OsteoarthitisNCT07715188
Low Dose Radiotherapy for Osteoarthritis
A study testing Low Dose Radiation Therapy in people with Osteoarthitis, run by Abramson Cancer Center at Penn Medicine at 2 sites in United States.
Trial summary
This single institution, multi-site, single arm prospective study will enroll patients with a history of OA and assess changes in pain and function after treatment with LDRT as measured by patient-reported outcomes. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Osteoarthitis
- What is being tested?
- Low Dose Radiation Therapy
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 113 participants
- Where
- 2 sitesUnited States
- Study dates
- 24 Jun 2026to Jun 2029
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- 18 years or older
- Diagnosis of OA >3 months in hips, knees, hands, shoulders, ankles or elbows.
- Refractory to standard of care therapies for OA or those who are being considered for more aggressive interventional treatment such as joint replacement, but more conservative treatment is desired.
- Provision of signed and dated informed consent.
Who cannot join
- Unable to reasonably complete study instruments.
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
United States2 sites, 2 recruiting
- Recruiting
Penn Presbyterian Medical Center
Philadelphia, Pennsylvania, 19104
Marlowe Estioko, BS, MS, 267-343-6483, Marlowe.Estioko@Pennmedicine.upenn.edu
Sonya George, BS, 267-760-7636, Sonya.George@PennMedicine.upenn.edu
- Recruiting
Perelman Center for Advanced Medicine
Philadelphia, Pennsylvania, 19104
Marlowe Estioko, BS, MS, 267-343-6483, Marlowe.Estioko@Pennmedicine.upenn.edu
Sonya George, BS, 267-760-7636, Sonya.George@PennMedicine.upenn.edu
About this study
Official title: A Prospective Study of Low Dose Radiotherapy for Osteoarthritis
This single institution, multi-site, single arm prospective study will enroll patients with a history of OA and assess changes in pain and function after treatment with LDRT as measured by patient-reported outcomes.
Read the detailed description
To evaluate the use of select instruments (BPI-SF, LEFS, UEFI, PROMIS Global) to detect changes in pain, function, and well-being in patients with OA who are refractory to or otherwise unable to receive other standard of care therapies.
- Conditions
- Osteoarthitis
- Being tested
- Low Dose Radiation Therapy
- Keywords
- Low Dose Radiotherapy, Osteoarthritis
- Medical subject headings
- Osteoarthritis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Low Dose Radiation TherapyRadiation
Participants will complete study intervention which consists of the BPI-SF, PROMIS Global v1.2, UEFI (for those with joint pain of the upper extremity) and/or LEFS (for those joint pain of the lower extremity) at baseline, 3-month and 1-year follow-up following 1 or 2 courses of standard of care LDRT.
| Study group | Role | What they receive |
|---|---|---|
| Single | Other | Participants will complete study intervention which consists of the BPI-SF, PROMIS Global v1.2, UEFI (for those with joint pain of the upper extremity) and/or LEFS (for those joint pain of the lower extremity) at baseline, 3-month and 1-year follow-up following 1 or 2 courses of standard of care LDRT. Receives: Radiation: Low Dose Radiation Therapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
To measure the percentage of subjects who experience a best response of 1 point or more on BPI-SF
Assess the degree of patient-reported pain prior to and after use of 1-2 courses of LDRT
Measured: Within 1 year
Secondary outcomes (4)
To measure the percentage of subjects who experience a best response of 1 point or more on BPI-SF
Assess the degree of patient-reported pain prior to and after 1 course of LDRT
Measured: at ~ 3 months
To measure change in the Patient-Reported Outcomes Measurement Information System (PROMIS) scores
Assess the degree of patient-reported global wellness prior to and after use of 1-2 courses of LDR.
Measured: From baseline at 3-month and 1-year follow-up
To measure change in LEFS scores as measured
Assess the degree of patient-reported lower extremity function prior to and after use of 1-2 courses of LDRT
Measured: From baseline at 3-month and 1-year follow-up
To measure change in UEFI scores as measured
Assess the degree of patient-reported upper extremity function prior to and after use of 1-2 courses of LDRT
Measured: From baseline at 3-month and 1-year follow-up
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Jul 2026
- Study start24 Jun 2026
- Primary completionJun 2029 (estimated)
- Study completionJun 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for OsteoarthitisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 113 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Abramson Cancer Center at Penn Medicine
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07715188
- Sponsor's protocol ID
- UPCC 02025
- Status last verified
- Jul 2026
- First submitted
- 15 Jul 2026
- Last updated
- 21 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 21 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Prospective Study of Low Dose Radiotherapy for Osteoarthritis
- ClinicalTrials.gov ID
- NCT07715188
- Acronym / sponsor ID
- UPCC 02025
- Conditions
- Osteoarthitis
- Keywords
- Low Dose Radiotherapy, Osteoarthritis
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 113 participants (estimated)
- Lead sponsor
- Abramson Cancer Center at Penn MedicineUniversity, hospital or other
- Study start
- 24 Jun 2026 (actual)
- Primary completion
- Jun 2029 (estimated)
- Study completion
- Jun 2029 (estimated)
- First posted
- 20 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This single institution, multi-site, single arm prospective study will enroll patients with a history of OA and assess changes in pain and function after treatment with LDRT as measured by patient-reported outcomes.
Detailed description
To evaluate the use of select instruments (BPI-SF, LEFS, UEFI, PROMIS Global) to detect changes in pain, function, and well-being in patients with OA who are refractory to or otherwise unable to receive other standard of care therapies.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Single | Other | Radiation: Low Dose Radiation TherapyParticipants will complete study intervention which consists of the BPI-SF, PROMIS Global v1.2, UEFI (for those with joint pain of the upper extremity) and/or LEFS (for those joint pain of the lower extremity) at baseline, 3-month and 1-year follow-up following 1 or 2 courses of standard of care LDRT. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- 18 years or older
- Diagnosis of OA >3 months in hips, knees, hands, shoulders, ankles or elbows.
- Refractory to standard of care therapies for OA or those who are being considered for more aggressive interventional treatment such as joint replacement, but more conservative treatment is desired.
- Provision of signed and dated informed consent.
Key exclusion criteria (1 listed)
- Unable to reasonably complete study instruments.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Low Dose Radiation TherapyParticipants will complete study intervention which consists of the BPI-SF, PROMIS Global v1.2, UEFI (for those with joint pain of the upper extremity) and/or LEFS (for those joint pain of the lower extremity) at baseline, 3-month and 1-year follow-up following 1 or 2 courses of standard of care LDRT. | Radiation | Single |
Primary outcome
To measure the percentage of subjects who experience a best response of 1 point or more on BPI-SF
Time frame: Within 1 year
Assess the degree of patient-reported pain prior to and after use of 1-2 courses of LDRT
4 secondary outcomes
To measure the percentage of subjects who experience a best response of 1 point or more on BPI-SF
Time frame: at ~ 3 months
To measure change in the Patient-Reported Outcomes Measurement Information System (PROMIS) scores
Time frame: From baseline at 3-month and 1-year follow-up
To measure change in LEFS scores as measured
Time frame: From baseline at 3-month and 1-year follow-up
To measure change in UEFI scores as measured
Time frame: From baseline at 3-month and 1-year follow-up
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Sep 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Low Dose Radiation Therapy in people with Osteoarthitis, run by Abramson Cancer Center at Penn Medicine at 2 sites in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 21 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Marlowe Estioko, BS, MS (267-343-6483, Marlowe.Estioko@Pennmedicine.upenn.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
To measure the percentage of subjects who experience a best response of 1 point or more on BPI-SF (time frame: Within 1 year). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Sep 2026.