Diabetic Neuropathic PainNCT07695181
Effectiveness of Pain Neuroscience Education Along With Neural Mobilization Versus Neural Mobilization Alone on Pain, Functional Disability And Quality of Life In Patients With Diabetic Neuropathic Pain
A study testing Pain Neurosciences Education + Neural Mobilization in people with Diabetic Neuropathic Pain, run by Ibadat International University, Islamabad at 1 site in Pakistan.
Trial summary
This is a randomized controlled trial aims to evaluate the comparative effect of Pain Neuroscience Education combined with neural mobilization versus neural mobilization alone in patients with diabetic neuropathic pain. Read more about this study
- Who is it for?
- Ages 40 years and older
- Conditions the study is for
- Diabetic Neuropathic Pain
- What is being tested?
- Pain Neurosciences Education + Neural Mobilization
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 sitePakistan
- Study dates
- 10 Jul 2026to 20 Jan 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age ≥ 40 years (WHO 2016 criteria) Diagnosed Type II diabetes mellitus Lower limb neuropathic pain ≥ 3 months Pain intensity ≥ 4/10 on NPRS Able to walk independently and follow instructions
Who cannot join
- Neurological disorders (e.g. stroke, Guillain-Barré) Lumbar disc herniation with radiculopathy Lower limb surgery or spinal fracture within 6 months Active diabetic foot ulcer Diagnosed cognitive impairment or severe infection
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan1 site
Positive Solution Clinic, Wah Cantt
Rawalpindi, Punjab Province, 46000
Mahjabeen Farooqui, MSPT, 3313666898, mahafarooqui0@gmail.com
Somiya Asif, MSPT, 3435322291, sumaiya.asif92@gmail.com
About this study
This is a randomized controlled trial aims to evaluate the comparative effect of Pain Neuroscience Education combined with neural mobilization versus neural mobilization alone in patients with diabetic neuropathic pain. This study will Compare pain intensity between intervention groups and assess functional disability outcomes. Furthermore, this will evaluate changes in quality of life and to analyze pain-related beliefs following PNE.
- Conditions
- Diabetic Neuropathic Pain
- Being tested
- Pain Neurosciences Education + Neural Mobilization
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Pain Neurosciences Education + Neural MobilizationOther
In Group A pain neuroscience Education will be given in adjunct with neural mobilization techniques Target nerves: Sciatic, tibial \& common peroneal Technique: Slider neurodynamic mobilization Dosage: 10-15 reps × 2-3 sets | Rest: 30-60 sec between sets Session duration: 15-20 minutes PNE: 20-30 min (weeks 1-2) → 10 min reinforcement (weeks 3-6) Methods: Simple diagrams, patient-friendly metaphors, video demonstrations
| Study group | Role | What they receive |
|---|---|---|
| Group A - Pain Neurosciences Education combined with Neural Mobilization | Experimental | Pain neuroscience education (PNE) will be delivered through structured educational sessions focusing on pain physiology, neural sensitization, and pain modulation. PNE: 20-30 min (weeks 1-2) → 10 min reinforcement (weeks 3-6) Methods: Simple diagrams, patient-friendly metaphors, video demonstrations. Neural mobilization techniques will be applied following standardized neurodynamic principles and patients' tolerance. Target nerves: Sciatic, tibial \& common peroneal Technique: Slider neurodynamic mobilization Dosage: 10-15 reps × 2-3 sets | Rest: 30-60 sec between sets Session duration: 15-20 minutes Receives: Other: Pain Neurosciences Education + Neural Mobilization |
| Group B - Neural Mobilization Alone | Active comparator | Neural mobilization techniques will be applied following standardized neurodynamic principles and patients' tolerance. Target nerves: Sciatic, tibial \& common peroneal Technique: Slider neurodynamic mobilization Dosage: 10-15 reps × 2-3 sets | Rest: 30-60 sec between sets Session duration: 15-20 minutes Receives: Other: Pain Neurosciences Education + Neural Mobilization |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pain intensity
Pain intensity will be evaluated using Numeric Pain Rating Scale
Measured: Baseline to week 6
Functional disability
Functional disability will be evaluated using Urdu version of Lower Extremity Functional Scale (LEFS)
Measured: Baseline to week 6
Quality of life
Quality of life will be evaluated by World Health Organization Quality Of Life-BREF
Measured: Baseline to week 6
Central sensitization
Central sensitization will be evaluated using Central Sensitization Inventory
Measured: Baseline to week 6
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Jul 2026
- Study start10 Jul 2026 (estimated)
- Primary completion10 Jan 2027 (estimated)
- Study completion20 Jan 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Diabetic Neuropathic PainStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- 2 parallel group; Group A - PNE + Neural Mobilization and Group B - Neural Mobilization Alone
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Ibadat International University, Islamabad
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07695181
- Sponsor's protocol ID
- IIUI/RERC/ADT/2026/05/265
- Status last verified
- Jul 2026
- First submitted
- 6 Jul 2026
- Last updated
- 10 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 10 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effectiveness of Pain Neuroscience Education Along With Neural Mobilization Versus Neural Mobilization Alone on Pain, Functional Disability And Quality of Life In Patients With Diabetic Neuropathic Pain
- ClinicalTrials.gov ID
- NCT07695181
- Acronym / sponsor ID
- IIUI/RERC/ADT/2026/05/265
- Conditions
- Diabetic Neuropathic Pain
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- Ibadat International University, IslamabadUniversity, hospital or other
- Study start
- 10 Jul 2026 (estimated)
- Primary completion
- 10 Jan 2027 (estimated)
- Study completion
- 20 Jan 2027 (estimated)
- First posted
- 10 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This is a randomized controlled trial aims to evaluate the comparative effect of Pain Neuroscience Education combined with neural mobilization versus neural mobilization alone in patients with diabetic neuropathic pain. This study will Compare pain intensity between intervention groups and assess functional disability outcomes. Furthermore, this will evaluate changes in quality of life and to analyze pain-related beliefs following PNE.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- 2 parallel group; Group A - PNE + Neural Mobilization and Group B - Neural Mobilization Alone
| Arm | Type | Receives |
|---|---|---|
| Group A - Pain Neurosciences Education combined with Neural Mobilization | Experimental | Other: Pain Neurosciences Education + Neural MobilizationPain neuroscience education (PNE) will be delivered through structured educational sessions focusing on pain physiology, neural sensitization, and pain modulation. PNE: 20-30 min (weeks 1-2) → 10 min reinforcement (weeks 3-6) Methods: Simple diagrams, patient-friendly metaphors, video demonstrations. Neural mobilization techniques will be applied following standardized neurodynamic principles and patients' tolerance. Target nerves: Sciatic, tibial \& common peroneal Technique: Slider neurodynamic mobilization Dosage: 10-15 reps × 2-3 sets | Rest: 30-60 sec between sets Session duration: 15-20 minutes |
| Group B - Neural Mobilization Alone | Active comparator | Other: Pain Neurosciences Education + Neural MobilizationNeural mobilization techniques will be applied following standardized neurodynamic principles and patients' tolerance. Target nerves: Sciatic, tibial \& common peroneal Technique: Slider neurodynamic mobilization Dosage: 10-15 reps × 2-3 sets | Rest: 30-60 sec between sets Session duration: 15-20 minutes |
Who may qualify
- Ages
- 40 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Age ≥ 40 years (WHO 2016 criteria) Diagnosed Type II diabetes mellitus Lower limb neuropathic pain ≥ 3 months Pain intensity ≥ 4/10 on NPRS Able to walk independently and follow instructions
Key exclusion criteria (1 listed)
- Neurological disorders (e.g. stroke, Guillain-Barré) Lumbar disc herniation with radiculopathy Lower limb surgery or spinal fracture within 6 months Active diabetic foot ulcer Diagnosed cognitive impairment or severe infection
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Pain Neurosciences Education + Neural MobilizationIn Group A pain neuroscience Education will be given in adjunct with neural mobilization techniques Target nerves: Sciatic, tibial \& common peroneal Technique: Slider neurodynamic mobilization Dosage: 10-15 reps × 2-3 sets | Rest: 30-60 sec between sets Session duration: 15-20 minutes PNE: 20-30 min (weeks 1-2) → 10 min reinforcement (weeks 3-6) Methods: Simple diagrams, patient-friendly metaphors, video demonstrations | Other | Group A - Pain Neurosciences Education combined with Neural Mobilization, Group B - Neural Mobilization Alone |
Primary outcome
Pain intensity
Time frame: Baseline to week 6
Pain intensity will be evaluated using Numeric Pain Rating Scale
Functional disability
Time frame: Baseline to week 6
Functional disability will be evaluated using Urdu version of Lower Extremity Functional Scale (LEFS)
Quality of life
Time frame: Baseline to week 6
Quality of life will be evaluated by World Health Organization Quality Of Life-BREF
Central sensitization
Time frame: Baseline to week 6
Central sensitization will be evaluated using Central Sensitization Inventory
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Jul 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Pain Neurosciences Education + Neural Mobilization in people with Diabetic Neuropathic Pain, run by Ibadat International University, Islamabad at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 10 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Roshan Farman, MSPT (+923188108470, 5012324032@student.iiui.edu.pk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pain intensity (time frame: Baseline to week 6). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Jul 2026.