OsteoarthritisArthritisNCT07696195
The Effectiveness of Resistance Training for Patients With Degenerative Arthritis After Surgery
A study testing Progressive Lower Extremity Resistance Exercise and Routine Postoperative Rehabilitation Care in people with Osteoarthritis and Osteoarthritis, Knee, run by Tzu Chi University at 1 site in Taiwan.
Trial summary
Osteoarthritis is a common degenerative disease that significantly impacts mobility and disability in older adults. This pilot randomized controlled study aimed to examine the effects of a three-month resistance training program on lower limb muscular endurance, balance performance, pain, and quality of life among… Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Osteoarthritis, Osteoarthritis, Knee
- What is being tested?
- Progressive Lower Extremity Resistance Exercise and Routine Postoperative Rehabilitation Care
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 24 participants
- Where
- 1 siteTaiwan
- Study dates
- 1 Mar 2025to 19 Aug 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- Diagnosis of osteoarthritis requiring first-time unilateral lower limb total joint arthroplasty
- No planned surgery on the contralateral limb
- Clear consciousness and ability to communicate in Mandarin or Taiwanese
- Independent ambulation before surgery
- Adequate vision and hearing (with correction if needed)
- Community-dwelling status
- Willing to participate in this study
Who cannot join
- Inability to ambulate independently
- Medical contraindications to exercise
- Severe musculoskeletal conditions other than osteoarthritis
- Same-day admission and surgery
- Bilateral joint arthroplasty
Trial locations and contacts
1 site in 1 country.
Taiwan1 site
Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Hualien City, Taiwan, 97060
About this study
Official title: The Effectiveness of Resistance Training for Patients With Degenerative Arthritis After Surgery- A Pilot Randomized Controlled Study
Osteoarthritis is a common degenerative disease that significantly impacts mobility and disability in older adults. This pilot randomized controlled study aimed to examine the effects of a three-month resistance training program on lower limb muscular endurance, balance performance, pain, and quality of life among patients who had undergone unilateral total knee arthroplasty. Twenty-four participants were randomly assigned to either the experimental group receiving resistance training or the control group receiving routine postoperative rehabilitation. The study evaluates and compares the effectiveness of these interventions to provide insights into incorporating resistance training into postoperative nursing care and recovery programs.
Read the detailed description
This study employed an interventional, experimental design with a three-month follow-up to investigate the effectiveness of a progressive lower extremity resistance training program for patients with osteoarthritis following unilateral total joint arthroplasty. The study adhered to the CONSORT guidelines for reporting clinical trials.
Participants were randomly allocated into two groups:
- Control Group: Received routine postoperative rehabilitation care.
- Experimental Group: Received a progressive lower extremity resistance exercise program in addition to routine care. The program utilized 1-kg ankle weights and included seated knee extension, standing hamstring curls, and hip abduction. Training sessions were performed three times per week for three months, with the training volume progressively adjusted as follows:
- 1st Postoperative Month: Performed on the non-operated limb only (2 sets per exercise).
- 2nd Postoperative Month: Continued on the non-operated limb (3 sets) and introduced to the operated limb (2 sets).
- 3rd Postoperative Month: Increased to 4 sets for the non-operated limb and 3 sets for the operated limb.
Each set consisted of 10 repetitions with a 1-minute rest between sets. Participants also received an illustrated exercise leaflet to enhance safety and adherence.
- Conditions
- Osteoarthritis, Osteoarthritis, Knee
- Being tested
- Progressive Lower Extremity Resistance Exercise, Routine Postoperative Rehabilitation Care
- Keywords
- Resistance Training, Total Knee Arthroplasty, Postoperative Rehabilitation, Muscular Endurance, Balance Performance
- Medical subject headings
- Osteoarthritis, Osteoarthritis, Knee
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Progressive Lower Extremity Resistance ExerciseBehavioural
A 3-month progressive resistance training program utilizing 1-kg ankle weights, including seated knee extension, standing hamstring curls, and hip abduction. Training sessions were performed 3 times per week, with progressive adjustments in training volume (sets and repetitions) for both operated and non-operated limbs over the 3-month period.
Routine Postoperative Rehabilitation CareBehavioural
Participants in the control group received routine postoperative rehabilitation care.
| Study group | Role | What they receive |
|---|---|---|
| Experimental Group | Experimental | Participants received a progressive lower extremity resistance exercise program using 1-kg ankle weights (including seated knee extension, standing hamstring curls, and hip abduction) 3 times per week for 3 months, in addition to routine postoperative care. Receives: Behavioral: Progressive Lower Extremity Resistance Exercise |
| Control Group | Active comparator | Participants received routine postoperative rehabilitation care. Receives: Behavioral: Routine Postoperative Rehabilitation Care |
What is being measured
The primary outcome is the main question the study is designed to answer.
Lower Extremity Muscle Endurance
Assessed using the 30-Second Chair Stand Test. This test measures the total number of completed stands a participant can perform from a seated position to a full stand within 30 seconds.
Measured: A higher number of completed stands means a better outcome (better lower extremity muscular endurance). To ensure safety for postoperative patients, a four-legged walker is placed in front of the chair during testing.
Secondary outcomes (1)
Balance Performance
Assessed using the 2.44-Meter Timed Up-and-Go-Based Chair Rise and Obstacle Navigation Test, which measures the time (in seconds) taken to complete the functional mobility task.
Measured: Shorter completion times (fewer seconds) mean a better outcome (better dynamic balance performance).
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Jul 2026
- Study start1 Mar 2025
- Primary completion22 May 2025
- Study completion19 Aug 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for OsteoarthritisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 24 participants (actual)
Sponsor and investigators
- Lead sponsor
- Tzu Chi University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Su-Jung Liao, Tzu Chi University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07696195
- Sponsor's protocol ID
- IRB114-014-B
- Acronym
- Arthritis
- Status last verified
- Jul 2026
- First submitted
- 1 Jul 2026
- Last updated
- 10 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Tian YR, Wu MC, Liao SJ. The effectiveness of resistance training for patients with degenerative arthritis after total joint arthroplasty: a pilot randomized controlled study. BMC Musculoskelet Disord. 2026 Aug 28;27(1):794. doi: 10.1186/s12891-026-10352-8.
PubMed 42786446
Study at a glance
From the registry record, last updated by the sponsor on 10 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effectiveness of Resistance Training for Patients With Degenerative Arthritis After Surgery- A Pilot Randomized Controlled Study
- ClinicalTrials.gov ID
- NCT07696195
- Acronym / sponsor ID
- Arthritis / IRB114-014-B
- Conditions
- Osteoarthritis, Osteoarthritis, Knee
- Keywords
- Resistance Training, Total Knee Arthroplasty, Postoperative Rehabilitation, Muscular Endurance, Balance Performance
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 24 participants (actual)
- Lead sponsor
- Tzu Chi UniversityUniversity, hospital or other
- Study start
- 1 Mar 2025 (actual)
- Primary completion
- 22 May 2025 (actual)
- Study completion
- 19 Aug 2025 (actual)
- First posted
- 10 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Osteoarthritis is a common degenerative disease that significantly impacts mobility and disability in older adults. This pilot randomized controlled study aimed to examine the effects of a three-month resistance training program on lower limb muscular endurance, balance performance, pain, and quality of life among patients who had undergone unilateral total knee arthroplasty. Twenty-four participants were randomly assigned to either the experimental group receiving resistance training or the control group receiving routine postoperative rehabilitation. The study evaluates and compares the effectiveness of these interventions to provide insights into incorporating resistance training into postoperative nursing care and recovery programs.
Detailed description
This study employed an interventional, experimental design with a three-month follow-up to investigate the effectiveness of a progressive lower extremity resistance training program for patients with osteoarthritis following unilateral total joint arthroplasty. The study adhered to the CONSORT guidelines for reporting clinical trials.
Participants were randomly allocated into two groups:
- Control Group: Received routine postoperative rehabilitation care.
- Experimental Group: Received a progressive lower extremity resistance exercise program in addition to routine care. The program utilized 1-kg ankle weights and included seated knee extension, standing hamstring curls, and hip abduction. Training sessions were performed three times per week for three months, with the training volume progressively adjusted as follows:
- 1st Postoperative Month: Performed on the non-operated limb only (2 sets per exercise).
- 2nd Postoperative Month: Continued on the non-operated limb (3 sets) and introduced to the operated limb (2 sets).
- 3rd Postoperative Month: Increased to 4 sets for the non-operated limb and 3 sets for the operated limb.
Each set consisted of 10 repetitions with a 1-minute rest between sets. Participants also received an illustrated exercise leaflet to enhance safety and adherence.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Experimental Group | Experimental | Behavioral: Progressive Lower Extremity Resistance ExerciseParticipants received a progressive lower extremity resistance exercise program using 1-kg ankle weights (including seated knee extension, standing hamstring curls, and hip abduction) 3 times per week for 3 months, in addition to routine postoperative care. |
| Control Group | Active comparator | Behavioral: Routine Postoperative Rehabilitation CareParticipants received routine postoperative rehabilitation care. |
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (7 listed)
- Diagnosis of osteoarthritis requiring first-time unilateral lower limb total joint arthroplasty
- No planned surgery on the contralateral limb
- Clear consciousness and ability to communicate in Mandarin or Taiwanese
- Independent ambulation before surgery
- Adequate vision and hearing (with correction if needed)
Key exclusion criteria (5 listed)
- Inability to ambulate independently
- Medical contraindications to exercise
- Severe musculoskeletal conditions other than osteoarthritis
- Same-day admission and surgery
- Bilateral joint arthroplasty
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Progressive Lower Extremity Resistance ExerciseA 3-month progressive resistance training program utilizing 1-kg ankle weights, including seated knee extension, standing hamstring curls, and hip abduction. Training sessions were performed 3 times per week, with progressive adjustments in training volume (sets and repetitions) for both operated and non-operated limbs over the 3-month period. | Behavioural | Experimental Group |
| Routine Postoperative Rehabilitation CareParticipants in the control group received routine postoperative rehabilitation care. | Behavioural | Control Group |
Primary outcome
Lower Extremity Muscle Endurance
Time frame: A higher number of completed stands means a better outcome (better lower extremity muscular endurance). To ensure safety for postoperative patients, a four-legged walker is placed in front of the chair during testing.
Assessed using the 30-Second Chair Stand Test. This test measures the total number of completed stands a participant can perform from a seated position to a full stand within 30 seconds.
1 secondary outcome
Balance Performance
Time frame: Shorter completion times (fewer seconds) mean a better outcome (better dynamic balance performance).
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Jul 2026.
- Derived from this study: PubMed 42786446Tian YR, Wu MC, Liao SJ. The effectiveness of resistance training for patients with degenerative arthritis after total joint arthroplasty: a pilot randomized controlled study. BMC Musculoskelet Disord. 2026 Aug 28;27(1):794. doi: 10.1186/s12891-026-10352-8.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Progressive Lower Extremity Resistance Exercise and Routine Postoperative Rehabilitation Care in people with Osteoarthritis and Osteoarthritis, Knee, run by Tzu Chi University at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 10 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Lower Extremity Muscle Endurance (time frame: A higher number of completed stands means a better outcome (better lower extremity muscular endurance). To ensure safety for postoperative patients, a four-legged walker is placed in front of the chair during testing.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07696195, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Jul 2026.