PreDiabetesNCT07713030
Comparative Effects of High-Intensity Interval Training and Continuous Endurance Training Among Prediabetic Patients
A study testing High-Intensity Interval Training and Continuous Endurance Training in people with PreDiabetes and Pre Diabetes, run by Riphah International University at 1 site in Pakistan.
Trial summary
Prediabetics is a condition where blood sugar levels are normal but not yet high enough to be diagnosed as type 2 diabetes. This phase offers a crucial point for timely intervention to delay or prevent type 2 diabetes. Read more about this study
- Who is it for?
- Ages 35 to 54 yearsHealthy volunteers can take part
- Conditions the study is for
- PreDiabetes, Pre Diabetes, Prediabetic State
- What is being tested?
- High-Intensity Interval Training and Continuous Endurance Training
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 80 participants
- Where
- 1 sitePakistan
- Study dates
- 1 May 2026to 1 Aug 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 35 to 54 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Sedentary lifestyle (Individuals reporting minimal structured physical activity e.g., <30 minutes of exercise per week) .
- Stable Medical Condition (No history of significant cardiovascular events, uncontrolled hypertension, or other major comorbidities).
- Stable Body Weight (Stable body weight with changes less than 3 kg in the past 6 months).
Who cannot join
- uncontrolled hypertension
- history of heart disease
- myocardial infarction
- stroke
- Use of Specific Medications (Current use of insulin or other medications affecting glucose metabolism or exercise response)
- Severe Obesity (Individuals with a BMI ≥ 40 kg/m)
Show all 9Show fewer
- High fasting blood glucose (Fasting blood glucose of >100mg.dl-1)
- Previous history of respiratory problems
- Smoking
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan1 site, 1 recruiting
- Recruiting
Rihpah international university Lahore campus
Lahore, Punjab Province, 40100
Misdaq Batool, MS PT, 03466584498, misdaaqbatool@yahoo.com.ph
Areeza Mansha, MS PT, 03363405060, Areeza154@gmail.com
About this study
Official title: Comparative Effects of High-Intensity Interval Training and Continuous Endurance Training on Glycemic Control, BMI, Vo₂ Max, Pulmonary Function, and Physical Activity Among Prediabetic Patients
Prediabetics is a condition where blood sugar levels are normal but not yet high enough to be diagnosed as type 2 diabetes. This phase offers a crucial point for timely intervention to delay or prevent type 2 diabetes. The objective of the study will be to find the effects of high intensity interval and continuous endurance training on glycemic control, BMI, Vo2 Max, pulmonary function and physical activity among prediabetic patients. Study design will be randomized control trial. Total 80 participants will be enrolled in study. The data will be collected from faculty of Riphah International University, Lahore. The study will be completed within 8 months after approval of synopsis. A simple random sampling will be used to assign the groups; group A and group B. Group A will be assigned high intensity interval training and group B will be assigned to continuous training.
Read the detailed description
Prediabetics is a condition where blood sugar levels are normal but not yet high enough to be diagnosed as type 2 diabetes. This phase offers a crucial point for timely intervention to delay or prevent type 2 diabetes. The objective of the study will be to find the effects of high intensity interval and continuous endurance training on glycemic control, BMI, Vo2 Max, pulmonary function and physical activity among prediabetic patients. Study design will be randomized control trial. Total 80 participants will be enrolled in study. The data will be collected from faculty of Riphah International University, Lahore. The study will be completed within 8 months after approval of synopsis. A simple random sampling will be used to assign the groups: group A and group B. Group A will be assigned high intensity interval training, and group B will be assigned to continuous training. Both interventions will be conducted over a 12-week period, with pre- and post-intervention assessments. Each exercise session constitutes a 5-minute warm up and finished with a 5-minute cool-down. Participants aged between 35 to 54 years with sedentary lifestyle, Stable medical condition, and stable body weight with changes less 3kg in the past 6 months will be included in this study. The study will exclude individuals with uncontrolled hypertension, history of heart disease, myocardial infarction and stroke and diagnosed type 2 diabetes, use of specific medications, severe obesity, high fasting blood glucose, previous history of respiratory problems, and smoking. Primary outcomes include changes in fasting blood glucose, HbA1c levels, and insulin sensitivity. Pre and post values of glucose level and FEV1, FVC and FEV1/FVC will be calculated. Secondary outcomes will assess BMI, VO₂ max through graded exercise testing, pulmonary function using spirometry, and physical activity levels measured by validated questionnaire of short form of IPAQ-SF. Data will be analysed using SPSS 24 and Shapiro wilks test will be applied to assess the normality of data. After assesing the normality of data paired sample/independent t test/ANOVA test will be applied to find which technique will be more beneficial for prediabetic patients.
- Conditions
- PreDiabetes, Pre Diabetes, Prediabetic State
- Being tested
- High-Intensity Interval Training, Continuous Endurance Training
- Keywords
- BMI, vo2 Max, glycemic control, Physical Activity, High-Intensity Interval Training
- Medical subject headings
- Prediabetic State, Glucose Intolerance, Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
High-Intensity Interval TrainingBehavioural
5 minutes warm up including walk
- 30s fast stairs climbing
- 60s slow walk down
- Repeat 5 to 6 rounds
- 5 minute stretching or slow walk (cool down)
Continuous Endurance TrainingBehavioural
5 to 10 minute walking (warm up )
- 25 to 30minutes at 60 to 70 %continuous training
- Continuous walk for 15 to 20 minutes.
- 5 to 10 minutes stretching (cool down)
| Study group | Role | What they receive |
|---|---|---|
| High-Intensity Interval Training | Active comparator | High intensity interval training is a training method that involves repeated bouts of short duration, highintensity exercise typicallyb performed at ≥ 85 -95% of maximal heart rate or vo2 max interspersed with period of low intensity recovery or complete rest. Receives: Behavioral: High-Intensity Interval Training |
| Continuous Endurance Training | Active comparator | Continuous endurance training also called moderate intensity continuous training involves sustained exercise at a moderate and steady intensity typically 60to 75% of vo2 max or maximal heart rate performed for a continuous duration without rest intervals Receives: Behavioral: Continuous Endurance Training |
What is being measured
The primary outcome is the main question the study is designed to answer.
fasting blood glucose
Participants were instructed to fast overnight for 8 to 12 hours. FBG was measured using an automated glucose analyzer
Measured: 12 weeks
Forced Vital Capacity
Spirometry using devices like a digital spirometry will be used. Forced Vital Capacity (FVC) will be measured in liters (L) using spirometry. FVC represents the maximum volume of air that can be forcefully exhaled after a maximal inspiration.
Measured: 12 weeks
Forced Expiratory Volume in One Second
Forced Expiratory Volume in One Second (FEV₁) will be measured in liters (L) using spirometry. FEV₁ represents the volume of air exhaled during the first second of a forced expiratory maneuver.
Measured: 12 weeks
FEV₁/FVC ratio
The FEV₁/FVC ratio will be expressed as a percentage (%) and calculated from spirometric measurements to assess the degree of airflow limitation.
Measured: 12 weeks
HbA1c
HbA1c was assesed through high performance liquid chromatography
Measured: 12 weeks
Secondary outcomes (3)
Body mass index (BMI)
Participants weight was measured using a calibrated digital scale with minimal clothing and no shoes height was measured using a wall mounted stadiometer with participants standing upright
Measured: 12 weeks
IPAQ (short form) questionnaire
International physical activity questionnaire is applicable for survey among 18 to 65 years to Assess the level of physical activity along different countries. It is developed in 2 Versions; first is long version (27 items), and the second is the short version (7 items). We will use IPAQ short version which consists of job, transport, domestic, and leisure time physical activity domains.
Moderate and high-intensity walking and sitting time activities are addressed in this questionnaire
Measured: 12 weeks
Maximal Oxygen Uptake (VO₂max)
In this research VO2 Max will be measured through a submaximal 6 mint walk test
Measured: 12 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Jul 2026
- Study start1 May 2026
- Primary completion1 Aug 2026 (estimated)
- Study completion1 Aug 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for PreDiabetesStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 80 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Arjumand Bano, MS, Principal investigator, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07713030
- Sponsor's protocol ID
- REC/RCR & AHS/25/0302
- Status last verified
- Jul 2026
- First submitted
- 8 Jun 2026
- Last updated
- 20 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Effects of High-Intensity Interval Training and Continuous Endurance Training on Glycemic Control, BMI, Vo₂ Max, Pulmonary Function, and Physical Activity Among Prediabetic Patients
- ClinicalTrials.gov ID
- NCT07713030
- Acronym / sponsor ID
- REC/RCR & AHS/25/0302
- Conditions
- PreDiabetes, Pre Diabetes, Prediabetic State
- Keywords
- BMI, vo2 Max, glycemic control, Physical Activity, High-Intensity Interval Training
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 80 participants (estimated)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 1 May 2026 (actual)
- Primary completion
- 1 Aug 2026 (estimated)
- Study completion
- 1 Aug 2026 (estimated)
- First posted
- 20 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Prediabetics is a condition where blood sugar levels are normal but not yet high enough to be diagnosed as type 2 diabetes. This phase offers a crucial point for timely intervention to delay or prevent type 2 diabetes. The objective of the study will be to find the effects of high intensity interval and continuous endurance training on glycemic control, BMI, Vo2 Max, pulmonary function and physical activity among prediabetic patients. Study design will be randomized control trial. Total 80 participants will be enrolled in study. The data will be collected from faculty of Riphah International University, Lahore. The study will be completed within 8 months after approval of synopsis. A simple random sampling will be used to assign the groups; group A and group B. Group A will be assigned high intensity interval training and group B will be assigned to continuous training.
Detailed description
Prediabetics is a condition where blood sugar levels are normal but not yet high enough to be diagnosed as type 2 diabetes. This phase offers a crucial point for timely intervention to delay or prevent type 2 diabetes. The objective of the study will be to find the effects of high intensity interval and continuous endurance training on glycemic control, BMI, Vo2 Max, pulmonary function and physical activity among prediabetic patients. Study design will be randomized control trial. Total 80 participants will be enrolled in study. The data will be collected from faculty of Riphah International University, Lahore. The study will be completed within 8 months after approval of synopsis. A simple random sampling will be used to assign the groups: group A and group B. Group A will be assigned high intensity interval training, and group B will be assigned to continuous training. Both interventions will be conducted over a 12-week period, with pre- and post-intervention assessments. Each exercise session constitutes a 5-minute warm up and finished with a 5-minute cool-down. Participants aged between 35 to 54 years with sedentary lifestyle, Stable medical condition, and stable body weight with changes less 3kg in the past 6 months will be included in this study. The study will exclude individuals with uncontrolled hypertension, history of heart disease, myocardial infarction and stroke and diagnosed type 2 diabetes, use of specific medications, severe obesity, high fasting blood glucose, previous history of respiratory problems, and smoking. Primary outcomes include changes in fasting blood glucose, HbA1c levels, and insulin sensitivity. Pre and post values of glucose level and FEV1, FVC and FEV1/FVC will be calculated. Secondary outcomes will assess BMI, VO₂ max through graded exercise testing, pulmonary function using spirometry, and physical activity levels measured by validated questionnaire of short form of IPAQ-SF. Data will be analysed using SPSS 24 and Shapiro wilks test will be applied to assess the normality of data. After assesing the normality of data paired sample/independent t test/ANOVA test will be applied to find which technique will be more beneficial for prediabetic patients.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| High-Intensity Interval Training | Active comparator | Behavioral: High-Intensity Interval TrainingHigh intensity interval training is a training method that involves repeated bouts of short duration, highintensity exercise typicallyb performed at ≥ 85 -95% of maximal heart rate or vo2 max interspersed with period of low intensity recovery or complete rest. |
| Continuous Endurance Training | Active comparator | Behavioral: Continuous Endurance TrainingContinuous endurance training also called moderate intensity continuous training involves sustained exercise at a moderate and steady intensity typically 60to 75% of vo2 max or maximal heart rate performed for a continuous duration without rest intervals |
Who may qualify
- Ages
- 35 to 54 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Sedentary lifestyle (Individuals reporting minimal structured physical activity e.g., <30 minutes of exercise per week) .
Key exclusion criteria (9 listed)
- uncontrolled hypertension
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| High-Intensity Interval Training5 minutes warm up including walk * 30s fast stairs climbing * 60s slow walk down * Repeat 5 to 6 rounds * 5 minute stretching or slow walk (cool down) | Behavioural | High-Intensity Interval Training |
| Continuous Endurance Training5 to 10 minute walking (warm up ) * 25 to 30minutes at 60 to 70 %continuous training * Continuous walk for 15 to 20 minutes. * 5 to 10 minutes stretching (cool down) | Behavioural | Continuous Endurance Training |
Primary outcome
fasting blood glucose
Time frame: 12 weeks
Participants were instructed to fast overnight for 8 to 12 hours. FBG was measured using an automated glucose analyzer
Forced Vital Capacity
Time frame: 12 weeks
Spirometry using devices like a digital spirometry will be used. Forced Vital Capacity (FVC) will be measured in liters (L) using spirometry. FVC represents the maximum volume of air that can be forcefully exhaled after a maximal inspiration.
Forced Expiratory Volume in One Second
Time frame: 12 weeks
Forced Expiratory Volume in One Second (FEV₁) will be measured in liters (L) using spirometry. FEV₁ represents the volume of air exhaled during the first second of a forced expiratory maneuver.
FEV₁/FVC ratio
Time frame: 12 weeks
The FEV₁/FVC ratio will be expressed as a percentage (%) and calculated from spirometric measurements to assess the degree of airflow limitation.
HbA1c
Time frame: 12 weeks
HbA1c was assesed through high performance liquid chromatography
3 secondary outcomes
Body mass index (BMI)
Time frame: 12 weeks
IPAQ (short form) questionnaire
Time frame: 12 weeks
Maximal Oxygen Uptake (VO₂max)
Time frame: 12 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Jul 2026.
- Individual participant dataSharing planned: No
Related trials for PreDiabetes
Not yet recruiting
Evaluation of the Effectiveness of Implementing a Screening Strategy for the Diagnosis of Prediabetes and Type 2 Diabetes Mellitus in Primary Health Care in a Brazilian Municipality
Diabetes Mellitus (Type 2), Prediabetes
Active, not recruiting
The Effect of Exercise and Nicotinamide Riboside Muscle Health and Insulin Resistance in Survivors of Childhood Cancer
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Not yet recruiting
Effects of Mango on Insulin Sensitivity in Prediabetes
Pre Diabetes
Not yet recruiting
Different Aerobic-to-Resistance Training Ratios in Adults Aged 50 Years and Older With Prediabetes
Prediabetes
Recruiting
Neuromodulation for Metabolic Dysfunction
Spinal Cord Injuries (SCI), Prediabetes / Type 2 Diabetes
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Arjumand Bano, MS principal investigator
Riphah International University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing High-Intensity Interval Training and Continuous Endurance Training in people with PreDiabetes and Pre Diabetes, run by Riphah International University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 20 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Muhammad Iqbal Tariq, Phd (333826752, iqbal.tariq@riphah.edu.pk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
fasting blood glucose (time frame: 12 weeks). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Jul 2026.