for cannulation of internal jugular vein. Read more about this study
- Who is it for?
- Ages 25 to 70 years
- Conditions the study is for
- Cannulation of Internal Jugular Vein
- What is being tested?
- Short-Axis Ultrasound-Guided Internal Jugular Vein Cannulation and Long-Axis Ultrasound-Guided Internal Jugular Vein Cannulation
- Type of treatment
- Injection or infusion, Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 10 participants
- Where
- 1 sitePakistan
- Study dates
- Oct 2026to Apr 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 25 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age 25-70 years.
- Either male or female gender.
- Undergoing cannulation of IJV.
Who cannot join
- Patients who will be on hemodialysis therapy through double lumen catheter in IJV, assessed by reviewing previous medical records.
- Patients who will have history of previous insertion of IJV line, assessed by reviewing previous medical records.
- Patients with history of neck surgery, assessed by reviewing previous medical records.
- Uncooperative patient.
- Platelet count < 50,000/mm3.
- International normalized ration 3 times upper normal limit (1.1).
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan1 site
National Hospital and Medical Center
Lahore, Punjab Province, 54000
National Hospital and Medical Center, +9242 111 17 18 19, info@nationalhospital.org
About this study
Official title: Comparison Between Short Axis and Long Axis For Cannulation Of Internal Jugular Vein in Terms Of First Pass Success
To compare the frequency of first pass success by short axis versus long axis for cannulation of internal jugular vein.
Read the detailed description
This randomized controlled trial aims to compare the effectiveness of short-axis and long-axis ultrasound-guided approaches for cannulation of the internal jugular vein (IJV) in terms of first-pass success. Central venous catheterization is a commonly performed procedure for invasive monitoring and administration of medications and fluids. Ultrasound guidance has improved the safety and success of IJV cannulation compared with traditional landmark-based techniques; however, uncertainty remains regarding the optimal ultrasound imaging approach.
A total of 60 eligible patients undergoing IJV cannulation will be enrolled and randomly allocated into two equal groups. Participants in Group A will undergo ultrasound-guided IJV cannulation using the short-axis approach, while participants in Group B will undergo cannulation using the long-axis approach. All procedures will be performed by the researcher under direct supervision using standardized ultrasound-guided techniques.
The primary objective is to compare the frequency of first-pass success between the two approaches. First-pass success is defined as successful IJV cannulation with a single skin puncture and without needle redirection. Baseline demographic and clinical characteristics will be recorded before the procedure. The findings of this study may help identify the preferred ultrasound-guided technique for maximizing first-pass success during IJV cannulation and potentially reducing procedure-related complications associated with multiple cannulation attempts.
- Conditions
- Cannulation of Internal Jugular Vein
- Being tested
- Short-Axis Ultrasound-Guided Internal Jugular Vein Cannulation, Long-Axis Ultrasound-Guided Internal Jugular Vein Cannulation
- Keywords
- Internal Jugular Vein, Catheterization, Central Venous, Ultrasonography, Ultrasound-Guided Procedures, Central Venous Catheters
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Short-Axis Ultrasound-Guided Internal Jugular Vein CannulationDevice
Internal jugular vein cannulation performed under ultrasound guidance using the short-axis approach. The transducer is placed in a transverse orientation at the level of the cricoid cartilage, allowing visualization of the internal jugular vein and carotid artery during needle insertion.
Long-Axis Ultrasound-Guided Internal Jugular Vein CannulationDevice
Internal jugular vein cannulation performed under ultrasound guidance using the long-axis approach. The transducer is rotated to obtain a longitudinal view of the internal jugular vein, allowing continuous visualization of the needle during vessel cannulation.
| Study group | Role | What they receive |
|---|---|---|
| Group A (Short-Axis Approach) | Active comparator | In this approach, IJV will be visualized by placing the transducer in a transverse orientation on the patient neck at the level of the cricoid cartilage. The needle will be inserted at 60° to the vertical and will be advanced toward the vein employing gentle aspiration on the attached syringe. Entry to the vein will be confirmed by visualizing indentation of the anterior wall of the vein followed by blood in the syringe and by visualizing the tip of the needle inside the vein. Guide wire will be passed followed by dilator insertion and finally central vein line. Receives: Device: Short-Axis Ultrasound-Guided Internal Jugular Vein Cannulation |
| Group B (Long-Axis Approach) | Active comparator | In this approach, the probe will be centered on the IJV and rotated through 90° in a clockwise direction resulting in long axis image of the vein. The needle insertion point will be directly beneath the most proximal end of the ultrasound probe. The needle will be inserted at 30° to the vertical and will be advanced toward the vein employing gentle aspiration. Entry to the vein will be confirmed by visualizing needle entry into the vein followed by aspiration of blood in the syringe. Guide wire will be inserted followed by dilator insertion and finally central vein line. Receives: Device: Long-Axis Ultrasound-Guided Internal Jugular Vein Cannulation |
What is being measured
The primary outcome is the main question the study is designed to answer.
First-Pass Success Rate of Ultrasound-Guided Internal Jugular Vein Cannulation
First-pass success rate of ultrasound-guided internal jugular vein cannulation, defined as successful venous cannulation with a single skin puncture and needle pass.
Measured: Assessed during the cannulation procedure (within 5 minutes of initiation of cannulation).
Secondary outcomes (6)
Total Cannulation Success Rate
Total cannulation success rate, defined as successful placement of the internal jugular venous catheter.
Measured: Assessed during the procedure (within 15 minutes).
Number of Needle Passes Required for Successful Cannulation
Total number of needle insertion attempts required to achieve successful ultrasound-guided internal jugular vein cannulation.
Measured: Recorded during the procedure.
Incidence of Hematoma Formation at the Cannulation Site
Occurrence of hematoma at the internal jugular vein cannulation site following ultrasound-guided catheter insertion.
Measured: Assessed immediately after the procedure and within 24 hours.
Incidence of Posterior Vessel Wall Puncture
Occurrence of unintended puncture of the posterior wall of the internal jugular vein during ultrasound-guided cannulation.
Measured: Assessed during the procedure.
Incidence of Pneumothorax Following Cannulation
Occurrence of pneumothorax associated with ultrasound-guided internal jugular vein cannulation.
Measured: Assessed within 24 hours following cannulation.
Overall Procedure-Related Complications
Frequency of procedure-related adverse events, including hematoma, posterior vessel wall puncture, pneumothorax, or other complications occurring during or after ultrasound-guided internal jugular vein cannulation.
Measured: Assessed during the procedure and up to 24 hours after cannulation.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Jul 2026
- Study startOct 2026 (estimated)
- Primary completionApr 2027 (estimated)
- Study completionApr 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Cannulation of Internal Jugular VeinStudies of the same condition, open and under way.
- More trials run by University of Health Sciences LahoreThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 10 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Health Sciences Lahore
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ahmad, University of Health Sciences Lahore
- Investigators
- Shahida Khawaja, MBBS, FCPS, Study chair, National Hospital and Medical Center
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07691554
- Sponsor's protocol ID
- 06-10-2023
- Status last verified
- Jul 2026
- First submitted
- 25 Jun 2026
- Last updated
- 10 Jul 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Shrestha GS, Gurung A, Koirala S. Comparison between long- and short-axis techniques for ultrasound-guided cannulation of internal jugular vein. Ann Card Anaesth. 2016 Apr-Jun;19(2):288-92. doi: 10.4103/0971-9784.179629.
PubMed 27052071Rath A, Mishra SB, Pati B, Dhar SK, Ipsita S, Samal S, Azim A. Short versus long axis ultrasound guided approach for internal jugular vein cannulations: A prospective randomized controlled trial. Am J Emerg Med. 2020 Apr;38(4):731-734. doi: 10.1016/j.ajem.2019.06.010. Epub 2019 Jun 14.
PubMed 31230925Tolson OW. Should central venous pressure be used to guide critical care management? Br J Hosp Med (Lond). 2022 Oct 2;83(10):1-3. doi: 10.12968/hmed.2022.0167. Epub 2022 Oct 11.
PubMed 36322446
Study at a glance
From the registry record, last updated by the sponsor on 10 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison Between Short Axis and Long Axis For Cannulation Of Internal Jugular Vein in Terms Of First Pass Success
- ClinicalTrials.gov ID
- NCT07691554
- Acronym / sponsor ID
- 06-10-2023
- Conditions
- Cannulation of Internal Jugular Vein
- Keywords
- Internal Jugular Vein, Catheterization, Central Venous, Ultrasonography, Ultrasound-Guided Procedures, Central Venous Catheters
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 10 participants (estimated)
- Lead sponsor
- University of Health Sciences LahoreUniversity, hospital or other
- Study start
- Oct 2026 (estimated)
- Primary completion
- Apr 2027 (estimated)
- Study completion
- Apr 2027 (estimated)
- First posted
- 9 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To compare the frequency of first pass success by short axis versus long axis for cannulation of internal jugular vein.
Detailed description
This randomized controlled trial aims to compare the effectiveness of short-axis and long-axis ultrasound-guided approaches for cannulation of the internal jugular vein (IJV) in terms of first-pass success. Central venous catheterization is a commonly performed procedure for invasive monitoring and administration of medications and fluids. Ultrasound guidance has improved the safety and success of IJV cannulation compared with traditional landmark-based techniques; however, uncertainty remains regarding the optimal ultrasound imaging approach.
A total of 60 eligible patients undergoing IJV cannulation will be enrolled and randomly allocated into two equal groups. Participants in Group A will undergo ultrasound-guided IJV cannulation using the short-axis approach, while participants in Group B will undergo cannulation using the long-axis approach. All procedures will be performed by the researcher under direct supervision using standardized ultrasound-guided techniques.
The primary objective is to compare the frequency of first-pass success between the two approaches. First-pass success is defined as successful IJV cannulation with a single skin puncture and without needle redirection. Baseline demographic and clinical characteristics will be recorded before the procedure. The findings of this study may help identify the preferred ultrasound-guided technique for maximizing first-pass success during IJV cannulation and potentially reducing procedure-related complications associated with multiple cannulation attempts.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Group A (Short-Axis Approach) | Active comparator | Device: Short-Axis Ultrasound-Guided Internal Jugular Vein CannulationIn this approach, IJV will be visualized by placing the transducer in a transverse orientation on the patient neck at the level of the cricoid cartilage. The needle will be inserted at 60° to the vertical and will be advanced toward the vein employing gentle aspiration on the attached syringe. Entry to the vein will be confirmed by visualizing indentation of the anterior wall of the vein followed by blood in the syringe and by visualizing the tip of the needle inside the vein. Guide wire will be passed followed by dilator insertion and finally central vein line. |
| Group B (Long-Axis Approach) | Active comparator | Device: Long-Axis Ultrasound-Guided Internal Jugular Vein CannulationIn this approach, the probe will be centered on the IJV and rotated through 90° in a clockwise direction resulting in long axis image of the vein. The needle insertion point will be directly beneath the most proximal end of the ultrasound probe. The needle will be inserted at 30° to the vertical and will be advanced toward the vein employing gentle aspiration. Entry to the vein will be confirmed by visualizing needle entry into the vein followed by aspiration of blood in the syringe. Guide wire will be inserted followed by dilator insertion and finally central vein line. |
Who may qualify
- Ages
- 25 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Age 25-70 years.
- Either male or female gender.
- Undergoing cannulation of IJV.
Key exclusion criteria (6 listed)
- Patients who will be on hemodialysis therapy through double lumen catheter in IJV, assessed by reviewing previous medical records.
- Patients who will have history of previous insertion of IJV line, assessed by reviewing previous medical records.
- Patients with history of neck surgery, assessed by reviewing previous medical records.
- Uncooperative patient.
- Platelet count < 50,000/mm3.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Short-Axis Ultrasound-Guided Internal Jugular Vein CannulationInternal jugular vein cannulation performed under ultrasound guidance using the short-axis approach. The transducer is placed in a transverse orientation at the level of the cricoid cartilage, allowing visualization of the internal jugular vein and carotid artery during needle insertion. | Device | Group A (Short-Axis Approach) |
| Long-Axis Ultrasound-Guided Internal Jugular Vein CannulationInternal jugular vein cannulation performed under ultrasound guidance using the long-axis approach. The transducer is rotated to obtain a longitudinal view of the internal jugular vein, allowing continuous visualization of the needle during vessel cannulation. | Device | Group B (Long-Axis Approach) |
Primary outcome
First-Pass Success Rate of Ultrasound-Guided Internal Jugular Vein Cannulation
Time frame: Assessed during the cannulation procedure (within 5 minutes of initiation of cannulation).
First-pass success rate of ultrasound-guided internal jugular vein cannulation, defined as successful venous cannulation with a single skin puncture and needle pass.
6 secondary outcomes
Total Cannulation Success Rate
Time frame: Assessed during the procedure (within 15 minutes).
Number of Needle Passes Required for Successful Cannulation
Time frame: Recorded during the procedure.
Incidence of Hematoma Formation at the Cannulation Site
Time frame: Assessed immediately after the procedure and within 24 hours.
Incidence of Posterior Vessel Wall Puncture
Time frame: Assessed during the procedure.
Incidence of Pneumothorax Following Cannulation
Time frame: Assessed within 24 hours following cannulation.
Overall Procedure-Related Complications
Time frame: Assessed during the procedure and up to 24 hours after cannulation.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Jul 2026.
- Background: PubMed 27052071Shrestha GS, Gurung A, Koirala S. Comparison between long- and short-axis techniques for ultrasound-guided cannulation of internal jugular vein. Ann Card Anaesth. 2016 Apr-Jun;19(2):288-92. doi: 10.4103/0971-9784.179629.
- Background: PubMed 31230925Rath A, Mishra SB, Pati B, Dhar SK, Ipsita S, Samal S, Azim A. Short versus long axis ultrasound guided approach for internal jugular vein cannulations: A prospective randomized controlled trial. Am J Emerg Med. 2020 Apr;38(4):731-734. doi: 10.1016/j.ajem.2019.06.010. Epub 2019 Jun 14.
- Background: PubMed 36322446Tolson OW. Should central venous pressure be used to guide critical care management? Br J Hosp Med (Lond). 2022 Oct 2;83(10):1-3. doi: 10.12968/hmed.2022.0167. Epub 2022 Oct 11.
- Should central venous pressure be used to guide critical care management?Link provided by the sponsor.
- Central venous catheterization in cancer patients with severe thrombocytopenia: Ultrasound-guide improves safety avoiding prophylactic platelet transfusionLink provided by the sponsor.
- Short versus long axis ultrasound guided approach for internal jugular vein cannulations: A prospective randomized controlled trialLink provided by the sponsor.
- Comparing 1st Pass Success Rate and Number of Attempts for Internal Jugular Vein Cannulation by USG Guided Approach: Short Axis versus Long Axis TechniqueLink provided by the sponsor.
- A Comparative Study of Internal Jugular Vein Cannulation under Ultrasound Guidance Using Short Axis or Long Axis View ApproachLink provided by the sponsor.
- Comparison between long- and short-axis techniques for ultrasound-guided cannulation of internal jugular veinLink provided by the sponsor.
- Individual participant dataSharing planned: No
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Shahida Khawaja, MBBS, FCPS study chair
National Hospital and Medical Center
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Short-Axis Ultrasound-Guided Internal Jugular Vein Cannulation and Long-Axis Ultrasound-Guided Internal Jugular Vein Cannulation in people with Cannulation of Internal Jugular Vein, run by University of Health Sciences Lahore at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 10 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Waleed Noor, MBBS FCPS (+923154960902, mrwaleed2394@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
First-Pass Success Rate of Ultrasound-Guided Internal Jugular Vein Cannulation (time frame: Assessed during the cannulation procedure (within 5 minutes of initiation of cannulation).). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07691554, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Jul 2026; AzTrials last refreshed its copy on 6 Nov 2026.