AnalgesiaNCT07700784
Radiofrequency in Knee Osteoarthritis
A study testing Laser genicular nerve ablation and Conventional radiofrequency genicular nerve ablation in people with Analgesia, run by Zagazig University.
Trial summary
Knee osteoarthritis is one of the most common causes of chronic pain and disability worldwide, particularly in middle-aged and elderly populations. It is characterised by progressive cartilage degeneration, subchondral bone remodelling, and synovial inflammation. Read more about this study
- Who is it for?
- Ages 40 to 75 yearsHealthy volunteers can take part
- Conditions the study is for
- Analgesia
- What is being tested?
- Laser genicular nerve ablation and Conventional radiofrequency genicular nerve ablation
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- No sites listed yet
- Study dates
- Aug 2026to Sep 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 75 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- American society of anesthesiologist's physical status class I, II- Body mass index (BMI): 18.5 - 29.9 kg/m2- Confirmation of knee OA on radiograph- Chronic knee pain ≥ 3 months.
Who cannot join
- History of clinically significant cardiac, hepatic, renal or neurological disease- Allergy to study medication- Coagulopathy- Infection at injection site
About this study
Official title: Efficacy of Ultrasound Guided Laser Genicular Nerves Ablation Versus Conventional Radiofrequancy For Chronic Knee Osteoarthritis Pain
Knee osteoarthritis is one of the most common causes of chronic pain and disability worldwide, particularly in middle-aged and elderly populations. It is characterised by progressive cartilage degeneration, subchondral bone remodelling, and synovial inflammation.
There were many trails to provide pain relief by using systemic opioids or Non steroidal anti inflammatory drugs (with side effects such as peptic ulcer and hepatic, renal impairment)
Read the detailed description
Knee osteoarthritis is one of the most common causes of chronic pain and disability worldwide, particularly in middle-aged and elderly populations. It is characterized by progressive cartilage degeneration, subchondral bone remodeling, and synovial inflammation.
There were many trails to provide pain relief by using systemic opioids or non steroidal anti inflammatory drugs (with side effects such as peptic ulcer and hepatic, renal impairment) In knee osteoarthritis .these nerves are believed to be sensitised, leading to increased pain signalling . This can result in chronic pain and discomfort in patients with knee osteoarthritis.
Radiofrequency targeting these nerves aims to provide pain relief by disrupting the pain signals transmitted through these nerves .
By selectively targeting the articular branches, these interventions can alleviate pain and improve the physical function and quality of life of patients with knee osteoarthritis. The positive therapeutic effect of radiofrequency on genicular nerves has been reported in many previous studies . However, little is known about its effects on patients with intractable knee pain.
- Conditions
- Analgesia
- Being tested
- Laser genicular nerve ablation, Conventional radiofrequency genicular nerve ablation
- Medical subject headings
- Agnosia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Laser genicular nerve ablationProcedure or surgery
Ultrasoud guided Laser genicular nerve ablation for pain relief in knee osteoarthritis
Conventional radiofrequency genicular nerve ablationProcedure or surgery
Conventional radiofrequency genicular nerve ablation for pain relief in knee osteoarthritis
| Study group | Role | What they receive |
|---|---|---|
| Laser genicular nerve ablation | Active comparator | Laser genicular nerve ablation Using ultrasound Receives: Procedure: Laser genicular nerve ablation |
| Conventional Radiofrequency genicular nerve ablation | Active comparator | Conventional Radiofrequency genicular nerve ablation using ultrasound Receives: Procedure: Conventional radiofrequency genicular nerve ablation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Visual Analogue scale pain score
To assess pain intensity using Visual Analogue Scale score between laser and radiofrequency group with score 10 indicates worst pain and score 0 indicates no pain.
Measured: 24 hour
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Jul 2026
- Study startAug 2026 (estimated)
- Primary completionAug 2027 (estimated)
- Study completionSep 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AnalgesiaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Zagazig University
- Sponsor type
- Other government
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07700784
- Sponsor's protocol ID
- Analgesia
- Status last verified
- Jun 2026
- First submitted
- 8 Jul 2026
- Last updated
- 14 Jul 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 14 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Efficacy of Ultrasound Guided Laser Genicular Nerves Ablation Versus Conventional Radiofrequancy For Chronic Knee Osteoarthritis Pain
- ClinicalTrials.gov ID
- NCT07700784
- Acronym / sponsor ID
- Analgesia
- Conditions
- Analgesia
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- Zagazig UniversityOther government
- Study start
- Aug 2026 (estimated)
- Primary completion
- Aug 2027 (estimated)
- Study completion
- Sep 2027 (estimated)
- First posted
- 14 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Knee osteoarthritis is one of the most common causes of chronic pain and disability worldwide, particularly in middle-aged and elderly populations. It is characterised by progressive cartilage degeneration, subchondral bone remodelling, and synovial inflammation.
There were many trails to provide pain relief by using systemic opioids or Non steroidal anti inflammatory drugs (with side effects such as peptic ulcer and hepatic, renal impairment)
Detailed description
Knee osteoarthritis is one of the most common causes of chronic pain and disability worldwide, particularly in middle-aged and elderly populations. It is characterized by progressive cartilage degeneration, subchondral bone remodeling, and synovial inflammation.
There were many trails to provide pain relief by using systemic opioids or non steroidal anti inflammatory drugs (with side effects such as peptic ulcer and hepatic, renal impairment) In knee osteoarthritis .these nerves are believed to be sensitised, leading to increased pain signalling . This can result in chronic pain and discomfort in patients with knee osteoarthritis.
Radiofrequency targeting these nerves aims to provide pain relief by disrupting the pain signals transmitted through these nerves .
By selectively targeting the articular branches, these interventions can alleviate pain and improve the physical function and quality of life of patients with knee osteoarthritis. The positive therapeutic effect of radiofrequency on genicular nerves has been reported in many previous studies . However, little is known about its effects on patients with intractable knee pain.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Laser genicular nerve ablation | Active comparator | Procedure: Laser genicular nerve ablationLaser genicular nerve ablation Using ultrasound |
| Conventional Radiofrequency genicular nerve ablation | Active comparator | Procedure: Conventional radiofrequency genicular nerve ablationConventional Radiofrequency genicular nerve ablation using ultrasound |
Who may qualify
- Ages
- 40 to 75 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- American society of anesthesiologist's physical status class I, II- Body mass index (BMI): 18.5 - 29.9 kg/m2- Confirmation of knee OA on radiograph- Chronic knee pain ≥ 3 months.
Key exclusion criteria (1 listed)
- History of clinically significant cardiac, hepatic, renal or neurological disease- Allergy to study medication- Coagulopathy- Infection at injection site
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Laser genicular nerve ablationUltrasoud guided Laser genicular nerve ablation for pain relief in knee osteoarthritis | Procedure or surgery | Laser genicular nerve ablation |
| Conventional radiofrequency genicular nerve ablationConventional radiofrequency genicular nerve ablation for pain relief in knee osteoarthritis | Procedure or surgery | Conventional Radiofrequency genicular nerve ablation |
Primary outcome
Visual Analogue scale pain score
Time frame: 24 hour
To assess pain intensity using Visual Analogue Scale score between laser and radiofrequency group with score 10 indicates worst pain and score 0 indicates no pain.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Jul 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
A study testing Laser genicular nerve ablation and Conventional radiofrequency genicular nerve ablation in people with Analgesia, run by Zagazig University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 14 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Visual Analogue scale pain score (time frame: 24 hour). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Jul 2026.