OsteoporosisNCT07709247
Salivary Cytokines, MMP-8 and Dental Caries in Osteoporosis Patients
An observational study of Osteoporosis and Dental Caries, run by Afyonkarahisar Health Sciences University at 1 site in Turkey (Türkiye).
Trial summary
This study examines saliva samples from patients with osteoporosis. The levels of cytokines and Matrix Metalloproteinase-8 (MMP-8) enzyme in saliva will be measured. Additionally, the dental caries status of participants will be evaluated. Read more about this study
- Who is it for?
- Ages 45 to 75 yearsHealthy volunteers can take part
- Conditions the study is for
- Osteoporosis, Dental Caries, Biomarkers
- How many people
- 30 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 10 Jul 2026to 10 Aug 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 45 to 75 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Patients diagnosed with osteoporosis who applied to the outpatient clinic. Saliva samples and dental caries status will be evaluated. Participants will be selected according to inclusion and exclusion criteria.
Who may be able to join
- Willing to give voluntary consent
- For Group 1, having been diagnosed with osteoporosis
- For Group 2, being systemically healthy and not having a diagnosis of -osteoporosis/osteopenia
Who cannot join
- Having a chronic inflammatory or autoimmune disease
- Using glucocorticoids, anti-anxiety medications, antidepressants, or antiepileptic drugs
- Having been diagnosed with any malignancy
- Having any endocrine disease Having undergone periodontal treatment within the last 6 months
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Afyonkarahisar Health Science University
Afyonkarahisar
About this study
Official title: Osteoporoz Hastalarında Tükürük Sitokin, Matrix Metalloproteinase 8 ve Diş Çürüğünün Değerlendirilmesi
This study examines saliva samples from patients with osteoporosis. The levels of cytokines and Matrix Metalloproteinase-8 (MMP-8) enzyme in saliva will be measured. Additionally, the dental caries status of participants will be evaluated. The aim of this study is to understand the relationship between osteoporosis and oral health. Only saliva samples will be collected from participants; no treatment or medication will be administered.
- Conditions
- Osteoporosis, Dental Caries, Biomarkers, Matrix Metalloproteinase 8
- Medical subject headings
- Osteoporosis, Dental Caries
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Osteoporosis Group | Patients diagnosed with osteoporosis. Saliva samples will be collected to measure cytokine levels and MMP-8. | |
| Control Group | Healthy individuals without osteoporosis. Saliva samples will be collected for comparison. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Salivary Cytokine Levels
Measurement of cytokine levels in saliva samples collected from osteoporosis patients
Measured: day 1
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Jul 2026
- Study start10 Jul 2026
- Primary completion20 Jul 2026
- Study completion10 Aug 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for OsteoporosisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- Afyonkarahisar Health Sciences University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Kübra Karaçam, Afyonkarahisar Health Sciences University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07709247
- Sponsor's protocol ID
- 2026/476
- Status last verified
- Jul 2026
- First submitted
- 12 Jul 2026
- Last updated
- 3 Nov 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 3 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Osteoporoz Hastalarında Tükürük Sitokin, Matrix Metalloproteinase 8 ve Diş Çürüğünün Değerlendirilmesi
- ClinicalTrials.gov ID
- NCT07709247
- Acronym / sponsor ID
- 2026/476
- Conditions
- Osteoporosis, Dental Caries, Biomarkers, Matrix Metalloproteinase 8
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Afyonkarahisar Health Sciences UniversityUniversity, hospital or other
- Study start
- 10 Jul 2026 (actual)
- Primary completion
- 20 Jul 2026 (actual)
- Study completion
- 10 Aug 2026 (actual)
- First posted
- 16 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study examines saliva samples from patients with osteoporosis. The levels of cytokines and Matrix Metalloproteinase-8 (MMP-8) enzyme in saliva will be measured. Additionally, the dental caries status of participants will be evaluated. The aim of this study is to understand the relationship between osteoporosis and oral health. Only saliva samples will be collected from participants; no treatment or medication will be administered.
Study design
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Osteoporosis Group | – | –Patients diagnosed with osteoporosis. Saliva samples will be collected to measure cytokine levels and MMP-8. |
| Control Group | – | –Healthy individuals without osteoporosis. Saliva samples will be collected for comparison. |
Who may qualify
- Ages
- 45 to 75 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Patients diagnosed with osteoporosis who applied to the outpatient clinic. Saliva samples and dental caries status will be evaluated. Participants will be selected according to inclusion and exclusion criteria.
Key inclusion criteria (3 listed)
- Willing to give voluntary consent
- For Group 1, having been diagnosed with osteoporosis
- For Group 2, being systemically healthy and not having a diagnosis of -osteoporosis/osteopenia
Key exclusion criteria (4 listed)
- Having a chronic inflammatory or autoimmune disease
- Using glucocorticoids, anti-anxiety medications, antidepressants, or antiepileptic drugs
- Having been diagnosed with any malignancy
- Having any endocrine disease Having undergone periodontal treatment within the last 6 months
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Salivary Cytokine Levels
Time frame: day 1
Measurement of cytokine levels in saliva samples collected from osteoporosis patients
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Nov 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Osteoporosis and Dental Caries, run by Afyonkarahisar Health Sciences University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Salivary Cytokine Levels (time frame: day 1). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Nov 2026.