Benign Prostate Hypertrophy(BPH)TURPNCT07718256
Bipolar Enucleation of the Prostate Versus Bipolar TURP
A study testing bTURP and BEEP in people with Benign Prostate Hypertrophy(BPH), run by Ain Shams University at 1 site in Egypt.
Trial summary
Bipolar enucleation of the prostate (BEEP) was introduced to treat patients with large prostate. The study compared the functional outcomes and perioperative complications of bipolar TURP and bipolar enucleation of large prostates above 80 gm. Read more about this study
- Who is it for?
- Ages 40 to 80 years, men only
- Conditions the study is for
- Benign Prostate Hypertrophy(BPH)
- What is being tested?
- bTURP and BEEP
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 120 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Jul 2025to 14 Jul 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 80 years
- Men only
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- All male patients above the age of 40 years who presented to the urology clinic in Ain Shams university hospitals with BPH with prostate size 80 - 120 g and have any of the following criteria:
- Voiding symptoms that are poorly responsive to medical treatment (IPSS more than 18 and Qmax less than 15 ml/sec)
- Persistent or recurrent attacks of urine retention due to BPH.
- Large bladder stones from BPH.
- Recurrent UTI due to BPH.
- Severe gross hematuria from BPH.
Who cannot join
- Patients with untreated or active UTI.
- Previous pelvic radiation or pelvicl trauma.
- Patients with anesthesia contraindications such as uncontrolled diabetes mellitus, severe coagulation disorders and severe cardiac diseases.
- Known or suspected neurogenic bladder.
- Urethral stricture or urethral cancer.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: A Comparative Study Of Clinical Outcomes Of Bipolar Enucleation Of The Prostate Versus Bipolar TURP In Management Of Benign Prostatic Hyperplasia : A Randomized Controlled Clinical Trial
Bipolar enucleation of the prostate (BEEP) was introduced to treat patients with large prostate. The study compared the functional outcomes and perioperative complications of bipolar TURP and bipolar enucleation of large prostates above 80 gm.
Read the detailed description
Recent literature suggests that enucleation techniques may provide superior functional results, reduced bleeding, and lower retreatment rates. Nevertheless, there remains limited high-quality randomized controlled data directly comparing bipolar TURP and bipolar enucleation of prostate as a head to head comparison regarding functional outcomes and peri-operative complications.
In this study, a randomized controlled trial was performed to compare bipolar enucleation of the prostate versus bipolar transurethral resection of the prostate in BPH regarding symptoms relief, residual adenoma, urine flow rate and post-operative morbidity.
- Conditions
- Benign Prostate Hypertrophy(BPH)
- Being tested
- bTURP, BEEP
- Medical subject headings
- Prostatic Hyperplasia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
bTURPProcedure or surgery
Also called TURIS
transurethral resection of the prostate by bipolar current
BEEPProcedure or surgery
Also called TUEP
endoscopic enucleation of the prostate by bipolar current
| Study group | Role | What they receive |
|---|---|---|
| bipolar TURP | Active comparator | transurethral resection of the prostate by bipolar current Receives: Procedure: bTURP |
| BEEP | Active comparator | endoscopic enucleation of the prostate by bipolar current Receives: Procedure: BEEP |
What is being measured
The primary outcome is the main question the study is designed to answer.
volume of residual prostatic adenoma
measurement of volume of residual prostatic adenoma post bipolar TURP and BEEP was done by pelvi-abdominal ultrasound
Measured: one month postoperative
change in international prostate symptoms score
The international prostate symptoms score is a patient-completed questionnaire for standardized assessment of lower urinary tract symptoms (LUTS). It includes seven questions that evaluate the following urinary symptoms:
- Weak urinary stream (0 : 5)
- Incomplete bladder emptying (0 : 5)
- Straining during urination (0 : 5)
- Intermittent urine flow (0 : 5)
- Increased urinary frequency (0 : 5)
- Urgency (0 : 5)
- Nocturia (0 : 5) Grade 1 (score = 0 - 7) : Mild LUTS Grade 2 (score = 8 - 19) : Moderate LUTS Grade 3 (score = 20 - 35) : Severe LUTS
Measured: pre-operative, one, three, six and twelve months postoperative
change in maximum urine flow rate(Q max)
Maximum urine flow rate was evaluated by Uroflowmetry
Measured: pre-operative, 1, 3, 6 and 12 months postoperative
Secondary outcomes (2)
change in post voiding residual urine
post voiding residual urine in bladder was evaluated by Trans-abdominal ultrasound
Measured: pre-operative, 1, 3, 6 and 12 months postoperative
operation time
Operation time was calculated from insertion of the cystoscope/resectoscope into the urethra to final removal of the scope
Measured: during operation
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Jul 2026
- Study start1 Jul 2025
- Primary completion30 Jun 2026
- Study completion14 Jul 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Benign Prostate Hypertrophy(BPH)Studies of the same condition, open and under way.
- More trials run by Ain Shams UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- one group had undergone bipolar TURP and the other group had undergone bipolar enucleation of the prostate
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 120 participants (actual)
Sponsor and investigators
- Lead sponsor
- Ain Shams University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Amgad Abdel Aziz, Ain Shams University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07718256
- Sponsor's protocol ID
- FMASU MS 56/2026
- Acronym
- TURP
- Status last verified
- Jul 2026
- First submitted
- 17 Jul 2026
- Last updated
- 31 Jul 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 31 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Comparative Study Of Clinical Outcomes Of Bipolar Enucleation Of The Prostate Versus Bipolar TURP In Management Of Benign Prostatic Hyperplasia : A Randomized Controlled Clinical Trial
- ClinicalTrials.gov ID
- NCT07718256
- Acronym / sponsor ID
- TURP / FMASU MS 56/2026
- Conditions
- Benign Prostate Hypertrophy(BPH)
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 120 participants (actual)
- Lead sponsor
- Ain Shams UniversityUniversity, hospital or other
- Study start
- 1 Jul 2025 (actual)
- Primary completion
- 30 Jun 2026 (actual)
- Study completion
- 14 Jul 2026 (actual)
- First posted
- 21 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Bipolar enucleation of the prostate (BEEP) was introduced to treat patients with large prostate. The study compared the functional outcomes and perioperative complications of bipolar TURP and bipolar enucleation of large prostates above 80 gm.
Detailed description
Recent literature suggests that enucleation techniques may provide superior functional results, reduced bleeding, and lower retreatment rates. Nevertheless, there remains limited high-quality randomized controlled data directly comparing bipolar TURP and bipolar enucleation of prostate as a head to head comparison regarding functional outcomes and peri-operative complications.
In this study, a randomized controlled trial was performed to compare bipolar enucleation of the prostate versus bipolar transurethral resection of the prostate in BPH regarding symptoms relief, residual adenoma, urine flow rate and post-operative morbidity.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
- Model description
- one group had undergone bipolar TURP and the other group had undergone bipolar enucleation of the prostate
| Arm | Type | Receives |
|---|---|---|
| bipolar TURP | Active comparator | Procedure: bTURPtransurethral resection of the prostate by bipolar current |
| BEEP | Active comparator | Procedure: BEEPendoscopic enucleation of the prostate by bipolar current |
Who may qualify
- Ages
- 40 to 80 years
- Sex
- Male only
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- All male patients above the age of 40 years who presented to the urology clinic in Ain Shams university hospitals with BPH with prostate size 80 - 120 g and have any of the following criteria:
- Voiding symptoms that are poorly responsive to medical treatment (IPSS more than 18 and Qmax less than 15 ml/sec)
- Persistent or recurrent attacks of urine retention due to BPH.
- Large bladder stones from BPH.
- Recurrent UTI due to BPH.
Key exclusion criteria (5 listed)
- Patients with untreated or active UTI.
- Previous pelvic radiation or pelvicl trauma.
- Patients with anesthesia contraindications such as uncontrolled diabetes mellitus, severe coagulation disorders and severe cardiac diseases.
- Known or suspected neurogenic bladder.
- Urethral stricture or urethral cancer.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| bTURPAlso: TURIStransurethral resection of the prostate by bipolar current | Procedure or surgery | bipolar TURP |
| BEEPAlso: TUEPendoscopic enucleation of the prostate by bipolar current | Procedure or surgery | BEEP |
Primary outcome
volume of residual prostatic adenoma
Time frame: one month postoperative
measurement of volume of residual prostatic adenoma post bipolar TURP and BEEP was done by pelvi-abdominal ultrasound
change in international prostate symptoms score
Time frame: pre-operative, one, three, six and twelve months postoperative
The international prostate symptoms score is a patient-completed questionnaire for standardized assessment of lower urinary tract symptoms (LUTS). It includes seven questions that evaluate the following urinary symptoms: * Weak urinary stream (0 : 5) * Incomplete bladder emptying (0 : 5) * Straining during urination (0 : 5) * Intermittent urine flow (0 : 5) * Increased urinary frequency (0 : 5) * Urgency (0 : 5) * Nocturia (0 : 5) Grade 1 (score = 0 - 7) : Mild LUTS Grade 2 (score = 8 - 19) : Moderate LUTS Grade 3 (score = 20 - 35) : Severe LUTS
change in maximum urine flow rate(Q max)
Time frame: pre-operative, 1, 3, 6 and 12 months postoperative
Maximum urine flow rate was evaluated by Uroflowmetry
2 secondary outcomes
change in post voiding residual urine
Time frame: pre-operative, 1, 3, 6 and 12 months postoperative
operation time
Time frame: during operation
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 31 Jul 2026.
- Individual participant dataSharing planned: No
Related trials for Benign Prostate Hypertrophy(BPH)
Recruiting
Clinical Study on Prostate Thermal Vapor Ablation Guided by MRI/TRUS Fusion Imaging
Benign Prostatic Hyperplasia (BPH)
Active, not recruitingPhase 4
Standard Versus Double Alpha Blockers Treatment for Symptomatic Benign Prostatic Obstruction
BPH (Benign Prostatic Hyperplasia)
Recruiting
Learning Curve of Tri-lobar HoLEP Versus En-bloc HoLEP
Benign Prostatic Hyperplasia With Outflow Obstruction
RecruitingObservational study
Impact of Long-term Dutasteride Use on Perioperative Outcomes of HoLEP
Prostatic Hyperplasia, Benign
Not yet recruitingPhase 4
Perioperative Dutasteride for Hemorrhage Control in Bipolar TURP Under Anticoagulation.
Benign Prostatic Hyperplasia, Postoperative Hemorrhage
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing bTURP and BEEP in people with Benign Prostate Hypertrophy(BPH), run by Ain Shams University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 31 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
volume of residual prostatic adenoma (time frame: one month postoperative). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 31 Jul 2026.