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Parkinson DiseaseNCT07723027

Effects of Whole Body Vibration Versus Proprioceptive Neuromuscular Facilitation Pattern With Rhythmic Based Training on Clinical Outcomes in Patients With Parkinson's Disease.

A study testing Whole Body Vibration with Rhythmic Based Training and Proprioceptive Neuromuscular Facilitation Pattern with Rhythm-Based Training in people with Parkinson Disease, run by Lahore University of Biological and Applied Sciences at 1 site in Pakistan.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

This study has important clinical, academic, and practical relevance in neuromuscular rehabilitation. Clinically, it aims to identify effective and tolerable rehabilitation strategies for individuals with Parkinson's disease by comparing whole-body vibration therapy with proprioceptive neuromuscular facilitation (PNF)… Read more about this study

Who is it for?
Ages 40 to 60 years
Conditions the study is for
Parkinson Disease
What is being tested?
Whole Body Vibration with Rhythmic Based Training and Proprioceptive Neuromuscular Facilitation Pattern with Rhythm-Based Training
Could I receive a placebo?
No, everyone receives an active treatment
How many people
42 participants
Where
1 sitePakistan
Study dates
1 May 2026to 9 Jul 2026
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 40 to 60 years
  • All sexes
  • No healthy volunteers
  • Adult

Who may be able to join

  • Age between 40 and 60 years.
  • Patients of both genders (male and female).
  • Parkinson's disease severity at Hoehn and Yahr (H\&Y) stage 2 and 3.
  • Ability to walk independently for 6 minutes without an assistive device.
  • Score greater than 40 on the Berg Balance Scale.

Who cannot join

  • Presence of impaired Cognition.
  • Significant Orthopedic and Musculoskeletal conditions that limit the adherence to exercise and WBV requirements.
  • Other medical conditions like thrombosis, cardiovascular conditions and medical implants that are contradicted for WBV.

Trial locations and contacts

1 site in 1 country.

Pakistan1 site
  • THQ Shakargarh

    Shakargarh, Punjab Province, 51580

Other trials in Pakistan

About this study

This study has important clinical, academic, and practical relevance in neuromuscular rehabilitation. Clinically, it aims to identify effective and tolerable rehabilitation strategies for individuals with Parkinson's disease by comparing whole-body vibration therapy with proprioceptive neuromuscular facilitation (PNF) patterns combined with rhythmic-based training, thereby supporting evidence-based physiotherapy practice and improving patient adherence. Academically, it contributes to the limited literature on comparative effectiveness of these interventions and incorporates patient-centered outcomes such as exercise perception, which are often underreported. From a practical and societal perspective, identifying a more acceptable and effective approach may enhance long-term participation in rehabilitation, potentially slow disease progression, improve quality of life, and reduce the overall healthcare burden associated with Parkinson's disease.

Read the detailed description

Parkinson's disease is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, leading to motor symptoms such as tremor, rigidity, bradykinesia, and postural instability. It also presents with non-motor symptoms including cognitive decline, autonomic dysfunction, and reduced quality of life. The title of the present study focuses on evaluating the effectiveness of a combined rehabilitation approach integrating rhythmic-based training, whole-body vibration, and proprioceptive neuromuscular facilitation to improve gait, balance, and functional mobility in individuals with Parkinson's disease. The proposed protocols involve structured rhythmic auditory cueing exercises to enhance movement coordination and timing, whole-body vibration sessions aimed at improving neuromuscular activation and muscle strength, and proprioceptive neuromuscular facilitation techniques to facilitate motor control, flexibility, and functional movement patterns; these interventions are delivered in a progressive manner, tailored to patient tolerance and disease severity, with close monitoring to ensure safety and adherence. The study design is a randomized clinical trial with two experimental groups. The study duration is expected to span 8 to 12 weeks, allowing sufficient time for neuromuscular adaptations and observable functional improvements while maintaining feasibility and participant compliance. Outcome measures include standardized and validated tools such as the Unified Parkinson's Disease Rating Scale for assessing disease severity, the Timed Up and Go test for functional mobility, the 10-Meter Walk Test for gait speed, the Mini-BESTest for dynamic balance, and quality of life scales to evaluate overall patient well-being; these measures are recorded at baseline and post-intervention to determine the effectiveness of the combined rehabilitation protocol, providing comprehensive insight into motor performance, balance control, and functional independence in individuals with Parkinson's disease.

Being tested
Whole Body Vibration with Rhythmic Based Training, Proprioceptive Neuromuscular Facilitation Pattern with Rhythm-Based Training
Keywords
Whole Body Vibration, Proprioceptive Neuromuscular Facilitation Pattern, Rhythmic Based Training, Clinical Outcomes
Medical subject headings
Parkinson Disease

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Whole Body Vibration with Rhythmic Based TrainingOther

    WBV will be applied during standing exercises using a vibration platform set at a frequency of 11 Hz and an amplitude of 3-6 mm (vertical oscillation). The intervention will be administered in intermittent cycles of 1 minute of vibration followed by 1 minute of rest, with a total cumulative exposure of 10-14 minutes per session (5-7 bouts). Concurrently, RBT will be delivered using an auditory metronome providing rhythmic cues synchronized with the exercise movements, with the tempo maintained between 110-130 beats per minute (BPM) to facilitate timing, coordination, and motor performance.

  • Proprioceptive Neuromuscular Facilitation Pattern with Rhythm-Based TrainingOther

    The patient will perform PNF Rhythmic Initiation (RI) D1 flexion and extension patterns for both upper and lower extremities in standing. The D1 flexion pattern involves shoulder extension, abduction, and external rotation progressing to flexion, adduction, and internal rotation, while the D1 extension pattern represents the reverse movement. The exercise will be progressed from passive to active-assisted and then to active-resistive movements to facilitate motor control and movement initiation. In addition, Rhythm-Based Training (RBT) will be applied using an auditory metronome to provide rhythmic cues synchronized with the active phase of the PNF movements, particularly during transitions between flexion and extension, with a consistent tempo of 110-130 beats per minute (BPM).

Study groups in NCT07723027
Study groupRoleWhat they receive
Whole Body Vibration with Rhythmic Based TrainingExperimentalWhole Body Vibration (WBV) and Rhythm-Based Training (RBT) are adjunct therapeutic interventions used to enhance functional mobility, balance, and motor coordination. WBV provides mechanical oscillatory stimuli to the body through a vibration platform, aiming to improve neuromuscular activation and postural control. RBT utilizes external auditory cues to guide movement timing, promoting auditory-motor entrainment and improving movement coordination and gait performance.
Receives: Other: Whole Body Vibration with Rhythmic Based Training
Proprioceptive Neuromuscular Facilitation Pattern with Rhythmic Based TrainingExperimentalProprioceptive Neuromuscular Facilitation (PNF) Rhythmic Initiation (RI) D1 patterns combined with Rhythm-Based Training (RBT) are used to facilitate motor learning, improve movement initiation, and enhance neuromuscular coordination. The D1 flexion and extension patterns of PNF target coordinated multi-planar upper and lower limb movements, progressing through passive, active-assisted, and active-resistive phases to improve motor control, normalize muscle tone, and increase movement efficiency. RBT provides external auditory cueing to enhance timing and rhythmic synchronization of voluntary movement.
Receives: Other: Proprioceptive Neuromuscular Facilitation Pattern with Rhythm-Based Training

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Timed Up and Go (TUG) Test

    The Timed Up and Go (TUG) test is a simple functional mobility assessment that measures the time taken (in seconds) to stand from a chair, walk 3 meters, turn, walk back, and sit down. It evaluates balance, gait, and functional mobility in a single task. Lower scores indicate better performance, with <10 seconds considered normal, 10-20 seconds indicating mostly independent mobility, and >20 seconds suggesting functional limitation. It is also commonly used as an indicator of fall risk, especially in neurological populations such as Parkinson's disease.

    Measured: [Time Frame: baseline, 8 weeks (post intervention), 12 weeks (follow up)]

  2. Unified Parkinson's Disease Rating Scale - Part III (UPDRS-III)

    The Unified Parkinson's Disease Rating Scale (UPDRS-III) is a clinician-administered tool used to evaluate motor impairment in Parkinson's disease. It assesses key motor domains including tremor, rigidity, bradykinesia, posture, gait, and postural stability through direct observation. Each item is scored on a 0-4 scale, where 0 represents normal function and 4 indicates severe impairment, with a maximum total score of 132. Higher scores reflect greater motor dysfunction. The scale is widely used for monitoring disease severity and progression in both clinical and research settings.

    Measured: [Time Frame: baseline, 8 weeks (post intervention), 12 weeks (follow up)]

  3. Mini-Balance Evaluation Systems Test (Mini-BESTest)

    The Mini-BESTest is a clinical balance assessment designed to evaluate dynamic balance and postural control across multiple systems, including anticipatory postural adjustments, reactive postural control, sensory orientation, and gait stability. It consists of 14 items scored from 0 to 2, with a total score ranging from 0 to 28, where higher scores indicate better balance performance. It is particularly sensitive in detecting balance impairments and fall risk in individuals with neurological conditions such as Parkinson's disease.

    Measured: [Time Frame: baseline, 8 weeks (post intervention), 12 weeks (follow up)]

  4. 10-Meter Walk Test (10MWT)

    The 10-Meter Walk Test (10MWT) is a standardized measure of gait speed, where the time taken to walk a central 10-meter distance is recorded and converted into meters per second (m/s). It assesses functional walking ability and mobility performance. The test can be performed at a comfortable or fast pace to evaluate functional capacity. It is widely used in Parkinson's disease to monitor gait impairments and response to rehabilitation, as gait speed is a strong indicator of overall functional status.

    Measured: [Time Frame: baseline, 8 weeks (post intervention), 12 weeks (follow up)]

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted23 Jul 2026
  2. Study start1 May 2026
  3. Primary completion9 Jul 2026
  4. Study completion9 Jul 2026

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Model description
This study will use a parallel-group randomized clinical design, with participants randomly allocated into two intervention groups. Group A will receive Whole Body Vibration (WBV) combined with Rhythm-Based Training (RBT), where participants perform standing exercises such as weight shifting and mini-squats on a vibrating platform at 11 Hz frequency and 3-6 mm amplitude, applied in 1-minute bouts with 1-minute rest intervals for a total of 10-14 minutes. Rhythmic auditory cueing using a metronome set at 110-130 BPM will be provided concurrently or prior to enhance coordination and movement timing, with sessions conducted 2-3 times per week. Group B will receive Proprioceptive Neuromuscular Facilitation (PNF) using Rhythmic Initiation D1 flexion and extension patterns in standing, progressing from passive to active and resistive movements, structured in 1-minute work and rest intervals, with integrated rhythmic cueing at 110-130 BPM to improve motor control and functional performance.
Masking
Double blind
Who is masked
Participant, Outcomes assessor
Enrolment
42 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07723027
Sponsor's protocol ID
UBAS/ERB/26/04/038
Status last verified
Jul 2026
First submitted
20 Jul 2026
Last updated
23 Jul 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Publications

  • Chang CM, Tsai CH, Lu MK, Tseng HC, Lu G, Liu BL, Lin HC. The neuromuscular responses in patients with Parkinson's disease under different conditions during whole-body vibration training. BMC Complement Med Ther. 2022 Jan 3;22(1):2. doi: 10.1186/s12906-021-03481-1.

    PubMed 34980075

Questions about this trial

What is this clinical trial studying?

A study testing Whole Body Vibration with Rhythmic Based Training and Proprioceptive Neuromuscular Facilitation Pattern with Rhythm-Based Training in people with Parkinson Disease, run by Lahore University of Biological and Applied Sciences at 1 site in Pakistan.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 23 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Timed Up and Go (TUG) Test (time frame: [Time Frame: baseline, 8 weeks (post intervention), 12 weeks (follow up)]). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07723027, which also lists 1 linked publication.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Jul 2026.

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