Iron Deficiency AnaemiaBFR-IDANCT07701213
Blood Flow Restriction and Aerobic Exercise in Iron Deficiency Anemia
A study testing aerobic exercise + blood flow restriction and aerobic exercise in people with Iron Deficiency Anaemia, run by Cairo University.
Trial summary
Preventing iron deficiency anemia is essential for strengthening adolescent health and ensuring their full development. Strategies such as improving nutrition, expanding the availability of iron-fortified products, implementing pharmacological prevention, and raising awareness play a crucial role in addressing this… Read more about this study
- Who is it for?
- Ages 19 to 25 years
- Conditions the study is for
- Iron Deficiency Anaemia
- What is being tested?
- aerobic exercise + blood flow restriction and aerobic exercise
- Type of treatment
- Medical device, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- No sites listed yet
- Study dates
- 25 Jul 2026to 5 Nov 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 19 to 25 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Hb more than 8 and less than 12 in females.
- Age: 19-25 year.
- BMI ranging from 25 to 29.9 kg/m2.
- No existing inflammatory conditions including rheumatoid arthritis disorders of the lower extremities.
- Physical activity level less than 150 min per week
Who cannot join
- unstable hypertension, venous thromboembolism, hypercoagulable states, varicose veins, pregnancy, and hemophilia.
- inherited or acquired red cell disorders (haemoglobinopathies).
- acute or chronic infections (malaria, tuberculosis, HIV),.
- severe anemia (Hb <8 g/dL).
- History of cardiovascular diseases.
- Nutritional anemia (B12/folate)
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- Pregnancy.
- Peripheral arterial disease.
- Intermittent claudication.
- Non smokers
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Impact of Blood Flow Restriction on Hematological Factors in Anemic Young Females
Preventing iron deficiency anemia is essential for strengthening adolescent health and ensuring their full development. Strategies such as improving nutrition, expanding the availability of iron-fortified products, implementing pharmacological prevention, and raising awareness play a crucial role in addressing this issue.
Read the detailed description
Anemia is a global public health problem affecting both developing and developed countries at all ages, with major consequences for human health as well as social and economic burden. Iron deficiency affects more than 2 billion people world wide, and iron deficiency anemia (IDA) remains to be the top cause of anemia.
For decades, blood flow restriction (BFR), originating from Japan, has become one of the most popular techniques in physiotherapy. To perform the BFR technique, a controlled tourniquet is performed, generating a gradual mechanical pressure just below it, affecting blood flow (both arterial and venous) and generating a hypoxia in the restricted area. For the realization of the tourniquet, mechanical cuffs are used, which are inflated and regulate the pressure generated in the compression zone, although nylon or elastic cuffs are also used for the realization of the tourniquet.
- Conditions
- Iron Deficiency Anaemia
- Being tested
- aerobic exercise + blood flow restriction, aerobic exercise
- Keywords
- Iron Deficiency Anemia, blood flow restriction
- Medical subject headings
- Anemia, Iron-Deficiency
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
aerobic exercise + blood flow restrictionDevice
Twenty five females will be subjected to supervised blood flow restriction combined with aerobic exercise program. participated in 3 months exercise training protocol, which included three walking training sessions per week on a treadmill set at a speed 3 km/h. They experienced 3 session/week and each session include 5-10 minutes .A pressure of between 140 and 200 mmHg was applied using a sphygmomanometer cuff placed at the thigh of the BFR group. The pressure of the cuff was increased until the participants adapted to the restriction stimulus during the early phase of training, and this pressure was maintained used during the training protocol. The strap pressure was increased by 10 mmHg per week, such that it reached 200 mmHg by the end of 12th week. The pressure on the thigh strap was abruptly released after five completions of the exercise set.
aerobic exerciseProcedure or surgery
participated in 3 months exercise training protocol, which included three walking training sessions per week on a treadmill set at a speed 3 km/h. They experienced 3 session/week and each session include 5-10 minutes warming up and five training sets (each lasting 2 min) with a 1 min rest period between each exercise session and ended with 5-10 minutes cooling down.
| Study group | Role | What they receive |
|---|---|---|
| Aerobic Exercise + Blood Flow Restriction | Experimental | 25 female will receive blood flow restriction with low intensity aerobic exercise participated in 3 months exercise training protocol, which included three walking training sessions per week on a treadmill set at a speed 3 km/h. They experienced 3 session/week and each session include 5-10 minutes warming up and five training sets (each lasting 2 min) with a 1 min rest period between each exercise session and ended with 5-10 minutes cooling down A pressure of between 140 and 200 mmHg was applied using a sphygmomanometer cuff placed at the thigh of the BFR group. Receives: Device: aerobic exercise + blood flow restriction |
| Aerobic Exercise | Active comparator | 25 subject participated in 3 months exercise training protocol, which included three walking training sessions per week on a treadmill set at a speed 3 km/h. They experienced 3 session/week and each session include 5-10 minutes warming up and five training sets (each lasting 2 min) with a 1 min rest period between each exercise session and ended with 5-10 minutes cooling down. Receives: Procedure: aerobic exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
haemoglobin concentration
Measured: Baseline and 12 weeks
Serum ferritin level
Measured: Baseline and at 12 weeks
Haematocrit
Measured: Baseline and at 12 weeks
Red blood cell (RBC) count
Measured: baseline and at 12 week
Mean corpuscular volume (MCV)
Measured: baseline and at 12 week
Mean corpuscular haemoglobin (MCH)
Measured: baseline and at 12 week
Secondary outcomes (3)
Functional capacity assessed using the Incremental Shuttle Walk Test (ISWT)
Measured: baseline and at 12 week
Quality of life assessed using the SF-36 questionnaire
Measured: baseline and at 12 week
Estimated maximal oxygen consumption (VO₂max) derived from the ISWT
Measured: baseline and at 12 week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Jul 2026
- Study start25 Jul 2026 (estimated)
- Primary completion30 Oct 2026 (estimated)
- Study completion5 Nov 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Iron Deficiency AnaemiaStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, noha sameh, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07701213
- Sponsor's protocol ID
- P.T.REC/012/006440
- Other IDs
- P.T.REC/012/006440
- Acronym
- BFR-IDA
- Status last verified
- Jul 2026
- First submitted
- 2 Jul 2026
- Last updated
- 14 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 14 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Impact of Blood Flow Restriction on Hematological Factors in Anemic Young Females
- ClinicalTrials.gov ID
- NCT07701213
- Acronym / sponsor ID
- BFR-IDA / P.T.REC/012/006440
- Conditions
- Iron Deficiency Anaemia
- Keywords
- Iron Deficiency Anemia, blood flow restriction
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 25 Jul 2026 (estimated)
- Primary completion
- 30 Oct 2026 (estimated)
- Study completion
- 5 Nov 2026 (estimated)
- First posted
- 14 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Preventing iron deficiency anemia is essential for strengthening adolescent health and ensuring their full development. Strategies such as improving nutrition, expanding the availability of iron-fortified products, implementing pharmacological prevention, and raising awareness play a crucial role in addressing this issue.
Detailed description
Anemia is a global public health problem affecting both developing and developed countries at all ages, with major consequences for human health as well as social and economic burden. Iron deficiency affects more than 2 billion people world wide, and iron deficiency anemia (IDA) remains to be the top cause of anemia.
For decades, blood flow restriction (BFR), originating from Japan, has become one of the most popular techniques in physiotherapy. To perform the BFR technique, a controlled tourniquet is performed, generating a gradual mechanical pressure just below it, affecting blood flow (both arterial and venous) and generating a hypoxia in the restricted area. For the realization of the tourniquet, mechanical cuffs are used, which are inflated and regulate the pressure generated in the compression zone, although nylon or elastic cuffs are also used for the realization of the tourniquet.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Aerobic Exercise + Blood Flow Restriction | Experimental | Device: aerobic exercise + blood flow restriction25 female will receive blood flow restriction with low intensity aerobic exercise participated in 3 months exercise training protocol, which included three walking training sessions per week on a treadmill set at a speed 3 km/h. They experienced 3 session/week and each session include 5-10 minutes warming up and five training sets (each lasting 2 min) with a 1 min rest period between each exercise session and ended with 5-10 minutes cooling down A pressure of between 140 and 200 mmHg was applied using a sphygmomanometer cuff placed at the thigh of the BFR group. |
| Aerobic Exercise | Active comparator | Procedure: aerobic exercise25 subject participated in 3 months exercise training protocol, which included three walking training sessions per week on a treadmill set at a speed 3 km/h. They experienced 3 session/week and each session include 5-10 minutes warming up and five training sets (each lasting 2 min) with a 1 min rest period between each exercise session and ended with 5-10 minutes cooling down. |
Who may qualify
- Ages
- 19 to 25 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Hb more than 8 and less than 12 in females.
- Age: 19-25 year.
- BMI ranging from 25 to 29.9 kg/m2.
- No existing inflammatory conditions including rheumatoid arthritis disorders of the lower extremities.
- Physical activity level less than 150 min per week
Key exclusion criteria (10 listed)
- unstable hypertension, venous thromboembolism, hypercoagulable states, varicose veins, pregnancy, and hemophilia.
- inherited or acquired red cell disorders (haemoglobinopathies).
- acute or chronic infections (malaria, tuberculosis, HIV),.
- severe anemia (Hb <8 g/dL).
- History of cardiovascular diseases.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| aerobic exercise + blood flow restrictionTwenty five females will be subjected to supervised blood flow restriction combined with aerobic exercise program. participated in 3 months exercise training protocol, which included three walking training sessions per week on a treadmill set at a speed 3 km/h. They experienced 3 session/week and each session include 5-10 minutes .A pressure of between 140 and 200 mmHg was applied using a sphygmomanometer cuff placed at the thigh of the BFR group. The pressure of the cuff was increased until the participants adapted to the restriction stimulus during the early phase of training, and this pressure was maintained used during the training protocol. The strap pressure was increased by 10 mmHg per week, such that it reached 200 mmHg by the end of 12th week. The pressure on the thigh strap was abruptly released after five completions of the exercise set. | Device | Aerobic Exercise + Blood Flow Restriction |
| aerobic exerciseparticipated in 3 months exercise training protocol, which included three walking training sessions per week on a treadmill set at a speed 3 km/h. They experienced 3 session/week and each session include 5-10 minutes warming up and five training sets (each lasting 2 min) with a 1 min rest period between each exercise session and ended with 5-10 minutes cooling down. | Procedure or surgery | Aerobic Exercise |
Primary outcome
haemoglobin concentration
Time frame: Baseline and 12 weeks
Serum ferritin level
Time frame: Baseline and at 12 weeks
Haematocrit
Time frame: Baseline and at 12 weeks
Red blood cell (RBC) count
Time frame: baseline and at 12 week
Mean corpuscular volume (MCV)
Time frame: baseline and at 12 week
Mean corpuscular haemoglobin (MCH)
Time frame: baseline and at 12 week
3 secondary outcomes
Functional capacity assessed using the Incremental Shuttle Walk Test (ISWT)
Time frame: baseline and at 12 week
Quality of life assessed using the SF-36 questionnaire
Time frame: baseline and at 12 week
Estimated maximal oxygen consumption (VO₂max) derived from the ISWT
Time frame: baseline and at 12 week
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Jul 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing aerobic exercise + blood flow restriction and aerobic exercise in people with Iron Deficiency Anaemia, run by Cairo University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 14 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact noha sameh donia, assisstant lecturer (01275600448, nohasameh92.ns@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
haemoglobin concentration (time frame: Baseline and 12 weeks). The study lists 6 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Jul 2026.