ElectromyographyNCT07699848
Active Versus Passive Sitting, Cognition and Energy
A study testing Chaircise, Chaircise + Dynamic Leg Exercise and Chaircise + Static Leg Exercise in people with Electromyography and Pressure Injury of Back, run by University of Miami at 1 site in United States.
Trial summary
The study will compare cognitive capacity, muscle utilization patterns, soft tissue seated pressure and caloric output during four seated conditions: 1. passive sitting in a regular chair; 2. passive sitting in an exercise chair; 3. sitting in the exercise chair during active dynamic exercise; and, 4. Read more about this study
- Who is it for?
- Ages 18 to 70 yearsHealthy volunteers can take part
- Conditions the study is for
- Electromyography, Pressure Injury of Back
- What is being tested?
- Chaircise, Chaircise + Dynamic Leg Exercise and Chaircise + Static Leg Exercise
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 35 participants
- Where
- 1 siteUnited States
- Study dates
- 23 Jun 2026to 30 Sep 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 70 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Adult (18-70)
Who cannot join
- Any current injury in the lower limb or trunk.
- Use of prescription drugs or supplements that may affect cardiovascular or neuromuscular responses.
- Reported lack of sleep or stress that may affect physiological responses to exercise.
- Cardiovascular, respiratory, neurologic, balance, metabolic, or musculoskeletal conditions that could increase risk during exercise testing
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Laboratory of Neuromuscular Research and Active Aging
Coral Gables, Florida, 33146
Joseph Signorile Joseph Signorile, PhD, 305-898-1458, jsignorile@miami.edu
Ethan J Elkins, MS, 3052844173, exe453@miami.edu
About this study
Official title: Differences in Muscle Utilization, Tissue Pressure, Cognitive Performance, and Caloric Output Among Active and Passive Sitting Positions.
The study will compare cognitive capacity, muscle utilization patterns, soft tissue seated pressure and caloric output during four seated conditions:
- passive sitting in a regular chair;
- passive sitting in an exercise chair;
- sitting in the exercise chair during active dynamic exercise; and,
- sitting in the chair during active static exercise.
- Conditions
- Electromyography, Pressure Injury of Back
- Being tested
- Chaircise, Chaircise + Dynamic Leg Exercise, Chaircise + Static Leg Exercise
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ChairciseBehavioural
A chair-based exercise program using a specialized chair that allows participants to lift their body weight.
Chaircise + Dynamic Leg ExerciseBehavioural
A chair-based exercise program performed using a specialized exercise chair equipped with a foot-operated lever. Participants repeatedly depress and release the foot-operated lever during the intervention period.
Chaircise + Static Leg ExerciseBehavioural
A chair-based exercise program performed using a specialized exercise chair equipped with a foot-operated lever. Participants depress and maintain pressure on the foot-operated lever during the intervention period.
| Study group | Role | What they receive |
|---|---|---|
| Passive Comparator: Traditional Chair | No intervention | Participant will sit in the traditional chair for the amount of time it takes them to read a scientific article. |
| Passive Comparator: Exercise Chair | Placebo comparator | Participant will sit in the exercise chair for the amount of time it takes them to read a scientific article. Receives: Behavioral: Chaircise |
| Experimental: Dynamic Leg Exercise in Exercise Chair | Experimental | Participant will sit in the exercise chair for the amount of time it takes them to read a scientific article while actively pushing down and releasing the foot operated lever as many times as possible. Receives: Behavioral: Chaircise + Dynamic Leg Exercise |
| Experimental: Static Leg Exercise in Exercise Chair | Experimental | Participant will sit in the exercise chair for the amount of time it takes them to read a scientific article while actively pushing down and holding the foot operated lever. Receives: Behavioral: Chaircise + Static Leg Exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
Differences in cognitive performance among chair conditions as measured by the Psychomotor Vigilance Test in number of key depressions
Cognitive performance will be assessed using the 3-minute Psychomotor Vigilance Test (PVT). During the test, participants will press the space bar as quickly as possible in response to the appearance of a visual stimulus on a computer screen. Performance will be measured as the total number of valid responses recorded during the test. Higher values indicate greater alertness, sustained attention, and reaction speed.
Measured: Approximately 3 minutes
Executive function among chair conditions as measured by the Stroop Test using words counted.
Executive function will be assessed using the Stroop Test, a cognitive task requiring participants to respond to color word stimuli. The outcome will be measured by total words counted, reported as the number of words.
Measured: Approximately 5 minutes.
Executive function among chair conditions as measured by the Stroop Test using error rate.
Executive function will be assessed using the Stroop Test, a cognitive task requiring participants to respond to color word stimuli. The outcome will be measured by error rate, reported as the percentage of errors.
Measured: Approximately 5 minutes.
Muscle activity among chair conditions using electromyography
Muscle activity will be assessed using surface electromyography (EMG). Muscle activation will be quantified as EMG amplitude, measured in microvolts (µV) from EMG recordings. Higher values indicate greater muscle activity.
Measured: Approximately 45 minutes
Peak seated tissue pressure among chair conditions using a pressure sensitive mat
Seated tissue pressure will be assessed using a pressure-sensitive mat placed on the seat surface of each chair. Peak pressure will be recorded to quantify the highest pressure exerted at the seating interface during each chair condition, measured in kilopascals. Higher values indicate greater localized pressure on seated tissues.
Measured: Approximately 15 minutes
Metabolic cost of sitting among the chair conditions using a portable oxygen consumption unit
Metabolic cost during sitting will be assessed under each chair condition using a portable indirect calorimetry device. Participants will wear a facemask that measures oxygen consumption (VO₂) and carbon dioxide production (VCO₂). These measurements will be used to estimate energy expenditure during the sitting period. Higher values indicate greater metabolic cost.
Measured: Approximately 25 minutes
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Jul 2026
- Study start23 Jun 2026
- Primary completion30 Sep 2027 (estimated)
- Study completion30 Sep 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for ElectromyographyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 35 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Miami
- Sponsor type
- University, hospital or other
- Collaborators
- Robot Studios
- Responsible party
- Principal investigator, Joseph Signorile, University of Miami
- Investigators
- Joseph J Signorile, PhD, Principal investigator, University of Miami - Coral Gables Campus
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07699848
- Sponsor's protocol ID
- 20260691
- Other IDs
- FP00021633
- Status last verified
- Aug 2026
- First submitted
- 7 Jul 2026
- Last updated
- 20 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Differences in Muscle Utilization, Tissue Pressure, Cognitive Performance, and Caloric Output Among Active and Passive Sitting Positions.
- ClinicalTrials.gov ID
- NCT07699848
- Acronym / sponsor ID
- 20260691
- Conditions
- Electromyography, Pressure Injury of Back
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 35 participants (estimated)
- Lead sponsor
- University of MiamiUniversity, hospital or other
- Collaborators
- Robot Studios
- Study start
- 23 Jun 2026 (actual)
- Primary completion
- 30 Sep 2027 (estimated)
- Study completion
- 30 Sep 2027 (estimated)
- First posted
- 13 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The study will compare cognitive capacity, muscle utilization patterns, soft tissue seated pressure and caloric output during four seated conditions:
- passive sitting in a regular chair;
- passive sitting in an exercise chair;
- sitting in the exercise chair during active dynamic exercise; and,
- sitting in the chair during active static exercise.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Passive Comparator: Traditional Chair | No intervention | –Participant will sit in the traditional chair for the amount of time it takes them to read a scientific article. |
| Passive Comparator: Exercise Chair | Placebo comparator | Behavioral: ChairciseParticipant will sit in the exercise chair for the amount of time it takes them to read a scientific article. |
| Experimental: Dynamic Leg Exercise in Exercise Chair | Experimental | Behavioral: Chaircise + Dynamic Leg ExerciseParticipant will sit in the exercise chair for the amount of time it takes them to read a scientific article while actively pushing down and releasing the foot operated lever as many times as possible. |
| Experimental: Static Leg Exercise in Exercise Chair | Experimental | Behavioral: Chaircise + Static Leg ExerciseParticipant will sit in the exercise chair for the amount of time it takes them to read a scientific article while actively pushing down and holding the foot operated lever. |
Who may qualify
- Ages
- 18 to 70 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Adult (18-70)
Key exclusion criteria (4 listed)
- Any current injury in the lower limb or trunk.
- Use of prescription drugs or supplements that may affect cardiovascular or neuromuscular responses.
- Reported lack of sleep or stress that may affect physiological responses to exercise.
- Cardiovascular, respiratory, neurologic, balance, metabolic, or musculoskeletal conditions that could increase risk during exercise testing
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| ChairciseA chair-based exercise program using a specialized chair that allows participants to lift their body weight. | Behavioural | Passive Comparator: Exercise Chair |
| Chaircise + Dynamic Leg ExerciseA chair-based exercise program performed using a specialized exercise chair equipped with a foot-operated lever. Participants repeatedly depress and release the foot-operated lever during the intervention period. | Behavioural | Experimental: Dynamic Leg Exercise in Exercise Chair |
| Chaircise + Static Leg ExerciseA chair-based exercise program performed using a specialized exercise chair equipped with a foot-operated lever. Participants depress and maintain pressure on the foot-operated lever during the intervention period. | Behavioural | Experimental: Static Leg Exercise in Exercise Chair |
Primary outcome
Differences in cognitive performance among chair conditions as measured by the Psychomotor Vigilance Test in number of key depressions
Time frame: Approximately 3 minutes
Cognitive performance will be assessed using the 3-minute Psychomotor Vigilance Test (PVT). During the test, participants will press the space bar as quickly as possible in response to the appearance of a visual stimulus on a computer screen. Performance will be measured as the total number of valid responses recorded during the test. Higher values indicate greater alertness, sustained attention, and reaction speed.
Executive function among chair conditions as measured by the Stroop Test using words counted.
Time frame: Approximately 5 minutes.
Executive function will be assessed using the Stroop Test, a cognitive task requiring participants to respond to color word stimuli. The outcome will be measured by total words counted, reported as the number of words.
Executive function among chair conditions as measured by the Stroop Test using error rate.
Time frame: Approximately 5 minutes.
Executive function will be assessed using the Stroop Test, a cognitive task requiring participants to respond to color word stimuli. The outcome will be measured by error rate, reported as the percentage of errors.
Muscle activity among chair conditions using electromyography
Time frame: Approximately 45 minutes
Muscle activity will be assessed using surface electromyography (EMG). Muscle activation will be quantified as EMG amplitude, measured in microvolts (µV) from EMG recordings. Higher values indicate greater muscle activity.
Peak seated tissue pressure among chair conditions using a pressure sensitive mat
Time frame: Approximately 15 minutes
Seated tissue pressure will be assessed using a pressure-sensitive mat placed on the seat surface of each chair. Peak pressure will be recorded to quantify the highest pressure exerted at the seating interface during each chair condition, measured in kilopascals. Higher values indicate greater localized pressure on seated tissues.
Metabolic cost of sitting among the chair conditions using a portable oxygen consumption unit
Time frame: Approximately 25 minutes
Metabolic cost during sitting will be assessed under each chair condition using a portable indirect calorimetry device. Participants will wear a facemask that measures oxygen consumption (VO₂) and carbon dioxide production (VCO₂). These measurements will be used to estimate energy expenditure during the sitting period. Higher values indicate greater metabolic cost.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Aug 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Joseph J Signorile, PhD principal investigator
University of Miami - Coral Gables Campus
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Chaircise, Chaircise + Dynamic Leg Exercise and Chaircise + Static Leg Exercise in people with Electromyography and Pressure Injury of Back, run by University of Miami at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 20 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Joseph Signorile J Joseph Signorile, PhD (3058981458, jsignorile@miami.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Differences in cognitive performance among chair conditions as measured by the Psychomotor Vigilance Test in number of key depressions (time frame: Approximately 3 minutes). The study lists 6 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Aug 2026.