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Removal of Intracanal MedicationCa(OH)2- CBCTNCT07719985

Removal of Intracanal Medicaments by Different Techniques Using Cone Beam Computed Tomography Analysis

A study testing Manual Dynamic Agitation, Sonic Activation and XP-Endo Finisher Activation in people with Removal of Intracanal Medication, run by Tanta University at 2 sites in Egypt.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
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Trial summary

the goal of this study is to evaluate the efficency of different activation techniques in removal of intracanal medication using cone beam computed tomography analysis Read more about this study

Who is it for?
Ages 20 to 40 years
Conditions the study is for
Removal of Intracanal Medication
What is being tested?
Manual Dynamic Agitation, Sonic Activation and XP-Endo Finisher Activation
Type of treatment
Surgery or procedure
Could I receive a placebo?
No, everyone receives an active treatment
How many people
30 participants
Where
2 sitesEgypt
Study dates
4 Aug 2026to Mar 2027
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 20 to 40 years
  • All sexes
  • No healthy volunteers
  • Adult

Who may be able to join

  • Restorable mature non-vital single canal anterior tooth with or without signs of periapical pathosis.
  • Teeth without anatomical variations
  • Medically free patients

Who cannot join

  • Non-restorable tooth
  • Retreatment cases
  • Teeth with root fractures
  • Teeth with root resorption

Trial locations and contacts

2 sites in 1 country. Contact the study team or a site near you to ask about taking part.

Mahmoud B Basuoni Aboseira, BDS contact

+21019469738

PG_191164@dent.tanta.edu.eg

Egypt2 sites, 2 recruiting
  • Tanta University, Faculty of Dentistry

    Tanta, Gharbia Governorate, 31527

    Mahmoud Basuoni Basuoni Aboseira, Investigator / Study Contact, +1019469738, PG_194464@dent.tanta.edu.eg

    Recruiting
  • Faculty of Dentistry, Tanta University

    Tanta, Gharbia Governorate, 31773

    Mahmoud B Basuoni Aboseira, BDS, +1019469738, PG_194464@dent.tanta.edu.eg

    Ahmed h labib, professor of endodontics

    Not yet recruiting

Other trials in Egypt

About this study

Official title: "Removal of Intracanal Medicament by Different Techniques: (Cone Beam Computed Tomography Analysis) (Clinical Study)"

the goal of this study is to evaluate the efficency of different activation techniques in removal of intracanal medication using cone beam computed tomography analysis

Read the detailed description

the primary etiological factors for pulpal and periradicular diseases are microorganisms. Therefore, the primary purpose of endodontic treatment is to completely eradicate microorganisms from the root canal. This is achieved through chemo-mechanical preparation of the canal, which includes proper cleaning and shaping by instrumentation and irrigation.

Complexity of the root canal system compromises the eradication of microorganisms completely by traditional methods. The remaining bacteria may multiply between appointments and reach the same previous concentration. Therefore, intracanal medicaments play an important role in canal disinfection.

Intracanal medication becomes more necessary in cases involving bacteria that are resistant to routine treatment, as well as in situations where successful completion of therapy is hindered by persistent pain or continuous exudate.

The concept is to temporarily fill the root canal with a material that would chemically and physically enhance eradication and prevent the proliferation of microorganisms.

The most commonly used intracanal medicament is calcium hydroxide (Ca(OH)2), Through releasing hydroxyl ions disrupts the structural integrity of bacterial cytoplasmic membranes. In addition, Ca(OH)₂ indirectly affects anaerobic microorganisms within the root canal through a reaction between calcium ions and aqueous carbon dioxide, resulting in degradation of bacterial lipopolysaccharides.

Moreover, the biological properties of Ca(OH)₂ as antimicrobial action, induction of hard tissue deposition, and promotion of improved tissue repair all of this make that it considered as the material of choice of intracanal medicament.

However , despite its benefits, Ca (OH)₂ remnants on the canal walls showed multiple disadvantages such as; affecting sealer penetration into dentinal tubules, weakening their final bond to dentin and delaying the setting of some sealers such as zinc oxide eugenol so, Ca (OH)₂ remnants still one of the obstacles during complete the root canal obturation and interference with the physical properties of sealers has been shown to increase apical leakage and eventually compromise the outcome of endodontic treatment.

Additional disadvantages of Ca (OH)₂ include the challenge of removing it from the root canal walls and complete removal of it prior to final obturation is critical. However, manual irrigation alone was unable to completely remove intracanal medicament regardless of the agent use Numerous methods have been suggested for the removal of Ca (OH)₂ from the root canal such as : (1) Manual irrigation with a syringe (2) Manual dynamic agitation (3) Canal brush (4) Passive ultrasonic irrigation (5) Sonic irrigation (6) XP-shaper (7) XP-finisher (8) Rins Endo (9) Endo vac Numerous methods have been used to assess the amount of Ca (OH)₂ remnants within the root canal. These include digital photographs, stereomicroscopy, scanning electron microscopy, and micro-computed tomography.

However, the recent availability of cone beam computed tomography (CBCT) is considered an accurate, noninvasive imaging technique and has been employed to evaluate the quantity of residual intracanal calcium hydroxide. CBCT provides a three-dimensional volume measurement without the need to section the specimens Group assignment

Patients will be randomly divided into three equally treated groups (n=10) According to the type of activation technique as follow:

Group 1: Manual Dynamic Agitation (MDA)* Group 2: Sonic Activation† Group 3: XP-finisher activation‡

After intracanal medicament placement, the volume of the medicament will be measured using CBCT analysis software†††. The patient will then be recalled after one week[19]. At the recall visit, the tooth will be isolated and the intracanal medicament will be removed according to the assigned group:

Group 1: MDA Group 2: Sonic Activation Group3: XP-finisher activation Following intracanal medicament removal according to each group, a second CBCT scan will be taken for evaluation. CBCT interpretation will be used to detect the remnants of intracanal medicament and measure its volume using the cone-beam analysis software After image evaluation, the canal will be dried with sterile paper points, and root canal obturation will be performed using gutta-percha cone* and a resin-based sealer*, employing the cold lateral condensation technique.

Being tested
Manual Dynamic Agitation, Sonic Activation, XP-Endo Finisher Activation

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Manual Dynamic AgitationProcedure or surgery

    Manual dynamic agitation was used for the removal of intracanal calcium hydroxide following standardized root canal preparation and irrigation.

  • Sonic ActivationProcedure or surgery

    Sonic activation was used for the removal of intracanal calcium hydroxide following standardized root canal preparation and irrigation.

  • XP-Endo Finisher ActivationProcedure or surgery

    XP-Endo Finisher activation was used for the removal of intracanal calcium hydroxide following standardized root canal preparation and irrigation.

Study groups in NCT07719985
Study groupRoleWhat they receive
Manual Dynamic Agitation (MDA)ExperimentalRemoval of intracanal calcium hydroxide using manual dynamic agitation
Receives: Procedure: Manual Dynamic Agitation
Sonic ActivationExperimentalRemoval of intracanal calcium hydroxide using sonic activation
Receives: Procedure: Sonic Activation
XP-Endo Finisher ActivationExperimentalRemoval of intracanal calcium hydroxide using XP-Endo Finisher activation
Receives: Procedure: XP-Endo Finisher Activation

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Volume of Remnants of Intracanal Calcium Hydroxide

    The volume of remnants of intracanal calcium hydroxide after removal using the assigned activation technique, measured by cone beam computed tomography (CBCT).

    Measured: 1 week after intracanal medicament placement

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted22 Jul 2026
  2. Study start4 Aug 2026
  3. Primary completionFeb 2027 (estimated)
  4. Study completionMar 2027 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
None (open label)
Enrolment
30 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07719985
Sponsor's protocol ID
END/5-26/3587
Acronym
Ca(OH)2- CBCT
Status last verified
Oct 2026
First submitted
17 Jul 2026
Last updated
6 Oct 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Questions about this trial

What is this clinical trial studying?

A study testing Manual Dynamic Agitation, Sonic Activation and XP-Endo Finisher Activation in people with Removal of Intracanal Medication, run by Tanta University at 2 sites in Egypt.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 6 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 2 sites in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Mahmoud B Basuoni Aboseira, BDS (+21019469738, PG_191164@dent.tanta.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Volume of Remnants of Intracanal Calcium Hydroxide (time frame: 1 week after intracanal medicament placement). It is what the study was designed to measure, not a finding.

Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Oct 2026.

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