Human Sinonasal Mucosal Spatial AtlasNCT07692243
Human Sinonasal Mucosa Heterogeneity Study
An observational study of Human Sinonasal Mucosal Spatial Atlas, run by First Affiliated Hospital, Sun Yat-Sen University at 1 site in China.
Trial summary
This observational study aims to better understand how the lining of the nose and sinuses differs across different sinonasal sites in humans, including participants with and without sinonasal inflammatory disease. Read more about this study
- Who is it for?
- Any ageHealthy volunteers can take part
- Conditions the study is for
- Human Sinonasal Mucosal Spatial Atlas
- How many people
- 100 participants
- Where
- 1 siteChina
- Study dates
- 1 Dec 2025to 31 Dec 2028
- How long will I take part?
- 1 Day
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Study population: The study population will include adult participants undergoing clinically indicated sinonasal surgery. Sinonasal mucosal tissue samples may be collected from different anatomical sites of the nasal cavity and paranasal sinuses when available during the planned surgical procedure. Participants may include individuals with sinonasal inflammatory disease as well as individuals undergoing surgery for non-inflammatory sinonasal conditions, depending on clinical availability and protocol requirements. No study-specific treatment or intervention will be assigned.
Who may be able to join
- Adults aged 18 years or older.
- Scheduled for clinically indicated sinonasal surgery.
- Sinonasal mucosal tissue can be collected during surgery without significant additional risk.
- Able and willing to provide written informed consent.
- Relevant clinical information is available.
Who cannot join
- Unable or unwilling to provide informed consent.
- Younger than 18 years of age.
- Tissue collection may interfere with standard care or increase surgical risk.
- History of sinonasal malignancy, sinonasal radiotherapy, or chemotherapy affecting sinonasal mucosa.
- Active systemic infection or severe systemic disease affecting study participation or interpretation.
- Use of systemic corticosteroids, immunosuppressants, or biologics within 4 weeks before surgery.
- Insufficient or poor-quality tissue for planned analyses.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
China1 site, 1 recruiting
- Recruiting
the First Affiliated Hospital of Sun Yat-sen University
Guangzhou, Guangdong, 510030
13016018473, yany38@mail2.sysu.edu.cn
yany38@mail2.sysu.edu.cn
About this study
Official title: Heterogeneity of Mucosa Across Different Human Sinonasal Sites: An Observational Study
This observational study aims to better understand how the lining of the nose and sinuses differs across different sinonasal sites in humans, including participants with and without sinonasal inflammatory disease. Mucosal tissue samples will be collected from participants who are undergoing clinically indicated sinonasal surgery. The study will compare tissue structure, gene expression, protein expression, and immune cell composition among different regions of the sinonasal mucosa.
By studying these differences, researchers hope to identify site-specific features of human sinonasal mucosa and improve understanding of normal and disease-related changes in the nose and sinuses. This study does not assign participants to any treatment or intervention. The findings may provide a foundation for future research on chronic rhinosinusitis, nasal polyps, and other sinonasal diseases.
Read the detailed description
The human sinonasal mucosa lines different regions of the nasal cavity and paranasal sinuses and plays an important role in mucosal defense, inflammation, and tissue homeostasis. However, the biological characteristics of mucosa from different sinonasal sites are not fully understood.
This observational study will collect sinonasal mucosal tissue samples from participants undergoing clinically indicated sinonasal surgery. Samples may be obtained from different anatomical sites of the sinonasal tract when available as part of the surgical procedure. No treatment or intervention will be assigned by the study.
Collected samples will be analyzed to compare site-specific features of human sinonasal mucosa, including tissue structure, gene expression patterns, protein expression profiles, and immune cell composition. Relevant clinical information may also be collected to support interpretation of the biological findings.
The purpose of this study is to characterize the heterogeneity of human sinonasal mucosa across different anatomical sites. The results may help improve understanding of normal sinonasal mucosal biology and provide a reference for future studies of chronic rhinosinusitis, nasal polyps, and other sinonasal inflammatory diseases.
- Conditions
- Human Sinonasal Mucosal Spatial Atlas
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| healthy control | healthy people | |
| CRSwNP | CRSwNP patient |
What is being measured
The primary outcome is the main question the study is designed to answer.
Site-Specific Heterogeneity of Human Sinonasal Mucosa
Differences in histological features, gene expression patterns, protein expression profiles, and immune cell composition will be compared among mucosal tissue samples collected from different anatomical sites of the human sinonasal tract. These analyses will be used to characterize site-specific biological features and support construction of a human sinonasal mucosal spatial atlas.
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Jul 2026
- Study start1 Dec 2025
- Primary completion31 Dec 2027 (estimated)
- Study completion31 Dec 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Human Sinonasal Mucosal Spatial AtlasStudies of the same condition, open and under way.
- More trials run by First Affiliated Hospital, Sun Yat-Sen UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Enrolment
- 100 participants (estimated)
- Target duration
- 1 Day
Sponsor and investigators
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Yanran Huang, First Affiliated Hospital, Sun Yat-Sen University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07692243
- Sponsor's protocol ID
- Human Sinonasal Mucosa Heterog
- Status last verified
- Jul 2026
- First submitted
- 25 Jun 2026
- Last updated
- 9 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 9 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Heterogeneity of Mucosa Across Different Human Sinonasal Sites: An Observational Study
- ClinicalTrials.gov ID
- NCT07692243
- Acronym / sponsor ID
- Human Sinonasal Mucosa Heterog
- Conditions
- Human Sinonasal Mucosal Spatial Atlas
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- First Affiliated Hospital, Sun Yat-Sen UniversityUniversity, hospital or other
- Study start
- 1 Dec 2025 (actual)
- Primary completion
- 31 Dec 2027 (estimated)
- Study completion
- 31 Dec 2028 (estimated)
- First posted
- 9 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This observational study aims to better understand how the lining of the nose and sinuses differs across different sinonasal sites in humans, including participants with and without sinonasal inflammatory disease. Mucosal tissue samples will be collected from participants who are undergoing clinically indicated sinonasal surgery. The study will compare tissue structure, gene expression, protein expression, and immune cell composition among different regions of the sinonasal mucosa.
By studying these differences, researchers hope to identify site-specific features of human sinonasal mucosa and improve understanding of normal and disease-related changes in the nose and sinuses. This study does not assign participants to any treatment or intervention. The findings may provide a foundation for future research on chronic rhinosinusitis, nasal polyps, and other sinonasal diseases.
Detailed description
The human sinonasal mucosa lines different regions of the nasal cavity and paranasal sinuses and plays an important role in mucosal defense, inflammation, and tissue homeostasis. However, the biological characteristics of mucosa from different sinonasal sites are not fully understood.
This observational study will collect sinonasal mucosal tissue samples from participants undergoing clinically indicated sinonasal surgery. Samples may be obtained from different anatomical sites of the sinonasal tract when available as part of the surgical procedure. No treatment or intervention will be assigned by the study.
Collected samples will be analyzed to compare site-specific features of human sinonasal mucosa, including tissue structure, gene expression patterns, protein expression profiles, and immune cell composition. Relevant clinical information may also be collected to support interpretation of the biological findings.
The purpose of this study is to characterize the heterogeneity of human sinonasal mucosa across different anatomical sites. The results may help improve understanding of normal sinonasal mucosal biology and provide a reference for future studies of chronic rhinosinusitis, nasal polyps, and other sinonasal inflammatory diseases.
Study design
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Target follow-up
- 1 Day
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| healthy control | – | –healthy people |
| CRSwNP | – | –CRSwNP patient |
Who may qualify
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
- Study population
- The study population will include adult participants undergoing clinically indicated sinonasal surgery. Sinonasal mucosal tissue samples may be collected from different anatomical sites of the nasal cavity and paranasal sinuses when available during the planned surgical procedure. Participants may include individuals with sinonasal inflammatory disease as well as individuals undergoing surgery for non-inflammatory sinonasal conditions, depending on clinical availability and protocol requirements. No study-specific treatment or intervention will be assigned.
Key inclusion criteria (5 listed)
- Adults aged 18 years or older.
- Scheduled for clinically indicated sinonasal surgery.
- Sinonasal mucosal tissue can be collected during surgery without significant additional risk.
- Able and willing to provide written informed consent.
- Relevant clinical information is available.
Key exclusion criteria (7 listed)
- Unable or unwilling to provide informed consent.
- Younger than 18 years of age.
- Tissue collection may interfere with standard care or increase surgical risk.
- History of sinonasal malignancy, sinonasal radiotherapy, or chemotherapy affecting sinonasal mucosa.
- Active systemic infection or severe systemic disease affecting study participation or interpretation.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Site-Specific Heterogeneity of Human Sinonasal Mucosa
Time frame: Baseline
Differences in histological features, gene expression patterns, protein expression profiles, and immune cell composition will be compared among mucosal tissue samples collected from different anatomical sites of the human sinonasal tract. These analyses will be used to characterize site-specific biological features and support construction of a human sinonasal mucosal spatial atlas.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Jul 2026.
- Individual participant dataSharing planned: No
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Human Sinonasal Mucosal Spatial Atlas, run by First Affiliated Hospital, Sun Yat-Sen University at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 9 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact YAN YAN, Master's Degree (+8613016018473, yany38@mail2.sysu.edu.cn), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Site-Specific Heterogeneity of Human Sinonasal Mucosa (time frame: Baseline). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Jul 2026.