HealthyPhase 1NCT07717918
A Study of BL1332 on Capsaicin-Induced Ocular Pain in Healthy Trial Participants
A Phase 1 study testing BL1332 eye drops in people with Healthy, run by Bausch & Lomb Incorporated at 1 site in United States.
Trial summary
Single center, double-masked study of BL1332 on Capsaicin-Induced Ocular Pain in Healthy Subjects Read more about this study
- Who is it for?
- Ages 18 to 65 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy
- What is being tested?
- BL1332 eye drops
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 28 participants
- Where
- 1 siteUnited States
- Study dates
- 6 Jul 2026to 5 Aug 2026
- Phase
- Phase 1
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Male or female ≥ 18 to ≤ 65 years of age.
- In good health, as assessed at Screening by the Investigator from past medical history, physical examination (abbreviated), and laboratory tests.
- Does not wear contact lenses, or is willing to refrain from wearing contact lenses for the duration of the study.
Who cannot join
- Women of childbearing potential or non-vasectomized males with partners of childbearing potential are not eligible unless they are using an effective method of contraception and agree to use an effective method of contraception until at least 30 days after study treatment.
- Any medical condition (systemic or ophthalmic) that may, in the opinion of the Investigator, preclude the safe administration of IP, safe participation in this study, or confound the assessment of safety or efficacy.
- Unwilling or unable to comply with the study protocol.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: A Phase 1B Study of BL1332 on Capsaicin-Induced Ocular Pain in Healthy Subjects
Single center, double-masked study of BL1332 on Capsaicin-Induced Ocular Pain in Healthy Subjects
- Conditions
- Healthy
- Being tested
- BL1332 eye drops, BL1332 Placebo eye drops
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
BL1332 eye dropsDrug
Taken 1 time
BL1332 Placebo eye dropsDrug
Taken 1 time
| Study group | Role | What they receive |
|---|---|---|
| BL1332 eye drops | Active comparator | Not described Receives: Drug: BL1332 eye drops |
| BL1332 Placebo eye drops | Placebo comparator | Not described Receives: Drug: BL1332 Placebo eye drops |
What is being measured
The primary outcome is the main question the study is designed to answer.
Ocular pain severity assessed by numeric pain rating scale (NPRS)
NPRS scale 0 to 10, with higher score reflecting worse pain
Measured: Assessed 5 seconds post-capsaicin dose
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Jul 2026
- Study start6 Jul 2026
- Primary completion5 Aug 2026
- Study completion5 Aug 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HealthyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 1
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 28 participants (actual)
Sponsor and investigators
- Lead sponsor
- Bausch & Lomb Incorporated
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07717918
- Sponsor's protocol ID
- BL-RX01-BL1332-1102
- Status last verified
- Sep 2026
- First submitted
- 16 Jul 2026
- Last updated
- 10 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- Yes
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 10 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Phase 1B Study of BL1332 on Capsaicin-Induced Ocular Pain in Healthy Subjects
- ClinicalTrials.gov ID
- NCT07717918
- Acronym / sponsor ID
- BL-RX01-BL1332-1102
- Conditions
- Healthy
- Phase
- Phase 1
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 28 participants (actual)
- Lead sponsor
- Bausch & Lomb IncorporatedIndustry (pharma, biotech, devices)
- Study start
- 6 Jul 2026 (actual)
- Primary completion
- 5 Aug 2026 (actual)
- Study completion
- 5 Aug 2026 (actual)
- First posted
- 21 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Single center, double-masked study of BL1332 on Capsaicin-Induced Ocular Pain in Healthy Subjects
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| BL1332 eye drops | Active comparator | Drug: BL1332 eye drops |
| BL1332 Placebo eye drops | Placebo comparator | Drug: BL1332 Placebo eye drops |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Male or female ≥ 18 to ≤ 65 years of age.
- In good health, as assessed at Screening by the Investigator from past medical history, physical examination (abbreviated), and laboratory tests.
- Does not wear contact lenses, or is willing to refrain from wearing contact lenses for the duration of the study.
Key exclusion criteria (3 listed)
- Women of childbearing potential or non-vasectomized males with partners of childbearing potential are not eligible unless they are using an effective method of contraception and agree to use an effective method of contraception until at least 30 days after study treatment.
- Any medical condition (systemic or ophthalmic) that may, in the opinion of the Investigator, preclude the safe administration of IP, safe participation in this study, or confound the assessment of safety or efficacy.
- Unwilling or unable to comply with the study protocol.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| BL1332 eye dropsTaken 1 time | Drug | BL1332 eye drops |
| BL1332 Placebo eye dropsTaken 1 time | Drug | BL1332 Placebo eye drops |
Primary outcome
Ocular pain severity assessed by numeric pain rating scale (NPRS)
Time frame: Assessed 5 seconds post-capsaicin dose
NPRS scale 0 to 10, with higher score reflecting worse pain
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Sep 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 1 study testing BL1332 eye drops in people with Healthy, run by Bausch & Lomb Incorporated at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 10 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 1 studies test a treatment in a small group of people for the first time or in a new way, mainly to check safety and find the right dose.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Ocular pain severity assessed by numeric pain rating scale (NPRS) (time frame: Assessed 5 seconds post-capsaicin dose). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Sep 2026.