Periodontal DiseaseNCT07711431
Association Between Periodontal Disease and Chronic Neck Pain
An observational study of Periodontal Disease and Chronic Neck Pain, run by Nigde Omer Halisdemir University at 1 site in Turkey (Türkiye).
Trial summary
This study investigates whether there is an association between periodontal disease (gum disease) and chronic neck pain and related functional disability. Participants aged 30-55 years will be grouped based on their periodontal health status (healthy, gingivitis, or periodontitis). Read more about this study
- Who is it for?
- Ages 30 to 55 yearsHealthy volunteers can take part
- Conditions the study is for
- Periodontal Disease, Chronic Neck Pain
- Type of treatment
- Injection or infusion
- How many people
- 123 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 11 Jul 2026to 15 Sep 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 55 years
- All sexes
- Healthy volunteers accepted
- Adult
Study population: Adults aged 30-55 years attending the Department of Periodontology, Faculty of Dentistry, Niğde Ömer Halisdemir University, who will be classified into three groups based on periodontal health status: clinically healthy periodontium, gingivitis, or periodontitis (Stage I-IV).
Who may be able to join
- Aged between 30 and 55 years
- Willing to participate and provide written informed consent
- Able to undergo periodontal examination and complete self-report questionnaires
Who cannot join
- Neck pain attributable to a specific identifiable cause (e.g., trauma, cervical disc herniation, spinal deformity, tumor, fracture)
- Systemic inflammatory or autoimmune disease
- Neurological disease affecting the cervical region
- Pregnancy
- Regular use of analgesic or anti-inflammatory medication
- Fewer than 20 remaining natural teeth
- History of periodontal treatment within the past 6 months
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Niğde Ömer Halisdemir University, Faculty of Dentistry
Niğde, Niğde Province, 51240
Şafak Necati Dönertaş, DDS, +905362119697, safak_necati@hotmail.com
About this study
Official title: Evaluation of the Association Between Periodontal Diseases and Chronic Non-Specific Neck Pain and Functional Disability: A Cross-Sectional Study
This study investigates whether there is an association between periodontal disease (gum disease) and chronic neck pain and related functional disability. Participants aged 30-55 years will be grouped based on their periodontal health status (healthy, gingivitis, or periodontitis). Neck pain intensity will be assessed using the Visual Analog Scale (VAS), and functional disability will be measured using the Neck Disability Index (NDI). The study aims to determine whether periodontal disease severity is linked to the severity of neck pain and disability, which may help clarify a potential connection between oral health and musculoskeletal health.
Read the detailed description
Periodontal disease is a chronic inflammatory condition affecting the tissues supporting the teeth, and has been increasingly linked to systemic inflammatory processes that may contribute to musculoskeletal pain conditions. Chronic non-specific neck pain is a common musculoskeletal complaint with a multifactorial etiology, and inflammatory mechanisms have been proposed as one potential contributing pathway.
This cross-sectional study aims to evaluate the association between periodontal disease status and chronic non-specific neck pain and related functional disability. Participants will undergo a periodontal examination, including assessment of gingival index, plaque index, bleeding on probing, probing depth, and radiographic bone loss, and will be classified into periodontal health categories according to the 2017 World Workshop classification of periodontal and peri-implant diseases and conditions.
Neck pain intensity and functional disability will be assessed using validated outcome measures. Associations between periodontal disease severity and neck pain/disability outcomes will be examined, along with potential confounding factors.
Findings from this study may contribute to a better understanding of the relationship between oral health and musculoskeletal health, and may inform future interdisciplinary approaches to patient assessment and care.
- Conditions
- Periodontal Disease, Chronic Neck Pain
- Keywords
- Periodontal Disease, Gingivitis, Periodontitis, Neck Pain, Neck Disability, Oral Health, Musculoskeletal Pain
- Medical subject headings
- Periodontal Diseases, Gingivitis, Periodontitis, Neck Pain, Musculoskeletal Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Healthy | Participants with a clinically healthy periodontium, showing no clinical signs of gingival inflammation, attachment loss, or bone loss on periodontal examination. | |
| Gingivitis | Participants diagnosed with gingivitis based on clinical periodontal examination, showing signs of gingival inflammation without attachment or bone loss. | |
| Periodontitis | Participants diagnosed with periodontitis (Stage I, II, III, or IV) according to the 2017 World Workshop classification of periodontal and peri-implant diseases and conditions. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Neck Pain Intensity (Visual Analog Scale, VAS)
Neck pain intensity will be assessed using the Visual Analog Scale (VAS), a 10-cm horizontal line ranging from 0 (no pain) to 10 (worst imaginable pain). Participants will mark the point that best represents their current level of neck pain. Scores will be compared across periodontal health groups (healthy, gingivitis, periodontitis).
Measured: Assessed at the time of study enrollment (baseline, single time point)
Neck-Related Functional Disability (Neck Disability Index, NDI)
Functional disability related to neck pain will be assessed using the Neck Disability Index (NDI), a validated 10-item self-report questionnaire evaluating the impact of neck pain on daily activities. Scores will be compared across periodontal health groups (healthy, gingivitis, periodontitis).
Measured: Assessed at the time of study enrollment (baseline, single time point)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Jul 2026
- Study start11 Jul 2026
- Primary completion15 Sep 2026 (estimated)
- Study completion15 Sep 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Periodontal DiseaseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Enrolment
- 123 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Nigde Omer Halisdemir University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Şafak Necati DÖNERTAŞ, Nigde Omer Halisdemir University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07711431
- Sponsor's protocol ID
- SND1
- Other IDs
- 2026/63
- Status last verified
- Jul 2026
- First submitted
- 14 Jul 2026
- Last updated
- 17 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 17 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of the Association Between Periodontal Diseases and Chronic Non-Specific Neck Pain and Functional Disability: A Cross-Sectional Study
- ClinicalTrials.gov ID
- NCT07711431
- Acronym / sponsor ID
- SND1
- Conditions
- Periodontal Disease, Chronic Neck Pain
- Keywords
- Periodontal Disease, Gingivitis, Periodontitis, Neck Pain, Neck Disability, Oral Health, Musculoskeletal Pain
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 123 participants (estimated)
- Lead sponsor
- Nigde Omer Halisdemir UniversityUniversity, hospital or other
- Study start
- 11 Jul 2026 (actual)
- Primary completion
- 15 Sep 2026 (estimated)
- Study completion
- 15 Sep 2026 (estimated)
- First posted
- 17 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study investigates whether there is an association between periodontal disease (gum disease) and chronic neck pain and related functional disability. Participants aged 30-55 years will be grouped based on their periodontal health status (healthy, gingivitis, or periodontitis). Neck pain intensity will be assessed using the Visual Analog Scale (VAS), and functional disability will be measured using the Neck Disability Index (NDI). The study aims to determine whether periodontal disease severity is linked to the severity of neck pain and disability, which may help clarify a potential connection between oral health and musculoskeletal health.
Detailed description
Periodontal disease is a chronic inflammatory condition affecting the tissues supporting the teeth, and has been increasingly linked to systemic inflammatory processes that may contribute to musculoskeletal pain conditions. Chronic non-specific neck pain is a common musculoskeletal complaint with a multifactorial etiology, and inflammatory mechanisms have been proposed as one potential contributing pathway.
This cross-sectional study aims to evaluate the association between periodontal disease status and chronic non-specific neck pain and related functional disability. Participants will undergo a periodontal examination, including assessment of gingival index, plaque index, bleeding on probing, probing depth, and radiographic bone loss, and will be classified into periodontal health categories according to the 2017 World Workshop classification of periodontal and peri-implant diseases and conditions.
Neck pain intensity and functional disability will be assessed using validated outcome measures. Associations between periodontal disease severity and neck pain/disability outcomes will be examined, along with potential confounding factors.
Findings from this study may contribute to a better understanding of the relationship between oral health and musculoskeletal health, and may inform future interdisciplinary approaches to patient assessment and care.
Study design
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Healthy | – | –Participants with a clinically healthy periodontium, showing no clinical signs of gingival inflammation, attachment loss, or bone loss on periodontal examination. |
| Gingivitis | – | –Participants diagnosed with gingivitis based on clinical periodontal examination, showing signs of gingival inflammation without attachment or bone loss. |
| Periodontitis | – | –Participants diagnosed with periodontitis (Stage I, II, III, or IV) according to the 2017 World Workshop classification of periodontal and peri-implant diseases and conditions. |
Who may qualify
- Ages
- 30 to 55 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
- Study population
- Adults aged 30-55 years attending the Department of Periodontology, Faculty of Dentistry, Niğde Ömer Halisdemir University, who will be classified into three groups based on periodontal health status: clinically healthy periodontium, gingivitis, or periodontitis (Stage I-IV).
Key inclusion criteria (3 listed)
- Aged between 30 and 55 years
- Willing to participate and provide written informed consent
- Able to undergo periodontal examination and complete self-report questionnaires
Key exclusion criteria (7 listed)
- Neck pain attributable to a specific identifiable cause (e.g., trauma, cervical disc herniation, spinal deformity, tumor, fracture)
- Systemic inflammatory or autoimmune disease
- Neurological disease affecting the cervical region
- Pregnancy
- Regular use of analgesic or anti-inflammatory medication
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Neck Pain Intensity (Visual Analog Scale, VAS)
Time frame: Assessed at the time of study enrollment (baseline, single time point)
Neck pain intensity will be assessed using the Visual Analog Scale (VAS), a 10-cm horizontal line ranging from 0 (no pain) to 10 (worst imaginable pain). Participants will mark the point that best represents their current level of neck pain. Scores will be compared across periodontal health groups (healthy, gingivitis, periodontitis).
Neck-Related Functional Disability (Neck Disability Index, NDI)
Time frame: Assessed at the time of study enrollment (baseline, single time point)
Functional disability related to neck pain will be assessed using the Neck Disability Index (NDI), a validated 10-item self-report questionnaire evaluating the impact of neck pain on daily activities. Scores will be compared across periodontal health groups (healthy, gingivitis, periodontitis).
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Jul 2026.
- Individual participant dataSharing planned: Undecided
Related trials for Periodontal Disease
Not yet recruitingObservational study
Periodontal Status and Biomarkers in MASLD
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Recruiting
Thermosensitive Hyaluronic Gel With Octenidine as an Adjunctive to Subgingival Instrumentation
Periodontal Disease
Active, not recruitingObservational study
A Retrospective Comparative Evaluation of Omega-3 and Resveratrol Supplementation in Patients With Periodontitis
Periodontitis
Recruiting
Effects of Different Activation Techniques on Antimicrobial Photodynamic Therapy in Apical Periodontitis
Apical Periodontitis, Endodontic Retreatment
Recruiting
Ozone Gel Versus Chlorohexidine Gel as an Adjunct to Non-Surgical Treatment of Stage II Periodontitis Grade B Among Smokers Patients
Ozone Gel, Chlorohexidine Gel
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Periodontal Disease and Chronic Neck Pain, run by Nigde Omer Halisdemir University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 17 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Şafak Necati Dönertaş, DDS (+905362119697, safak_necati@hotmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Neck Pain Intensity (Visual Analog Scale, VAS) (time frame: Assessed at the time of study enrollment (baseline, single time point)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Jul 2026.