Healthy VolunteersNCT07700186
Skin Barrier Function in Women Using UV Nail Lamps
An observational study of Healthy Volunteers, run by University of Split, School of Medicine at 1 site in Croatia.
Trial summary
The goal of this observational study is to compare objective parameters of skin barrier function between healthy adult women who regularly use UV lamps during nail treatments and women who do not use UV lamps. Read more about this study
- Who is it for?
- Ages 18 to 50 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- Healthy Volunteers
- How many people
- 40 participants
- Where
- 1 siteCroatia
- Study dates
- 12 Jan 2026to 29 Jun 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- Women only
- Healthy volunteers accepted
- Adult
Study population: Healthy adult women recruited from the general population. Participants will be classified into two groups based on their self-reported use of UV nail lamps during nail treatments: regular users of UV nail lamps and women who do not regularly use UV nail lamps and have natural nails.
Who may be able to join
- Healthy adult women (≥18 years of age)
- Willing and able to provide written informed consent
- Willing to complete the study questionnaire
Who cannot join
- Active skin diseases (e.g., psoriasis, vitiligo, or other dermatological conditions)
- Allergic contact dermatitis
- Pregnancy or breastfeeding
- Use of topical or systemic corticosteroids, immunosuppressive drugs, or antihistamines
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Comparison of Objective Skin Barrier Function Parameters Between Women Who Use and Women Who Do Not Use UV Nail Lamps for Nail Treatments
The goal of this observational study is to compare objective parameters of skin barrier function between healthy adult women who regularly use UV lamps during nail treatments and women who do not use UV lamps.
The main questions it aims to answer are:
Read more
- Do women who regularly use UV lamps for nail treatments show differences in skin barrier function compared to women who do not use UV lamps?
- Are transepidermal water loss, skin hydration, and erythema associated with regular exposure to UV lamps used for nail treatments?
- Does the duration of UV lamp use influence skin barrier function parameters?
Researchers will compare women who regularly use UV lamps during nail treatments with women who have natural nails and do not regularly expose their hands to UV lamps.
Participants will:
- Attend a single study visit.
- Complete a short questionnaire regarding nail care habits and duration of UV lamp use.
- Undergo non-invasive measurements of skin barrier function on the hands, including transepidermal water loss, skin hydration, and erythema assessments.
- Conditions
- Healthy Volunteers
- Keywords
- UV nail lamps, Gel manicure, Skin barrier function, Transepidermal water loss (TEWL), Skin hydration, Erythema
- Medical subject headings
- Erythema
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Regular UV Nail Lamp Users | Healthy adult women who regularly undergo nail treatments involving exposure to UV lamps. | |
| Non-Users of UV Nail Lamps | Healthy adult women who do not regularly undergo nail treatments involving exposure to UV lamps and have natural nails. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Transepidermal Water Loss (TEWL)
Skin barrier function will be assessed by measuring transepidermal water loss using a Tewameter TM 300 probe. Values will be expressed in g/m²/h
Measured: Day 1 (single study visit)
Change in Skin Hydration
Hydration of the stratum corneum will be assessed using a Corneometer CM 825 probe.
Measured: Day 1 (single study visit)
Change in Skin Erythema
Skin erythema will be assessed using a Mexameter MX 18 probe.
Measured: Day 1 (single study visit)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Jul 2026
- Study start12 Jan 2026
- Primary completion29 Jun 2026
- Study completion29 Jun 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Healthy VolunteersStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Enrolment
- 40 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Split, School of Medicine
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Josipa Bukić, Principal investigator, University of Split, School of Medicine
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07700186
- Sponsor's protocol ID
- 2181-198-03-04-26-0035
- Status last verified
- Oct 2026
- First submitted
- 7 Jul 2026
- Last updated
- 6 Oct 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 6 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Objective Skin Barrier Function Parameters Between Women Who Use and Women Who Do Not Use UV Nail Lamps for Nail Treatments
- ClinicalTrials.gov ID
- NCT07700186
- Acronym / sponsor ID
- 2181-198-03-04-26-0035
- Conditions
- Healthy Volunteers
- Keywords
- UV nail lamps, Gel manicure, Skin barrier function, Transepidermal water loss (TEWL), Skin hydration, Erythema
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 40 participants (actual)
- Lead sponsor
- University of Split, School of MedicineUniversity, hospital or other
- Study start
- 12 Jan 2026 (actual)
- Primary completion
- 29 Jun 2026 (actual)
- Study completion
- 29 Jun 2026 (actual)
- First posted
- 13 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this observational study is to compare objective parameters of skin barrier function between healthy adult women who regularly use UV lamps during nail treatments and women who do not use UV lamps.
The main questions it aims to answer are:
- Do women who regularly use UV lamps for nail treatments show differences in skin barrier function compared to women who do not use UV lamps?
- Are transepidermal water loss, skin hydration, and erythema associated with regular exposure to UV lamps used for nail treatments?
- Does the duration of UV lamp use influence skin barrier function parameters?
Researchers will compare women who regularly use UV lamps during nail treatments with women who have natural nails and do not regularly expose their hands to UV lamps.
Participants will:
- Attend a single study visit.
- Complete a short questionnaire regarding nail care habits and duration of UV lamp use.
- Undergo non-invasive measurements of skin barrier function on the hands, including transepidermal water loss, skin hydration, and erythema assessments.
Study design
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Regular UV Nail Lamp Users | – | –Healthy adult women who regularly undergo nail treatments involving exposure to UV lamps. |
| Non-Users of UV Nail Lamps | – | –Healthy adult women who do not regularly undergo nail treatments involving exposure to UV lamps and have natural nails. |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult
- Study population
- Healthy adult women recruited from the general population. Participants will be classified into two groups based on their self-reported use of UV nail lamps during nail treatments: regular users of UV nail lamps and women who do not regularly use UV nail lamps and have natural nails.
Key inclusion criteria (3 listed)
- Healthy adult women (≥18 years of age)
- Willing and able to provide written informed consent
- Willing to complete the study questionnaire
Key exclusion criteria (4 listed)
- Active skin diseases (e.g., psoriasis, vitiligo, or other dermatological conditions)
- Allergic contact dermatitis
- Pregnancy or breastfeeding
- Use of topical or systemic corticosteroids, immunosuppressive drugs, or antihistamines
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Change in Transepidermal Water Loss (TEWL)
Time frame: Day 1 (single study visit)
Skin barrier function will be assessed by measuring transepidermal water loss using a Tewameter TM 300 probe. Values will be expressed in g/m²/h
Change in Skin Hydration
Time frame: Day 1 (single study visit)
Hydration of the stratum corneum will be assessed using a Corneometer CM 825 probe.
Change in Skin Erythema
Time frame: Day 1 (single study visit)
Skin erythema will be assessed using a Mexameter MX 18 probe.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Josipa Bukić principal investigator
University of Split, School of Medicine
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Healthy Volunteers, run by University of Split, School of Medicine at 1 site in Croatia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Croatia. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Transepidermal Water Loss (TEWL) (time frame: Day 1 (single study visit)). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Oct 2026.