Obesity & OverweightNCT07705724
Effect Of Whole or Skimmed Milk Greek Yogurt on Integrated Muscle Protein Synthesis, Glucose Homeostasis, and Cognition in Post-Menopausal Women
A study testing Skimmed vs Whole Milk Greek Yogurt in people with Obesity & Overweight and Women, run by University of Arkansas at 1 site in United States.
Trial summary
The study will examine the impact of adding two servings per day of skimmed or whole milk Greek yogurt on integrated muscle protein synthesis (iMPS), blood sugar control, and cognition in post-menopausal women with overweight and obesity. Read more about this study
- Who is it for?
- Ages 50 to 65 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- Obesity & Overweight, Women, Menopause
- What is being tested?
- Skimmed vs Whole Milk Greek Yogurt
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Oct 2026to 1 Apr 2029
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 to 65 years
- Women only
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Aged 50 to 65 years
- Body mass index ≥25 to <40 kg/m2 or body fat ≥36%
- Able to provide informed consent
- Absence of menstruation for ≥12 months without the use of hormonal contraceptives, or one of the following:
- Another medical cause of menopause e.g., history of bilateral oophorectomy
- Clinician-confirmed menopausal status for those with hysterectomy and retained/unknown ovaries
- Partial/total hysterectomy ≥12 months ago and current age ≥55 years
Who cannot join
- Allergy or intolerance to dairy products (other allergies or intolerances may be excluded if they are not compatible with the study meals and how they are prepared)
- Conditions, medications, or recent changes in medications that cause participants to be metabolically unstable (e.g., renal, cardiovascular, thyroid, polycystic ovary syndrome, type-1 and type-2 diabetes)
- Gastric bypass/bariatric surgery in the previous 5 years
- Pregnancy or nursing in the prior 12 months
- Weight loss or gain >5 kg in the last two months
- Unable or unwilling to suspend use of blood thinning medications and non-steroidal anti-inflammatory drugs for the duration of the study
Show all 9Show fewer
- Unwilling to abstain from vigorous exercise for the study period
- Does not or will not eat all foods on the standardized diet (e.g., allergies, intolerances, or taste preferences)
- Participants may be excluded at the Principal Investigator's discretion if their health or body composition is not compatible with the required study procedures
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site
University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205
David D Church, PhD, 501-526-5769, dchurch@uams.edu
About this study
Official title: Effect Of Whole or Skimmed Milk Greek Yogurt on Integrated Muscle Protein Synthesis, Glucose Homeostasis, And Cognition in Post-Menopausal Women
The study will examine the impact of adding two servings per day of skimmed or whole milk Greek yogurt on integrated muscle protein synthesis (iMPS), blood sugar control, and cognition in post-menopausal women with overweight and obesity.
- Conditions
- Obesity & Overweight, Women, Menopause
- Being tested
- Skimmed vs Whole Milk Greek Yogurt
- Keywords
- Muscle Protein Synthesis, Protein Turnover, Glycemic Control, Cognition, Post-Menopause, Women, Protein, Dairy
- Medical subject headings
- Obesity, Overweight
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Skimmed vs Whole Milk Greek YogurtOther
Participants will be randomized to receive a standardized diet with either skimmed milk or whole milk Greek yogurt.
| Study group | Role | What they receive |
|---|---|---|
| Skimmed Milk Greek Yogurt | Active comparator | Participants will consume two servings per day of skimmed milk Greek yogurt. Receives: Other: Skimmed vs Whole Milk Greek Yogurt |
| Whole Milk Greek Yogurt | Active comparator | Participants will consume two servings per day of whole milk Greek yogurt. Receives: Other: Skimmed vs Whole Milk Greek Yogurt |
What is being measured
The primary outcome is the main question the study is designed to answer.
Integrated Muscle Protein Synthesis (iMPS)
Integrated muscle protein synthesis expressed as the fractional synthetic rate (%/day).
Measured: 1 week
Secondary outcomes (1)
Glucose Homeostasis
Mean glucose and mean amplitude of glucose excursions (MAGE) as determined from continuous glucose monitors (CGMs) (mg/dL).
Measured: 1 week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Jul 2026
- Study start1 Oct 2026 (estimated)
- Primary completion1 Oct 2028 (estimated)
- Study completion1 Apr 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Obesity & OverweightStudies of the same condition, open and under way.
- More trials run by University of ArkansasThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Arkansas
- Sponsor type
- University, hospital or other
- Collaborators
- National Dairy Council
- Responsible party
- Sponsor
- Investigators
- David D Church, PhD, Principal investigator, University of Arkansas
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07705724
- Sponsor's protocol ID
- 300136
- Status last verified
- Jul 2026
- First submitted
- 7 Jul 2026
- Last updated
- 30 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 30 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect Of Whole or Skimmed Milk Greek Yogurt on Integrated Muscle Protein Synthesis, Glucose Homeostasis, And Cognition in Post-Menopausal Women
- ClinicalTrials.gov ID
- NCT07705724
- Acronym / sponsor ID
- 300136
- Conditions
- Obesity & Overweight, Women, Menopause
- Keywords
- Muscle Protein Synthesis, Protein Turnover, Glycemic Control, Cognition, Post-Menopause, Women, Protein, Dairy
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- University of ArkansasUniversity, hospital or other
- Collaborators
- National Dairy Council
- Study start
- 1 Oct 2026 (estimated)
- Primary completion
- 1 Oct 2028 (estimated)
- Study completion
- 1 Apr 2029 (estimated)
- First posted
- 15 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The study will examine the impact of adding two servings per day of skimmed or whole milk Greek yogurt on integrated muscle protein synthesis (iMPS), blood sugar control, and cognition in post-menopausal women with overweight and obesity.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Skimmed Milk Greek Yogurt | Active comparator | Other: Skimmed vs Whole Milk Greek YogurtParticipants will consume two servings per day of skimmed milk Greek yogurt. |
| Whole Milk Greek Yogurt | Active comparator | Other: Skimmed vs Whole Milk Greek YogurtParticipants will consume two servings per day of whole milk Greek yogurt. |
Who may qualify
- Ages
- 50 to 65 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (7 listed)
- Aged 50 to 65 years
- Body mass index ≥25 to <40 kg/m2 or body fat ≥36%
- Able to provide informed consent
- Absence of menstruation for ≥12 months without the use of hormonal contraceptives, or one of the following:
Key exclusion criteria (9 listed)
- Allergy or intolerance to dairy products (other allergies or intolerances may be excluded if they are not compatible with the study meals and how they are prepared)
- Conditions, medications, or recent changes in medications that cause participants to be metabolically unstable (e.g., renal, cardiovascular, thyroid, polycystic ovary syndrome, type-1 and type-2 diabetes)
- Gastric bypass/bariatric surgery in the previous 5 years
- Pregnancy or nursing in the prior 12 months
- Weight loss or gain >5 kg in the last two months
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Skimmed vs Whole Milk Greek YogurtParticipants will be randomized to receive a standardized diet with either skimmed milk or whole milk Greek yogurt. | Other | Skimmed Milk Greek Yogurt, Whole Milk Greek Yogurt |
Primary outcome
Integrated Muscle Protein Synthesis (iMPS)
Time frame: 1 week
Integrated muscle protein synthesis expressed as the fractional synthetic rate (%/day).
1 secondary outcome
Glucose Homeostasis
Time frame: 1 week
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Jul 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
David D Church, PhD principal investigator
University of Arkansas
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Skimmed vs Whole Milk Greek Yogurt in people with Obesity & Overweight and Women, run by University of Arkansas at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 30 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact David D. Church, PhD (501-526-5769, dchurch@uams.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Integrated Muscle Protein Synthesis (iMPS) (time frame: 1 week). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Jul 2026.