Neuro-ophthalmological ConditionsESNOPED-UKNCT07711886
Understanding Vision Problems Linked to the Brain and Nerves in People Seen at Our Eye Clinic
An observational study of Neuro-ophthalmological Conditions, run by The Royal Wolverhampton Hospitals NHS Trust.
Trial summary
The reason for the recognised lack of epidemiological data of all NO conditions presenting to eye departments is attributed to the fact that they often fall in the grey zones between neuro-ophthalmologists, neurosurgeons and neurologists. . Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Neuro-ophthalmological Conditions
- How many people
- 840 participants
- Where
- No sites listed yet
- Study dates
- Jan 2027to Dec 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Consecutive patients seen at the Royal Wolverhampton NHS Trust's Eye Department who have a NO diagnosis and meet the eligibility criteria will be selected.
Who may be able to join
- Participants aged ≥ 18 years.
- Participants seen at the Royal Wolverhampton NHS Trust's Eye Department.
- Participants with a diagnosis of NO.
Who cannot join
- Participants aged < 18 years.
- Participants who do not have a diagnosis of NO.
- Participants who have opted out of their data being used for research (National Data Opt-out).
About this study
Official title: Epidemiological Study of Neuro-ophthalmological Presentations in an Eye Department in the UK
The reason for the recognised lack of epidemiological data of all NO conditions presenting to eye departments is attributed to the fact that they often fall in the grey zones between neuro-ophthalmologists, neurosurgeons and neurologists.
. It is anticipated that the findings of the study may then help to support better service planning and resource allocation, as well as identifying any early recognition of rare or emerging patterns.
Read the detailed description
The current study proposes to collect prospective data on patients seen within an eye department in the UK. The findings of such a prospective study will help to improve understanding of the NO disease burden and temporal trends. It will also help to further identify the demographic and systemic associations of NO conditions. It is anticipated that the findings of the study may then help to support better service planning and resource allocation, as well as identifying any early recognition of rare or emerging patterns. This may help to design clinics with the view to incorporate identifiable multidisciplinary inputs from neurology, neuro-surgery, radiology and emergency services, who are the recognised key stakeholders for the management of NO conditions. Real-world data in such a cohort of NO conditions may also help to detect rare associations or novel disease presentations.
- Conditions
- Neuro-ophthalmological Conditions
- Being tested
- No Intervention: Observational Cohort
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
No Intervention: Observational CohortOther
no intervention required
What is being measured
The primary outcome is the main question the study is designed to answer.
Analysis of the incidence and patterns of presentation of common NO conditions compared to other published studies.
Measured: From enrollment to 12 months
Secondary outcomes (2)
Concordance rates between initial and final diagnosis.
Measured: From enrollment to 12 months
Detailed analysis of rare presentations, with a view to share knowledge gained from this in educational meetings.
Measured: From enrollment to 12 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Jul 2026
- Study startJan 2027 (estimated)
- Primary completionDec 2027 (estimated)
- Study completionDec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Neuro-ophthalmological ConditionsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 840 participants (estimated)
Sponsor and investigators
- Lead sponsor
- The Royal Wolverhampton Hospitals NHS Trust
- Sponsor type
- Other government
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07711886
- Sponsor's protocol ID
- 2026EYE149
- Acronym
- ESNOPED-UK
- Status last verified
- Aug 2026
- First submitted
- 14 Jul 2026
- Last updated
- 21 Aug 2026
- Results posted
- No
- FDA-regulated drug
- No
Study at a glance
From the registry record, last updated by the sponsor on 21 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Epidemiological Study of Neuro-ophthalmological Presentations in an Eye Department in the UK
- ClinicalTrials.gov ID
- NCT07711886
- Acronym / sponsor ID
- ESNOPED-UK / 2026EYE149
- Conditions
- Neuro-ophthalmological Conditions
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 840 participants (estimated)
- Lead sponsor
- The Royal Wolverhampton Hospitals NHS TrustOther government
- Study start
- Jan 2027 (estimated)
- Primary completion
- Dec 2027 (estimated)
- Study completion
- Dec 2027 (estimated)
- First posted
- 17 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The reason for the recognised lack of epidemiological data of all NO conditions presenting to eye departments is attributed to the fact that they often fall in the grey zones between neuro-ophthalmologists, neurosurgeons and neurologists.
. It is anticipated that the findings of the study may then help to support better service planning and resource allocation, as well as identifying any early recognition of rare or emerging patterns.
Detailed description
The current study proposes to collect prospective data on patients seen within an eye department in the UK. The findings of such a prospective study will help to improve understanding of the NO disease burden and temporal trends. It will also help to further identify the demographic and systemic associations of NO conditions. It is anticipated that the findings of the study may then help to support better service planning and resource allocation, as well as identifying any early recognition of rare or emerging patterns. This may help to design clinics with the view to incorporate identifiable multidisciplinary inputs from neurology, neuro-surgery, radiology and emergency services, who are the recognised key stakeholders for the management of NO conditions. Real-world data in such a cohort of NO conditions may also help to detect rare associations or novel disease presentations.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Consecutive patients seen at the Royal Wolverhampton NHS Trust's Eye Department who have a NO diagnosis and meet the eligibility criteria will be selected.
Key inclusion criteria (3 listed)
- Participants aged ≥ 18 years.
- Participants seen at the Royal Wolverhampton NHS Trust's Eye Department.
- Participants with a diagnosis of NO.
Key exclusion criteria (3 listed)
- Participants aged < 18 years.
- Participants who do not have a diagnosis of NO.
- Participants who have opted out of their data being used for research (National Data Opt-out).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| No Intervention: Observational Cohortno intervention required | Other | – |
Primary outcome
Analysis of the incidence and patterns of presentation of common NO conditions compared to other published studies.
Time frame: From enrollment to 12 months
2 secondary outcomes
Concordance rates between initial and final diagnosis.
Time frame: From enrollment to 12 months
Detailed analysis of rare presentations, with a view to share knowledge gained from this in educational meetings.
Time frame: From enrollment to 12 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Aug 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
An observational study of Neuro-ophthalmological Conditions, run by The Royal Wolverhampton Hospitals NHS Trust.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 21 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Analysis of the incidence and patterns of presentation of common NO conditions compared to other published studies. (time frame: From enrollment to 12 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Aug 2026.