Apical PeriodontitisNCT07700394
Different Treatment Options For Mature Teeth With Apical Periodontitis
A study testing root canal treatment and intracanal medicament, Regeneration and Regeneration with BMPs in people with Apical Periodontitis, run by Sara Tariq Elemam at 1 site in Egypt.
Trial summary
A randomized control trial which aim to compare the healing potential for the following treatment options for mature teeth with apical periodontitis: Group I: Conventional root canal treatment (CRT) Group II: Regenerative endodontic treatment (RET) using a blood clot scaffold Group III: RET using a blood clot scaffold… Read more about this study
- Who is it for?
- Ages 18 to 30 yearsHealthy volunteers can take part
- Conditions the study is for
- Apical Periodontitis
- What is being tested?
- root canal treatment and intracanal medicament, Regeneration and Regeneration with BMPs
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Dec 2021to 1 Apr 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Patients aged 18-30 years
- Healthy patients with no systemic diseases or known allergic reactions
- Mature permanent molars diagnosed with pulp necrosis
- Presence of a medium sized periapical lesion confirmed clinically and radiographically (PAI=3,4,5)
Who cannot join
- Patients with generalized chronic periodontitis
- Presence of small periapical lesions (PAI=1,2)
- Periodontal pockets > 3 mm
- Presence of systemic diseases or known hypersensitivity to any material used in the study
Trial locations and contacts
1 site in 1 country.
About this study
Official title: A Comparison Between Different Treatment Options For Mature Teeth With Apical Periodontitis: A Randomized Control Trial
A randomized control trial which aim to compare the healing potential for the following treatment options for mature teeth with apical periodontitis:
Group I: Conventional root canal treatment (CRT) Group II: Regenerative endodontic treatment (RET) using a blood clot scaffold Group III: RET using a blood clot scaffold loaded with recombinant human BMPs (rhBMPs)
- Conditions
- Apical Periodontitis
- Being tested
- root canal treatment and intracanal medicament, Regeneration, Regeneration with BMPs
- Medical subject headings
- Periapical Periodontitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
root canal treatment and intracanal medicamentProcedure or surgery
conventional root canal treatment with obturation
RegenerationProcedure or surgery
Regeneration using induction of bleeding
Regeneration with BMPsProcedure or surgery
RET using a blood clot scaffold loaded with recombinant human BMPs (rhBMPs)
| Study group | Role | What they receive |
|---|---|---|
| Conventional RCT | Active comparator | Not described Receives: Procedure: root canal treatment and intracanal medicament |
| RET using a BMPs | Experimental | Not described Receives: Procedure: Regeneration with BMPs |
| Regenerative endodontic treatment | Experimental | Not described Receives: Procedure: Regeneration |
What is being measured
The primary outcome is the main question the study is designed to answer.
Healing in terms of volumetric change of lesion analyzed by CBCT
Measured: 1 year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Jul 2026
- Study start1 Dec 2021
- Primary completion1 Apr 2026
- Study completion1 Apr 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Apical PeriodontitisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- Sara Tariq Elemam
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Sara Tariq Elemam, Ain Shams University
- Investigators
- Shehab El Din Mohamed Saber, PHD, Study director, Faculty of dentistry Ain Shams University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07700394
- Sponsor's protocol ID
- ID-0917
- Status last verified
- Jun 2026
- First submitted
- 1 Jul 2026
- Last updated
- 15 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 15 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Comparison Between Different Treatment Options For Mature Teeth With Apical Periodontitis: A Randomized Control Trial
- ClinicalTrials.gov ID
- NCT07700394
- Acronym / sponsor ID
- ID-0917
- Conditions
- Apical Periodontitis
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Sara Tariq ElemamUniversity, hospital or other
- Study start
- 1 Dec 2021 (actual)
- Primary completion
- 1 Apr 2026 (actual)
- Study completion
- 1 Apr 2026 (actual)
- First posted
- 14 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
A randomized control trial which aim to compare the healing potential for the following treatment options for mature teeth with apical periodontitis:
Group I: Conventional root canal treatment (CRT) Group II: Regenerative endodontic treatment (RET) using a blood clot scaffold Group III: RET using a blood clot scaffold loaded with recombinant human BMPs (rhBMPs)
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Conventional RCT | Active comparator | Procedure: root canal treatment and intracanal medicament |
| RET using a BMPs | Experimental | Procedure: Regeneration with BMPs |
| Regenerative endodontic treatment | Experimental | Procedure: Regeneration |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Patients aged 18-30 years
- Healthy patients with no systemic diseases or known allergic reactions
- Mature permanent molars diagnosed with pulp necrosis
- Presence of a medium sized periapical lesion confirmed clinically and radiographically (PAI=3,4,5)
Key exclusion criteria (4 listed)
- Patients with generalized chronic periodontitis
- Presence of small periapical lesions (PAI=1,2)
- Periodontal pockets > 3 mm
- Presence of systemic diseases or known hypersensitivity to any material used in the study
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| root canal treatment and intracanal medicamentconventional root canal treatment with obturation | Procedure or surgery | Conventional RCT |
| RegenerationRegeneration using induction of bleeding | Procedure or surgery | Regenerative endodontic treatment |
| Regeneration with BMPsRET using a blood clot scaffold loaded with recombinant human BMPs (rhBMPs) | Procedure or surgery | RET using a BMPs |
Primary outcome
Healing in terms of volumetric change of lesion analyzed by CBCT
Time frame: 1 year
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Jul 2026.
- Individual participant dataSharing planned: Undecided
Related trials for Apical Periodontitis
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Effects of Different Activation Techniques on Antimicrobial Photodynamic Therapy in Apical Periodontitis
Apical Periodontitis, Endodontic Retreatment
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Post-operative Pain and Clinical Outcome After Single-cone Obturation With a Calcium Silicate-based Versus Epoxy Resin Sealer
Post Operative Pain, Acute, Irreversible Pulpitis (Toothache)
Not yet recruiting
PRP-Assisted Regenerative Endodontics Versus Conventional Root Canal Treatment in Mature Necrotic Teeth
Pulp Necrosis, Apical Periodontitis
Not yet recruiting
Influence of Continuous Rotation Versus Reciprocation Motion of MG3 Blue Rotary File on Postoperative Pain and Intracanal Bacterial Reduction of Teeth With Necrotic Pulps.
Necrotic Pulps With no Apical Periodontitis
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Shehab El Din Mohamed Saber, PHD study director
Faculty of dentistry Ain Shams University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing root canal treatment and intracanal medicament, Regeneration and Regeneration with BMPs in people with Apical Periodontitis, run by Sara Tariq Elemam at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 15 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Healing in terms of volumetric change of lesion analyzed by CBCT (time frame: 1 year). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Jul 2026.