Colorectal CancerNCT07708415
The Correlation of Postoperative Polyp Recurrence and Colorectal Cancer
An observational study of Colorectal Cancer and Polyps, run by Gansu Provincial Hospital at 1 site in China.
Trial summary
Postoperative endoscopic polyp recurrence correlation of colorectal cancer: a retrospective cohort open-label study Read more about this study
- Who is it for?
- Ages 18 to 80 years
- Conditions the study is for
- Colorectal Cancer, Polyps
- What is being tested?
- Endoscopic polypectomy
- Type of treatment
- Surgery or procedure
- How many people
- 3,000 participants
- Where
- 1 siteChina
- Study dates
- 1 Jul 2026to 31 Dec 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Patients who underwent radical surgery for colon cancer at Gansu Provincial People's Hospital from January 2015 to December 2024 and regularly completed colonoscopy follow-up after surgery were selected as the research subjects.After the completion of the prediction model construction, we will include 3-5 external queues for external validation.
Who may be able to join
- Patients who underwent radical surgery for colon cancer at Gansu Provincial People's Hospital from January 2015 to December 2024 and regularly completed colonoscopy follow-up after surgery were selected as the research subjects. Inclusion criteria:
- Diagnosed with colon cancer through histopathological examination ; Undergoing radical R0 resection ； Complete Colonoscopy follow-up after surgery less than 12 months.
Who cannot join
- With adenomatous polyposis , Lynch syndrome and Peutz-Jeghers syndrome； Combined inflammatory bowel disease; Polyp were present before surgery and have not been completely removed； With distant metastasis or local recurrence； Clinical data is missing and can not be analyzed.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
China1 site
Gansu provincial hospital
Lanzhou, Gansu, 730000
Xu Zhang, M.D., +8613919497484, xzhang2019@lzu.edu.cn
About this study
Official title: Postoperative Endoscopic Polyp Recurrence Correlation With Pathological Status Classification of Colorectal Cancer: a Multicenter, Retrospective Cohort Open-label Study
Postoperative endoscopic polyp recurrence correlation of colorectal cancer: a retrospective cohort open-label study
Read the detailed description
This study aims to address the gaps in existing research by focusing on the high-risk group of colorectal cancer patients post-radical surgery, systematically reviewing potential factors influencing polyp recurrence, further clarifying independent risk factors for postoperative polyp recurrence in this population, and constructing a predictive model that better aligns with the clinical needs of such patients, thereby providing more precise references for developing personalized follow-up strategies in clinical practice.
- Conditions
- Colorectal Cancer, Polyps
- Being tested
- Endoscopic polypectomy
- Keywords
- Colorectal Cancer, Polyp recurrence, Pathomics, Prognostic model
- Medical subject headings
- Colorectal Neoplasms, Polyps
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Endoscopic polypectomyProcedure or surgery
Endoscopic polypectomy
| Study group | Role | What they receive |
|---|---|---|
| Postoperative endoscopic polyp recurrence of colorectal cancer | Corhort of colorectal cancer patients undergoing colonoscopy follow-up after surgery Receives: Procedure: Endoscopic polypectomy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Adenoma recurrence after colorectal surgery
Postoperative colonoscopy review of colorectal cancer patients reveals adenoma recurrence
Measured: Postoperative；follow up till 5 years
Colitisafter colorectal surgery
Postoperative colonoscopy review of colorectal cancer patients reveals adenoma recurrence
Measured: Postoperative；follow up till 5 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Jul 2026
- Study start1 Jul 2026 (estimated)
- Primary completion31 Dec 2026 (estimated)
- Study completion31 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Colorectal CancerStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 3,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Gansu Provincial Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Xu Zhang, Gansu Provincial Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07708415
- Sponsor's protocol ID
- Colorectal cancer and polyp
- Status last verified
- Jul 2026
- First submitted
- 3 Jul 2026
- Last updated
- 16 Jul 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Galjart B, Hoppener DJ, Aerts JGJV, Bangma CH, Verhoef C, Grunhagen DJ. Follow-up strategy and survival for five common cancers: A meta-analysis. Eur J Cancer. 2022 Oct;174:185-199. doi: 10.1016/j.ejca.2022.07.025. Epub 2022 Aug 27.
PubMed 36037595IJspeert JEG, Bretthauer M, Jover R, Dekker E; Dutch colonoscopy surveillance working group. Balancing benefit and burden: rethinking post-polypectomy colonoscopy surveillance strategies. Lancet Gastroenterol Hepatol. 2026 Aug;11(8):720-726. doi: 10.1016/S2468-1253(26)00128-7. Epub 2026 Jun 19.
PubMed 42320508Ebert MP, Reichermeier S, Klug L, Lynen Jansen P, Pox C. Clinical Practice Guideline: Colorectal Cancer-Diagnosis, Treatment, Prevention, and Long-Term Follow-Up Care. Dtsch Arztebl Int. 2025 Dec 26;122(26):729-734. doi: 10.3238/arztebl.m2025.0196. Epub 2025 Dec 26.
PubMed 41195479Laven-Law G, Symonds EL, Simpson K, Coats M, De Silva M, Hollington P, Cock C, Wassie MM. Risk of Advanced Colorectal Neoplasia at Follow-up Colonoscopy After Synchronous Adenoma and Clinically Significant Serrated Polyp. Clin Gastroenterol Hepatol. 2026 Feb;24(2):544-553. doi: 10.1016/j.cgh.2025.07.023. Epub 2025 Aug 5.
PubMed 40774589
Study at a glance
From the registry record, last updated by the sponsor on 16 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Postoperative Endoscopic Polyp Recurrence Correlation With Pathological Status Classification of Colorectal Cancer: a Multicenter, Retrospective Cohort Open-label Study
- ClinicalTrials.gov ID
- NCT07708415
- Acronym / sponsor ID
- Colorectal cancer and polyp
- Conditions
- Colorectal Cancer, Polyps
- Keywords
- Colorectal Cancer, Polyp recurrence, Pathomics, Prognostic model
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 3,000 participants (estimated)
- Lead sponsor
- Gansu Provincial HospitalUniversity, hospital or other
- Study start
- 1 Jul 2026 (estimated)
- Primary completion
- 31 Dec 2026 (estimated)
- Study completion
- 31 Dec 2026 (estimated)
- First posted
- 16 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Postoperative endoscopic polyp recurrence correlation of colorectal cancer: a retrospective cohort open-label study
Detailed description
This study aims to address the gaps in existing research by focusing on the high-risk group of colorectal cancer patients post-radical surgery, systematically reviewing potential factors influencing polyp recurrence, further clarifying independent risk factors for postoperative polyp recurrence in this population, and constructing a predictive model that better aligns with the clinical needs of such patients, thereby providing more precise references for developing personalized follow-up strategies in clinical practice.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Postoperative endoscopic polyp recurrence of colorectal cancer | – | Procedure: Endoscopic polypectomyCorhort of colorectal cancer patients undergoing colonoscopy follow-up after surgery |
Who may qualify
- Ages
- 18 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Patients who underwent radical surgery for colon cancer at Gansu Provincial People's Hospital from January 2015 to December 2024 and regularly completed colonoscopy follow-up after surgery were selected as the research subjects.After the completion of the prediction model construction, we will include 3-5 external queues for external validation.
Key inclusion criteria (2 listed)
- Patients who underwent radical surgery for colon cancer at Gansu Provincial People's Hospital from January 2015 to December 2024 and regularly completed colonoscopy follow-up after surgery were selected as the research subjects. Inclusion criteria:
- Diagnosed with colon cancer through histopathological examination ; Undergoing radical R0 resection ； Complete Colonoscopy follow-up after surgery less than 12 months.
Key exclusion criteria (1 listed)
- With adenomatous polyposis , Lynch syndrome and Peutz-Jeghers syndrome； Combined inflammatory bowel disease; Polyp were present before surgery and have not been completely removed； With distant metastasis or local recurrence； Clinical data is missing and can not be analyzed.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Endoscopic polypectomyEndoscopic polypectomy | Procedure or surgery | Postoperative endoscopic polyp recurrence of colorectal cancer |
Primary outcome
Adenoma recurrence after colorectal surgery
Time frame: Postoperative；follow up till 5 years
Postoperative colonoscopy review of colorectal cancer patients reveals adenoma recurrence
Colitisafter colorectal surgery
Time frame: Postoperative；follow up till 5 years
Postoperative colonoscopy review of colorectal cancer patients reveals adenoma recurrence
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Jul 2026.
- Background: PubMed 36037595Galjart B, Hoppener DJ, Aerts JGJV, Bangma CH, Verhoef C, Grunhagen DJ. Follow-up strategy and survival for five common cancers: A meta-analysis. Eur J Cancer. 2022 Oct;174:185-199. doi: 10.1016/j.ejca.2022.07.025. Epub 2022 Aug 27.
- Results publication: PubMed 42320508IJspeert JEG, Bretthauer M, Jover R, Dekker E; Dutch colonoscopy surveillance working group. Balancing benefit and burden: rethinking post-polypectomy colonoscopy surveillance strategies. Lancet Gastroenterol Hepatol. 2026 Aug;11(8):720-726. doi: 10.1016/S2468-1253(26)00128-7. Epub 2026 Jun 19.
- Results publication: PubMed 41195479Ebert MP, Reichermeier S, Klug L, Lynen Jansen P, Pox C. Clinical Practice Guideline: Colorectal Cancer-Diagnosis, Treatment, Prevention, and Long-Term Follow-Up Care. Dtsch Arztebl Int. 2025 Dec 26;122(26):729-734. doi: 10.3238/arztebl.m2025.0196. Epub 2025 Dec 26.
- Results publication: PubMed 40774589Laven-Law G, Symonds EL, Simpson K, Coats M, De Silva M, Hollington P, Cock C, Wassie MM. Risk of Advanced Colorectal Neoplasia at Follow-up Colonoscopy After Synchronous Adenoma and Clinically Significant Serrated Polyp. Clin Gastroenterol Hepatol. 2026 Feb;24(2):544-553. doi: 10.1016/j.cgh.2025.07.023. Epub 2025 Aug 5.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Colorectal Cancer and Polyps, run by Gansu Provincial Hospital at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 16 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Adenoma recurrence after colorectal surgery (time frame: Postoperative；follow up till 5 years). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07708415, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Jul 2026.