Dermatochalasis of Upper EyelidCOMPRESS-BLEPHNCT07701265
Does Unilateral Compression Dressing Reduce Postoperative Swelling and Bruising After Upper Eyelid Blepharoplasty?
A study testing Compression Dressing (CD) and No Dressing (Standard Postoperative Care) in people with Dermatochalasis of Upper Eyelid, run by Fatma Poslu Karademir at 1 site in Turkey (Türkiye).
Trial summary
This study evaluated whether applying a compression dressing to one eyelid after upper eyelid blepharoplasty (eyelid lift surgery) reduces swelling, bruising, and discomfort compared to the untreated eyelid. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Dermatochalasis of Upper Eyelid
- What is being tested?
- Compression Dressing (CD) and No Dressing (Standard Postoperative Care)
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 56 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 23 Jun 2025to 28 Nov 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Adult patients (≥18 years) with bilateral upper eyelid dermatochalasis scheduled for upper eyelid blepharoplasty
- Willingness and ability to provide written informed consent
- Ability to comply with the postoperative follow-up schedule (postoperative days 1, 7, 30, and 90)
Who cannot join
- History of prior upper eyelid surgery
- Unilateral dermatochalasis
- Previous eyelid trauma
- Congenital eyelid anomalies
- Blepharochalasis syndrome
- Coagulopathy
- Combined indication for ptosis repair and blepharoplasty
- Severe bilateral visual impairment precluding safe application of compression dressing
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Beyoglu Eye Training and Research Hospital
Istanbul, Istanbul, 34421
About this study
Official title: The Effect of Compression Dressing on Postoperative Outcomes After Upper Eyelid Blepharoplasty: A Randomized, Controlled, Observer-Blinded Evaluation Study
This study evaluated whether applying a compression dressing to one eyelid after upper eyelid blepharoplasty (eyelid lift surgery) reduces swelling, bruising, and discomfort compared to the untreated eyelid. In this randomized trial, each participant underwent bilateral upper eyelid blepharoplasty; after surgery, one eyelid was randomly assigned to receive a compression dressing for 24 hours, while the other eyelid received no dressing and served as the internal control. Outcomes including eyelid swelling, bruising, pain, aesthetic appearance, and corneal health were assessed by masked observers on postoperative days 1, 7, 30, and 90. The goal of this study was to determine whether routine use of compression dressing provides a measurable clinical benefit after this common cosmetic and functional eyelid surgery.
Read the detailed description
This was a prospective, randomized, controlled, observer-masked, within-subject (split-eye) trial conducted at a single academic center between June and November 2025. Adult patients with bilateral dermatochalasis scheduled for upper eyelid blepharoplasty were enrolled. Following bilateral surgery performed by a single surgeon, one eyelid of each patient was randomly assigned by coin toss to receive a compression dressing (folded sterile gauze secured with elastic tape, left in place for 24 hours), while the contralateral eyelid received no dressing and served as the internal control. All patients received standardized postoperative care, including bilateral cold compresses and topical medications.
Two masked investigators independently assessed postoperative edema (5-point ordinal scale), ecchymosis (ImageJ-based area quantification), and aesthetic outcome (Global Aesthetic Improvement Scale) from standardized clinical photographs obtained on postoperative days 1, 7, 30, and 90; disagreements were resolved by a third masked investigator. Postoperative pain (visual analog scale) and patient comfort preference were recorded on day 1. Best corrected visual acuity and corneal fluorescein staining (Oxford grading scale) were assessed at each follow-up visit to evaluate ocular surface safety. Between-group comparisons were performed using the Wilcoxon signed-rank test, with Holm-Bonferroni correction applied across outcomes at each visit to account for multiple comparisons.
- Conditions
- Dermatochalasis of Upper Eyelid
- Being tested
- Compression Dressing (CD), No Dressing (Standard Postoperative Care)
- Keywords
- Upper eyelid blepharoplasty, Compression dressing, Postoperative edema, Postoperative ecchymosis, Split-eye design, Eyelid surgery
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Compression Dressing (CD)Procedure or surgery
A compression dressing consisting of folded sterile gauze pads followed by a dry gauze layer, secured with elastic tape (Clivex®, Climed Healthcare, Türkiye), applied to one upper eyelid immediately after bilateral upper eyelid blepharoplasty and left in place for 24 hours. The contralateral eyelid remained uncovered and undressed, serving as the internal control.
No Dressing (Standard Postoperative Care)Procedure or surgery
The contralateral upper eyelid received standard postoperative care without a compression dressing, remaining uncovered. All other postoperative treatments (topical antibiotic ointment, cooling protocol, medications) were identical to the compression dressing side.
| Study group | Role | What they receive |
|---|---|---|
| Compression Dressing (CD) | Experimental | Upper eyelid randomly assigned to receive a compression dressing (folded sterile gauze secured with elastic tape) for 24 hours after surgery. Receives: Procedure: Compression Dressing (CD) |
| No Dressing (ND) | Active comparator | Contralateral upper eyelid receiving standard postoperative care without compression dressing, serving as the internal control. Receives: Procedure: No Dressing (Standard Postoperative Care) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Postoperative eyelid edema
Standardized clinical photographs assessed by masked observers using a 5-point ordinal edema grading scale.
Measured: Postoperative day 1, postoperative day 7, postoperative day 30, postoperative day 90
Postoperative ecchymosis
Standardized clinical photographs analysed using ImageJ software and graded by masked observers.
Measured: Postoperative day 1, postoperative day 7, postoperative day 30, postoperative day 90
Secondary outcomes (5)
Postoperative pain
Visual analogue scale (0-10)
Measured: Postoperative day 1
Patient comfort
Patient questionnaire comparing comfort between the compression dressing and control eyelids.
Measured: Postoperative day 1
Corneal staining
Fluorescein staining graded according to the Oxford grading scale.
Measured: Postoperative days 1, 7, 30 and 90
Global aesthetic improvement
Global Aesthetic Improvement Scale assessed by masked observers using standardized clinical photographs.
Measured: Postoperative days 1, 7, 30 and 90
Best corrected visual acuity
Best corrected visual acuity measured in logarithm of the minimum angle of resolution units.
Measured: Baseline, postoperative days 1, 7, 30 and 90
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Jul 2026
- Study start23 Jun 2025
- Primary completion28 Nov 2025
- Study completion28 Nov 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Dermatochalasis of Upper EyelidStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- This study used a within-participant, split-eye design rather than a traditional temporal crossover. Each patient's two upper eyelids were simultaneously and randomly allocated (by coin toss) to receive either compression dressing or no dressing during the same surgical session, with the contralateral eyelid serving as the internal control, rather than each participant receiving both interventions sequentially over time.
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 56 participants (actual)
Sponsor and investigators
- Lead sponsor
- Fatma Poslu Karademir
- Sponsor type
- Other government
- Responsible party
- Sponsor-investigator, Fatma Poslu Karademir, Beyoglu Eye Research and Education Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07701265
- Sponsor's protocol ID
- BLF-25-01
- Acronym
- COMPRESS-BLEPH
- Status last verified
- Jul 2026
- First submitted
- 8 Jul 2026
- Last updated
- 14 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Poslu Karademir F, Sagdic Ozcelik S, Cetin Efe A, Ulas MG, Diri I, Taskapili M. The effect of compression dressing on postoperative outcomes after upper eyelid blepharoplasty: a randomized, controlled, observer-blinded evaluation study. Int Ophthalmol. 2026 Sep 9;46(1):382. doi: 10.1007/s10792-026-04233-1.
PubMed 42711437
Study at a glance
From the registry record, last updated by the sponsor on 14 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Compression Dressing on Postoperative Outcomes After Upper Eyelid Blepharoplasty: A Randomized, Controlled, Observer-Blinded Evaluation Study
- ClinicalTrials.gov ID
- NCT07701265
- Acronym / sponsor ID
- COMPRESS-BLEPH / BLF-25-01
- Conditions
- Dermatochalasis of Upper Eyelid
- Keywords
- Upper eyelid blepharoplasty, Compression dressing, Postoperative edema, Postoperative ecchymosis, Split-eye design, Eyelid surgery
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 56 participants (actual)
- Lead sponsor
- Fatma Poslu KarademirOther government
- Study start
- 23 Jun 2025 (actual)
- Primary completion
- 28 Nov 2025 (actual)
- Study completion
- 28 Nov 2025 (actual)
- First posted
- 14 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study evaluated whether applying a compression dressing to one eyelid after upper eyelid blepharoplasty (eyelid lift surgery) reduces swelling, bruising, and discomfort compared to the untreated eyelid. In this randomized trial, each participant underwent bilateral upper eyelid blepharoplasty; after surgery, one eyelid was randomly assigned to receive a compression dressing for 24 hours, while the other eyelid received no dressing and served as the internal control. Outcomes including eyelid swelling, bruising, pain, aesthetic appearance, and corneal health were assessed by masked observers on postoperative days 1, 7, 30, and 90. The goal of this study was to determine whether routine use of compression dressing provides a measurable clinical benefit after this common cosmetic and functional eyelid surgery.
Detailed description
This was a prospective, randomized, controlled, observer-masked, within-subject (split-eye) trial conducted at a single academic center between June and November 2025. Adult patients with bilateral dermatochalasis scheduled for upper eyelid blepharoplasty were enrolled. Following bilateral surgery performed by a single surgeon, one eyelid of each patient was randomly assigned by coin toss to receive a compression dressing (folded sterile gauze secured with elastic tape, left in place for 24 hours), while the contralateral eyelid received no dressing and served as the internal control. All patients received standardized postoperative care, including bilateral cold compresses and topical medications.
Two masked investigators independently assessed postoperative edema (5-point ordinal scale), ecchymosis (ImageJ-based area quantification), and aesthetic outcome (Global Aesthetic Improvement Scale) from standardized clinical photographs obtained on postoperative days 1, 7, 30, and 90; disagreements were resolved by a third masked investigator. Postoperative pain (visual analog scale) and patient comfort preference were recorded on day 1. Best corrected visual acuity and corneal fluorescein staining (Oxford grading scale) were assessed at each follow-up visit to evaluate ocular surface safety. Between-group comparisons were performed using the Wilcoxon signed-rank test, with Holm-Bonferroni correction applied across outcomes at each visit to account for multiple comparisons.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- This study used a within-participant, split-eye design rather than a traditional temporal crossover. Each patient's two upper eyelids were simultaneously and randomly allocated (by coin toss) to receive either compression dressing or no dressing during the same surgical session, with the contralateral eyelid serving as the internal control, rather than each participant receiving both interventions sequentially over time.
| Arm | Type | Receives |
|---|---|---|
| Compression Dressing (CD) | Experimental | Procedure: Compression Dressing (CD)Upper eyelid randomly assigned to receive a compression dressing (folded sterile gauze secured with elastic tape) for 24 hours after surgery. |
| No Dressing (ND) | Active comparator | Procedure: No Dressing (Standard Postoperative Care)Contralateral upper eyelid receiving standard postoperative care without compression dressing, serving as the internal control. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Adult patients (≥18 years) with bilateral upper eyelid dermatochalasis scheduled for upper eyelid blepharoplasty
- Willingness and ability to provide written informed consent
- Ability to comply with the postoperative follow-up schedule (postoperative days 1, 7, 30, and 90)
Key exclusion criteria (8 listed)
- History of prior upper eyelid surgery
- Unilateral dermatochalasis
- Previous eyelid trauma
- Congenital eyelid anomalies
- Blepharochalasis syndrome
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Compression Dressing (CD)A compression dressing consisting of folded sterile gauze pads followed by a dry gauze layer, secured with elastic tape (Clivex®, Climed Healthcare, Türkiye), applied to one upper eyelid immediately after bilateral upper eyelid blepharoplasty and left in place for 24 hours. The contralateral eyelid remained uncovered and undressed, serving as the internal control. | Procedure or surgery | Compression Dressing (CD) |
| No Dressing (Standard Postoperative Care)The contralateral upper eyelid received standard postoperative care without a compression dressing, remaining uncovered. All other postoperative treatments (topical antibiotic ointment, cooling protocol, medications) were identical to the compression dressing side. | Procedure or surgery | No Dressing (ND) |
Primary outcome
Postoperative eyelid edema
Time frame: Postoperative day 1, postoperative day 7, postoperative day 30, postoperative day 90
Standardized clinical photographs assessed by masked observers using a 5-point ordinal edema grading scale.
Postoperative ecchymosis
Time frame: Postoperative day 1, postoperative day 7, postoperative day 30, postoperative day 90
Standardized clinical photographs analysed using ImageJ software and graded by masked observers.
5 secondary outcomes
Postoperative pain
Time frame: Postoperative day 1
Patient comfort
Time frame: Postoperative day 1
Corneal staining
Time frame: Postoperative days 1, 7, 30 and 90
Global aesthetic improvement
Time frame: Postoperative days 1, 7, 30 and 90
Best corrected visual acuity
Time frame: Baseline, postoperative days 1, 7, 30 and 90
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Jul 2026.
- Derived from this study: PubMed 42711437Poslu Karademir F, Sagdic Ozcelik S, Cetin Efe A, Ulas MG, Diri I, Taskapili M. The effect of compression dressing on postoperative outcomes after upper eyelid blepharoplasty: a randomized, controlled, observer-blinded evaluation study. Int Ophthalmol. 2026 Sep 9;46(1):382. doi: 10.1007/s10792-026-04233-1.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Compression Dressing (CD) and No Dressing (Standard Postoperative Care) in people with Dermatochalasis of Upper Eyelid, run by Fatma Poslu Karademir at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 14 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Postoperative eyelid edema (time frame: Postoperative day 1, postoperative day 7, postoperative day 30, postoperative day 90). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07701265, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Jul 2026.