Removal of Intracanal MedicationCa(OH)2- CBCTNCT07719985
Removal of Intracanal Medicaments by Different Techniques Using Cone Beam Computed Tomography Analysis
A study testing Manual Dynamic Agitation, Sonic Activation and XP-Endo Finisher Activation in people with Removal of Intracanal Medication, run by Tanta University at 2 sites in Egypt.
Trial summary
the goal of this study is to evaluate the efficency of different activation techniques in removal of intracanal medication using cone beam computed tomography analysis Read more about this study
- Who is it for?
- Ages 20 to 40 years
- Conditions the study is for
- Removal of Intracanal Medication
- What is being tested?
- Manual Dynamic Agitation, Sonic Activation and XP-Endo Finisher Activation
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 2 sitesEgypt
- Study dates
- 4 Aug 2026to Mar 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 40 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Restorable mature non-vital single canal anterior tooth with or without signs of periapical pathosis.
- Teeth without anatomical variations
- Medically free patients
Who cannot join
- Non-restorable tooth
- Retreatment cases
- Teeth with root fractures
- Teeth with root resorption
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt2 sites, 2 recruiting
- Recruiting
Tanta University, Faculty of Dentistry
Tanta, Gharbia Governorate, 31527
Mahmoud Basuoni Basuoni Aboseira, Investigator / Study Contact, +1019469738, PG_194464@dent.tanta.edu.eg
- Not yet recruiting
Faculty of Dentistry, Tanta University
Tanta, Gharbia Governorate, 31773
Mahmoud B Basuoni Aboseira, BDS, +1019469738, PG_194464@dent.tanta.edu.eg
Ahmed h labib, professor of endodontics
About this study
Official title: "Removal of Intracanal Medicament by Different Techniques: (Cone Beam Computed Tomography Analysis) (Clinical Study)"
the goal of this study is to evaluate the efficency of different activation techniques in removal of intracanal medication using cone beam computed tomography analysis
Read the detailed description
the primary etiological factors for pulpal and periradicular diseases are microorganisms. Therefore, the primary purpose of endodontic treatment is to completely eradicate microorganisms from the root canal. This is achieved through chemo-mechanical preparation of the canal, which includes proper cleaning and shaping by instrumentation and irrigation.
Complexity of the root canal system compromises the eradication of microorganisms completely by traditional methods. The remaining bacteria may multiply between appointments and reach the same previous concentration. Therefore, intracanal medicaments play an important role in canal disinfection.
Intracanal medication becomes more necessary in cases involving bacteria that are resistant to routine treatment, as well as in situations where successful completion of therapy is hindered by persistent pain or continuous exudate.
The concept is to temporarily fill the root canal with a material that would chemically and physically enhance eradication and prevent the proliferation of microorganisms.
The most commonly used intracanal medicament is calcium hydroxide (Ca(OH)2), Through releasing hydroxyl ions disrupts the structural integrity of bacterial cytoplasmic membranes. In addition, Ca(OH)₂ indirectly affects anaerobic microorganisms within the root canal through a reaction between calcium ions and aqueous carbon dioxide, resulting in degradation of bacterial lipopolysaccharides.
Moreover, the biological properties of Ca(OH)₂ as antimicrobial action, induction of hard tissue deposition, and promotion of improved tissue repair all of this make that it considered as the material of choice of intracanal medicament.
However , despite its benefits, Ca (OH)₂ remnants on the canal walls showed multiple disadvantages such as; affecting sealer penetration into dentinal tubules, weakening their final bond to dentin and delaying the setting of some sealers such as zinc oxide eugenol so, Ca (OH)₂ remnants still one of the obstacles during complete the root canal obturation and interference with the physical properties of sealers has been shown to increase apical leakage and eventually compromise the outcome of endodontic treatment.
Additional disadvantages of Ca (OH)₂ include the challenge of removing it from the root canal walls and complete removal of it prior to final obturation is critical. However, manual irrigation alone was unable to completely remove intracanal medicament regardless of the agent use Numerous methods have been suggested for the removal of Ca (OH)₂ from the root canal such as : (1) Manual irrigation with a syringe (2) Manual dynamic agitation (3) Canal brush (4) Passive ultrasonic irrigation (5) Sonic irrigation (6) XP-shaper (7) XP-finisher (8) Rins Endo (9) Endo vac Numerous methods have been used to assess the amount of Ca (OH)₂ remnants within the root canal. These include digital photographs, stereomicroscopy, scanning electron microscopy, and micro-computed tomography.
However, the recent availability of cone beam computed tomography (CBCT) is considered an accurate, noninvasive imaging technique and has been employed to evaluate the quantity of residual intracanal calcium hydroxide. CBCT provides a three-dimensional volume measurement without the need to section the specimens Group assignment
Patients will be randomly divided into three equally treated groups (n=10) According to the type of activation technique as follow:
Group 1: Manual Dynamic Agitation (MDA)* Group 2: Sonic Activation† Group 3: XP-finisher activation‡
After intracanal medicament placement, the volume of the medicament will be measured using CBCT analysis software†††. The patient will then be recalled after one week[19]. At the recall visit, the tooth will be isolated and the intracanal medicament will be removed according to the assigned group:
Group 1: MDA Group 2: Sonic Activation Group3: XP-finisher activation Following intracanal medicament removal according to each group, a second CBCT scan will be taken for evaluation. CBCT interpretation will be used to detect the remnants of intracanal medicament and measure its volume using the cone-beam analysis software After image evaluation, the canal will be dried with sterile paper points, and root canal obturation will be performed using gutta-percha cone* and a resin-based sealer*, employing the cold lateral condensation technique.
- Conditions
- Removal of Intracanal Medication
- Being tested
- Manual Dynamic Agitation, Sonic Activation, XP-Endo Finisher Activation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Manual Dynamic AgitationProcedure or surgery
Manual dynamic agitation was used for the removal of intracanal calcium hydroxide following standardized root canal preparation and irrigation.
Sonic ActivationProcedure or surgery
Sonic activation was used for the removal of intracanal calcium hydroxide following standardized root canal preparation and irrigation.
XP-Endo Finisher ActivationProcedure or surgery
XP-Endo Finisher activation was used for the removal of intracanal calcium hydroxide following standardized root canal preparation and irrigation.
| Study group | Role | What they receive |
|---|---|---|
| Manual Dynamic Agitation (MDA) | Experimental | Removal of intracanal calcium hydroxide using manual dynamic agitation Receives: Procedure: Manual Dynamic Agitation |
| Sonic Activation | Experimental | Removal of intracanal calcium hydroxide using sonic activation Receives: Procedure: Sonic Activation |
| XP-Endo Finisher Activation | Experimental | Removal of intracanal calcium hydroxide using XP-Endo Finisher activation Receives: Procedure: XP-Endo Finisher Activation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Volume of Remnants of Intracanal Calcium Hydroxide
The volume of remnants of intracanal calcium hydroxide after removal using the assigned activation technique, measured by cone beam computed tomography (CBCT).
Measured: 1 week after intracanal medicament placement
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Jul 2026
- Study start4 Aug 2026
- Primary completionFeb 2027 (estimated)
- Study completionMar 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Removal of Intracanal MedicationStudies of the same condition, open and under way.
- More trials run by Tanta UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Tanta University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mahmoud Basuoni Basuoni Aboseira, Tanta University
- Investigators
- Ahmed H Labib, professor of endodontics, Principal investigator, Faculty of Dentistry, Tanta UniversityMohammed F Ali Mansour, lecturer of endodontics, Study director, Faculty of Dentistry, Tanta University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07719985
- Sponsor's protocol ID
- END/5-26/3587
- Acronym
- Ca(OH)2- CBCT
- Status last verified
- Oct 2026
- First submitted
- 17 Jul 2026
- Last updated
- 6 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 6 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- "Removal of Intracanal Medicament by Different Techniques: (Cone Beam Computed Tomography Analysis) (Clinical Study)"
- ClinicalTrials.gov ID
- NCT07719985
- Acronym / sponsor ID
- Ca(OH)2- CBCT / END/5-26/3587
- Conditions
- Removal of Intracanal Medication
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Tanta UniversityUniversity, hospital or other
- Study start
- 4 Aug 2026 (actual)
- Primary completion
- Feb 2027 (estimated)
- Study completion
- Mar 2027 (estimated)
- First posted
- 22 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
the goal of this study is to evaluate the efficency of different activation techniques in removal of intracanal medication using cone beam computed tomography analysis
Detailed description
the primary etiological factors for pulpal and periradicular diseases are microorganisms. Therefore, the primary purpose of endodontic treatment is to completely eradicate microorganisms from the root canal. This is achieved through chemo-mechanical preparation of the canal, which includes proper cleaning and shaping by instrumentation and irrigation.
Complexity of the root canal system compromises the eradication of microorganisms completely by traditional methods. The remaining bacteria may multiply between appointments and reach the same previous concentration. Therefore, intracanal medicaments play an important role in canal disinfection.
Intracanal medication becomes more necessary in cases involving bacteria that are resistant to routine treatment, as well as in situations where successful completion of therapy is hindered by persistent pain or continuous exudate.
The concept is to temporarily fill the root canal with a material that would chemically and physically enhance eradication and prevent the proliferation of microorganisms.
The most commonly used intracanal medicament is calcium hydroxide (Ca(OH)2), Through releasing hydroxyl ions disrupts the structural integrity of bacterial cytoplasmic membranes. In addition, Ca(OH)₂ indirectly affects anaerobic microorganisms within the root canal through a reaction between calcium ions and aqueous carbon dioxide, resulting in degradation of bacterial lipopolysaccharides.
Moreover, the biological properties of Ca(OH)₂ as antimicrobial action, induction of hard tissue deposition, and promotion of improved tissue repair all of this make that it considered as the material of choice of intracanal medicament.
However , despite its benefits, Ca (OH)₂ remnants on the canal walls showed multiple disadvantages such as; affecting sealer penetration into dentinal tubules, weakening their final bond to dentin and delaying the setting of some sealers such as zinc oxide eugenol so, Ca (OH)₂ remnants still one of the obstacles during complete the root canal obturation and interference with the physical properties of sealers has been shown to increase apical leakage and eventually compromise the outcome of endodontic treatment.
Additional disadvantages of Ca (OH)₂ include the challenge of removing it from the root canal walls and complete removal of it prior to final obturation is critical. However, manual irrigation alone was unable to completely remove intracanal medicament regardless of the agent use Numerous methods have been suggested for the removal of Ca (OH)₂ from the root canal such as : (1) Manual irrigation with a syringe (2) Manual dynamic agitation (3) Canal brush (4) Passive ultrasonic irrigation (5) Sonic irrigation (6) XP-shaper (7) XP-finisher (8) Rins Endo (9) Endo vac Numerous methods have been used to assess the amount of Ca (OH)₂ remnants within the root canal. These include digital photographs, stereomicroscopy, scanning electron microscopy, and micro-computed tomography.
However, the recent availability of cone beam computed tomography (CBCT) is considered an accurate, noninvasive imaging technique and has been employed to evaluate the quantity of residual intracanal calcium hydroxide. CBCT provides a three-dimensional volume measurement without the need to section the specimens Group assignment
Patients will be randomly divided into three equally treated groups (n=10) According to the type of activation technique as follow:
Group 1: Manual Dynamic Agitation (MDA)* Group 2: Sonic Activation† Group 3: XP-finisher activation‡
After intracanal medicament placement, the volume of the medicament will be measured using CBCT analysis software†††. The patient will then be recalled after one week[19]. At the recall visit, the tooth will be isolated and the intracanal medicament will be removed according to the assigned group:
Group 1: MDA Group 2: Sonic Activation Group3: XP-finisher activation Following intracanal medicament removal according to each group, a second CBCT scan will be taken for evaluation. CBCT interpretation will be used to detect the remnants of intracanal medicament and measure its volume using the cone-beam analysis software After image evaluation, the canal will be dried with sterile paper points, and root canal obturation will be performed using gutta-percha cone* and a resin-based sealer*, employing the cold lateral condensation technique.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Manual Dynamic Agitation (MDA) | Experimental | Procedure: Manual Dynamic AgitationRemoval of intracanal calcium hydroxide using manual dynamic agitation |
| Sonic Activation | Experimental | Procedure: Sonic ActivationRemoval of intracanal calcium hydroxide using sonic activation |
| XP-Endo Finisher Activation | Experimental | Procedure: XP-Endo Finisher ActivationRemoval of intracanal calcium hydroxide using XP-Endo Finisher activation |
Who may qualify
- Ages
- 20 to 40 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Restorable mature non-vital single canal anterior tooth with or without signs of periapical pathosis.
- Teeth without anatomical variations
- Medically free patients
Key exclusion criteria (4 listed)
- Non-restorable tooth
- Retreatment cases
- Teeth with root fractures
- Teeth with root resorption
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Manual Dynamic AgitationManual dynamic agitation was used for the removal of intracanal calcium hydroxide following standardized root canal preparation and irrigation. | Procedure or surgery | Manual Dynamic Agitation (MDA) |
| Sonic ActivationSonic activation was used for the removal of intracanal calcium hydroxide following standardized root canal preparation and irrigation. | Procedure or surgery | Sonic Activation |
| XP-Endo Finisher ActivationXP-Endo Finisher activation was used for the removal of intracanal calcium hydroxide following standardized root canal preparation and irrigation. | Procedure or surgery | XP-Endo Finisher Activation |
Primary outcome
Volume of Remnants of Intracanal Calcium Hydroxide
Time frame: 1 week after intracanal medicament placement
The volume of remnants of intracanal calcium hydroxide after removal using the assigned activation technique, measured by cone beam computed tomography (CBCT).
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Oct 2026.
- Individual participant dataSharing planned: No
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Ahmed H Labib, professor of endodontics principal investigator
Faculty of Dentistry, Tanta University
Mohammed F Ali Mansour, lecturer of endodontics study director
Faculty of Dentistry, Tanta University
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Manual Dynamic Agitation, Sonic Activation and XP-Endo Finisher Activation in people with Removal of Intracanal Medication, run by Tanta University at 2 sites in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 6 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Mahmoud B Basuoni Aboseira, BDS (+21019469738, PG_191164@dent.tanta.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Volume of Remnants of Intracanal Calcium Hydroxide (time frame: 1 week after intracanal medicament placement). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Oct 2026.