ThirstNCT07699809
Administration of a 'Thirst Relieve Kit' Versus Placebo in Patients After Hospital-based Bowel Preparation for Colonoscopy and Assessment of Thirst Intensity
A study testing lemon popsicle and Water blister pack in people with Thirst and Bowel Preparation for Colonoscopy, run by Hospital Sirio-Libanes at 1 site in Brazil.
Trial summary
The goal of this study is to evaluate whether a "thirst kit" (lemon popsicle) is effective in reducing thirst intensity in patients undergoing hospital bowel preparation for colonoscopy. The study also aims to assess the impact of the thirst kit on associated symptoms and patient satisfaction. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Thirst, Bowel Preparation for Colonoscopy, Colonoscopy
- What is being tested?
- lemon popsicle and Water blister pack
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 158 participants
- Where
- 1 siteBrazil
- Study dates
- 8 Dec 2025to 1 Sep 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- both sexes
- aged 18 years or older, with clear awareness and good cooperation
- who underwent colonoscopy with hospital bowel preparation
Who cannot join
- any risk of oral fluid aspiration
- swallowing disorders
- post-operative advanced head and neck surgeries
- advanced head and neck neoplasia, active oral diseases (oral mucosal lesions, stomatitis, among others)
- history of gastric surgeries (gastrectomized, upper gastrointestinal tract surgeries for obesity)
- use of GLP-1 analog medications and derivatives in the last 10 days according to hospital protocol (e.g., semaglutide, liraglutide, dulaglutide, tirzepatide...)
- history of dementia.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Brazil1 site, 1 recruiting
- Recruiting
Hospital Sírio Libanês
São Paulo, São Paulo
About this study
The goal of this study is to evaluate whether a "thirst kit" (lemon popsicle) is effective in reducing thirst intensity in patients undergoing hospital bowel preparation for colonoscopy. The study also aims to assess the impact of the thirst kit on associated symptoms and patient satisfaction. The main questions it aims to answer are:
- Does the thirst kit reduce the intensity of thirst after bowel preparation for colonoscopy?
- Does the thirst kit reduce symptoms such as dry mouth and dry throat?
- How satisfied are patients when using the thirst kit compared to a placebo?
Read more
Researchers will compare the thirst kit to a placebo to determine its effectiveness in managing thirst during the pre-colonoscopy period.
Participants will:
- Be randomly assigned to receive either the thirst kit (lemon popsicle) or a placebo
- Use the assigned intervention during the hospital preparation period for colonoscopy
- Rate thirst intensity, associated symptoms, and satisfaction using numerical scales
- Conditions
- Thirst, Bowel Preparation for Colonoscopy, Colonoscopy
- Being tested
- lemon popsicle, Water blister pack
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
lemon popsicleOther
Also called Thirst kit relife
The intervention group receives a "Thirst relife kit A" consisting of an encouraging message and a 60g lemon-flavored popsicle from the Jundiá® brand (Ingredients: water, sugar, glucose syrup, concentrated lemon juice, citric acid, thickeners, artificial flavoring).
Water blister packOther
The control group receives a "Thirst Relife Kit B" consisting of the same encouraging message, a cotton ball, and a 10 ml blister pack of distilled water.
| Study group | Role | What they receive |
|---|---|---|
| Intervention | Experimental | Group lemon popsicle: Group that will receive the lemon popsicle Receives: Other: lemon popsicle |
| Placebo | Placebo comparator | Group placebo: Group that will recive de placebo (water blister) Receives: Other: Water blister pack |
What is being measured
The primary outcome is the main question the study is designed to answer.
The primary outcome of the study is the intensity of thirst, assessed using a numerical scale (0-10) after administration of the thirst kit or placebo.
The intensity of thirst, measured using a numerical scale from 0 to 10, was assessed after administration of the thirst kit or placebo in patients undergoing hospital preparation for colonoscopy.
Measured: 10 minutes before the sedation for the exam starts (when the patient arrives in the examination room)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Jul 2026
- Study start8 Dec 2025
- Primary completion12 Aug 2026 (estimated)
- Study completion1 Sep 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for ThirstStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Care provider, Investigator, Outcomes assessor
- Enrolment
- 158 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Hospital Sirio-Libanes
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07699809
- Sponsor's protocol ID
- AVAP-NG ID = 3998
- Status last verified
- Mar 2026
- First submitted
- 7 Apr 2026
- Last updated
- 13 Jul 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
1. International Agency for Research on Cancer. GLOBOCAN 2020: estimated cancer incidence, mortality and prevalence worldwide in 2020. Lyon: IARC; 2021. 2. Islami F, Ward EM, Sung H, Cronin KA, Tangka FKL, Sherman RL, et al. Annual report to the nation on the status of cancer, part I: National cancer statistics. J Natl Cancer Inst. 2021. 3. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209-49. 4. Winawer SJ, Zauber AG, O'Brien MJ, Ho MN, Gottlieb L, Sternberg SS, et al. Randomized comparison of surveillance intervals after colonoscopic removal of newly diagnosed adenomatous polyps: the National Polyp Study Workgroup. N Engl J Med. 1993;328(13):901-6. 5. Winawer SJ, Zauber AG, Ho MN, O'Brien MJ, Gottlieb LS, Sternberg SS, et al. Prevention of colorectal cancer by colonoscopic polypectomy: the National Polyp Study Workgroup. N Engl J Med. 1993;329(27):1977-81. 6. Knudsen AB, Rutter CM, Peterse EFP, Lietz AP, Seguin CL, Meester RGS, et al. Colorectal cancer screening: an updated modeling study for the US Preventive Services Task Force. JAMA. 2021;325(19):1998-2011. doi:10.1001/jama.2021.5746. 7. Froehlich F, Wietlisbach V, Gonvers JJ, Burnand B, Vader JP. Impact of colonic cleansing on quality and diagnostic yield of colonoscopy: the European Panel of Appropriateness of Gastrointestinal Endoscopy European multicenter study. Gastrointest Endosc. 2005;61(3):378-84. 8. Parente F, Marino B, Crosta C. Bowel preparation before colonoscopy in the era of mass screening for colorectal cancer: a practical approach. Dig Liver Dis. 2009;41(2):87-95. doi:10.1016/j.dld.2008.06.005. 9. Green SM, Leroy PL, Roback MG, Irwin MG, Andolfatto G, Babl FE, et al. An international multidisciplinary consensus statement on fasting before procedural sedation in adults and children. Anaesthesia. 2020;75(3):374-85. doi:10
Study at a glance
From the registry record, last updated by the sponsor on 13 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Administration of a 'Thirst Relieve Kit' Versus Placebo in Patients After Hospital-based Bowel Preparation for Colonoscopy and Assessment of Thirst Intensity
- ClinicalTrials.gov ID
- NCT07699809
- Acronym / sponsor ID
- AVAP-NG ID = 3998
- Conditions
- Thirst, Bowel Preparation for Colonoscopy, Colonoscopy
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 158 participants (estimated)
- Lead sponsor
- Hospital Sirio-LibanesUniversity, hospital or other
- Study start
- 8 Dec 2025 (actual)
- Primary completion
- 12 Aug 2026 (estimated)
- Study completion
- 1 Sep 2026 (estimated)
- First posted
- 13 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this study is to evaluate whether a "thirst kit" (lemon popsicle) is effective in reducing thirst intensity in patients undergoing hospital bowel preparation for colonoscopy. The study also aims to assess the impact of the thirst kit on associated symptoms and patient satisfaction. The main questions it aims to answer are:
- Does the thirst kit reduce the intensity of thirst after bowel preparation for colonoscopy?
- Does the thirst kit reduce symptoms such as dry mouth and dry throat?
- How satisfied are patients when using the thirst kit compared to a placebo?
Researchers will compare the thirst kit to a placebo to determine its effectiveness in managing thirst during the pre-colonoscopy period.
Participants will:
- Be randomly assigned to receive either the thirst kit (lemon popsicle) or a placebo
- Use the assigned intervention during the hospital preparation period for colonoscopy
- Rate thirst intensity, associated symptoms, and satisfaction using numerical scales
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (care provider, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Intervention | Experimental | Other: lemon popsicleGroup lemon popsicle: Group that will receive the lemon popsicle |
| Placebo | Placebo comparator | Other: Water blister packGroup placebo: Group that will recive de placebo (water blister) |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- both sexes
- aged 18 years or older, with clear awareness and good cooperation
- who underwent colonoscopy with hospital bowel preparation
Key exclusion criteria (7 listed)
- any risk of oral fluid aspiration
- swallowing disorders
- post-operative advanced head and neck surgeries
- advanced head and neck neoplasia, active oral diseases (oral mucosal lesions, stomatitis, among others)
- history of gastric surgeries (gastrectomized, upper gastrointestinal tract surgeries for obesity)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| lemon popsicleAlso: Thirst kit relifeThe intervention group receives a "Thirst relife kit A" consisting of an encouraging message and a 60g lemon-flavored popsicle from the Jundiá® brand (Ingredients: water, sugar, glucose syrup, concentrated lemon juice, citric acid, thickeners, artificial flavoring). | Other | Intervention |
| Water blister packThe control group receives a "Thirst Relife Kit B" consisting of the same encouraging message, a cotton ball, and a 10 ml blister pack of distilled water. | Other | Placebo |
Primary outcome
The primary outcome of the study is the intensity of thirst, assessed using a numerical scale (0-10) after administration of the thirst kit or placebo.
Time frame: 10 minutes before the sedation for the exam starts (when the patient arrives in the examination room)
The intensity of thirst, measured using a numerical scale from 0 to 10, was assessed after administration of the thirst kit or placebo in patients undergoing hospital preparation for colonoscopy.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Jul 2026.
- Background1. International Agency for Research on Cancer. GLOBOCAN 2020: estimated cancer incidence, mortality and prevalence worldwide in 2020. Lyon: IARC; 2021. 2. Islami F, Ward EM, Sung H, Cronin KA, Tangka FKL, Sherman RL, et al. Annual report to the nation on the status of cancer, part I: National cancer statistics. J Natl Cancer Inst. 2021. 3. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209-49. 4. Winawer SJ, Zauber AG, O'Brien MJ, Ho MN, Gottlieb L, Sternberg SS, et al. Randomized comparison of surveillance intervals after colonoscopic removal of newly diagnosed adenomatous polyps: the National Polyp Study Workgroup. N Engl J Med. 1993;328(13):901-6. 5. Winawer SJ, Zauber AG, Ho MN, O'Brien MJ, Gottlieb LS, Sternberg SS, et al. Prevention of colorectal cancer by colonoscopic polypectomy: the National Polyp Study Workgroup. N Engl J Med. 1993;329(27):1977-81. 6. Knudsen AB, Rutter CM, Peterse EFP, Lietz AP, Seguin CL, Meester RGS, et al. Colorectal cancer screening: an updated modeling study for the US Preventive Services Task Force. JAMA. 2021;325(19):1998-2011. doi:10.1001/jama.2021.5746. 7. Froehlich F, Wietlisbach V, Gonvers JJ, Burnand B, Vader JP. Impact of colonic cleansing on quality and diagnostic yield of colonoscopy: the European Panel of Appropriateness of Gastrointestinal Endoscopy European multicenter study. Gastrointest Endosc. 2005;61(3):378-84. 8. Parente F, Marino B, Crosta C. Bowel preparation before colonoscopy in the era of mass screening for colorectal cancer: a practical approach. Dig Liver Dis. 2009;41(2):87-95. doi:10.1016/j.dld.2008.06.005. 9. Green SM, Leroy PL, Roback MG, Irwin MG, Andolfatto G, Babl FE, et al. An international multidisciplinary consensus statement on fasting before procedural sedation in adults and children. Anaesthesia. 2020;75(3):374-85. doi:10
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing lemon popsicle and Water blister pack in people with Thirst and Bowel Preparation for Colonoscopy, run by Hospital Sirio-Libanes at 1 site in Brazil.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 13 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Brazil. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Carlos Frederico Sparapan Marques (+5511996250751, carlos.frederico@hc.fm.usp.br), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The primary outcome of the study is the intensity of thirst, assessed using a numerical scale (0-10) after administration of the thirst kit or placebo. (time frame: 10 minutes before the sedation for the exam starts (when the patient arrives in the examination room)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07699809, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Jul 2026.